scholarly journals Interpretation of volume kinetics in terms of pharmacokinetic principles

Author(s):  
Byung-Moon Choi
Keyword(s):  
2018 ◽  
Vol 40 (5) ◽  
pp. 710-716 ◽  
Author(s):  
Joo-Hyun Lee ◽  
Yeong-Jin Choo ◽  
Yong-Hun Lee ◽  
Jin-Ho Rhim ◽  
Soo-Han Lee ◽  
...  

1999 ◽  
Vol 46 (2) ◽  
pp. 133-141 ◽  
Author(s):  
Christer Svensén ◽  
Sari Ponzer ◽  
Robert G. Hahn

2014 ◽  
Vol 58 (10) ◽  
pp. 1258-1266 ◽  
Author(s):  
R. G. HAHN ◽  
H. BAHLMANN ◽  
L. NILSSON

2011 ◽  
Vol 28 ◽  
pp. 1
Author(s):  
R. G. Hahn ◽  
J. Zdolsek ◽  
Y. Li
Keyword(s):  

2018 ◽  
Author(s):  
I. Herrada ◽  
P. Barthe ◽  
M. Van Heusden ◽  
K DeGuillen ◽  
L Mammri ◽  
...  

ABSTRACTA complete description of the pathways and mechanisms of protein folding requires a detailed structural and energetic characterization of the folding energy landscape. Simulations, when corroborated by experimental data yielding global information on the folding process, can provide this level of insight. Molecular Dynamics (MD) has been associated often to force spectroscopy experiments to decipher the unfolding mechanism of titin Ig-like single- or multi-domain, the giant multi-modular protein from sarcomere, yielding information on the sequential events during titin unfolding under stretching. Here, we used high-pressure NMR to monitor the unfolding of titin I27 Ig-like single-domain and tandem. Since this method brings residue-specific information on the folding process, it can provide quasi-atomic details on this process, without the help of MD simulations. Globally, the results of our high-pressure analysis are in agreement with previous results obtained by the association of experimental measurements and MD simulation and/or protein engineering, although the intermediate folding state caused by the early detachment of the AB ß-sheet, often reported in previous works based on MD or force spectroscopy, cannot be detected. On the other hand, the A’G parallel ß-sheet of the ß-sandwich has been confirmed as the Achilles heel of the 3D scaffold: its disruption yields complete unfolding, with very similar characteristics (free energy, unfolding volume, kinetics constant rates) for the two constructs.


Author(s):  
Kedarnath Rane ◽  
Prashant Date

The issues of metallic scrap management and its utilization in manufacturing plants are nowadays intensely considered to address essential sustainability guidelines. Efficient recycling procedure for shop floor metallic scrap is not yet available because of abundance and contamination of nonmetallic constituents. Other ferrous metallic scrap are melted and purified during secondary steelmaking to get products in the form of blooms and billets are obtained. This study illustrates the potential of powder technology (powder metallurgy (PM) and metal injection molding (MIM)) based process for solid-state recycling and attainment of usable products. Industrially downgraded grinding sludge is pulverized and used as a raw material. Results showed properties of sintered parts are significantly improved due to in-situ reduction and densification during sintering. Recyclability Index (RI) was created to compare the effect of process variables on obtained products. Based on RI, recycled ferrous parts have about 70% comparable properties with equivalent pure iron parts. Complex reduction and sintering behavior in MIM, particularly, diffusion and pore volume kinetics limits applicability of MIM with this recycling approach. However, few industrial parts were developed and manufactured by PM based approach to validate the applicability of this novel recycling-cum-manufacturing process for the production of porous parts.


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