scholarly journals Localized nasal cavity, sinus, and massive bilateral orbital involvement by human T cell leukemia virus 1 adult T cell lymphoma, with epidermal hypertrophy due to mite infestation

Rare Tumors ◽  
2010 ◽  
Vol 2 (4) ◽  
pp. 59 ◽  
Author(s):  
Kathleen Laveaux ◽  
Constantine A. Axiotis ◽  
Helen Durkin ◽  
Albert S. Braverman
Keyword(s):  
T Cell ◽  
Nasal Cavity ◽  
Cell Lymphoma ◽  
Leukemia Virus ◽  
T Cell Lymphoma ◽  
Mite Infestation ◽  
Cell Leukemia ◽  
Orbital Involvement ◽  
Human T Cell ◽  
T Cell Leukemia Virus

scholarly journals Slithering Through the Bone Marrow: Loiasis in a Patient With Human T-Cell Leukemia Virus-1-Associated Adult T-Cell Lymphoma

2020 ◽  
Vol 7 (12) ◽  
Author(s):  
Carl Boodman ◽  
Daniel Marko ◽  
Yoav Keynan
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
Cell Lymphoma ◽  
Leukemia Virus ◽  
T Cell Lymphoma ◽  
Cell Leukemia ◽  
Loa Loa ◽  
Human T Cell ◽  
T Cell Leukemia Virus

Abstract Loiasis is a filarial disease endemic to areas of Central and West Africa. We present a case of Loa loa microfilaremia in a patient with HTLV-1-related adult T-cell lymphoma. This case may suggest the possible role of cellular immunity in controlling microfilaria burden.

Orbital T-cell Lymphoma Human T-cell Leukemia Virus-I Infection

Ophthalmology ◽  
1988 ◽  
Vol 95 (1) ◽  
pp. 110-115 ◽  
Author(s):  
Simeon A. Lauer ◽  
Joel Fischer ◽  
Joan Jones ◽  
Samuel Gartner ◽  
Janice Dutcher ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Leukemia Virus ◽  
T Cell Lymphoma ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Human T Cell ◽  
T Cell Leukemia Virus

scholarly journals Full-Genome Characterization of Simian T-Cell Leukemia Virus Type 1 Subtype b from a Wild-Born Captive Gorilla gorilla gorilla with T-Cell Lymphoma

2017 ◽  
Vol 5 (43) ◽  
Author(s):  
Ahidjo Ayouba ◽  
Annelies Michem ◽  
Martine Peeters ◽  
Francis Vercammen
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Leukemia Virus ◽  
Gorilla Gorilla ◽  
T Cell Lymphoma ◽  
Cell Leukemia Virus Type ◽  
B Genome ◽  
Subtype B ◽  
Human T Cell ◽  
T Cell Leukemia Virus

ABSTRACT There are four lineages of primate T-cell lymphocytic viruses (human T-cell lymphocytic virus [HTLV]/simian T-cell lymphocytic virus [STLV]), which are further divided into subtypes. To date, there is only one full-length HTLV-1 subtype b genome available. Here, we report the genome of a new STLV-1 subtype b from a 43-year-old male gorilla with T-cell lymphoma.

scholarly journals Targeting JAK/STAT Signaling Antagonizes Resistance to Oncolytic Reovirus Therapy Driven by Prior Infection with HTLV-1 in Models of T-Cell Lymphoma

Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1406
Author(s):  
Shariful Islam ◽  
Claudia M. Espitia ◽  
Daniel O. Persky ◽  
Jennifer S. Carew ◽  
Steffan T. Nawrocki
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Leukemia Virus ◽  
Treatment Options ◽  
T Cell Lymphoma ◽  
Retroviral Infection ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
Novel Approach ◽  
T Cell Leukemia Virus

Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that infects at least 10 million people worldwide and is associated with the development of T-cell lymphoma (TCL). The treatment of TCL remains challenging and new treatment options are urgently needed. With the goal of developing a novel therapeutic approach for TCL, we investigated the activity of the clinical formulation of oncolytic reovirus (Reolysin, Pelareorep) in TCL models. Our studies revealed that HTLV-1-negative TCL cells were highly sensitive to Reolysin-induced cell death, but HTLV-1-positive TCL cells were resistant. Consistent with these data, reovirus displayed significant viral accumulation in HTLV-1-negative cells, but failed to efficiently replicate in HTLV-1-positive cells. Transcriptome analyses of HTLV-1-positive vs. negative cells revealed a significant increase in genes associated with retroviral infection including interleukin-13 and signal transducer and activator of transcription 5 (STAT5). To investigate the relationship between HTLV-1 status and sensitivity to Reolysin, we infected HTLV-1-negative cells with HTLV-1. The presence of HTLV-1 resulted in significantly decreased sensitivity to Reolysin. Treatment with the JAK inhibitor ruxolitinib suppressed STAT5 phosphorylation and expression of the key anti-viral response protein MX1 and enhanced the anti-TCL activity of Reolysin in both HTLV-1-positive and negative cells. Our data demonstrate that the inhibition of the JAK/STAT pathway can be used as a novel approach to antagonize the resistance of HTLV-1-positive cells to oncolytic virus therapy.

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