scholarly journals Acute liver failure due to Human Herpesvirus 6 in an infant

2012 ◽  
Vol 34 (5) ◽  
Author(s):  
G.M. Tronconi ◽  
B. Mariani ◽  
R. Pajno ◽  
M. Fomasi ◽  
L. Cococcioni ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6

Human herpesvirus-6 infection: A prospective study evaluating HHV-6 DNA levels in liver from children with acute liver failure

2008 ◽  
Vol 80 (6) ◽  
pp. 1051-1057 ◽  
Author(s):  
Laurent Chevret ◽  
David Boutolleau ◽  
Nadia Halimi-Idri ◽  
Sophie Branchereau ◽  
Catherine Baujard ◽  
...  
Keyword(s):  
Liver Failure ◽  
Prospective Study ◽  
Acute Liver Failure ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
A Prospective Study

scholarly journals Acute Liver Failure in an Adolescent Male Induced by Human Herpesvirus 6 (HHV-6): A Case Report With Literature Review

2018 ◽  
Vol 49 (2) ◽  
pp. 165-174 ◽  
Author(s):  
Adam M Szewc ◽  
Steve Taylor ◽  
Gary D Cage ◽  
Jeffery Jacobsen ◽  
Ozlem Pinar Bulut ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Human Herpesvirus ◽  
Adolescent Male ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6

Human Herpesvirus 6 Reactivation in DRESS With Acute Liver Failure

2017 ◽  
Vol 101 (7) ◽  
pp. e224-e225
Author(s):  
Vincent Descamps ◽  
Florence Brunet-Possenti
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6

scholarly journals Evaluating for Human Herpesvirus 6 in the Liver Explants of Children With Liver Failure of Unknown Etiology

2018 ◽  
Vol 220 (3) ◽  
pp. 361-369 ◽  
Author(s):  
Christine H Yang ◽  
Malaya K Sahoo ◽  
Megan Fitzpatrick ◽  
Audrey H Lau ◽  
Benjamin A Pinsky ◽  
...  
Keyword(s):  
Liver Failure ◽  
Liver Transplant ◽  
Small Sample Size ◽  
Quantitative Polymerase Chain Reaction ◽  
Human Herpesvirus ◽  
Small Sample ◽  
Unknown Etiology ◽  
Human Herpesvirus 6 ◽  
Formalin Fixed Paraffin Embedded ◽  
Herpesvirus 6

AbstractBackgroundLiver failure of unknown etiology (LFUE) has a transplant-free survival rate <25%. Human herpesvirus 6 (HHV-6) may be associated with LFUE, but studies are limited by small sample size.MethodsWe identified all children who underwent liver transplant for LFUE at a single quaternary children’s hospital; 51/65 cases could be age matched with controls (children who underwent liver transplant for metabolic liver disease). Quantitative polymerase chain reaction for HHV-6 was performed on DNA from formalin-fixed paraffin-embedded liver explant tissue.ResultsHHV-6 was detected in 34/51 cases (66.7%) and 19/51 controls (37.3%) (P = .005). Average HHV-6 viral load was 213207 copies/106 cells in positive cases (range: 7293–1102030) and 38115 copies/106 cells in positive controls (range: 1382–122375) (P = .0008). HHV-6 was present significantly more often in cases compared to controls in patients younger than 6 years. In particular, in patients younger than 3 years, HHV-6 was present in 13/27 cases (48.1%) and 2/27 controls (7.4%) (P = .0009).ConclusionsHHV-6 was detected in liver explants significantly more often and in higher quantities in children transplanted for LFUE compared to controls, suggesting HHV-6 should be evaluated in young children who present with LFUE.

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