scholarly journals Insulin Secretion and Insulin Resistance in Newly Diagnosed, Drug Naïve Prediabetes and Type 2 Diabetes Patients With/Without Metabolic Syndrome

2006 ◽  
Vol 30 (3) ◽  
pp. 198 ◽  
Author(s):  
Sang Youl Rhee ◽  
Suk Chon ◽  
Seungjoon Oh ◽  
Sung Woon Kim ◽  
Jin-Woo Kim ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Insulin Secretion ◽  
Newly Diagnosed ◽  
Drug Naïve ◽  
Diabetes Patients

scholarly journals Relationship of Hemoglobin A1c withβCell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Xinguo Hou ◽  
Jinbo Liu ◽  
Jun Song ◽  
Chuan Wang ◽  
Kai Liang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Hemoglobin A1c ◽  
Cell Function ◽  
Binary Logistic Regression Analysis ◽  
Model Assessment ◽  
Newly Diagnosed ◽  
Drug Naïve ◽  
Diabetes Patients

Objective. To investigate changes in the glycated hemoglobin A1c (A1c) level and those inβcell function and insulin resistance in newly diagnosed and drug naive type 2 diabetes patients and to evaluate the relationship between them.Design and Methods. A total of 818 newly diagnosed diabetic individuals who were ≥40 years of age were recruited. The subjects were grouped by A1c values (<6.5%, 6.5–7%, 7-8%, 8-9%, and ≥9%). The homeostasis model assessment (HOMA) was used to evaluate pancreaticβcell function (HOMA-β) and insulin resistance (HOMA-IR). ANOVA,t-tests, and binary logistic regression analysis were used for data analysis.Results. Compared with subjects with A1c values <6.5%, individuals with an A1c of 6.5–7% exhibited an increased HOMA-βindex. However, the HOMA-βindex was significantly decreased at A1c values ≥7% and further decreased by 9.3% and by 23.7%, respectively, at A1c values of 7-8% and 8-9%. As A1c increased to ≥9%, a 62% reduction inβcell function was observed, independently of age, gender, body mass index (BMI), blood pressure (BP), blood lipids, and hepatic enzyme levels. Meanwhile, insulin resistance was significantly increased with an increase in A1c values.Conclusions. Elevated A1c values (≥7%) were associated with substantial reductions inβcell function.

scholarly journals The Relationship between Serum 25-Hydroxy Vitamin D and Insulin Sensitivity and  β-Cell Function in Newly Diagnosed Type 2 Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Yuan Gao ◽  
Xinchi Wu ◽  
Qi Fu ◽  
Yanyun Li ◽  
Tao Yang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Insulin Secretion ◽  
Insulin Sensitivity ◽  
Cell Function ◽  
Newly Diagnosed ◽  
25 Hydroxy Vitamin D ◽  
The Relationship ◽  
Diabetes Patients

The aim of this study was to investigate the relationship between serum 25-hydroxy vitamin D (25-OHD) and insulin sensitivity andβ-cell function in newly diagnosed type 2 diabetes. 395 newly diagnosed type 2 diabetes patients were enrolled in this study. Venous blood samples were collected at 0 min, 30 min, and 120 min of OGTT to measure serum glucose and insulin. Matsuda ISI and HOMA-IR were used to determine insulin sensitivity. The ratio of 0–120 min area under curve of insulin to glucose (insulin release index, INSR) was calculated as surrogate index ofβ-cell insulin secretion function. The products of insulin secretion indices multiplied by Matsuda insulin sensitivity index were used as disposition indices. Patients were divided into three groups according to tertiles (T1, T2, and T3) of 25-OHD concentration. There was significant difference among three groups for HOMA-IR, Matsuda ISI, and INSR. HOMA-IR, Matsuda ISI, INSR, and DI were undifferentiated among three groups in male patients. But HOMA-IR, Matsuda ISI, and INSR were significantly different among three groups in female patients after being adjusted by confounding factors. In conclusion, serum 25-OHD is associated with insulin sensitivity andβ-cell function for female newly diagnosed type 2 diabetes patients, and the association is ambiguous in males.

scholarly journals Obesity and Insulin Resistance According to Age in Newly Diagnosed Type 2 Diabetes Patients in Korea

2016 ◽  
Vol 31 (2) ◽  
pp. 157
Author(s):  
Ju Won Lee ◽  
Nam Kyu Kim ◽  
Hyun Joon Park ◽  
Jun Yeob Lee ◽  
Seon Yoon Choi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Newly Diagnosed ◽  
Diabetes Patients
Sign in / Sign up

Export Citation Format

Share Document