Role of Nitric Oxide, Asymmetric Dimethylarginine and Endothelial Dysfunction in Arteriovenous Fistula Failure: Should We be More Hopeful with Nebivolol?

2013 ◽  
Vol 5 (1) ◽  
pp. 8-12
Author(s):  
Yalcin Solak ◽  
Zeynep Biyik ◽  
Mehmet Kanbay
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Arteriovenous Fistula ◽  
Asymmetric Dimethylarginine

scholarly journals The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of Preeclampsia—Review

2019 ◽  
Vol 20 (11) ◽  
pp. 2757 ◽  
Author(s):  
Weronika Dymara-Konopka ◽  
Marzena Laskowska
Keyword(s):  
Nitric Oxide ◽  
Asymmetric Dimethylarginine ◽  
Disease Process ◽  
Endothelial Activation ◽  
Morbidity And Mortality ◽  
Clinical Implications ◽  
Target Tissue ◽  
Vessel Involvement

Preeclampsia is a serious, pregnancy-specific, multi-organ disease process of compound aetiology. It affects 3–6% of expecting mothers worldwide and it persists as a leading cause of maternal and foetal morbidity and mortality. In fact, hallmark features of preeclampsia (PE) result from vessel involvement and demonstrate maternal endothelium as a target tissue. Growing evidence suggests that chronic placental hypoperfusion triggers the production and release of certain agents that are responsible for endothelial activation and injury. In this review, we will present the latest findings on the role of nitric oxide, asymmetric dimethylarginine (ADMA), and homocysteine in the etiopathogenesis of preeclampsia and their possible clinical implications.

scholarly journals Concentrations of the Selected Biomarkers of Endothelial Dysfunction in Response to Antiepileptic Drugs: A Literature Review

2019 ◽  
Vol 25 ◽  
pp. 107602961985942 ◽  
Author(s):  
Beata Sarecka-Hujar ◽  
Izabela Szołtysek-Bołdys ◽  
Ilona Kopyta ◽  
Barbara Dolińska ◽  
Andrzej Sobczak
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Endothelial Dysfunction ◽  
Literature Review ◽  
Antiepileptic Drug ◽  
Asymmetric Dimethylarginine ◽  
The Body ◽  
Biochemical Processes ◽  
The Brain

Epilepsy is a disease arising from morphological and metabolic changes in the brain. Approximately 60% of patients with seizures can be controlled with 1 antiepileptic drug (AED), while in others, polytherapy is required. The AED treatment affects a number of biochemical processes in the body, including increasing the risk of cardiovascular diseases (CVDs). It is indicated that the duration of AED therapy with some AEDs significantly accelerates the process of atherosclerosis. Most of AEDs increase levels of homocysteine (HCys) as well as may affect concentrations of new, nonclassical risk factors for atherosclerosis, that is, asymmetric dimethylarginine (ADMA) and homoarginine (hArg). Because of the role of these parameters in the pathogenesis of CVD, knowledge of HCys, ADMA, and hArg concentrations in patients with epilepsia treated with AED, both pediatric and adult, appears to be of significant importance.

The Role of Nitric Oxide Synthase Inhibition by Asymmetric Dimethylarginine in the Pathophysiology of Preeclampsia

2010 ◽  
Vol 69 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Rainer H. Böger ◽  
Anke Diemert ◽  
Edzard Schwedhelm ◽  
Nicole Lüneburg ◽  
Renke Maas ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Asymmetric Dimethylarginine ◽  
Oxide Synthase
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