scholarly journals Sterile "Abscess" of the Spleen and the Sickle Cell Trait

2018 ◽  
Vol 10 (1) ◽  
pp. 2018003 ◽  
Author(s):  
Lucio Luzzatto
Keyword(s):  
Plasmodium Falciparum ◽  
Case Report ◽  
Falciparum Malaria ◽  
Ultrasound Imaging ◽  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Plasmodium Falciparum Malaria ◽  
Splenic Infarction ◽  
Sterile Abscess

Dear Editor:I read with interest the case report by Dr P Magro et al. [MJHID 9: e2017023, 2017] regarding a boy with sickle cell trait (AS), who was appropriately treated for Plasmodium falciparum malaria and who, upon ultrasound imaging, was thought to have multiple abscesses in the spleen, eventually interpreted as splenic infarction. 

scholarly journals COVID-19 as a trigger for splenic infarction in a patient with sickle cell trait: a case report

2021 ◽  
pp. 100047
Author(s):  
Álvaro Alejandre-de-Oña ◽  
Jaime Alonso-Muñoz ◽  
Pablo Demelo-Rodríguez ◽  
Jorge del-Toro-Cervera ◽  
Francisco Galeano-Valle
Keyword(s):  
Case Report ◽  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Splenic Infarction

scholarly journals Clinically uncomplicated Plasmodium falciparum malaria with high schizontaemia: A case report

2008 ◽  
Vol 7 (1) ◽  
pp. 57 ◽  
Author(s):  
Khin Lwin ◽  
Elizabeth A Ashley ◽  
Stephane Proux ◽  
Kamolrat Silamut ◽  
François Nosten ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Case Report ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria ◽  
Uncomplicated Plasmodium Falciparum Malaria

scholarly journals Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait

Blood ◽  
2012 ◽  
Vol 119 (16) ◽  
pp. 3808-3814 ◽  
Author(s):  
Lauren Gong ◽  
Catherine Maiteki-Sebuguzi ◽  
Philip J. Rosenthal ◽  
Alan E. Hubbard ◽  
Chris J. Drakeley ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Relative Density ◽  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Plasmodium Falciparum Malaria ◽  
Force Of Infection ◽  
Symptomatic Malaria ◽  
Molecular Force ◽  
High Parasite Density ◽  
Within Subjects

AbstractSickle cell trait (HbAS) is known to be protective against Plasmodium falciparum malaria, but it is unclear when during the course of infection this protection occurs and whether protection is innate or acquired. To address these questions, a cohort of 601 children 1-10 years of age were enrolled in Kampala, Uganda, and followed for 18 months for symptomatic malaria and asymptomatic parasitemia. Genotyping was used to detect and follow individual parasite clones longitudinally within subjects. Children with HbAS were protected against the establishment of parasitemia, as assessed by the molecular force of infection at older but not younger ages (at 2 years of age: incidence rate ratio [IRR] = 1.16; 95% confidence interval [95% CI], 0.62-2.19; P = .6; at 9 years of age: IRR = 0.50; 95% CI, 0.28-0.87; P = .01), suggesting an acquired mechanism of protection. Once parasitemic, children with HbAS were less likely to progress to symptomatic malaria, with protection again being the most pronounced at older ages (at 2 years of age: relative risk [RR] = 0.92; 95% CI, 0.77-1.10; P = .3; at 9 years of age: RR = 0.68; 95% CI, 0.51-0.91; P = .008). Conversely, the youngest children were best protected against high parasite density (at 2 years of age: relative density = 0.24; 95% CI, 0.10-0.54; P = .001; at 9 years of age: relative density = 0.59; 95% CI, 0.30-1.19; P = .14), suggesting an innate mechanism of protection against this end point.

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