scholarly journals Evaluation of antidepressant-like effect Lavandulifolia stachys in the forced swimming test in comparison with imipramine and fluoxetine

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Shirali Kharamin ◽  
Saeed Razmeh ◽  
Mona Nabovvati ◽  
Karim Moradian ◽  
Samaneh Rahimi ◽  
...  
Keyword(s):  
Forced Swimming Test ◽  
Antidepressant Drug ◽  
Behavioral Responses ◽  
Forced Swimming ◽  
Saline Control ◽  
Control Group ◽  
Health Issues ◽  
Treatment Of Depression ◽  
Antidepressant Effects ◽  
Swimming Test

Depression is a global problem associated with multiple social and health issues. In the present study, we analyzed the antidepressant effects of Lavandulifolia stachys, an herbal planton forced swimming test (FST). In this study, 36 rats were used. We gavaged the aqueous extract of plant (50, 100, 150 mg/kg), imipramine and fluoxetine (20 mg/kg) as standard antidepressant drug and normal saline for control group for a week. Then, their behavioral responses including climbing, swimming and immobility were recorded during the 5-min FST. Our experiments showed significant effects of Lavandulifolia stachys on swimming and immobility but not effect on climbing behaviors. Imipramine and fluoxetine increased climbing and swimming, respectively, and both reduced immobility, compared to saline control. Finally, our results show the extract of Lavandulifolia stachys could play an important role in treatment of depression like fluoxetine.

scholarly journals Antidepressant Effects of Apocynum venetum Leaves in a Forced Swimming Test.

2001 ◽  
Vol 24 (7) ◽  
pp. 848-851 ◽  
Author(s):  
Veronika BUTTERWECK ◽  
Sansei NISHIBE ◽  
Tsutomu SASAKI ◽  
Masaru UCHIDA
Keyword(s):  
Forced Swimming Test ◽  
Forced Swimming ◽  
Antidepressant Effects ◽  
Apocynum Venetum ◽  
Swimming Test

scholarly journals Antidepressant and Antiamnesic Potential of Foeniculum vulgare

2020 ◽  
pp. 131-138 ◽  
Author(s):  
Afshan Abbas ◽  
Rahila Ikram ◽  
Faiza Hasan ◽  
Abeer Adil ◽  
Uzair Nisar ◽  
...  
Keyword(s):  
Water Maze ◽  
Forced Swimming Test ◽  
Forced Swimming ◽  
Antidepressant Effect ◽  
Control Group ◽  
Enhancement Effect ◽  
Foeniculum Vulgare ◽  
Group 3 ◽  
Swimming Test ◽  
Group 2

Aim: To evaluate the antiamnesic and antidepressant effect of Foeniculum vulgare whole crushed seeds. Study Design: Laboratory based randomized control study. Place and Duration of Study: Department of Pharmacology, University of Karachi between January 2018 to August 2018.  Methodology: Thirty swiss albino mice and wistar rats were divided equally in three groups. Control group was fed on standard rodent diet, group 2 was fed on 2% Foeniculum vulgare diet and group 3 was given 4% Foeniculum vulgare diet. Antidepressant activity was assessed using forced swimming test. Memory enhancement effect was evaluated by stationary rod test, passive avoidance test and water maze test. Results: Increased duration of struggling time was noted in both group 2 and group 3 as compared to control in forced swimming test. Decrease in time to reach platform in both water maze and stationary rod test was recorded in both the study group (group 2 & 3). Increase in step through latency was also seen in group 2 and group 3 as compared to control group. Conclusion: The results showed the memory enhancing and antidepressant actions of Foeniculum.

scholarly journals Evaluation of the comparison of anti-depressant effects of oral fluoxetine and riluzole in albino rats by using the forced swimming test model

2021 ◽  
Vol 10 (4) ◽  
pp. 391
Author(s):  
Hansraj Kumar ◽  
Akash Chandra ◽  
Uma Shankar Prasad Keshri ◽  
Rajiv Kumar
Keyword(s):  
Selective Serotonin Reuptake Inhibitors ◽  
Forced Swimming Test ◽  
Antidepressant Activity ◽  
Forced Swimming ◽  
Control Group ◽  
Albino Rats ◽  
Test Duration ◽  
Test Model ◽  
Significant Difference ◽  
Swimming Test

Background: Depression is a group of disorders results from a combination of multiple etiologic factors- genetic, biochemical, psychodynamic and socio-environmental. A depression consists of following clinical features as sadness, apathy, changes in sleep pattern, impaired concentration, feeling of shame or guilt and thoughts of dying or death. Fluoxetine and riluzole both are used for the treatment of depression in human being. Fluoxetine is SSRI (selective serotonin reuptake inhibitors) and riluzole is anxiolytic and mood stabilizer.Methods: Healthy male albino rats weighing between 150-200 grams were taken for the present study. Study animals were divided into three groups randomly with each group consisting of ten animals. Drugs were powdered with help of mortar and pestle and mixed in gum acacia solution. Appropriate volume of the freshly prepared solution was administered orally daily between 9 am to 10 am to all animal as per their individual body weight. Group A administered 1ml of 0.9% normal saline orally and serves as control group. Group B administered 0.4 mg of fluoxetine orally. Group C administered 2 mg of riluzole orally. Animals were evaluated for antidepressant activity using model- forced swimming test.Results: The results in the forced swimming test were assessed by duration of immobility in last 4 minutes of total 6 minute test duration. Antidepressant activity is indicated by the reduction in the duration of immobility i.e. lesser the duration more the efficacy. The results have been expressed as mean±standard deviation of duration of immobility in seconds during 6 minute period.Conclusions: There was significant difference in antidepressant activity of fluoxetine with antidepressant activity of riluzole. Riluzole showed antidepressant activity after two weeks of starting the drugs.

Anti-Fatigue Activity of Soy Isoflavones in Mice

2014 ◽  
Vol 955-959 ◽  
pp. 537-540
Author(s):  
Lian Hai Jin ◽  
Xing Yu Zhao ◽  
Ying Xin Qin ◽  
Wen He Zhu ◽  
Zheng Li Luo
Keyword(s):  
Exercise Tolerance ◽  
Biochemical Parameters ◽  
Forced Swimming Test ◽  
Soy Isoflavones ◽  
Forced Swimming ◽  
Control Group ◽  
Time To Exhaustion ◽  
Distilled Water ◽  
Swimming Time ◽  
Swimming Test

In the present study, we investigated the anti-fatigue activity in male Kunming mice with Soy isoflavones using a forced swimming test. Mice were divided into four groups (three Soy isoflavones administered groups and a control group). The control group was gavaged with distilled water and Soy isoflavones administered groups were gavaged with Soy isoflavones (10, 20 and 40mg/10g body weight /d). After four weeks, a forced swimming test was performed and the biochemical parameters related to fatigue were examined. The results suggested that Soy isoflavones could extend the swimming time to exhaustion of the mice. This indicated that Soy isoflavones had anti-fatigue activity and could elevate the exercise tolerance.

Possible involvement of ATP-sensitive potassium channels in the antidepressant-like effects of gabapentin in mouse forced swimming test

2017 ◽  
Vol 95 (7) ◽  
pp. 795-802 ◽  
Author(s):  
Sattar Ostadhadi ◽  
Reyhaneh Akbarian ◽  
Abbas Norouzi-Javidan ◽  
Vahid Nikoui ◽  
Samira Zolfaghari ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Forced Swimming Test ◽  
Anticonvulsant Drug ◽  
Forced Swimming ◽  
Acute Administration ◽  
Beneficial Effects ◽  
Locomotor Movement ◽  
Treatment Of Depression ◽  
Swimming Test ◽  
First Time

Gabapentin as an anticonvulsant drug also has beneficial effects in treatment of depression. Previously, we showed that acute administration of gabapentin produced an antidepressant-like effect in the mouse forced swimming test (FST) by a mechanism that involves the inhibition of nitric oxide (NO). Considering the involvement of NO in adenosine triphosphate (ATP)-sensitive potassium channels (KATP), in the present study we investigated the involvement of KATP channels in antidepressant-like effect of gabapentin. Gabapentin at different doses (5–10 mg/kg) and fluoxetine (20 mg/kg) were administrated by intraperitoneal route, 60 and 30 min, respectively, before the test. To clarify the probable involvement of KATP channels, mice were pretreated with KATP channel inhibitor or opener. Gabapentin at dose 10 mg/kg significantly decreased the immobility behavior of mice similar to fluoxetine (20 mg/kg). Co-administration of subeffective dose (1 mg/kg) of glibenclamide (inhibitor of KATP channels) with gabapentin (3 mg/kg) showed a synergistic antidepressant-like effect. Also, subeffective dose of cromakalim (opener of KATP channels, 0.1 mg/kg) inhibited the antidepressant-like effect of gabapentin (10 mg/kg). None of the treatments had any impact on the locomotor movement. Our study, for the first time, revealed that antidepressant-like effect of gabapentin in mice is mediated by blocking the KATP channels.

Antidepressant-like Effect of Baccharis Ilimita in the Forced Swimming Test in Mice

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
A. Kikko ◽  
P. Koerich ◽  
E. Bondan ◽  
F. Nunes ◽  
M. Pizzolatti ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Open Field ◽  
Leaf Extract ◽  
Forced Swimming Test ◽  
Positive Control ◽  
Forced Swimming ◽  
Control Group ◽  
Swiss Mice ◽  
Immobility Time ◽  
Swimming Test

The aim of the present work was to investigate if flowers extract (FE) and leaf extract (LE) of Baccharis ilimita (Asteraceae) induced antidepressant-like effect. Previous phytochemical investigations have shown the presence of structurally and biogenetically diverse secondary metabolites in this gene, such as flavonoids, diterpenes and triterpenes. Male Swiss mice were injected with FE and LE (12.5; 25.0 or 50.0 mg/kg; i.p.) or saline (S) and after 30 min, they were tested in the forced swimming test (FST). The results showed that FE and LE (50 mg/kg) decreased the duration of immobility time in comparison to the control group (S: 114.8s ± 10.23; FE50: 47.52s ± 9.45; LE50: 53.36s ± 10.38). However, the 12.5 and 25.0 mg/kg doses had no effect on the immobility time in comparison to the control group. The FE and LE did not produce any change in ambulation in mice when tested in an open field. The imipramine (IMP; 15.0 mg/kg i.p.) was used as the positive control. Our results suggested that FE and LE of Baccharis ilimita presents antidepressant-like effect in mice. Such results suggest that the antidepressant-like effect may be attributed at lest partially the flavonoids or the interaction of the active(s) principle(s) present in this plant.Descritores:Baccharis ilimita. Forced swimming test. Depression. Mice.

scholarly journals Adenylyl Cyclase (AC) Mediates the Antidepressant-Like Effects of Tropisetron on a Mouse Model of Maternal Separation Stress

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Ali Hosseinzadeh ◽  
Shakiba Nasiri Boroujeni ◽  
Elham Saghaei ◽  
Zahra Loriooini ◽  
Saeid Habibian Dehkordi ◽  
...  
Keyword(s):  
Effective Dose ◽  
Adenylyl Cyclase ◽  
Maternal Separation ◽  
Forced Swimming Test ◽  
Forced Swimming ◽  
Control Group ◽  
Immobility Time ◽  
Swimming Test ◽  
Medicinal Properties

The adenylyl cyclase (AC) pathway is involved in the pathophysiology of depression. Finding new antidepressants with high medicinal properties and low side effects is warranted. Therefore, this study was designed to determine the antidepressant-like effect of tropisetron on a maternal separation (MS) model in mice, considering the possible role of AC. NMRI male mice were divided into eleven groups. The control group was treated with saline and MS groups were treated with saline, tropisetron (a 5-HT3 receptor antagonist) at doses of 1, 3, and 5 mg/kg; forskolin (an activator of AC) at doses of 5, 10, and 25 mg/kg; a subeffective dose of forskolin with a subeffective dose of tropisetron; and an effective dose of tropisetron plus an effective dose of NB001 (3 mg/kg) (an AC inhibitor). After treatment, animals were subjected to behavioral tests including the forced swimming test (FST), splash test, and open field test (OFT). We showed that MS caused depressive-like behaviors determined as an increase in the immobility time in the forced swimming test (FST) and decreased grooming time in the splash test. Our results showed that administration of tropisetron, as well as forskolin, mitigated the depressive-like behaviors in MS mice. We found that coadministration of a subeffective dose of tropisetron plus a subeffective dose of forskolin potentiated the antidepressant-like effect of tropisetron. However, coadministration of an effective dose of NB001 with an effective dose of tropisetron did not significantly affect the antidepressant-like effect of tropisetron. We concluded that the antidepressant-like effects of tropisetron on MS mice are partially mediated through the adenylyl cyclase pathway.

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