scholarly journals Italian Chronic Cerebrospinal Venous Insufficiency National Epidemiological Observatory methodology and preliminary data

2015 ◽  
Vol 3 (3) ◽  
Author(s):  
Sandro Mandolesi ◽  
Aldo D'Alessandro ◽  
Marco Matteo Ciccone ◽  
Annapaola Zito ◽  
Tarcisio Niglio ◽  
...  
Keyword(s):  
Preliminary Data ◽  
Venous Insufficiency ◽  
Color Doppler ◽  
Position Statement ◽  
Chronic Cerebrospinal Venous Insufficiency ◽  
Medical Centers ◽  
Relapsing Remitting ◽  
Statistical Program ◽  
Asymptomatic Subjects ◽  
Type 3

The aim of our work is to describe the Memnet program’s use and potential and to show the data of Italian Chronic Cerebrospinal Venous Insufficiency (CCSVI)-National Epidemiological Observatory (NEO) activity in the first three years (http://www.osservatorioccsvi. org). From 2011 to 2014, all echo-color- Doppler (ECD) assessments were stored by Mem-net program into CCSVI-NEO web site (http://www.mem-net.it). Mem-net is a tool for multicenter data collection based on the International Society for Neurovascular Disease consensus and position statement, where we can insert patients (pts) history, neurological visits, ECD assessments, different examinations, therapies and surgical procedures. The website provides an epidemiological and statistical program for data analysis in real time. At present, 7 medical centers, affiliated to CCSVI-NEO, input their symptomatic and asymptomatic subjects with CCSVI. Data were storage using the Mem-net program. We analyzed data of only four centers on seven (Rome, Bari, Cagliari and Benevento). Total pts number with multiple sclerosis (MS) was 1109, mean age 46.0±13.4 [male 422 (38.05%); female 687 (61.95%)]. CCSVI positive pts were 937 (84.49%), CCSVI negative pts were 172 (15.51%). The CCSVI type 1 subjects were 530 (56.56%), CCSVI type 2 subjects were 20 (2.13%), CCSVI type 3 subjects were 387 (41.30%). We found 800 (85.38%) pts with criterion 1; 725 (77.37%) with criterion 2; 519 (55.39%) with criterion 3; 483 (51.55%) with criterion 4; 88 (9.39%) with criterion 5. The venous hemodynamic insufficiency severity score mean score was 3.8; the CCSVI mean score was 2.8; the MEM mean score was 34.7; the expanded disability status scale mean score was 4.5; the disease mean duration was 12.5±5.7 years. MS clinical types were divided as follows: relapsing-remitting pts were 449 (47.92%), Secondary progressive pts were 144 (15.37%), primary progressive pts were 72 (7.68%). The CCSVI-NEO database and Memnet software may be useful medical and researching tools for recording, storing, analyzing and studying ECD and vascular data. Preliminary data of NEO show an elevated prevalence of CCSVI in MS.

Prevalence study of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis: preliminary data

2012 ◽  
Vol 117 (5) ◽  
pp. 855-864 ◽  
Author(s):  
R. Floris ◽  
D. Centonze ◽  
S. Fabiano ◽  
M. Stefanini ◽  
S. Marziali ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Preliminary Data ◽  
Venous Insufficiency ◽  
Prevalence Study ◽  
Chronic Cerebrospinal Venous Insufficiency

scholarly journals Three patterns of chronic cerebrospinal venous insufficiency in Ménière syndrome patients: Diagnosis and treatment options

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Aldo Messina ◽  
Girolamo Garofalo ◽  
Antonella Faletra ◽  
Davide Piraino
Keyword(s):  
Venous Insufficiency ◽  
Color Doppler ◽  
Treatment Options ◽  
Specific Treatment ◽  
Color Doppler Ultrasound ◽  
Control Analysis ◽  
Rehabilitative Treatment ◽  
Chronic Cerebrospinal Venous Insufficiency ◽  
Ultrasound Evaluation ◽  
One Year

Identification techniques of the three different chronic cerebrospinal venous insufficiency patterns and related treatment options are in an initial phase of evaluation and analysis. Our purpose is to describe the appropriate management, proposing a tailored approach for each one. We identified three different Ménière syndrome patients in our Audiology Department, diagnosing the corresponding chronic cerebrospinal venous insufficiency pattern by Echo-color Doppler ultrasound evaluation and treating by venous angioplasty or rehabilitative treatment according to the internal jugular and vertebral veins anomalies found in each patient. According to the pattern, after specific treatment, echo-color-Doppler control analysis revealed a normalized venous outflow correlated to Ménière symptoms reduction and/or progressive disappearance during one year follow up. An adequate analysis of venous cerebral and ear outflow and a tailored treatment may represent an effective option when chronic cerebrospinal venous insufficiency is correctly diagnosed.

Venous Hemodynamic Insufficiency Severity Score variation after endovascular treatment of chronic cerebrospinal venous insufficiency

2014 ◽  
Vol 30 (4) ◽  
pp. 250-256 ◽  
Author(s):  
Filippo Scalise ◽  
Eugenio Novelli ◽  
Massimiliano Farina ◽  
Luciano Barbato ◽  
Salvatore Spagnolo
Keyword(s):  
Endovascular Treatment ◽  
Severity Score ◽  
Venous Insufficiency ◽  
Color Doppler ◽  
Disability Score ◽  
Chronic Cerebrospinal Venous Insufficiency ◽  
Group A ◽  
Edss Score ◽  
Group B

Introduction Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular condition characterized by anomalies of the internal jugular veins (IJVs) and/or azygos veins with disturbed flow and formation of collateral venous channels. The presence of CCSVI has been associated with multiple sclerosis (MS). Percutaneous venous angioplasty (PVA) has been proposed to improve extracranial outflow; however, a non-invasive, post-procedural follow-up outcome measure has not been established. Aim of the study To evaluate the short-term hemodynamic follow-up of CCSVI after PVA using color Doppler ultrasound (CDU) and to investigate whether hemodynamic variation correlated with clinical variation. Materials and methods Forty-five patients affected by MS with confirmed CCSVI underwent IJVs PVA. Venous hemodynamic (VH) parameters indicative of CCSVI and the Venous Hemodynamic Insufficiency Severity Score (VHISS) were evaluated by CDU at baseline and 3 months post-PVA. Concurrently, the MS-related disability status (EDSS) was evaluated. Results The VH parameters and VHISS 3 months after IJVs PVA significantly decreased: the VH parameters −32.1% and the VHISS −33.8% ( p < 0.001). The EDSS score 3 months after IJVs PVA was significantly lower than the baseline (−5.5%, p < 0.001). Using the median value of the VHISS variation as the cut-off, we were able to identify two groups of patients: responders, group A; and non-responders, group B. The EDSS score variation at 3 months was 0.310 in group A and 0.275 in group B ( p = 0.746). Conclusions CCSVI endovascular treatment can induce an improvement in VH parameters and the VHISS. The neurological disability score (EDSS) also improved after PVA; however, there was no correlation to the VHISS variation after PVA, MS type and duration.

Chronic cerebrospinal venous insufficiency in Ménière disease

2014 ◽  
Vol 30 (4) ◽  
pp. 274-279 ◽  
Author(s):  
Federica Di Berardino ◽  
Dario Carlo Alpini ◽  
Pietro Maria Bavera ◽  
Piero Cecconi ◽  
Mario Farabola ◽  
...  
Keyword(s):  
Venous Insufficiency ◽  
Endolymphatic Hydrops ◽  
Color Doppler ◽  
Vestibular Disorder ◽  
Predisposing Factor ◽  
Meniere Disease ◽  
Venous Flow ◽  
Chronic Cerebrospinal Venous Insufficiency ◽  
Contrast Enhanced ◽  
Menière Disease

Objectives The aim of this study was to focus on patients suffering from cochleo-vestibular disorder with and without Ménière disease (MD) in order to verify whether chronic cerebrospinal drainage abnormalities could play a role in the etiopathogenesis of endolymphatic hydrops. Methods Fifty-two volunteers were enrolled and subdivided into two groups: 24 definite MD and 28 not-MD. Both magnetic resonance venography imaging with contrast-enhanced imaging of the venous cerebrospinal system (MRV) and venous echo-color Doppler (ECD) were performed. Results MRV showed abnormalities in 83% of MD and 57% of not-MD subjects ( p < 0.001). Asymmetrical cervical venous flow, assessed by MRV, was confirmed by ECD in 62.5% of MD but in only 21.5% of not-MD subjects ( p<0.001). Conclusion Chronic cerebrospinal venous insufficiency might be the anatomical background, which provides a predisposing factor for the development of endolymphatic hydrops in MD patients.

Incidence and distribution of extravascular compression of extracranial venous pathway in patients with chronic cerebrospinal venous insufficiency and multiple sclerosis

2013 ◽  
Vol 29 (7) ◽  
pp. 476-479 ◽  
Author(s):  
Radak Djordje ◽  
Ilijevski Nenad ◽  
Kolar Jovo ◽  
Sagić Dragan ◽  
Antonić Želimir ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Venous Insufficiency ◽  
Doppler Sonography ◽  
Color Doppler ◽  
Cervical Vertebrae ◽  
Computer Tomographic ◽  
Chronic Cerebrospinal Venous Insufficiency ◽  
Carotid Bulb ◽  
Multiple Sclerosis Patients ◽  
Tomographic Angiography

Objective To examine the incidence and distribution of extravascular compression of the extracranial venous pathway (the jugular and/or azygous veins) in multiple sclerosis patients with chronic cerebrospinal venous insufficiency evaluated by mulitislice computer tomographic angiography. Methods and results Study group consisted of 51 consecutive patients with multiple sclerosis in whom chronic cerebrospinal venous insufficiency was diagnosed by color Doppler sonography (CDS). Mulitislice computer tomographic angiography was performed in all patients, and it revealed significant extravascular compression (>70%) of extracranial venous pathway in 26 patients (51%), while in 25 patients (49%) no significant extravascular compression was seen. Extracranial compression due to transverse processus of cervical vertebrae was seen in 23 patients, carotid bulb compression was seen in two patients, and in one case, compression presented as a thoracic outlet syndrome. Conclusion Our data indicate that extravascular compression of the extracranial venous pathway is frequent in multiple sclerosis patients with chronic cerebrospinal venous insufficiency, and that it is mainly due to compression caused by transverse processus of cervical vertebrae. Further studies are needed to evaluate potential clinical implications of this phenomenon.

Chronic cerebrospinal venous insufficiency is not associated with chronic venous disorders: A case–control study

2014 ◽  
Vol 30 (10) ◽  
pp. 736-738
Author(s):  
Maurizio A Leone ◽  
Olga Raymkulova ◽  
Piergiorgio Lochner ◽  
Laura Bolamperti ◽  
Gianandrea Rivadossi ◽  
...  
Keyword(s):  
Family History ◽  
Venous Insufficiency ◽  
Ad Hoc ◽  
Varicose Veins ◽  
Color Doppler ◽  
Chronic Cerebrospinal Venous Insufficiency ◽  
History Of ◽  
The Relationship ◽  
Venous Disorders ◽  
Control Study

Objectives To evaluate the relationship between chronic cerebrospinal venous insufficiency (CCSVI) and the presence of a Chronic Venous Disorder (CVD). Method We included 55 subjects with CCSVI aged >18 years, and 186 controls without CCSVI. Each subject was evaluated with color Doppler sonography in accordance with Zamboni’s five criteria, examined by two neurologists and interviewed with an ad-hoc designed form. The neurologists and the sonographers were mutually blinded. CVD were classified according to CEAP. Results Mean age was 42 years (SD = 9) in cases and 43 years (10) in controls ( p = ns). The odds ratios in subjects CCSVI were 0.6 (0.2–2.2) for CEAP 1, 0.9 (0.2–4.5) for CEAP 2, and 1.0 (0.6–1.9) for family history of varicose veins. The prevalence of CVD and, family history of varicose veins, was similar between cases and controls for each Zamboni criterion. Conclusions We found no association of CCSVI with the presence of CVD or family history of varicose veins.

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