scholarly journals Dedifferentiated Liposarcoma of the Esophagus: A Case Report and Selected Review of the Literature

Rare Tumors ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 201-202 ◽  
Author(s):  
Christopher L. Brett ◽  
Daniel H. Miller ◽  
Liuyan Jiang ◽  
Herbert C. Wolfsen ◽  
Steven Attia ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Case Report ◽  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Radical Resection ◽  
Dedifferentiated Liposarcoma ◽  
Review Of The Literature ◽  
Pleomorphic Sarcoma ◽  
Disease Free

Soft tissue sarcomas of the esophagus represent an extremely rare cause of esophageal masses, and an even smaller proportion of these tumors represent dedifferentiated liposarcomas. We present a case of a 75-year-old gentleman presenting with dysphagia found to have a 5 cm pedunculated mass in the cervical esophagus, originating at the cricopharyngeus. This was found to have involvement limited to the superficial mucosa by endoscopic ultrasound, and the lesion was subsequently resected endoscopically. Pathology demonstrated an undifferentiated pleomorphic sarcoma later determined to represent dedifferentiated liposarcoma after fluorescence in situ hybridization analysis. The patient received no additional adjuvant therapy and remains disease free 20 months from the procedure. While treatment experience is limited, our case demonstrates that in selected patients, sustained local control can be obtained without radical resection.

scholarly journals Monophasic Synovial Sarcoma of the Infratemporal Fossa—Case Report and Review of the Literature

2017 ◽  
Vol 13 (01) ◽  
pp. 01
Author(s):  
Ignacio Mendoza ◽  
Ilson Sepúlveda ◽  
Geraldine Ayres ◽  
◽  
◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
South America ◽  
Head And Neck ◽  
Synovial Sarcoma ◽  
Infratemporal Fossa ◽  
Soft Tissue Sarcomas ◽  
Complete Resection ◽  
Review Of The Literature ◽  
Histological Features

Synovial sarcoma (SS) represents about 10% of all soft tissue sarcomas. It is believed that its origin would be found in cells that are related neither to ultrastructural nor to histological features of the synovial tissue. Head and neck is very rarely affected, with the lower extremities being most frequent. Complete resection with or without radiotherapy and chemotherapy is currently considered the best available therapy. This time we present the case of a patient with SS located in the infratemporal fossa, its diagnosis, treatment and evolution. According to our knowledge it is the first reported case in South America.

scholarly journals Giant gastric lipossarcoma: case report and review of the literature

2016 ◽  
Vol 14 (4) ◽  
pp. 557-560 ◽  
Author(s):  
Jacques Matone ◽  
◽  
Samuel Okazaki ◽  
Gabriel Naman Maccapani ◽  
Thiago Trolez Amancio ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Soft Tissue ◽  
Gastrointestinal Bleeding ◽  
Soft Tissue Sarcomas ◽  
Review Of The Literature ◽  
Genetic Causes

ABSTRACT Liposarcoma is one of the most common soft tissue sarcomas in adults, occurring in 15 to 20% of all patients with sarcoma. Primary liposarcoma of the stomach is rare. We report a case of patient with giant gastric liposarcoma who underwent surgery after a gastrointestinal bleeding. Preoperative hystopathological diagnosis was not established, even after three biopsy attempts. We discuss differential diagnosis, genetic causes, diagnosis strategies and treatment.

scholarly journals Dedifferentiated Liposarcoma Arising in an Esophageal Polyp: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Jorge Torres-Mora ◽  
Ann Moyer ◽  
Mark Topazian ◽  
Jeffrey Alexander ◽  
Tsung-Teh Wu ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Case Report ◽  
Fluorescence In Situ Hybridization ◽  
Gene Amplification ◽  
Dedifferentiated Liposarcoma ◽  
Well Differentiated

Liposarcoma is one of the most common sarcomas in adults, but only rarely presents as an esophageal primary. There have been several reports of well-differentiated liposarcoma (WDL) arising in the esophagus, but we present a case of dedifferentiated liposarcoma (DL) presenting as a large esophageal polyp. We believe this is the first reported case of DL of the esophagus with morphologic evidence of both well-differentiated and dedifferentiated components. The diagnosis was confirmed by demonstration of CPM gene amplification by fluorescence in situ hybridization (FISH).

scholarly journals Undifferentiated Pleomorphic Sarcoma of Pancreas: A Case Report and Review of the Literature for the Last Updates

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Behnam Sanei ◽  
Amirhosein Kefayat ◽  
Melika Samadi ◽  
Parvin Goli ◽  
Mohammad Hossein Sanei ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Poor Prognosis ◽  
Digestive System ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas ◽  
Pancreatic Tumors ◽  
Review Of The Literature ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pancreas Head ◽  
Pleomorphic Sarcoma

The most prevalent type of soft tissue sarcoma is undifferentiated pleomorphic sarcoma (UPS) or previously known as malignant fibrous histiocytoma. It accounts over 20% of all soft tissue sarcomas and occurs most frequently in the extremities, trunk, and retroperitoneum. However, it has been rarely observed in the digestive system. Pancreas sarcoma represents less than 1% of all pancreatic tumors, and primary UPS of the pancreas is even rarer. It exhibits high recurrence and poor prognosis. In this case, a 72-year-old woman with a UPS tumor which was located in the pancreas head and neck without adhesion to the retroperitoneum will be discussed.

scholarly journals Spinal intradural extra-arachnoid inflammatory myofibroblastic tumor (IMT): Case report and review of the literature

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Chuan Cheng ◽  
◽  
kun Wang ◽  
Cao Yang ◽  
Xinghuo Wu ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
In Situ Hybridization ◽  
Case Report ◽  
Fluorescence In Situ Hybridization ◽  
Molecular Genetics ◽  
Inflammatory Myofibroblastic Tumor ◽  
Review Of The Literature

In recent years, molecular genetics studies have highlighted the pathogenesis of IMT, more and more studies have been conducted to explore ALK gene. Literaturelly, the expression of ALK gene in IMT is very rare in central nervous system, while is relative common in non-central nervous system. The present case is the first reported patient with spinal intradural extra-arachnoid Inflammatory Myofibroblastic Tumor (IMT) with overexpressed ALK1. Preoperatively, the case was initially diagnosed as spinal lymphoma. ALK abnormalities was determined by immunohistochemistry and Fluorescence in Situ Hybridization (FISH). Spinal IMT has no definite features either clinically or in the imaging manifestations. The disease should be considered when excluding other possible diseases. Keywords: Inflammatory myofibroblastic tumor; Intradural; ALK; Spine.

scholarly journals Fine needle aspiration biopsy diagnosis of dedifferentiated liposarcoma: Cytomorphology and MDM2 amplification by FISH

CytoJournal ◽  
2010 ◽  
Vol 7 ◽  
pp. 5 ◽  
Author(s):  
Hatem Q. Al-Maghraby ◽  
Walid E. Khalbuss ◽  
Uma N. M. Rao ◽  
Kathleen Cieply ◽  
Sanja Dacic ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Soft Tissue ◽  
Needle Aspiration ◽  
Soft Tissue Tumors ◽  
Dedifferentiated Liposarcoma ◽  
Cell Block ◽  
Fine Needle ◽  
Spindle Cells ◽  
Ancillary Studies

Lipomatous mesenchymal tumors constitute the most common type of soft tissue tumors. Well-differentiated liposarcoma (WDLS) can undergo dedifferentiation to a nonlipogenic sarcoma of variable histologic grade. In the recent literature, amplification of the murine double minute 2 (MDM2) oncogene, which has a role in cell cycle control, has been successful in distinguishing WDLS from benign lesions. We present a case of dedifferentiated liposarcoma diagnosed by fine-needle aspiration (FNA), using cytomorphology and ancillary studies (immunocytochemistry and fluorescent in-situ hybridization). An 85-year old female presented to our institution with a firm soft tissue mass of the right buttock. The FNA showed atypical spindle cells, osteoclast-like giant cells and extracellular dense matrix material. The cell block showed cellular groups of highly atypical spindle cells with osteoid and adipose tissue. Fluorescence in situ hybridization (FISH) studies performed on the cell block demonstrated amplification of the MDM2 gene. In addition, the findings were morphologically compatible with the previously resected retroperitoneal dedifferentiated liposarcoma with areas of osteosarcoma. This rare case illustrates the usefulness of FNA and ancillary studies in the diagnosis and subclassification of soft tissue tumors. To the best of our knowledge, this is the first report of MDM2 FISH positivity in a liposarcoma diagnosed by FNA.

Sebaceous carcinoma in situ as a diagnostic entity. Case report and review of the literature.

2018 ◽  
Vol 2 (2) ◽  
pp. 136-141
Author(s):  
Leart Berdica ◽  
Teona Bushati ◽  
Alfred Aga ◽  
Erisa Kola ◽  
Rustem Celami ◽  
...  
Keyword(s):  
Case Report ◽  
Carcinoma In Situ ◽  
Sebaceous Carcinoma ◽  
Review Of The Literature
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