scholarly journals Characterization of a new ultrasound device for clinical diagnosis

2019 ◽  
Vol 8 (2) ◽  
Author(s):  
Valentina Tavoni
Keyword(s):  
Clinical Diagnosis ◽  
Ultrasound Device

Not available

Recently discovered hypothalamic-pituitary hormones.

1976 ◽  
Vol 22 (1) ◽  
pp. 5-15 ◽  
Author(s):  
W B Malarkey
Keyword(s):  
Luteinizing Hormone ◽  
Clinical Diagnosis ◽  
Subsequent Development ◽  
Peptide Hormones ◽  
Pituitary Hormones ◽  
Isolation And Characterization ◽  
Inhibiting Factor ◽  
Hypothalamic Hormones ◽  
Clinical Disorders

Abstract In recent years a variety of peptide hormones have been isolated from the mammalian hypothalamus and pituitary. Several hypothalamic hormones, including thyroliberin (thyrotropin-releasing factory), luliberin (luteinizing hormone-releasing factor), and somatostatin (somatotropin release-inhibiting factor), have been characterized and synthesized. The subsequent development of radioimmunoassays for these hormones has made possible the study of their physiology. The measurement of prolactin in serum and the release of pituitary hormones after the administration of the hypothalamic hormones has proved to be useful in clinical diagnosis. The use of hypothalamic hormones in treating various clinical disorders and the isolation and characterization of new releasing and inhibiting hormones in the hypothalamus are actively being investigated.

scholarly journals Postmortem Characterization of Patients With Clinical Diagnosis of Plasmodium vivax Malaria: To What Extent Does This Parasite Kill?

2012 ◽  
Vol 55 (8) ◽  
pp. e67-e74 ◽  
Author(s):  
Marcus V. G. Lacerda ◽  
Silvio C. P. Fragoso ◽  
Maria G. C. Alecrim ◽  
Márcia A. A. Alexandre ◽  
Belisa M. L. Magalhães ◽  
...  
Keyword(s):  
Plasmodium Vivax ◽  
Clinical Diagnosis ◽  
Vivax Malaria ◽  
Plasmodium Vivax Malaria

Familial chylomicronemia syndrome: Clinical and molecular characterization of individuals with clinical diagnosis in Portugal

2020 ◽  
Vol 315 ◽  
pp. e205-e206
Author(s):  
A.C. Alves ◽  
L.B. Abrantes ◽  
S. Sequeira ◽  
O. Moldovan ◽  
C. Nunes ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Clinical Diagnosis

Molecular characterization of Chilean patients with a clinical diagnosis of Noonan syndrome

2014 ◽  
Vol 27 (3-4) ◽  
Author(s):  
Fernando A. Rodríguez ◽  
Nancy Unanue ◽  
María Isabel Hernández ◽  
Karen E. Heath ◽  
Fernando Cassorla
Keyword(s):  
Molecular Characterization ◽  
Clinical Diagnosis ◽  
Noonan Syndrome

Immunoproteomics characterization of Leishmania panamensis proteins for potential clinical diagnosis of mucosal Leishmaniasis

2021 ◽  
Author(s):  
Arley José Caraballo‐Guzmán ◽  
Juan David Ospina‐Villa ◽  
Angela Patricia Cuesta‐Caicedo ◽  
Miryan Margot Sánchez‐Jiménez
Keyword(s):  
Clinical Diagnosis ◽  
Mucosal Leishmaniasis ◽  
Leishmania Panamensis

scholarly journals Performance characterization of PCR-free whole genome sequencing for clinical diagnosis

2020 ◽  
Author(s):  
Ningzhi Zhang ◽  
Meizhen Zhou ◽  
Fanwei Zeng ◽  
Xiaodan Wang ◽  
Fengxia Liu ◽  
...  
Keyword(s):  
Whole Genome Sequencing ◽  
Clinical Diagnosis ◽  
Genome Sequencing ◽  
Whole Genome ◽  
Library Preparation ◽  
Experimental Parameters ◽  
Variant Detection ◽  
Disease Related Genes ◽  
Library Preparation Protocol

AbstractPurposeTo evaluate the performance of PCR-free whole genome sequencing (WGS) for clinical diagnosis, and thereby revealing how experimental parameters affect variant detection.MethodsAll the 5 NA12878 samples were sequenced using MGISEQ-2000. NA12878 samples underwent WGS with differing DNA input and library preparation protocol (PCR-based versus PCR-free protocols for library preparation). The DP (depth of coverage) and GQ (genotype quality) of each sample were compared. We developed a systematic WGS pipeline for the analysis of down-sampling samples of the 5 NA12878 samples. The performance of each sample was measured for sensitivity, coverage of depth and breadth of coverage of disease-related genes and CNVs.ResultsIn general, NA12878-2 (PCR-free WGS) showed better DP and GQ distribution than NA12878-1 (PCR-based WGS). With a mean depth of ~40X, the sensitivity of homozyous and heterozygous SNPs of NA12878-2 showed higher sensitivity (>99.77% and > 99.82%) than NA12878-1, and positive predictive value (PPV) exceeded 99.98% and 99.07%. The sensitivity and PPV of homozygous and heterozygous indels for NA12878-2 (PCR-free WGS) showed great improvement than NA128878-1. The breadths of coverage for disease-related genes and CNVs are slightly better for samples with PCR-free library preparation protocol than the sample with PCR-based library preparation protocol. DNA input also influences the performance of variant detection in samples with PCR-free WGS.ConclusionDifferent experimental parameters may affect variant detection for clinical WGS. Clinical scientists should know the range of sensitivity of variants for different methods of WGS, which would be useful when interpreting and delivering clinical reports.

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