scholarly journals Autologous fat transplantation for the treatment of trapeziometacarpal joint osteoarthritis

2020 ◽  
Author(s):  
Mario Alessandri Bonetti ◽  
Giuseppe Rovere ◽  
Camillo Fulchignoni ◽  
Vincenzo De Santis ◽  
Antonio Ziranu ◽  
...  
Keyword(s):  
Cartilage Regeneration ◽  
Fat Grafting ◽  
Fat Graft ◽  
Cochrane Library ◽  
Autologous Fat Grafting ◽  
Autologous Fat ◽  
Treatment Techniques ◽  
Autologous Fat Transplantation ◽  
Trapeziometacarpal Joint Osteoarthritis ◽  
New Treatment

Rhizarthrosis is a progressive and disabling pathology affecting the carpometacarpal joint. It’s very common in elderly patients and typically affects postmenopausal women. The diagnosis of rhizarthrosis is mainly made by using different physical examination tests and by evaluating the type of pain and it’s then confirmed by imaging. Over the last few years increasing attention has been devoted to the assessment of new treatment techniques for rhizarthrosis. In this context intra-articular injection of autologous fat grafting for cartilage regeneration has demonstrated promising results in experimental settings as an alternative to open surgery procedures. The aim of this study was therefore to sum up the evidences available so far on autologous fat grafting as an emerging treatment for patients affected by carpometacarpal rizarthrosis. An electronic literature research was carried out on Pubmed, Google Scholars and Cochrane Library using “fat grafting”, “fat graft”, “adipose”, “fat transfer” and “lipoaspirate” as search terms. Authors believe autologous fat grafting is an interesting technique, that hand surgeon should keep in mind especially in early stages of rhizarthrosis were pain has not been solved with non-surgical treatment.

scholarly journals FTY720 Improves the Survival of Autologous Fat Grafting by Modulating Macrophages Toward M2 Polarization Via STAT3 Pathway

2021 ◽  
Vol 30 ◽  
pp. 096368972110529
Author(s):  
Yi Yi ◽  
Weijie Hu ◽  
Wenchang Lv ◽  
Chongru Zhao ◽  
Mingchen Xiong ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Graft Survival ◽  
Fat Grafting ◽  
Fat Graft ◽  
M2 Macrophage ◽  
M2 Macrophages ◽  
Autologous Fat Grafting ◽  
Autologous Fat ◽  
Stat3 Pathway

Autologous fat grafting (AFG) is widely regarded as an important method for breast reconstruction after mastectomy among breast cancer (BC) patients. FTY720 has been proved to affect macrophage polarization and improve the sensitivity of postoperative BC treatment. This study aimed to explore FTY720 function and underlying mechanism in fat transplantation. The C57BL/6 J mice that received AFG were randomly divided into two groups treated with saline and FTY720, respectively. The fat graft samples were obtained at week 1, 2, 4, and 12 post-transplantation. Graft volumes, graft structures, M2 macrophages, and STAT3 protein expression were estimated by histological examination, immunofluorescence, flow cytometry, and western blot, respectively. In vitro, mouse preadipocytes were stimulated with FTY720 treated-M2 macrophages conditioned medium (FTY720-M2-CM) to evaluate the adipogenesis effect. The level of adipogenic mRNA expression in preadipocytes was detected by RT-PCR. The in vivo results showed that FTY720 treatment significantly enhanced the fat graft retention, structure integrity, and neovascularization, indicating the potential of FTY720 in improving graft survival. The histology results showed more polarized M2 macrophage presented in the FTY720 group. In the in vitro assay, after FTY720-M2-CM treatment, the 3T3-L1 preadipocytes showed the increased triglyceride content and adipogenic mRNA expression, including FABP4, C/EBP-α, Adipoq, and PPARγ. Furthermore, FTY720 treatment up-regulated the expression level of M2 biomarker CD206, Arg-1, Fizz-1, which could be weakened by the STAT3 inhibitor. Together, this study confirmed the potential efficacy of FTY720 in improving graft survival in the AFG model, possibly mediated by polarizing macrophages to M2 type through activating the STAT3 pathway.

scholarly journals Tear trough – Anatomy and treatment by autologous fat grafting

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Chang Yung Chia
Keyword(s):  
Subcutaneous Fat ◽  
Anatomical Study ◽  
Personal Characteristic ◽  
Fat Grafting ◽  
Fat Graft ◽  
Autologous Fat Grafting ◽  
Autologous Fat ◽  
Tear Trough ◽  
Grafting Technique ◽  
Thin Skin

<p>Tear trough is the main irregularity at midface, of which treatment is difficult. There is no agreement in literature about its anatomy and best treatment. The author presented an anatomical study and personal autologous fat grafting technique for tear trough treatment. Anatomical dissections were done on two fresh cadavers to examine the skin, subcutaneous, muscle and bone layers, spaces, and attachments. Safety and efficacy were evaluated via retrospective analysis of the last 200 consecutive procedures performed by the author. Tear trough is caused by the abrupt transition of the palpebral orbicular oculi muscle (OOM) (<em>i.e.</em>, thin skin without subcutaneous fat compartment) to the orbital OOM (<em>i.e.</em>, thicker skin with malar fat compartment). The tear trough region is located at the OOM bony origin at the medial canthus where no specific ligament was found. The grafted fat volume stabilized at two or three months after the procedure, instead of six months as stated in literature, with excellent results and no severe complications. Tear trough is a personal characteristic, a natural anatomical depression caused by subcutaneous irregularity and can worsen with age. The lack of volume is not effectively corrected by surgeries and thus it must be filled. Fat grafting has several advantages over alloplastic fillers, although it may be more difficult. Fat graft is autologous and abundant, and tissue transplantation could enhance skin quality. Fat grafting is a simple, safe, and effective solution for adding extra volume to correct the deflation phenomenon of the midface aging process. There is no specific anatomical plane for volume injection; the fat graft must be evenly distributed in the deep and superficial plane for uniformity.</p>

scholarly journals Comparison of the Efficacy and Safety of Cell-Assisted Lipotransfer and Platelet-Rich Plasma Assisted Lipotransfer: What Should We Expect from a Systematic Review with Meta-Analysis?

2021 ◽  
Vol 30 ◽  
pp. 096368972198960
Author(s):  
Aizhen Chen ◽  
Li Zhang ◽  
Penghong Chen ◽  
Chaoyu Zhang ◽  
Shijie Tang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Survival Rate ◽  
Platelet Rich Plasma ◽  
Meta Analysis ◽  
Fat Grafting ◽  
Cochrane Library ◽  
Efficacy And Safety ◽  
Autologous Fat Grafting ◽  
Autologous Fat ◽  
Fat Survival

Due to the high absorption rate of traditional autologous fat grafting, cell-assisted lipotransfer (CAL) and platelet-rich plasma (PRP)-assisted lipotransfer were developed. The purpose of this article was to evaluate the efficacy and safety of CAL and PRP in promoting the survival of autologous fat grafting through systematic review and meta-analysis. We searched Pubmed, Cochrane Library, Web of Science, and EMBASE for clinical studies on CAL and PRP-assisted lipotransfer published from January 2010 to January 2020. Then a meta-analysis was performed to assess the efficacy of CAL and PRP-assisted lipotransfer through data analysis of fat survival rate. We also assessed the incidence of complications and multiple operations to analyze their safety. A total of 36 studies (1697 patients) were included in this review. Regardless of the recipient area, CAL and PRP-assisted lipotransfer significantly improved the fat survival rate (CAL vs non-CAL: 71% vs 48%, P < 0.0001; PRP vs non-PRP: 70% vs 40%, P < 0.0001; CAL vs PRP: 71% vs 70%, P = 0.7175). However, in large-volume fat grafting, such as breast reconstruction, both increased the incidence of complications and did not decrease the frequency of multiple operations after lipotransfer. Further prospective studies are needed to evaluate the clinical benefits of CAL and PRP-assisted lipotransfer.

scholarly journals Efficacy, safety and complications of autologous fat grafting to the eyelids and periorbital area: A systematic review and meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0248505
Author(s):  
Fan Yang ◽  
Zhaohua Ji ◽  
Liwei Peng ◽  
Ting Fu ◽  
Kun Liu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Fat Grafting ◽  
Cochrane Library ◽  
Efficacy And Safety ◽  
Autologous Fat Grafting ◽  
Autologous Fat ◽  
Satisfaction Rate ◽  
High Satisfaction ◽  
High Satisfaction Rate

Background In recent years, autologous fat grafting (AFG), also known as fat transfer or lipofilling, has been widely performed for periorbital rejuvenation and defect correction, although the evidence regarding its efficacy and safety is still lacking. Besides, with respect to the periorbital region, it is invariably the earliest appearance area of the facial aging phenomenon. Therefore, a systematic review and meta-analysis is needed to evaluate the efficacy and safety of this technique. Methods A literature search was performed in PubMed, Embase, and the Cochrane library databases on November 20, 2020, adhering to the PRISMA guidelines, to identify all relevant articles. Then, a data extraction and standardization process was performed to assess all outcome data. Ultimately, the data were assessed using a random effects regression model with comprehensive meta-analysis software. Results Thirty-nine studies consisting of 3 cohorts and 36 case series with a total of 4046 cases were included. Meta-analysis revealed a relatively high satisfaction rate of 90.9% (95% CI, 86.4%–94.0%). Frequent complications in 4046 patients receiving AFG were edema, chemosis, and contour irregularity, with an overall complication rate of 7.9% (95% CI, 4.8%–12.8%). Conclusion This systematic review and meta-analysis showed that AFG for rejuvenation of eyelids and periorbital area provided a high satisfaction rate and did not result in severe complications. Therefore, AFG might be performed safely for periorbital rejuvenation and reconstruction.

Autologous fat grafting; it almost seems too good to be true

Burns ◽  
2017 ◽  
Vol 43 (3) ◽  
pp. 690-691
Author(s):  
M.E.H. Jaspers ◽  
K.M. Brouwer ◽  
E. Middelkoop ◽  
P.P.M. van Zuijlen
Keyword(s):  
Fat Grafting ◽  
Autologous Fat Grafting ◽  
Autologous Fat
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