scholarly journals Metasomatic iron and alkali calcic (MIAC) system frameworks: a TGI-6 task force to help de-risk exploration for IOCG, IOA and affiliated primary critical metal deposits

2021 ◽  
Author(s):  
L Corriveau ◽  
J -F Montreuil ◽  
O Blein ◽  
E Potter ◽  
M Ansari ◽  
...  
Keyword(s):  
Iron Oxide ◽  
First Nations ◽  
Task Force ◽  
Mineral Exploration ◽  
Critical Metals ◽  
Near Surface ◽  
Critical Metal ◽  
Wide Range ◽  
Metamorphic Terranes ◽  
Mining Districts

Australia's and China's resources (e.g. Olympic Dam Cu-U-Au-Ag and Bayan Obo REE deposits) highlight how discovery and mining of iron oxide copper-gold (IOCG), iron oxide±apatite (IOA) and affiliated primary critical metal deposits in metasomatic iron and alkali-calcic (MIAC) mineral systems can secure a long-term supply of critical metals for Canada and its partners. In Canada, MIAC systems comprise a wide range of undeveloped primary critical metal deposits (e.g. NWT NICO Au-Co-Bi-Cu and Québec HREE-rich Josette deposits). Underexplored settings are parts of metallogenic belts that extend into Australia and the USA. Some settings, such as the Camsell River district explored by the Dene First Nations in the NWT, have infrastructures and 100s of km of historic drill cores. Yet vocabularies for mapping MIAC systems are scanty. Ability to identify metasomatic vectors to ore is fledging. Deposit models based on host rock types, structural controls or metal associations underpin the identification of MIAC-affinities, assessment of systems' full mineral potential and development of robust mineral exploration strategies. This workshop presentation reviews public geoscience research and tools developed by the Targeted Geoscience Initiative to establish the MIAC frameworks of prospective Canadian settings and global mining districts and help de-risk exploration for IOCG, IOA and affiliated primary critical metal deposits. The knowledge also supports fundamental research, environmental baseline assessment and societal decisions. It fulfills objectives of the Canadian Mineral and Metal Plan and the Critical Mineral Mapping Initiative among others. The GSC-led MIAC research team comprises members of the academic, private and public sectors from Canada, Australia, Europe, USA, China and Dene First Nations. The team's novel alteration mapping protocols, geological, mineralogical, geochemical and geophysical framework tools, and holistic mineral systems and petrophysics models mitigate and solve some of the exploration and geosciences challenges posed by the intricacies of MIAC systems. The group pioneers the use of discriminant alteration diagrams and barcodes, the assembly of a vocab for mapping and core logging, and the provision of field short courses, atlas, photo collections and system-scale field, geochemical, rock physical properties and geophysical datasets are in progress to synthesize shared signatures of Canadian settings and global MIAC mining districts. Research on a metamorphosed MIAC system and metamorphic phase equilibria modelling of alteration facies will provide a foundation for framework mapping and exploration of high-grade metamorphic terranes where surface and near surface resources are still to be discovered and mined as are those of non-metamorphosed MIAC systems.

Development and Validation of a New Scoring Tool to Evaluate the Clinical Evolution of Adult Patients with Nonsegmental Vitiligo

Dermatology ◽  
2021 ◽  
pp. 1-9
Author(s):  
María Luisa Peralta-Pedrero ◽  
Denisse Herrera-Bringas ◽  
Karla Samantha Torres-González ◽  
Martha Alejandra Morales-Sánchez ◽  
Fermín Jurado Santa-Cruz ◽  
...  
Keyword(s):  
Body Surface ◽  
Task Force ◽  
Intraclass Correlation ◽  
The Body ◽  
Response To Treatment ◽  
Similar Response ◽  
Clinical Evolution ◽  
Wide Range ◽  
Patient Reported ◽  
Extreme Groups

<b><i>Background:</i></b> Vitiligo has an unpredictable course and a variable response to treatment. Furthermore, the improvement of some vitiligo lesions cannot be considered a guarantee of a similar response to the other lesions. Instruments for patient-reported outcome measures (PROM) can be an alternative to measure complex constructions such as clinical evolution. <b><i>Objective:</i></b> The aim of this study was to validate a PROM that allows to measure the clinical evolution of patients with nonsegmental vitiligo in a simple but standardized way that serves to gather information for a better understanding of the disease. <b><i>Methods:</i></b> The instrument was created through expert consensus and patient participation. For the validation study, a prospective cohort design was performed. The body surface area affected was measured with the Vitiligo Extension Score (VES), the extension, the stage, and the spread by the evaluation of the Vitiligo European Task Force assessment (VETFa). Reliability was determined with test-retest, construct validity through hypothesis testing, discriminative capacity with extreme groups, and response capacity by comparing initial and final measurements. <b><i>Results:</i></b> Eighteen semi-structured interviews and 7 cognitive interviews were conducted, and 4 dermatologists were consulted. The instrument Clinical Evolution-Vitiligo (CV-6) was answered by 119 patients with a minimum of primary schooling. A wide range was observed in the affected body surface; incident and prevalent cases were included. The average time to answer the CV-6 was 3.08 ± 0.58 min. In the test-retest (<i>n</i> = 53), an intraclass correlation coefficient was obtained: 0.896 (95% CI 0.82–0.94; <i>p</i> &#x3c; 0.001). In extreme groups, the mean score was 2 (2–3) and 5 (4–6); <i>p</i> &#x3c; 0.001. The initial CV-6 score was different from the final one and the change was verified with VES and VETFa (<i>p</i> &#x3c; 0.05, <i>n</i> = 92). <b><i>Conclusions:</i></b> The CV-6 instrument allows patient collaboration, it is simple and brief, and it makes it easier for the doctor to focus attention on injuries that present changes at the time of medical consultation.

scholarly journals Mineral Physicochemistry Underlying Feature-Based Extraction of Mineral Abundance and Composition from Shortwave, Mid and Thermal Infrared Reflectance Spectra

Minerals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 347
Author(s):  
Carsten Laukamp ◽  
Andrew Rodger ◽  
Monica LeGras ◽  
Heta Lampinen ◽  
Ian C. Lau ◽  
...  
Keyword(s):  
Mineral Exploration ◽  
Relevant Information ◽  
Ore Deposits ◽  
Reflectance Spectra ◽  
Full Potential ◽  
Infrared Reflectance ◽  
Vibrational Modes ◽  
Diagnostic Features ◽  
Wide Range ◽  
Mineral Assemblages

Reflectance spectroscopy allows cost-effective and rapid mineral characterisation, addressing mineral exploration and mining challenges. Shortwave (SWIR), mid (MIR) and thermal (TIR) infrared reflectance spectra are collected in a wide range of environments and scales, with instrumentation ranging from spaceborne, airborne, field and drill core sensors to IR microscopy. However, interpretation of reflectance spectra is, due to the abundance of potential vibrational modes in mineral assemblages, non-trivial and requires a thorough understanding of the potential factors contributing to the reflectance spectra. In order to close the gap between understanding mineral-diagnostic absorption features and efficient interpretation of reflectance spectra, an up-to-date overview of major vibrational modes of rock-forming minerals in the SWIR, MIR and TIR is provided. A series of scripts are proposed that allow the extraction of the relative intensity or wavelength position of single absorption and other mineral-diagnostic features. Binary discrimination diagrams can assist in rapidly evaluating mineral assemblages, and relative abundance and chemical composition of key vector minerals, in hydrothermal ore deposits. The aim of this contribution is to make geologically relevant information more easily extractable from reflectance spectra, enabling the mineral resources and geoscience communities to realise the full potential of hyperspectral sensing technologies.

scholarly journals Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Morteza Hasanzadeh Kafshgari ◽  
Delf Kah ◽  
Anca Mazare ◽  
Nhat Truong Nguyen ◽  
Monica Distaso ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Hela Cells ◽  
Release Kinetics ◽  
Drug Loading ◽  
Oxide Nanoparticles ◽  
Site Specific ◽  
Therapeutic Drugs ◽  
Wide Range

Abstract Hollow titanium dioxide (TiO2) nanotubes offer substantially higher drug loading capacity and slower drug release kinetics compared to solid drug nanocarriers of comparable size. In this report, we load TiO2 nanotubes with iron oxide nanoparticles to facilitate site-specific magnetic guidance and drug delivery. We generate magnetic TiO2 nanotubes (TiO2NTs) by incorporating a ferrofluid containing Ø ≈ 10 nm iron oxide nanoparticles in planar sheets of weakly connected TiO2 nanotubes. After thermal annealing, the magnetic tubular arrays are loaded with therapeutic drugs and then sonicated to separate the nanotubes. We demonstrate that magnetic TiO2NTs are non-toxic for HeLa cells at therapeutic concentrations (≤200 µg/mL). Adhesion and endocytosis of magnetic nanotubes to a layer of HeLa cells are increased in the presence of a magnetic gradient field. As a proof-of-concept, we load the nanotubes with the topoisomerase inhibitor camptothecin and achieve a 90% killing efficiency. We also load the nanotubes with oligonucleotides for cell transfection and achieve 100% cellular uptake efficiency. Our results demonstrate the potential of magnetic TiO2NTs for a wide range of biomedical applications, including site-specific delivery of therapeutic drugs.

Article Commentary: Defining New Directions for More Effective Management of Surgical Pain in the United States: Highlights of the Inaugural Surgical Pain Congress™

2014 ◽  
Vol 80 (3) ◽  
pp. 219-228 ◽  
Author(s):  
Girish P. Joshi ◽  
David E. Beck ◽  
Roger Hill Emerson ◽  
Thomas M. Halaszynski ◽  
Jonathan S. Jahr ◽  
...  
Keyword(s):  
Patient Satisfaction ◽  
Pain Management ◽  
Best Practice ◽  
Task Force ◽  
Unmet Need ◽  
The United States ◽  
Cost Of Care ◽  
Inaugural Meeting ◽  
Surgical Pain ◽  
Wide Range

Despite advances in pharmacologic options for the management of surgical pain, there appears to have been little or no overall improvement over the last two decades in the level of pain experienced by patients. The importance of adequate and effective surgical pain management, however, is clear, because inadequate pain control 1) has a wide range of undesirable physiologic and immunologic effects; 2) is associated with poor surgical outcomes; 3) has increased probability of readmission; and 4) adversely affects the overall cost of care as well as patient satisfaction. There is a clear unmet need for a national surgical pain management consensus task force to raise awareness and develop best practice guidelines for improving surgical pain management, patient safety, patient satisfaction, rapid postsurgical recovery, and health economic outcomes. To comprehensively address this need, the multidisciplinary Surgical Pain Congress™ has been established. The inaugural meeting of this Congress (March 8 to 10, 2013, Celebration, Florida) evaluated the current surgical pain management paradigm and identified key components of best practices.

Structural interpretation using refraction velocities from marine seismic surveys

Geophysics ◽  
1986 ◽  
Vol 51 (1) ◽  
pp. 12-19 ◽  
Author(s):  
James F. Mitchell ◽  
Richard J. Bolander
Keyword(s):  
Sedimentary Rock ◽  
Seismic Energy ◽  
Seismic Survey ◽  
Subsurface Structure ◽  
Seismic Reflection Data ◽  
Near Surface ◽  
Reflection Data ◽  
Wide Range ◽  
Streamer Length ◽  
Set Up

Subsurface structure can be mapped using refraction information from marine multichannel seismic data. The method uses velocities and thicknesses of shallow sedimentary rock layers computed from refraction first arrivals recorded along the streamer. A two‐step exploration scheme is described which can be set up on a personal computer and used routinely in any office. It is straightforward and requires only a basic understanding of refraction principles. Two case histories from offshore Peru exploration demonstrate the scheme. The basic scheme is: step (1) shallow sedimentary rock velocities are computed and mapped over an area. Step (2) structure is interpreted from the contoured velocity patterns. Structural highs, for instance, exhibit relatively high velocities, “retained” by buried, compacted, sedimentary rocks that are uplifted to the near‐surface. This method requires that subsurface structure be relatively shallow because the refracted waves probe to depths of one hundred to over one thousand meters, depending upon the seismic energy source, streamer length, and the subsurface velocity distribution. With this one requirement met, we used the refraction method over a wide range of sedimentary rock velocities, water depths, and seismic survey types. The method is particularly valuable because it works well in areas with poor seismic reflection data.

scholarly journals Complex Concentrated Alloys for Substitution of Critical Raw Materials in Applications for Extreme Conditions

Materials ◽  
2021 ◽  
Vol 14 (5) ◽  
pp. 1197
Author(s):  
Dumitru Mitrica ◽  
Ioana Cristina Badea ◽  
Beatrice Adriana Serban ◽  
Mihai Tudor Olaru ◽  
Denisa Vonica ◽  
...  
Keyword(s):  
Raw Materials ◽  
Extreme Environment ◽  
Extreme Conditions ◽  
The European Union ◽  
Critical Metals ◽  
Research Directions ◽  
Level Of Involvement ◽  
General Evaluation ◽  
Critical Metal ◽  
Critical Raw Materials

The paper is proposing a mini-review on the capability of the new complex concentrated alloys (CCAs) to substitute or reduce the use of critical raw materials in applications for extreme conditions. Aspects regarding the regulations and expectations formulated by the European Union in the most recent reports on the critical raw materials were presented concisely. A general evaluation was performed on the CCAs concept and the research directions. The advantages of using critical metals for particular applications were presented to acknowledge the difficulty in the substitution of such elements with other materials. In order to establish the level of involvement of CCAs in the reduction of critical metal in extreme environment applications, a presentation was made of the previous achievements in the field and the potential for the reduction of critical metal content through the use of multi-component compositions.

Overburden geochemical signature of the Lac des Iles platinum group element deposit, northwestern Ontario, Canada

2007 ◽  
Vol 44 (8) ◽  
pp. 1151-1168 ◽  
Author(s):  
Peter J Barnett
Keyword(s):  
Mineral Exploration ◽  
Shallow Groundwater ◽  
Soil System ◽  
Near Surface ◽  
Rock Fragments ◽  
The North ◽  
Northwestern Ontario ◽  
Airborne Contamination ◽  
The Many ◽  
Lac Des Iles

Many previously published studies of the behaviour of Pt and Pd in till and soils have been done in areas of complex stratigraphy or very thin overburden cover, making the interpretation of soil results difficult because of the many variables associated with these settings. At the Lac des Iles mine site in northwestern Ontario, there are excellent exposures of the overburden in a series of exploration trenches. Glacial dispersal trains can be observed in till (C horizon) geochemistry (e.g., Ni, Cr, Cu, and Co). Regional geochemical dispersal trains of elements, such as Ni, Cr, Mg, and Co associated with the North Lac des Iles intrusion, can be detected for about 4 km beyond the western margin of the Mine Block intrusion. Entire dispersal trains range from 5 to 7 km in length and about 1 to 2 km in width. The dispersal of North Lac des Iles intrusion rock fragments tends to mask the response of the Mine Block intrusion. Dispersal trains of Pt and Pd are not well defined and tend to be very short, <1 km in length, due to the initial low concentrations of these elements in C-horizon till samples from the Lac Des Iles area. An exception to this is the Pd dispersal train originating from the high-grade zone that is up to 3 km long. Pd, Pt, Ni, and Cu appear to be moving both within and out of the soil system downslope into surface and shallow groundwater. It is suggested that these elements, to varying degrees, are moving in solution. Airborne contamination from mine operations of the humus has adversely affected the ability to determine the effectiveness of humus sampling for mineral exploration at Lac des Iles. The airborne contamination likely influences the geochemical results from surface water, shallow groundwater, and near-surface organic bog samples, particularly for the elements Pd and Pt.

The Research and Application of Artificial Intelligence in the Field of Intelligent Robot

2014 ◽  
Vol 898 ◽  
pp. 763-766
Author(s):  
Zhi Hao Li
Keyword(s):  
Artificial Intelligence ◽  
Environmental Changes ◽  
Vision System ◽  
Mineral Exploration ◽  
Intelligent Robot ◽  
Application Range ◽  
Intelligent Robots ◽  
External Data ◽  
Wide Range ◽  
Artificial Intelligence Application

The research and application of artificial intelligence has a very wide range in intelligent robot field. Intelligent robot can not only make use of artificial intelligence gain access to external data, information, (such as stereo vision system, face recognition and tracking, etc.), and then deal with it so as to exactly describe external environment, and complete a task independently, owing the ability of learning knowledge, but also have self-many kinds of artificial intelligence like judgment and decision making, processing capacity and so on. It can make corresponding decision according to environmental changes. Its application range is expanding. In deep sea exploration, star exploration, mineral exploration, heavy pollution, domestic service, entertainment clubs, health care and so on, the figure of intelligent robots artificial intelligence application can all be seen.

Basin-Wide Connections of Upper-Ocean Temperature Variability in the Equatorial Indian Ocean

2021 ◽  
pp. 1-50
Author(s):  
Ge Song ◽  
Bohua Huang ◽  
Rongcai Ren ◽  
Zeng-Zhen Hu
Keyword(s):  
Indian Ocean ◽  
Equatorial Indian Ocean ◽  
Reanalysis Data ◽  
Upper Ocean ◽  
Ocean Temperature ◽  
Ocean Reanalysis ◽  
Near Surface ◽  
Surface Warming ◽  
Transition Mechanism ◽  
Wide Range

AbstractIn this paper, the interannual variability of upper-ocean temperature in the equatorial Indian Ocean (IO) and its basin-wide connections are investigated using 58-year (1958-2015) comprehensive monthly mean ocean reanalysis data. Three leading modes of an empirical orthogonal function (EOF) analysis dominate the variability of upper-ocean temperature in the equatorial IO in a wide range of timescales. A coherent interannual band within the first two EOF modes identifies an oscillation between the zonally tilting thermocline across the equatorial IO in its peak phases and basin-wide displacement of the equatorial thermocline in its transitional phases. Consistent with the recharge oscillation paradigm, this oscillation is inherent of the equatorial IO with a quasi-periodicity around 15 months, in which the wind-induced off-equatorial Rossby waves near 5°S-10°S provide the phase-transition mechanism. This intrinsic IO oscillation provides the biennial component in the observed IOD variations. The third leading mode shows a nonlinear long-term trend of the upper-ocean temperature, including the near-surface warming along the equatorial Indian Ocean, accompanied by cooling trend in the lower thermocline originating further south. Such vertical contrary trends may lead to an enhanced stratification in the equatorial IO.

Evaporite Palynology: a case study on the Permian (Lopgingian) Zechstein Sea

2021 ◽  
pp. jgs2020-174
Author(s):  
Martha E. Gibson ◽  
David J. Bodman
Keyword(s):  
Thermal Conductivity ◽  
Heat Flux ◽  
Rapid Growth ◽  
Western Europe ◽  
Thermal Maturity ◽  
Near Surface ◽  
Wide Range ◽  
Terrestrial Environments ◽  
Insight Into

Evaporites characterize the Lopingian of Europe but present obstacles for biostratigraphic analysis. Here we present a case study for processing the Lopingian Zechstein Group evaporites of central-western Europe for the recovery of palynomorph assemblages. We demonstrate that full recovery is easily achieved with two main modes of palynomorph preservation observed; palynomorphs are either exceptionally well-preserved and orange-brown in colour, or poorly-preserved, brown-black, opaque and fragmented. The latter are reminiscent of palynomorphs of high thermal maturity. However, we propose that the intact nature of preservation is a result of the rapid growth of near-surface halite crystals, with their darkening a consequence of locally-enhanced heat flux due to the relatively high thermal conductivity of salt. This case study has enabled novel insight into an otherwise undescribed environment, and demonstrates the utility and possibility of extracting palynomorphs from a variety of rock salt types. This method should be applicable to a wide range of ancient evaporite and could also be applied to other Permian evaporite systems, which are used as analogues for extra-terrestrial environments.

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