scholarly journals A retrospective case series of computer-controlled total intravenous anaesthesia in dogs presented for neurosurgery

Author(s):  
K.E. Joubert ◽  
N. Keller ◽  
C.J. Du Plessis

This article describes the anaesthetic management and use of total intravenous anaesthesia (TIVA) for neurosurgery in 4 dogs. Propofol in conjunction with morphine was used for the maintenance of anaesthesia. Anaesthesia was induced with either thiopentone or propofol. The program Stelpump (a target-controlled infusion program) was run on a laptop and connected to a syringe driver via an RS 232 cable. The program was found to be reliable and safe for the administration of TIVA in dogs. Invasive monitoring was required in order to monitor cardiovascular changes during surgery. Ventilation was controlled to maintain the end-tidal carbon dioxide below 40 mm Hg. The anaesthesia was characterised by haemodynamic stability. The haemodynamic stability was probably the result of the choice of TIVA and balanced anaesthesia. Intracranial pressure and oedema was controlled with dexamethasone, mannitol and ventilatory management either in combination or alone. Three dogs survived to hospital discharge and 1 dog was euthanased 2 weeks later due to tumour metastasis. The development and characterisation of the anaesthetic effects of TIVA needs to be elucidated in order to provide clinicians with rational guidelines for the appropriate use of TIVA in veterinary medicine.

Author(s):  
T. Brighton Dzikiti

Intravenous anaesthesia is gradually becoming popular in veterinary practice. Traditionally, general anaesthesia is induced with intravenous drugs and then maintained with inhalation agents. Inhalation anaesthetic agents cause more significant dose-dependent cardiorespiratory depression than intravenous anaesthetic drugs, creating a need to use less of the inhalation anaesthetic agents for maintenance of general anaesthesia by supplementing with intravenous anaesthesia drugs. Better still, if anaesthesia is maintained completely with intravenous anaesthetic drugs, autonomic functions remain more stable intra-operatively. Patient recovery from anaesthesia is smoother and there is less pollution of the working environment than happens with inhalation anaesthetic agents. Recently, a number of drugs with profiles (pharmacokinetic and pharmacodynamic) suitable for prolonged intravenous anaesthesia have been studied, mostly in humans and, to a certain extent, in dogs and horses. There is currently very little scientific information on total intravenous anaesthesia in goats, although, in the past few years, some scholarly scientific articles on drugs suitable for partial intravenous anaesthesia in goats have been published. This review article explored the information available on drugs that have been assessed for partial intravenous anaesthesia in goats, with the aim of promoting incorporation of these drugs into total intravenous anaesthesia protocols in clinical practice. That way, balanced anaesthesia, a technique in which drugs are included in anaesthetic protocols for specific desired effects (hypnosis, analgesia, muscle relaxation, autonomic stabilisation) may be utilised in improving the welfare of goats undergoing general anaesthesia.


Author(s):  
Gareth E. Zeiler ◽  
Eva Rioja ◽  
Charlie Boucher ◽  
Adrian S.W. Tordiffe

This case series describes the anaesthetic management of two sibling Bengal tiger (Panthera tigris tigris) cubs that were found to have spontaneous femur fractures due to severe nutritional secondary hyperparathyroidism. Both cubs received a combination of medetomidine (25 µg/kg) and ketamine (4 mg/kg) intramuscularly and were maintained with isoflurane in oxygen. An epidural injection of morphine (0.1 mg/kg) and ropivacaine (1.6 mg/kg) was administered to both tigers, which allowed a low end-tidal isoflurane concentration to be maintained throughout the femur fracture reduction operations. Both cubs experienced profound bradycardia and hypotension during general anaesthesia, and were unresponsive to anticholinergic treatment. Possible causes for these cardiovascular complications included: drug pharmacodynamics (medetomidine, morphine, isoflurane), decreased sympathetic tone due to the epidural (ropivacaine) and hypothermia. These possible causes are discussed in detail.


2011 ◽  
Vol 106 (2) ◽  
pp. 272-276 ◽  
Author(s):  
W Tiefenthaler ◽  
D Pehboeck ◽  
E Hammerle ◽  
P Kavakebi ◽  
A Benzer

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1777
Author(s):  
Miguel Gozalo-Marcilla ◽  
Simone Katja Ringer

Recovery remains the most dangerous phase of general anaesthesia in horses. The objective of this publication was to perform a structured literature review including levels of evidence (LoE) of each study with the keywords “recovery anaesthesia horse”, entered at once, in the search browsers PubMed and Web of Science. The two authors independently evaluated each candidate article. A final list with 444 articles was obtained on 5 April 2021, classified as: 41 “narrative reviews/expert opinions”, 16 “retrospective outcome studies”, 5 “surveys”, 59 “premedication/sedation and induction drugs”, 27 “maintenance with inhalant agents”, 55 “maintenance with total intravenous anaesthesia (TIVA)”, 3 “TIVA versus inhalants”, 56 “maintenance with partial intravenous anaesthesia (PIVA)”, 27 “other drugs used during maintenance”, 18 “drugs before/during recovery”, 18 “recovery systems”, 21 “respiratory system in recovery”, 41 “other factors”, 51 “case series/reports” and 6 “systems to score recoveries”. Of them, 167 were LoE 1, 36 LoE 2, 33 LoE 3, 110 LoE 4, 90 LoE 5 and 8 could not be classified based on the available abstract. This review can be used as an up-to-date compilation of the literature about recovery after general anaesthesia in adult horses that tried to minimise the bias inherent to narrative reviews.


1995 ◽  
Vol 23 (5) ◽  
pp. 574-582 ◽  
Author(s):  
A. A. Van Den Berg ◽  
D. Savva ◽  
N. M. Honjol ◽  
N. V. Rama Prabhu

Two hundred and thirty-five consecutive Saudi patients aged between two and fifty-three years undergoing elective tympanoplasty (n = 32), septorhinoplasty (n = 68) or adenotonsillectomy (n=135) were studied. They were randomized to receive either a total intravenous anaesthetic (10 ears, 23 noses, 44 throats) consisting of propofol for induction of anaesthesia followed by a propofol infusion, a combined intravenous-inhalational anaesthetic (11 ears, 22 noses, 46 throats) consisting of the above with isoflurane in oxygen-enriched air, or a balanced inhalational anaesthetic (11 ears, 23 noses, 45 throats) consisting of thiopentone for induction of anaesthesia and oxygen in nitrous oxide with isoflurane for maintenance. During tympanoplasty, all three anaesthetic techniques produced stable heart rates and arterial pressures. During septorhinoplasty, blood pressure rose in patients who received total intravenous anaesthesia, while combined and balanced techniques produced haemodynamic stability. During adenotonsillectomy, total intravenous anaesthesia produced a rise in both heart rate and blood pressure, the combined technique produced a rise in heart rate alone while balanced anaesthesia produced haemodynamic stability. Postoperatively, vomiting, pain scores and analgesic requirements were similar following all three types of anaesthetic within each surgical site subgroup. Our findings support the choice of balanced inhalational anaesthesia for all three types of ENT surgery and, where cost and facilities permit, total intravenous anaesthesia for tympanoplasty and combined intravenous-inhalational anaesthesia for septorhinoplasty.


2019 ◽  
Vol 26 (05) ◽  
Author(s):  
Ijaz Sheikh ◽  
Samina Aslam ◽  
Humaira Ahmad ◽  
Muhammad Rauf

Introduction: Porpofol is currently available popular intravenous anaesthetic agent. It is widely used for induction and maintenance of anaesthesia. Its main advantages are rapid induction and recovery, antiemetic and anticonvulsant effects. It has been used successfully for tracheal intubation without muscle relaxant, day surgery and for insertion of laryngeal mask airway. Its main disadvantages are pain on injection, dose dependent hypotension and severe bradycardia after induction. Objectives: The objective of the study was to compare mean hemodynamic changes using propofol as total intravenous anaesthesia with balanced anaesthesia technique (thiopentone-isoflurane-nitrousoxide). Setting: Department of Anaesthesia, Allied Hospital, Faisalabad. Duration: 6 months after approval of synopsis, from 18-7-2014 to 17-1-2015. Study Design: Randomized control trial. Results: In our study, out of 60 cases(30 in each group), 70%(n=21) in Group-A and 63.33%(n=19) in Group-B were between 12-30 years of age while 30%(n=9) in Group-A and 36.67%(n=11) in Group-B were between 31-60 years of age, mean+sd was calculated as 27.90+8.91 and 29.8+8.49 years respectively. 60%(n=18) in Group-A and 53.33%(n=16) in Group-B were male while 40%(n=12) in Group-A and 46.67%(n=14) in Group-B were females. Comparison of mean hemodynamic changes using propofol as total intravenous anaesthesia with balanced anaesthesia technique (thiopentone-isoflurane-nitrous oxide) shows that heart rate after intubation in Group-A was 83.4+2.36 and 90.36+1.95 in Group-B, p value was 0.001 while mean arterial pressure in Group-A was recorded as 78.6+2.25 and in Group-B 89.43+1.73, p value was 0.000. Conclusion: Propofol as total intravenous anaesthesia shows significanly better stability in haemodynamics when comapred with balanced anaesthesia technique (thiopentone-isoflurane-nitrous oxide) in surgical procedures.


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