scholarly journals Comparison of prognostic scales for patients with metastatic spine disease

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Anton Denisov ◽  
Nikita S. Zaborovsky ◽  
Dmitry A. Ptashnikov ◽  
Dmitry A. Mikhailov ◽  
Sergey V. Masevnin ◽  
...  
Keyword(s):  
Roc Analysis ◽  
Neurological Status ◽  
Spinal Tumors ◽  
Analysis Software ◽  
Software Environment ◽  
Prognostic Accuracy ◽  
Metastatic Lesions ◽  
Spinal Lesions ◽  
Spinal Cord Decompression ◽  
Statistical Analysis Software

This is one-centre retrospective study with the aim to identify the scale, which provides the most accurate prediction of life expectancy in patients with metastatic lesions in spine. A retrospective analysis of clinical data of 138 patients with metastatic spinal tumors. Patients underwent spinal cord decompression and instrumented stabilization of affected area. We evaluated the general condition according to the Karnofsky and ECOG scales, the presence of metastases in the visceral organs, spine and other bones, the neurological status and conduction of the medical therapy before spinal surgery. Observed clinical parameters were converted to Tokuhashi, Tomita, and Katagiri scales. For statistical analysis, software environment R 3.4.1 was used. Assessment of prognostic accuracy was performed using ROC analysis. The Tokuhashi scale showed AUC 0.605 (95% CI 0.586-0.616), Tomita scale showed AUC 0.708 (95% CI 0.573-0.842), Katagiri scale showed AUC 0.650 (95% CI 0.508-0.792). The best results for survival rate predicting after surgical treatment for metastatic spinal lesions were shown the Tomita scale.

scholarly journals Extradural Spinal Tumors: Report of 36 Cases and Review of Literature

2016 ◽  
Vol 13 (1) ◽  
pp. 3-10
Author(s):  
Gopal R Sharma ◽  
Nilam Khadka ◽  
Rajiv Jha ◽  
Dhurba R Adhikari ◽  
Prakash Bista
Keyword(s):  
Back Pain ◽  
Soft Tissues ◽  
Relevant Literature ◽  
Bone Cyst ◽  
Neurological Status ◽  
Motor Deficit ◽  
Spinal Tumors ◽  
Metastatic Lesions ◽  
Wide Range

About 55% of spinal tumors are extradural arising from vertebral bodies, epidural and surrounding neural and soft tissues. More than 90% of extradural spinal tumors are metastatic lesions. Extradural spinal tumors are common cause of back pain, sensory motor deficit and sphincters dysfunction. The wide range of lesions and varied clinical profile, make management of spinal extradural tumors a challenging task for any neurosurgeon.Aim of this study is to analyze and discuss the results of extradural spinal tumors after surgical treatment and relevant literature will be reviewed.This is a retrospective study of 36 patients who were operated for spinal extradural tumors between May 1999 and December 2012 in our institute.Follow up period ranged from 3 years to 12 years. Functional neurological outcome was assessed by McCormick's grading. There were 20 male and 16 female and age ranged from 10 to 80 years. 30 patients presented with back pain and 15 had radicular pain. On presentation 18 patients had motor sensory deficit and 15 had sphincters dysfunction. Most common involved level of spines were thoracic followed by cervical and lumbar.Gross total excision of masses were carried out in all cases. Common pathologies were neurofibromas (16), Ewing's sarcoma (7), granulomas (3), metastatic lesions (2), angiolipoma (2), chondroma (2), aneurysmal bone cyst (1), plasmacytoma (1), rabdomyosarcoma (1) and neuroblastoma (1).Out of 14 patients who harbored malignant pathology 12 patients received radio and chemotherapy. Post operative wound infection occurred in 5 patients. Regarding post operative neurological status, 18 patients showed improvement, 6 patients remained same and 12 patients had deteriorated neurology. Tumor recurrence occurred in 15 patients; 12 patients with malignant and 3 patients with benign lesions on follow up period. There was no surgery related mortality, however, 11 patients died during 3 years follow up period due to adverse pathology they were having.Nepal Journal of Neuroscience 13:3-10, 2016

scholarly journals Effectiveness of the surgical intervention in the quality of life and survival of patients with metastatic lesions in the spine

2014 ◽  
Vol 13 (1) ◽  
pp. 57-62
Author(s):  
Luiz Cláudio Lacerda Rodrigues ◽  
Adalberto Bortoletto ◽  
Marcelo Hide Matsumoto
Keyword(s):  
Quality Of Life ◽  
Pain Relief ◽  
Surgical Intervention ◽  
Neurological Status ◽  
Lumbar Region ◽  
Metastatic Lesions ◽  
Spinal Lesions ◽  
Pathologic Fractures ◽  
The Impact

OBJECTIVE: To evaluate the impact of surgical treatment of metastatic epidural spinal lesions on the quality of life of patients, pain relief and survival. METHODS: Patients with single or double spinal lesions, in good clinical conditions to undergo surgery, were included. Staging and prognostic evaluation were performed, based on imaging studies, according to the criteria of Enneking and Tokuhashi, and neurological status (Frankel), pain (visual analogue scale, VAS) and quality of life index (Oswestry) were also assessed. Survival was calculated. RESULTS: The study included 67 patients, 34 men and 33 women, aged 13-88 years (mean: 53). Most had the breast (23 cases) as the primary site of the tumor and metastasis in the lumbar region, especially in L2 and L3. Pathologic fractures were diagnosed in 45 patients. The mean VAS score was initially 9 (5-10) reducing in the second day after surgery to 2 (1-7) and to 1 (0-6) in the first and sixth months. Following 6 months, 18 deaths were observed (one intraoperatively, five in the first month and 12 at 6 months). The neurological status was correlated with survival: patients who were Frankel E before surgery showed increased survival. CONCLUSION: The surgery does not influence patient survival, except for patients with neurological deficits, who have a worse prognosis. Treatment of metastatic lesions is often palliative, but patients present improved neurological and pain relief and few complications after surgery, justifying surgical intervention.

Contrast-Enhanced MRI with Magnetization Transfer Effect in the Imaging of Brain Metastatic Lesions

2017 ◽  
pp. 8-17
Author(s):  
A. A. Ermakova ◽  
O. Yu. Borodin ◽  
M. Yu. Sannikov ◽  
S. D. Koval ◽  
V. Yu. Usov
Keyword(s):  
Comparative Analysis ◽  
Roc Analysis ◽  
Magnetization Transfer ◽  
Metastatic Lesion ◽  
Transfer Effect ◽  
Wilcoxon Test ◽  
Post Contrast ◽  
Metastatic Lesions ◽  
The Brain ◽  
Non Parametric

Purpose: to investigate the diagnostic opportunities of contrast  magnetic resonance imaging with the effect of magnetization transfer effect in the diagnosis of focal metastatic lesions in the brain.Materials and methods.Images of contrast MRI of the brain of 16  patients (mean age 49 ± 18.5 years) were analysed. Diagnosis of  the direction is focal brain lesion. All MRI studies were carried out  using the Toshiba Titan Octave with magnetic field of 1.5 T. The  contrast agent is “Magnevist” at concentration of 0.2 ml/kg was  used. After contrasting process two T1-weighted studies were  performed: without T1-SE magnetization transfer with parameters of pulse: TR = 540 ms, TE = 12 ms, DFOV = 24 sm, MX = 320 × 224  and with magnetization transfer – T1-SE-MTC with parameters of pulse: ΔF = −210 Hz, FA(МТС) = 600°, TR = 700 ms, TE = 10 ms,  DFOV = 23.9 sm, MX = 320 x 224. For each detected metastatic  lesion, a contrast-to-brain ratio (CBR) was calculated. Comparative  analysis of CBR values was carried out using a non-parametric  Wilcoxon test at a significance level p < 0.05. To evaluate the  sensitivity and specificity of the techniques in the detection of  metastatic foci (T1-SE and T1-SE-MTC), ROC analysis was used. The sample is divided into groups: 1 group is foci ≤5 mm in size, 2  group is foci from 6 to 10 mm, and 3 group is foci >10 mm. Results.Comparative analysis of CBR using non-parametric Wilcoxon test showed that the values of the CBR on T1-weighted  images with magnetization transfer are significantly higher (p  <0.001) that on T1-weighted images without magnetization transfer. According to the results of the ROC analysis, sensitivity in detecting  metastases (n = 90) in the brain on T1-SE-MTC and T1-SE was  91.7% and 81.6%, specificity was 100% and 97.6%, respectively.  The accuracy of the T1-SE-MTC is 10% higher in comparison with  the technique without magnetization transfer. Significant differences (p < 0.01) between the size of the foci detected in post-contrast T1- weighted images with magnetization transfer and in post-contrast  T1-weighted images without magnetization transfer, in particular for  foci ≤5 mm in size, were found. Conclusions1. Comparative analysis of CBR showed significant (p < 0.001)  increase of contrast between metastatic lesion and white matter on  T1-SE-MTC in comparison with T1-SE.2. The sensitivity, specificity and accuracy of the magnetization transfer program (T1-SE-MTC) in detecting foci of  metastatic lesions in the brain is significantly higher (p < 0.01), relative to T1-SE.3. The T1-SE-MTC program allows detecting more foci in comparison with T1-SE, in particular foci of ≤5 mm (96% and 86%, respectively, with p < 0.05).

METASTATIC LESION OF THE SPINE: DIAGNOSIS AND TACTICS OF SURGICAL TREATMENT

2019 ◽  
Vol 65 (6) ◽  
pp. 868-876
Author(s):  
Anton Yarikov ◽  
Anton Yermolaev ◽  
Igor Smirnov ◽  
Anton Denisov ◽  
Olga Perlmutter ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
Epidemiological Studies ◽  
Metastatic Lesion ◽  
Spinal Cord Damage ◽  
Metastatic Lesions ◽  
Spinal Lesions ◽  
Cancer Pathology ◽  
Surgical Methods ◽  
The Stability ◽  
Methods Of Treatment

Epidemiological studies show an increase in the number of people with cancer. Bone metastases are a frequent manifestation of generalized cancer, because it is in malignant tumors of the spine more often than other bones of the skeleton becomes a target for metastasis. The article describes in detail the methods of diagnosis of spinal lesions in cancer pathology. Particular attention is paid to the scales reflecting the severity of the patient’s condition, the degree of spinal cord damage, the severity of pain in metastasis to the spine, the prognosis of survival in oncovertebrology and evaluation of the stability of the spine in metastatic lesions. Further, the paper presents non-radical (decompression, vertebroplasty) and radical (spondylectomy, corporectomy) surgical methods of treatment

Regression Analysis on Influences of Hem Parameters on Flare Sagging of Semi-Circular Skirt

2011 ◽  
Vol 331 ◽  
pp. 594-598
Author(s):  
Hong Ni
Keyword(s):  
Regression Analysis ◽  
Statistical Analysis ◽  
Measured Data ◽  
Silk Fabric ◽  
Linear Regression Equation ◽  
Analysis Software ◽  
Wool Fabrics ◽  
Object Of Study ◽  
The Relationship ◽  
Statistical Analysis Software

Select 45 pieces of silk, cotton and wool fabrics in total, with semi-circular skirt modeling as object of study, investigate the relationship between flare sagging in straight & inclined grains of skirt pieces and fabric types, analyze the influence of hem parameters on flare sagging of semi-circular skirt and obtain multiple linear regression equation by disposing the measured data with SPSS statistical analysis software. The study result shows that the skirt hem of silk fabric is sagging more significantly than that of cotton and wool fabrics and there is a multi-linear relationship between semi-circular flare sagging and parameters.The research of this subject has both theoretical value and practical value.

Rhotics of Taos, New Mexico Spanish: Variation and Change

2018 ◽  
Vol 11 (1) ◽  
pp. 215-264
Author(s):  
Donny A. Vigil
Keyword(s):  
New Mexico ◽  
Statistical Analysis ◽  
Multivariate Statistical Analysis ◽  
Speech Analysis ◽  
Analysis Software ◽  
Multivariate Statistical ◽  
Conditioning Factors ◽  
Word Position ◽  
Statistical Analysis Software ◽  
Age And Sex

Abstract Although some researchers report the normative production of the rhotics in Traditional New Mexico Spanish, others have reported variability, including the presence of an English-like vocalized rhotic. In the present study, 29 speakers of Spanish from Taos, a city in northern New Mexico, were interviewed and the rhotics of their speech were categorized, quantified and analyzed using speech analysis and multivariate statistical analysis software. The results show variation and change when compared to previous reports (both recent and of over a century ago). In spontaneous and elicited speech, ten distinct rhotic variants, subsequently recoded into five categories, were observed and quantified. Moreover, approximant and assibilated variants have notable frequencies and conditioning factors. VARBRUL analyses reveal phonological context, stress, word position, age, and sex as significant conditioning factors.

scholarly journals Avaliação técnica do dispositivo de fechamento vascular Exoseal-Cordis®

2017 ◽  
Vol 16 (2) ◽  
pp. 98-103
Author(s):  
Altino Ono Moraes ◽  
Rogério Yoshikazu Nabeshima ◽  
Ericsson Fernando Viotto ◽  
Marcelo Hiroshi Estevam Yoshida ◽  
Jihad Mohamad Mansour Abdallah ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Analysis Software ◽  
Statistical Analysis Software

Resumo Contexto Os dispositivos de oclusão vascular (DOV) permitem rápida remoção da bainha introdutora de um acesso arterial, reduzindo o tempo de hemostasia, a restrição do paciente ao leito e as complicações no sítio de punção. Objetivos Avaliar a eficácia e possíveis complicações do uso de dispositivo de oclusão arterial comparado com a compressão manual. Métodos Estudo longitudinal prospectivo randomizado com 20 pacientes no período de dezembro de 2014 a julho de 2015 em Maringá (PR). Foram divididos em dois grupos: aqueles que utilizaram DOV (grupo DOV) e aqueles submetido apenas a compressão manual (grupo CM). Realizaram-se exames de ultrassom Doppler para avaliar a espessura pele-artéria pré e pós-procedimento e verificou-se o tempo de compressão e de deambulação. Os dados foram analisados pelo Programa Statistical Analysis Software. Resultados Um total de 60% dos pacientes eram do sexo masculino e a média de idade de ambos os grupos foi de aproximadamente 60 anos. Não houve diferença na espessura pele-artéria entre os grupos. O tempo de compressão no grupo DOV foi de 2 minutos e no grupo CM foi de 21±2,11 minutos (p = 0,0005), e o tempo para retorno de movimentos no membro inferior puncionado foi de 2,35±0,75 horas no grupo DOV e de 6 horas no grupo CM (p = 0,0005). Não houve complicações. Conclusões Neste estudo a hemostasia por compressão manual foi tão efetiva quanto o uso de DOV, embora o tempo de compressão e o tempo para retorno às atividades sejam menores nos pacientes submetidos ao uso do dispositivo.

Analysis of Machining Workshop Manufacturing Based on Unit K Means Clustering

2014 ◽  
Vol 945-949 ◽  
pp. 3152-3155
Author(s):  
Di Liang ◽  
Fen Kong ◽  
Dan Dan Xu ◽  
Gui Zhi Sun
Keyword(s):  
Statistical Analysis ◽  
Machine Tool ◽  
Clustering Analysis ◽  
Clustering Algorithm ◽  
Work Efficiency ◽  
Analysis Software ◽  
The Cost ◽  
Mechanical Machining ◽  
Statistical Analysis Software

In order to improve the mechanical machining enterprise work efficiency, reduce the cost of enterprise, the process of enterprise existence of similar parts processing by cluster was analysized, using K-means clustering algorithm and the statistical analysis software SPSS with K means clustering analysis function, which grouped the machine tool matrix, and then realized the unit manufacturing.

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