scholarly journals The role of mouse models in translational cancer research: present and future directions

2017 ◽  
Vol 1 (3) ◽  
Author(s):  
Manuela Porru ◽  
Carlo Leonetti
Keyword(s):  
Mouse Models ◽  
Predictive Value ◽  
Human Cancer ◽  
Animal Experiments ◽  
Attrition Rate ◽  
Future Directions ◽  
Classical Models ◽  
State Of Research ◽  
New Compounds

A major issue in the research for new anticancer therapeutics is represented by the low number of new compounds approved for clinical use in comparison to the good success rate reported in preclinical studies. This high attrition rate could be attributed to many factors including the unsatisfactory predictive value of experiments performed in animals. To this purpose, general opinions suggest that classical models as murine tumors and xenografts do not mimic the complexity of human cancer diseases and that the use and integration of different relevant mouse models could improve the efficiency of the drug development process. In this review, we overview the present state of research in the field of mouse models for cancer and describe the advantages and limitations of the different models. Finally, strategies for improving the predictive value of animal experiments will be also discussed.

On Future Directions in Pathology

1982 ◽  
Vol 40 ◽  
pp. 274-277
Author(s):  
Benjamin F. Trump ◽  
Irene K. Berezesky ◽  
Raymond T. Jones
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Clinical Pathology ◽  
Future Directions ◽  
Diagnostic Pathology ◽  
The Past ◽  
Transmission Electron ◽  
Organ Systems ◽  
The Many

The role of electron microscopy and associated techniques is assured in diagnostic pathology. At the present time, most of the progress has been made on tissues examined by transmission electron microscopy (TEM) and correlated with light microscopy (LM) and by cytochemistry using both plastic and paraffin-embedded materials. As mentioned elsewhere in this symposium, this has revolutionized many fields of pathology including diagnostic, anatomic and clinical pathology. It began with the kidney; however, it has now been extended to most other organ systems and to tumor diagnosis in general. The results of the past few years tend to indicate the future directions and needs of this expanding field. Now, in addition to routine EM, pathologists have access to the many newly developed methods and instruments mentioned below which should aid considerably not only in diagnostic pathology but in investigative pathology as well.

Investigating the role of BAFF in different mouse models of allergic asthma

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
A Lorenz ◽  
M Busse ◽  
K Dalüge ◽  
AK Behrendt ◽  
G Hansen ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
Mouse Models
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