scholarly journals Epitheliogenesis imperfecta in a crossbred Holstein calf, southwestern Iran

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Shahrzad Azizi ◽  
Mehdi Amirmohammadi ◽  
Reza Kheirandish ◽  
Paria Dahesh
Keyword(s):  
Antibiotic Therapy ◽  
Autosomal Recessive ◽  
Domestic Animals ◽  
Skin Defect ◽  
Topical Cream ◽  
Hind Limbs ◽  
Mucous Membranes ◽  
Southwestern Iran ◽  
Gross Examination ◽  
Cutaneous Epithelium

Epitheliogenesis imperfect (EI) is a rare autosomal recessive skin defect that is clinically identified with absence of cutaneous epithelium of the limbs, muzzle and nostrils as well as oral mucous membranes. This congenital newborn desease is reported mainly in domestic animals. The present study described EI in a 13 day-old, female crossbred Holstein calf. Gross examination showed epithelium agenesis of two front and hind limbs skin around the carpal and tarsal joints, and also extensive areas of the metacarpal and metatarsal regions. The calf died 5 days after antibiotic therapy and use of topical cream.

scholarly journals Determination of the Carnitine and Acylcarnitine Profile in Patients with Lipoid Proteinosis

2019 ◽  
Author(s):  
Ataman Gönel ◽  
Ismail Koyuncu ◽  
Mustafa Aksoy ◽  
Hakim Celik
Keyword(s):  
Autosomal Recessive ◽  
Storage Disease ◽  
Lysosomal Storage ◽  
Serum Samples ◽  
Internal Organs ◽  
Lipoid Proteinosis ◽  
Acylcarnitine Profile ◽  
Mucous Membranes ◽  
Healthy Control

Background and objectives: Lipoid proteinosis (LP) is an autosomal recessive transfer lysosomal storage disease, characterised by the accumulation of hyalin substance in the mucous membranes, skin, internal organs and brain, for which there is no biochemical diagnostic method. The aim of this study was to determine the carnitine and acylcarnitine metabolic profile with LC-MS/MS in LP patients and thereby examine the potential of this as a new biochemical method in the determination of biochemical markers in LP patients. Materials and Methods: In this study, 27 carnitine and acylcarnitine esters were measured with LC-MS/MS in serum samples taken from 14 healthy control subjects and 14 patients who presented at the Skin and Venereal Diseases Polyclinic and were diagnosed with LP as a result of clinical, radiological and histopathological examinations. Results: The results of the study showed that C0 (free carnitine) C3, C4, C4:DC, C5DC, C6, C8, C14:1, C14:2, C16 and C18 acylcarnitines were statistically significantly reduced in the LP patients (p<0.05, p<0.01). Conclusions: It was concluded that the application of carnitine profile screening, which is an inexpensive, rapid and reliable method, could make a contribution to the differential diagnosis as aa supporting laboratory test in individuals with suspected LP.

scholarly journals Topic inhaled antibiotic therapy in children with prolonged adenoiditis

2019 ◽  
Vol 64 (3) ◽  
pp. 87-90
Author(s):  
I. M. Kirichenko
Keyword(s):  
Antibiotic Therapy ◽  
Respiratory Tract Infections ◽  
Upper Respiratory Tract ◽  
Secondary Immunodeficiency ◽  
Frequent Use ◽  
Systemic Antibiotic Therapy ◽  
Mucous Membranes ◽  
Upper Respiratory ◽  
Tract Infections ◽  
Systemic Antibiotics

Currently the issue of antibiotic resistance is urgent due to the unreasonable prescription of systemic antibiotics in the treatment of the upper respiratory tract infections. Frequent use of systemic antibiotic therapy in childhood leads to disruption of the microbiota and the development of secondary immunodeficiency. Alternative topical antibiotic therapy together with mucolytics allows the antibiotic to penetrate directly to the inflammation site and destroy biofilms. The article outlines the use of thiamphenicol glycinate acetylcysteinate in children with prolonged adenoiditis. In Russia this antibiotic is presented by Fluimucil® IT; it is manufactured in the form of a lyophilisate for both injectable solutions and solutions for inhalations and irrigation of mucous membranes. Thiamphenicol glycinate acetylcysteinate helps to improve the course of the disease, in some cases, to avoid invasive procedures and reduce the use of systemic antibiotics.

scholarly journals Tetanus in a male mix breed horse from Jataí Municipality, Goiás: Case report

2020 ◽  
Vol 9 (7) ◽  
pp. e784974378
Author(s):  
Rodrigo Silva Oliveira ◽  
Reiner Silveira de Moraes ◽  
Severino Ernesto Rezende Vilela ◽  
Felipe Augusto Pereira ◽  
Andreia Vitor Couto do Amaral ◽  
...  
Keyword(s):  
Anaerobic Bacterium ◽  
Clinical Signs ◽  
Final Diagnosis ◽  
Domestic Animals ◽  
The Body ◽  
Clostridium Tetani ◽  
Main Complaint ◽  
Hind Limbs ◽  
The City ◽  
Breed Horse

Tetanus is an infectious disease caused by the toxin of Clostridium tetani, a gram-positive anaerobic bacterium that affect domestic animals and humans. On February 17, 2019, veterinary medical care was requested at a property located in the city of Jataí, Goiás to attend the case of an undefined breed male horse of approximately 15 years of age, chestnut hair, weighing 400 kg. During the consultation, the main complaint was lameness and prolapse of third eyelid. At the clinical examination, the animal showed spasticity, rigid walking, distant hind limbs, third eyelid prolapse, hyperesthesia, extended neck, tail away from the body, mild dyspnea, intense sweating, distended nostrils and erect and immobile ears. Based on the physical examination of the animal, as well as the clinical signs presented, the final diagnosis of tetanus was established and therefore, the treatment was immediately instituted with intravenous anti-tetanus serum and antibiotic therapy. Hence, this paper aims to report a case of tetanus in equine, elucidating the main clinical signs and implemented treatment.

scholarly journals Autosomal Recessive Polycystic Kidney Disease (ARPKD)

2018 ◽  
Vol 1 (1) ◽  
pp. 13-14
Author(s):  
Dumitru Vasile Adrian ◽  
Maria Sajin ◽  
Mariana Costache
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Autosomal Recessive ◽  
Final Diagnosis ◽  
Renal Parenchyma ◽  
Polycystic Kidney ◽  
Polycystic Liver ◽  
Caroli Syndrome ◽  
The University ◽  
Gross Examination

Autosomal recessive polycystic kidney disease (ARPKD) is an important inherited cause of chronic kidney disease with an estimated incidence of 1 in 20,000 live births [1-3]. Mutations of the PKHD1 (polycystic kidney and hepatic disease 1) gene located on chromosome 6p12, are responsible for the entire spectrum of ARPKD [2]. Almost 40% of all affected cases are either stillborn or will die in the neonatal period, due to respiratory insufficiency or kidney failure. In most cases, this disease is accompanied by congenital hepatic fibrocystic lesions (specifically malformation of the liver plate -Meyenburg complex) or by Caroli syndrome [3]. We report a case of a newborns with ARPKD who died within 2 days after birth. Autopsy was performed in the Department of Pathology of the University Emergency Hospital in Bucharest. After a thorough, we established the diagnosis of ARPKD based on specific histological features of this disease, which, as in our case, may establish the final diagnosis without further need for genetic testing. Gross examination revealed hugely enlarged kidneys with cystically dilated collecting ducts that replaced the renal parenchyma almost completely (Figure1). The lungs were mildly hypoplastic. Microscopic examination confirmed the suspicion and showed typical features of ARPKD: numerous radially elongated cysts lined by cuboidal epithelium, decreased renal parenchyma and few restant rudimentary glomeruli (Figure2). The liver showed dilated portal spaces, with multiple irregularly branching bile ducts and extensive fibrosis consistent with Meyenburg complex (Figure3), classically associated with polycystic liver disease.

scholarly journals Stingray envenomation and injury in a dog

2021 ◽  
Vol 2 (1) ◽  
pp. 1-5
Author(s):  
Olutoye Adegboye ◽  
Olusegun Adegboye
Keyword(s):  
Veterinary Medicine ◽  
Case Report ◽  
Antibiotic Therapy ◽  
Case Reports ◽  
Domestic Animals ◽  
Cartilaginous Fish ◽  
Future Research ◽  
Clinical Knowledge ◽  
Poor Management

Abstract The stingray, a seemingly harmless cartilaginous fish, is capable of causing painful injuries and envenomation in humans. There is no known peer reviewed case report involving dogs in a veterinary journal at the time of writing this case report. Poor management of the condition or overzealous attempts to remove embedded barbs has resulted in complications in humans. This case report presents an effective approach to the treatment of stingray envenomation in dogs which is likely to be reproducible in other domestic animals. Clearly elucidated are the principles behind antibiotic therapy in the treatment of stingray injuries and the benefit of lignocaine injection in cases of embedded stingers. There is a need for case reports to enhance clinical knowledge of stingray management in domestic animals. This case report, thus, serves as an impetus for future research in this area of veterinary medicine.

scholarly journals Horses from Xiongnu Elite Burial Complex Tsaram

2021 ◽  
Vol 1 (35) ◽  
pp. 205-215
Author(s):  
Alexey A. Tishkin ◽  
◽  
Natalya A. Plasteeva ◽  
Sergey S. Minyaev ◽  
◽  
...  
Keyword(s):  
Cervical Vertebrae ◽  
Domestic Animals ◽  
Morphological Description ◽  
Limb Bones ◽  
Hind Limbs ◽  
Northern Edge ◽  
Males And Females ◽  
Funeral Practice ◽  
The Republic ◽  
Bone Remains

The paper presents morphological description of horse remains from the elite burial complex Tsaram dated to the Xiongnu period. The complex is located in the Kyakhtinsky district of the Republic of Buryatia (Russia) and consists of one central burial № 7 and accompanying funerary objects. In the grave pit of the largest burial a typical Han chariot was found, which was damaged during later intrusions. The skeletal remains (skull, two cervical vertebrae, metapodials and phalanges) belonged to one stallion were excavated near the chariot. At the northern edge of the grave pit the sacrificial complex with numerous remains of domestic animals was discovered. The animal sacrifice included remains of 25 horse individuals, both males and females. All bone remains originate from incomplete skeletons: only bones of the head, distal parts of the forelimbs and hind limbs are presented. The anatomical composition of the skeletons suggests that in the funeral practice horse skins were used instead of whole carcasses. Among sacrificed horses, adult and senile individuals predominated. The number of young individuals is small, while juveniles are absent. The withers height attributes horses to the small, short and medium Vitt's categories. The chariot horse had a larger body size than other horses. The morphometric analysis demonstrates that Tsaram horses are different in the size and proportions of the limb bones from the Paziryk and Bulan-Kobin horses.

Metabolomics in Lipoid Proteinosis

2020 ◽  
Vol 7 (1) ◽  
pp. 32-41
Author(s):  
Ataman Gonel ◽  
Ismail Koyuncu ◽  
Mustafa Aksoy ◽  
Hakim Celik
Keyword(s):  
Biochemical Markers ◽  
Autosomal Recessive ◽  
Storage Disease ◽  
Lysosomal Storage ◽  
Biochemical Method ◽  
Serum Samples ◽  
Internal Organs ◽  
Lipoid Proteinosis ◽  
Mucous Membranes ◽  
Healthy Control

Background: Lipoid proteinosis (LP) is an autosomal recessive transfer lysosomal storage disease that is characterized by the accumulation of hyalin substance in the mucous membranes, skin, internal organs, and brain. Thus far, no biochemical diagnostic method has been identified. Objective: The aim of this study was to determine the carnitine and acylcarnitine metabolic profiles of LP patients and to examine the potential of LC-MS/MS as a new biochemical method for the identification of biochemical markers. Methods: In this study, 27 carnitine and acylcarnitine esters were measured with LCMS/ MS in serum samples taken from 14 healthy control subjects and 14 patients. The patients, who presented at the Skin and Venereal Diseases Polyclinic, were diagnosed with LP on the basis of clinical, radiological, and histopathological examinations. Results: The results of the study showed that the C0 (free carnitine) C3, C4, C4:DC, C5DC, C6, C8, C14:1, C14:2, C16, and C18 acylcarnitines were statistically significantly reduced in the LP patients (p < 0.05, p < 0.01). Conclusion: It was concluded that the application of carnitine profile screening, an inexpensive, rapid, and reliable method, as a supporting laboratory test could make a contribution to the differential diagnosis for individuals with suspected LP.

scholarly journals Brucellosis - diagnostic dilemma: Case report

2002 ◽  
Vol 130 (3-4) ◽  
pp. 95-99
Author(s):  
Biljana Bojic ◽  
Milica Vujosevic ◽  
Svetlana Nikolic ◽  
Olga Dulovic ◽  
Jelica Grebenarevic ◽  
...  
Keyword(s):  
Case Report ◽  
Antibiotic Therapy ◽  
Medical Practice ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Epidemiological Data ◽  
Domestic Animals ◽  
Symptomatic Therapy ◽  
Diagnostic Dilemma ◽  
General Medical Practice

The authors present a case of a 20-year old student from Belgrade, who was admitted to the Institute of Infectious Diseases with fever, muscle and spine pains, strong headacke and malice. During the clinical examination bilateral sacroileitis was found. Serological analyses confirmed brucellosis. Epidemiological data showed that she lived in Kosovo and Metohia in 1997, where she consumed diary products from domestic animals this might be the reason of the acquired infection. With appropriate antibiotic therapy (aminoglycoside, doxicyclin, rifampicin), symptomatic therapy and rehabilitation the disease had favorable outcome; there was no recidive. The authors point out the importance of specific microbiological examinations of patients with fever of unknown origin, especially if the patient has the symptoms that are compatible with brucellosis. In our case it was sacroileitis, as a characteristic complication. As brucellosis is endemic in some parts of our country, there is always a possibility of brucellosis in general medical practice.

Typical Radiological Findings of Lipoid Proteinosis of Urbach and Wiethe

2009 ◽  
Vol 22 (4) ◽  
pp. 439-442
Author(s):  
K.G. Srinivasan ◽  
S. Ramprabananth ◽  
S. Srividya ◽  
K.P. Ushanandhini
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Autosomal Recessive ◽  
Early Initiation ◽  
Radiological Findings ◽  
Lipoid Proteinosis ◽  
Mucous Membranes

Lipoid proteinosis is a rare autosomal recessive dermatosis, which can be congenital or have onset in infancy. It is characterized by the progressive deposition of an amorphous hyaline substance with a glycoprotein constitution in the skin and mucous membranes and presents as papular lesions that can aggregate forming plaques with a yellowish discoloration. We present a case of lipoid proteinosis in a seven-year-old boy where characteristic calcifications in the medial temporal lobe helped in early initiation of treatment.

scholarly journals Scarlet fever on the background of toxicodermia in a child: case report and mini-review

2021 ◽  
Vol 16 (1) ◽  
pp. 47-51
Author(s):  
S. Nykytyuk ◽  
O. Mochulska ◽  
S. Levenets ◽  
T. Vorontsova
Keyword(s):  
Case Report ◽  
Allergic Reaction ◽  
Antibiotic Therapy ◽  
Clinical Picture ◽  
Scarlet Fever ◽  
Clinical Symptoms ◽  
Hemolytic Streptococcus ◽  
Beta Hemolytic Streptococcus ◽  
Mucous Membranes ◽  
Rapid Regression

The article presents a case of scarlet fever on the background of toxicodermia in a 12-year-old girl. The disease most probably developed in response to a combination of etiological factors such as bacterial infection and allergic reaction to exotoxins. The clinical picture was dubious, involving mucous membranes of the nose, mouth, and skin. Parenteral administration of glucocorticoids, antihistamines, detoxification, antibiotic therapy, and topical treatment led to rapid regression of clinical symptoms and prevented the development of complications. Sometimes, it is difficult to determine the etiology of toxicodermia combined with scarlet fever. Physicians should examine all patients with allergodermatoses for the presence of beta-hemolytic streptococcus and antibodies.

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