scholarly journals Cortical activation following chronic transcranial direct current stimulation in patients with minimally conscious state: a NIRS-based assessment associated to behavioral and plastic response

2019 ◽  
Vol 8 (2) ◽  
Author(s):  
Nicola Lamberti ◽  
Sofia Straudi ◽  
Valentina Bonsangue ◽  
Andrea Montis ◽  
Susanna Lavezzi ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Minimally Conscious State ◽  
Conscious State ◽  
Cortical Activation ◽  
Plastic Response ◽  
Direct Current Stimulation ◽  
Minimally Conscious

Not available

Poster 57 Transcranial Direct Current Stimulation for Minimally Conscious State: A Case Report

PM&R ◽  
2015 ◽  
Vol 7 ◽  
pp. S110-S110
Author(s):  
Nicole Burns ◽  
Sheital Bavishi ◽  
Marcia Bockbrader ◽  
Brittani Basobas ◽  
Alexandra V. Nielsen
Keyword(s):  
Case Report ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Minimally Conscious State ◽  
Conscious State ◽  
Direct Current Stimulation ◽  
Minimally Conscious

scholarly journals Therapeutic Use of Transcranial Direct Current Stimulation in the Rehabilitation of Prolonged Disorders of Consciousness

2021 ◽  
Vol 12 ◽  
Author(s):  
Davide Aloi ◽  
Antonio Incisa della Rocchetta ◽  
Alice Ditchfield ◽  
Sean Coulborn ◽  
Davinia Fernández-Espejo
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Minimally Conscious State ◽  
Conscious State ◽  
Small Sample ◽  
Disorders Of Consciousness ◽  
Electrode Placement ◽  
Functional Improvement ◽  
Complex Needs ◽  
Direct Current Stimulation

Patients with Prolonged Disorders of Consciousness (PDOC) have catastrophic disabilities and very complex needs for care. Therapeutic options are very limited, and patients often show little functional improvement over time. Neuroimaging studies have demonstrated that a significant number of PDOC patients retain a high level of cognitive functioning, and in some cases even awareness, and are simply unable to show this with their external behavior - a condition known as cognitive-motor dissociation (CMD). Despite vast implications for diagnosis, the discovery of covert cognition in PDOC patients is not typically associated with a more favorable prognosis, and the majority of patients will remain in a permanent state of low responsiveness. Recently, transcranial direct current stimulation (tDCS) has attracted attention as a potential therapeutic tool in PDOC. Research to date suggests that tDCS can lead to clinical improvements in patients with a minimally conscious state (MCS), especially when administered over multiple sessions. While promising, the outcomes of these studies have been highly inconsistent, partially due to small sample sizes, heterogeneous methodologies (in terms of both tDCS parameters and outcome measures), and limitations related to electrode placement and heterogeneity of brain damage inherent to PDOC. In addition, we argue that neuroimaging and electrophysiological assessments may serve as more sensitive biomarkers to identify changes after tDCS that are not yet apparent behaviorally. Finally, given the evidence that concurrent brain stimulation and physical therapy can enhance motor rehabilitation, we argue that future studies should focus on the integration of tDCS with conventional rehabilitation programmes from the subacute phase of care onwards, to ascertain whether any synergies exist.

scholarly journals Transcranial direct current stimulation over the right DLPFC selectively modulates subprocesses in working memory

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4906 ◽  
Author(s):  
Jiarui Wang ◽  
Jinhua Tian ◽  
Renning Hao ◽  
Lili Tian ◽  
Qiang Liu
Keyword(s):  
Working Memory ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Working Memory Capacity ◽  
Brain Regions ◽  
Cortical Activation ◽  
Direct Current Stimulation ◽  
Difficult Condition ◽  
Cathodal Tdcs ◽  
The Right

Background Working memory, as a complex system, consists of two independent components: manipulation and maintenance process, which are defined as executive control and storage process. Previous studies mainly focused on the overall effect of transcranial direct current stimulation (tDCS) on working memory. However, little has been known about the segregative effects of tDCS on the sub-processes within working memory. Method Transcranial direct current stimulation, as one of the non-invasive brain stimulation techniques, is being widely used to modulate the cortical activation of local brain areas. This study modified a spatial n-back experiment with anodal and cathodal tDCS exertion on the right dorsolateral prefrontal cortex (DLPFC), aiming to investigate the effects of tDCS on the two sub-processes of working memory: manipulation (updating) and maintenance. Meanwhile, considering the separability of tDCS effects, we further reconfirmed the causal relationship between the right DLPFC and the sub-processes of working memory with different tDCS conditions. Results The present study showed that cathodal tDCS on the right DLPFC selectively improved the performance of the modified 2-back task in the difficult condition, whereas anodal tDCS significantly reduced the performance of subjects and showed an speeding-up tendency of response time. More precisely, the results of discriminability index and criterion showed that only cathodal tDCS enhanced the performance of maintenance in the difficult condition. Neither of the two tDCS conditions affected the performance of manipulation (updating). Conclusion These findings provide evidence that cathodal tDCS of the right DLPFC selectively affects maintenance capacity. Besides, cathodal tDCS also serves as an interference suppressor to reduce the irrelevant interference, thereby indirectly improving the working memory capacity. Moreover, the right DLPFC is not the unique brain regions for working memory manipulation (updating).

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