Recognizing and Assessing Risk Factors for Difficult-to-Treat Depression and Treatment-Resistant Depression

2016 ◽  
Vol 77 (09) ◽  
pp. e1154-e1154 ◽  
Author(s):  
Bradley Gaynes
Keyword(s):  
Risk Factors ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

Socio-demographic and clinical risk factors of treatment-resistant depression: A Danish population-based cohort study

2020 ◽  
Vol 261 ◽  
pp. 221-229 ◽  
Author(s):  
Frederikke Hordam Gronemann ◽  
Martin Balslev Jorgensen ◽  
Merete Nordentoft ◽  
Per Kragh Andersen ◽  
Merete Osler
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Population Based ◽  
Clinical Risk Factors ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Danish Population ◽  
Clinical Risk ◽  
Resistant Depression

scholarly journals Resistant depression: criteria for determination, risk factors and therapeutic strategies

2017 ◽  
Vol 2 (3) ◽  
pp. 020338
Author(s):  
Olena Khaustova
Keyword(s):  
Risk Factors ◽  
Atypical Antipsychotics ◽  
Therapeutic Response ◽  
Therapeutic Strategies ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Duration Of Treatment ◽  
Resistance To Treatment ◽  
Step Model ◽  
Resistant Depression

Background Therapy of resistant depression raises a number of diagnostic and therapeutic problems, requires the solution of a number of methodological issues. A scientific discussion continues around the definition of depression resistance, assessment of the degree of reduction of depressive symptoms, the level of social and role functioning of patients; the improvement of models for determining the degree of resistance to various types of depression therapy continues; new methods of therapy and new algorithms of combined therapy are being developed. The ultimate goal of all these efforts should be practical recommendations for determining therapeutic options for the treatment of patients with resistant depression, which will help doctors make informed decisions on intervention strategies. Aim To analyze the therapeutic possibilities of treating depressive disorders that are resistant to therapy. Methods Publications from the Pubmed, MEDLINE, the Cochrane Library, Web of Science, Google Scholar databases were analyzed. Tags: depression, treatment, resistance, psevdoresistence, therapeutic response, resistance to treatment, strategies for treatment of resistant depression. Results The terminology related to resistant depression was defined: lack of a therapeutic response, adequate dose, adequate duration of treatment, antidepressant intolerance, pseudo-resistance, relative resistance to treatment, absolute resistance to treatment, treatment of resistant depression, remission, recovery. Models for determining the resistance of depression have been described: the Thase & Rush model; European stepped model; A step model of the Massachusetts hospital; Step model of Maudsley; Form of the history of treatment with antidepressants. Risk factors for treatment of resistant depression were identified, and the main therapeutic strategies were described: optimization, switching, augmentation, combination and non-drug therapy. Particular attention is paid to the use of atypical antipsychotics, in particular arapiprazole, as the augmentation strategy. A complex approach is described, which includes various combinations of the above strategies. Conclusion Each case of treatment-resistant depression has its own unique characteristics and requires careful evaluation to determine the correct diagnosis and the quality of the therapeutic response. Equally important for building an adequate treatment plan is evaluating risk factors for the treatment of resistant depression. There is a wide variety of options for the treatment of resistant depression, so each therapeutic strategy should be used to help patients with treatment-resistant depression. The combination of antidepressant therapy and atypical antipsychotics with antidepressant properties in combination with psychotherapeutic intervention and adherence to adequate doses and duration of treatment may be a choice strategy for patients with treatment-resistant depression.

scholarly journals Metabolic Risk Factors and Cardiovascular Safety in Ketamine Use for Treatment Resistant Depression

2020 ◽  
Vol Volume 16 ◽  
pp. 2539-2551 ◽  
Author(s):  
Joanna Szarmach ◽  
Wiesław Jerzy Cubała ◽  
Adam Włodarczyk ◽  
Maria Gałuszko-Węgielnik
Keyword(s):  
Risk Factors ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Cardiovascular Safety ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

WHOLE EXOME SEQUENCING REVEALS RISK FACTORS IN TREATMENT RESISTANT DEPRESSION

2019 ◽  
Vol 29 ◽  
pp. S934-S935
Author(s):  
Alessandro Serretti ◽  
Chiara Fabbri ◽  
Diego Albani ◽  
Siegfried Kasper ◽  
Joseph Zohar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Exome Sequencing ◽  
Whole Exome Sequencing ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Whole Exome ◽  
Resistant Depression

Incidence of, Risk Factors for, and Changes Over Time in Treatment-Resistant Depression in Denmark

2018 ◽  
Vol 79 (4) ◽  
Author(s):  
Frederikke Hordam Gronemann ◽  
Martin B. Jorgensen ◽  
Merete Nordentoft ◽  
Per K. Andersen ◽  
Merete Osler
Keyword(s):  
Risk Factors ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Time In Treatment ◽  
Resistant Depression ◽  
Changes Over Time ◽  
Over Time

S117. Risk Factors for Treatment Resistant Depression

2019 ◽  
Vol 85 (10) ◽  
pp. S342
Author(s):  
Suhayl Nasr ◽  
Anand Popli ◽  
Burdette Wendt
Keyword(s):  
Risk Factors ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

scholarly journals Personality Traits as Risk Factors for Treatment-Resistant Depression

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63756 ◽  
Author(s):  
Michio Takahashi ◽  
Yukihiko Shirayama ◽  
Katsumasa Muneoka ◽  
Masatoshi Suzuki ◽  
Koichi Sato ◽  
...  
Keyword(s):  
Risk Factors ◽  
Personality Traits ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression
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