A Review of Current Bipolar Disorder Treatment Guidelines

2012 ◽  
Vol 73 (03) ◽  
pp. e12 ◽  
Author(s):  
Alan Podawiltz
Keyword(s):  
Bipolar Disorder ◽  
Treatment Guidelines ◽  
Disorder Treatment

Trends in the psychopharmacological treatment of bipolar disorder: a nationwide register-based study

2015 ◽  
Vol 28 (2) ◽  
pp. 75-84 ◽  
Author(s):  
Louise Bjørklund ◽  
Henriette Thisted Horsdal ◽  
Ole Mors ◽  
Søren Dinesen Østergaard ◽  
Christiane Gasse
Keyword(s):  
Bipolar Disorder ◽  
Atypical Antipsychotics ◽  
Tricyclic Antidepressants ◽  
Treatment Guidelines ◽  
Treatment Patterns ◽  
Central Research ◽  
Cross Sectional ◽  
Psychopharmacological Treatment ◽  
Research Register ◽  
Disorder Treatment

ObjectiveIn bipolar disorder, treatment with antidepressants without concomitant use of mood stabilisers (antidepressant monotherapy) is associated with development of mania and rapid cycling and is therefore not recommended. The present study aimed to investigate the psychopharmacological treatment patterns in bipolar disorder over time, with a focus on antidepressant monotherapy.MethodsCohort study with annual cross-sectional assessment of the use of psychotropic medications between 1995 and 2012 for all Danish residents aged 10 years or older with a diagnosis of bipolar disorder registered in the Danish Psychiatric Central Research Register. Users of a given psychotropic medication were defined as individuals having filled at least one prescription for that particular medication in the year of interest.ResultsWe identified 20 618 individuals with bipolar disorder. The proportion of patients with bipolar disorder using antidepressants, atypical antipsychotics and anticonvulsants increased over the study period, while the proportion of patients using lithium, typical antipsychotics and benzodiazepines/sedatives decreased. The proportion of patients treated with antidepressant monotherapy decreased from 20.5% in 1997 to 12.1% in 2012, and among antidepressant users, the proportion in monotherapy decreased from 47.7% to 23.9%, primarily driven by a decrease in the use of tricyclic antidepressants.ConclusionThe results show an increase in the proportion of patients with bipolar disorder being treated with antidepressants in the period from 1997 to 2012. However, in accordance with international treatment guidelines, the extent of antidepressant monotherapy decreased during the same period.

Staging and neuroprogression in bipolar disorder: treatment implications

2017 ◽  
Author(s):  
Ives Cavalcante Passos ◽  
Flávio Kapczinski
Keyword(s):  
Bipolar Disorder ◽  
Treatment Guidelines ◽  
Current Treatment ◽  
Behaviour Therapy ◽  
Brain Circuits ◽  
Cognitive Behaviour ◽  
Disorder Treatment ◽  
Clinical Questions ◽  
The Brain ◽  
Progressive Course

It is known that if, not all, a substantial proportion of patients with bipolar disorder (BD) present a progressive course with functional and cognitive impairment. In addition, patients with BD and multiple mood episodes have a worse response to lithium and cognitive behaviour therapy. However, many current treatment guidelines do not take these clinical features that change with illness progression into account. In order to clarify these clinical questions, the term ‘neuroprogression’ was conceptualized as the pathological rewiring of the brain that takes place in parallel with the clinical deterioration in the course of BD. It provides a heuristic basis for conceptualizing the biochemical foundation of changes in brain circuits related to the progressive course of BD. Herein, we aim to review risk factors, biological underpinnings, and treatment implications related to neuroprogression in BD.

Subjective experience of bipolar disorder, treatment adherence and stigma

2009 ◽  
Author(s):  
Martha Sajatovic ◽  
William J. Meyer ◽  
Douglas Smith ◽  
Elizabeth Singer ◽  
Kristin A. Cassidy ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Treatment Adherence ◽  
Subjective Experience ◽  
Disorder Treatment

scholarly journals Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid inDictyostelium discoideum

2018 ◽  
Vol 11 (9) ◽  
pp. dmm035600 ◽  
Author(s):  
Elizabeth Kelly ◽  
Devdutt Sharma ◽  
Christopher J. Wilkinson ◽  
Robin S. B. Williams
Keyword(s):  
Bipolar Disorder ◽  
Valproic Acid ◽  
Diacylglycerol Kinase ◽  
Disorder Treatment

scholarly journals Interpersonal and social rhythm therapy for adolescents with bipolar disorder: treatment development and results from an open trial

2010 ◽  
Vol 27 (5) ◽  
pp. 457-464 ◽  
Author(s):  
Stefanie A. Hlastala ◽  
Julie S. Kotler ◽  
Jon M. McClellan ◽  
Elizabeth A. McCauley
Keyword(s):  
Bipolar Disorder ◽  
Open Trial ◽  
Treatment Development ◽  
Social Rhythm ◽  
Disorder Treatment

Prevalence and predictors of physician recommendations for medication adjustment in bipolar disorder treatment

2018 ◽  
Vol 238 ◽  
pp. 666-673 ◽  
Author(s):  
Dominic Hodgkin ◽  
Maureen T. Stewart ◽  
Elizabeth L. Merrick ◽  
Ye Zhang Pogue ◽  
Noreen A. Reilly-Harrington ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Disorder Treatment ◽  
Physician Recommendations ◽  
Medication Adjustment
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