scholarly journals Primary nasopharyngeal interdigitating dendritic cell tumor presentation and response to radiation therapy

Rare Tumors ◽  
2010 ◽  
Vol 2 (1) ◽  
pp. 27-30 ◽  
Author(s):  
Neal E Dunlap ◽  
Randell L Woodford ◽  
Asal N Shoushtari ◽  
James F Reibel ◽  
Michael G Douvas ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Primary Tumor ◽  
Cervical Lymphadenopathy ◽  
Complete Response ◽  
Large Mass ◽  
Primary Site ◽  
Cell Tumor ◽  
Dendritic Cell Differentiation ◽  
Pet Ct ◽  
Disease Free

We report the case of a primary nasopharyngeal interdigitating dendritic cell tumor (IDDCT). A 25-year old male presented with bilateral decreased hearing, double vision, and ataxia. Flexible nasopharyngoscopy reviewed a large mass obstructing and filling the entire nasopharynx. MRI and PET-CT confirmed the presence of the primary tumor and demonstrated bilateral cervical lymphadenopathy. Biopsy of the nasopharynx revealed a hematolymphoid neoplasm with dendritic cell differentiation, most consistent with an IDDCT. The lesion was unresectable. The patient was treated with definitive radiotherapy to 66 Gy to the primary tumor and 50 Gy to the bilateral cervical lymphatics using an IMRT technique. A complete response was achieved and the patient remains disease free at the primary site 23 months after completion of radiotherapy.

scholarly journals Successful Use of a Multidisciplinary Approach to Treat a Perforated Duodenal Malignant Lymphoma in an Elderly Patient

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Tomoko Takagishi ◽  
Yuta Niimi ◽  
Goshi Matsuki ◽  
Shinta Nagano ◽  
Junsuke Hinami ◽  
...  
Keyword(s):  
Malignant Lymphoma ◽  
Multidisciplinary Approach ◽  
B Cell Lymphoma ◽  
Complete Response ◽  
Duodenal Wall ◽  
Abdominal Ct ◽  
Pet Ct ◽  
Life Threatening ◽  
Consolidation Radiotherapy ◽  
Disease Free

Treatment of duodenal malignant lymphoma is difficult due to life-threatening complications such as intestinal obstruction, perforation, and pancreatitis. Thus, multidisciplinary procedures are required alongside surgical intervention. Contrast abdominal CT images of a 75-year-old female suffering from vomiting revealed thickening of the duodenal wall (from the second to third segment). Gastrojejunostomy and biopsy identified the tumor as diffuse large B-cell lymphoma. A diagnosis of stage II duodenal lymphoma was made. The lymphoma continued to grow, resulting in jaundice and intestinal perforation, which was first treated with two cycles of rituximab and antibiotics. Thereafter, less intensive chemotherapy (two cycles each of R-mini-CHP, CHP, and R-CHOP) was administered, which led to significant improvement upon assessment by PET-CT. Residual lymphoma was treated with consolidation radiotherapy (50 Gy in 25 fractions) over 5 weeks after chemotherapy. The patient attained a complete response and has been disease-free for more than 4 years. Thus, duodenal perforated lymphoma can be treated successfully using a multidisciplinary approach that combines surgery, immunochemotherapy, and radiation therapy.

Value of positron emission tomography (PET) scan in treatment decision making for nodal metastases in head and neck squamous cell cancer

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 5577-5577
Author(s):  
B. Mehrotra ◽  
R. Roy ◽  
N. Radhakrishnan ◽  
E. Gabalski ◽  
D. Myssiorek ◽  
...  
Keyword(s):  
Primary Tumor ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Primary Site ◽  
Response To Therapy ◽  
Pet Scan ◽  
Pet Scans ◽  
Disease Free ◽  
Neck Squamous Cell Cancer

5577 Background: Management of neck disease in patients with Head and Neck Squamous cell cancer (HNC) who are initially treated with combined radiation and chemotherapy (CRT) remains controversial. Standard treatment options include neck dissection (ND) or close observation. More recently PET scans have been used to stage and monitor response to therapy in patients with HNC. We performed a retrospective analysis of patients diagnosed with HNC stages N2b or higher, treated with combined CRT, and who were monitored for disease response by PET scans. Our observations on the utility of PET scans in monitoring response to therapy and in determining the role of elective NDs in this setting are reported. Methods: A retrospective review of medical records of all patients diagnosed at our institution with HNC Stages TxN2b, N2c or N3 between the years 2002 and 2005 was undertaken. IRB approval was obtained for this study.To be eligible for this analysis, patients must have had baseline and follow up PET scans at the end of CRT and prior to ND. Data regarding age, gender, primary tumor site, stage, baseline and follow up PET scan results, operative pathology of ND when performed, and local control were recorded. Results: Fifteen patients were identified. Median age was 55 years (range 37–76). Male: Female ratio was 13:2. Primary site of tumor was Pharynx (Base of tongue: n = 3, tonsil: n = 11); Lip and oral cavity: n = 1. Stages: IVa : n = 12; IVb: n = 3. N stage: N2b: n = 12; N2c: n = 1; N3: n = 2. Post CRT, all patients were followed with serial clinical examinations, PET ± CT scans. 13 of 15 patients had negative PET activity in the neck at the completion of CRT and remain disease free in the neck at a median follow up of one year. Post treatment PET scans were positive at the primary site in 2 of 15 patients; and positive in the neck in 2 of 15 patients. These 4 patients underwent ND after completing CRT. Operative pathology was positive for nodal disease in 2 of 4 patients who had persistent mild or significant activity on PET scan either at the primary site or in the neck. Conclusions: Post CRT PET negativity in the neck and at the site of primary tumor is associated with continued disease free status in the neck and these patients may be managed conservatively without requiring a neck dissection. No significant financial relationships to disclose.

The utility of PET-CT after preoperative chemoradiation in predicting treatment outcomes in locally advanced esophageal cancer.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 182-182
Author(s):  
Gary Lewis ◽  
Bin S. Teh ◽  
Shraddha Dalwadi ◽  
Stephen Chiang ◽  
Edward Brian Butler ◽  
...  
Keyword(s):  
Overall Survival ◽  
Pathologic Complete Response ◽  
Disease Free Survival ◽  
Complete Response ◽  
Preoperative Chemoradiation ◽  
Survival Outcomes ◽  
Free Survival ◽  
Pet Ct ◽  
Pre Treatment ◽  
Disease Free

182 Background: In the treatment of gastroesophageal junction (GEJ) cancer, trimodality treatment with preoperative chemoradiation followed by surgery is the standard of care. However, predicting patient survival outcomes remains difficult. One possible means of predicting outcomes is comparing pre-treatment PET-CT with post-treatment PET-CT to see if a favorable response on imaging correlates with survival outcomes. Methods: We conducted a retrospective chart review of locally advanced GEJ cancer patients who underwent preoperative chemoradiotherapy followed by esophagectomy with negative margins. All patients underwent two PET-CT scans (before and after preoperative chemoradiation). We compared PET-CT imaging results and pathology results with survival outcomes. Values such as pre-treatment max SUV, post-treatment max SUV, change in max SUV, percent residual max SUV, complete response on PET-CT, and pathologic complete response were analyzed for potential impacts on recurrence rates and survival outcomes. Results: Forty patients had sufficient data to be included in our study. The median follow-up was 22.5 months. The majority of patients were male (82.5%), Caucasian (84.2%) and had adenocarcinoma histology (97.5%). Altogether, 75% of patients had stage III disease and 67.5% had locoregional nodal involvement. The majority (90%) of patients received some form of taxane and platinum based chemotherapy. Pre-treatment max SUV, post-treatment max SUV, change in max SUV, percent residual max SUV, and complete response on PET-CT were not associated with local recurrence, regional recurrence, disease-free survival, or overall survival. Pathologic complete response was associated with a decrease in the rate of distant metastasis ( P= 0.021) but not disease-free survival ( P= 0.411) or overall survival ( P= 0.878). Conclusions: Response on PET-CT after preoperative chemoradiation is not a predictive factor for recurrence, disease-free survival, or overall survival. Pathologic complete response predicted for a decrease in the rate of distant metastasis but not disease-free survival or overall survival.

The role of whole body 18F-FDG PET/CT scan in patients with carcinoma of unknown primary

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e22051-e22051
Author(s):  
M. Hu ◽  
J. Yu ◽  
N. Liu ◽  
L. Kong ◽  
P. Zhang
Keyword(s):  
Ct Scan ◽  
Primary Tumor ◽  
Fdg Pet ◽  
Primary Site ◽  
Unknown Primary ◽  
Tumor Site ◽  
Primary Tumor Site ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Pet Ct Scan

e22051 Background: Carcinoma of unknown primary (CUP) is a heterogeneous group of tumors and usually follows an aggressive biological and clinical behavior. Difficult challenges in oncology which the identification of the primary tumor and a complete disease staging could offer a more rational and efficient treatment in order to improve the survival time. Our aim was to evaluate the role of 18F-FDG PET/CT scan with two aspects: detection of the primary site, and estimation of tumor biological behavior which essential for the development of new, individual and targeted effective therapies. Methods: One hundred and seventeen patients presenting with histologically confirmed metastatic carcinoma (76 lymph nodes, 41 visceral biopsy proven) of unknown primary site were included in this retrospective study. The evaluations as follows had not revealed a primary site: detailed medical history, full physical and laboratory examinations, and diagnostic imaging methods. All patients underwent PET/CT. Results: In 42 (35.90%) patients, a primary tumor site which was confirmed by follow-up or surgery was showed by PET/CT. In 15 (12.82%) patients, the primary tumor site was suggested by PET/CT but not confirmed. In 60 (51.28%) patients, the primary tumor site was not localized modifying the stage of disease. In the other 17 (14.53%) patients, PET/CT scan identified further unexpected metastases. Overall, the following oncological treatment was influenced by the PET/CT scan, in a total of 38 (32.47%) patients. Between the adenocarcinoma and squamous cell carcinoma groups, no significant difference in SUVmax was found ( t=1.191, p = 0.244). A significantly higher SUVmax was found among patients with poorly or undifferentiated carcinoma compared with patients with well to moderately ( t=4.013, p<0.01) differentiation; In 42 patients with a confirmed primary tumor site, the SUVmax of Metastatic tumours have a closely relationship correlate with those of primary tumours, ( r=0.738, p<0.01). Furthermore, a significantly higher SUVmax was found among metastases compared with primary tumors ( t=3.470, p<0.01). Conclusions: Our data strongly support 18F-FDG PET/ CT imagings not only provide new insights in the diagnosis and staging of patients with CUP, but also evaluate biologic characters of tissue. 1 No significant financial relationships to disclose.

scholarly journals Prostanoids Play a Major Role in the Primary Tumor-Induced Inhibition of Dendritic Cell Differentiation

2002 ◽  
Vol 168 (9) ◽  
pp. 4333-4343 ◽  
Author(s):  
Claudia C. Sombroek ◽  
Anita G. M. Stam ◽  
Allan J. Masterson ◽  
Sinéad M. Lougheed ◽  
Marcel J. A. G. Schakel ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Dendritic Cell ◽  
Primary Tumor ◽  
Dendritic Cell Differentiation

scholarly journals Pivotal role of PET/CT in characterization of occult metastasis with undetermined origin

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Ashraf Anas Zytoon ◽  
Elsayed Elmekkawy Elsayed ◽  
Amr Ibrahim Nassar ◽  
Koji Murakami
Keyword(s):  
Diagnostic Accuracy ◽  
Primary Tumor ◽  
Primary Site ◽  
The Body ◽  
Primary Tumor Site ◽  
Predictive Values ◽  
Accuracy Test ◽  
Test Study ◽  
Pet Ct

Abstract Background The purpose of this multicenter diagnostic accuracy test study was conducted to assess the role of positron emission tomography/computed tomography in the detection of primary tumor in cases of metastasis of undetermined primary site, to estimate its capability in detecting additional lesions as well as evaluating disease burden and staging. This multicentric diagnostic accuracy test study included 175 patients with pathologically proven, radiologically, and/or clinically suspected metastatic lesions of undetermined primary site. Clinical, surgical, and histopathologic findings and correlative imaging modalities were used to assess the results of PET/CT; the accuracy of PET/CT was expressed in terms of sensitivity and specificity, positive and negative predictive values. Results The study included 175 patients; PET-CT-positive lesions suggestive of primary malignant tumors were detected in 105 out of 175 patients. These lesions were pathologically proven to be malignant (true positive) in 100/175 patients (57.1%). Five out of 175 patients (2.9%) proved to be falsely positive after pathologic assessment; 70 out of 175 patients (40%) were negative for detection of primary malignancy all over the body by PET/CT (true negative) with no false negative results. PET/CT achieved a sensitivity of 100%, and specificity of 93.3% in detection of unknown primary tumor location. Conclusion PET/CT is an effective modality for early detection of the primary tumor site in patients with cancer of undetermined primary (CUP) which facilitates early selection of appropriate treatment protocols that will improve patients’ prognosis.

Follicular dendritic cell tumor as an unknown primary tumor

2007 ◽  
Vol 12 (1) ◽  
pp. 56-58 ◽  
Author(s):  
Yoshihiro Yakushijin ◽  
Hisaharu Shikata ◽  
Katsumi Kito ◽  
Kohichi Ohshima ◽  
Kensuke Kojima ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Primary Tumor ◽  
Follicular Dendritic Cell ◽  
Cell Tumor ◽  
Unknown Primary ◽  
Unknown Primary Tumor ◽  
Follicular Dendritic Cell Tumor ◽  
Follicular Dendritic
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