Genetic Investigation of Major Histocompatibility Complex Class-I Related RAET1 Genes for Association in a Glomerulonephritis Population

2012 ◽  
Vol 4 (2) ◽  
pp. 48-50
Author(s):  
Dwaine R. Vance ◽  
Theresa A. Bennett ◽  
Alexander P. Maxwell ◽  
Amy Jayne McKnight
Keyword(s):  
Kidney Disease ◽  
Nucleotide Polymorphisms ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Single Nucleotide ◽  
Risk Genes ◽  
Histocompatibility Complex ◽  
Stage Renal Disease ◽  
End Stage ◽  
Provisional Data

Chromosome 6q22–27 harbors risk genes for kidney disease. We evaluated 1,434 individuals with glomerulonephritis (cases) and 603 unaffected individuals (controls) for RAET1 genes at 6q22–27 using samples from the Medical Research Council/Kidney Research UK Glomerulonephritis DNA bank in a 2-stage approach. Top ranked single nucleotide polymorphisms were also geno-typed in kidney transplant recipients (n=571) and their respective donors (n=520) as controls to evaluate association with end-stage renal disease (ESRD). Provisional data suggested that rs9397070 in the RAET1G gene was associated with susceptibility to glomerulonephritis [Odds ratio (OR) 1.24, 95%; confidence interval (CI): 1.01–1.54, P=0.04] and further supported by additional genotyping (OR 1.22, 95% CI: 1.03–1.42, P=0.02). Genotyping the renal transplant population did not identify any significant association with ESRD. The RAET1 gene family contains candidate genes for kidney disease; however, common RAET1 gene polymorphisms are not identified as strong genetic risk factors for glomerulonephritis in these white populations.

Kidney Transplantation 1: An Overview--Recipient Evaluation and Immunosuppression

2017 ◽  
Author(s):  
Belinda T. Lee ◽  
Anil Chandraker ◽  
Jamil Azzi ◽  
Martina M McGrath
Keyword(s):  
Kidney Transplantation ◽  
Human Leukocyte ◽  
Basic Knowledge ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Early Management ◽  
Leukocyte Antigen ◽  
Medical Evaluation ◽  
Stage Renal Disease ◽  
End Stage

Kidney transplantation remains the optimal renal replacement therapy for patients with end-stage renal disease (ESRD). A timely referral to kidney transplantation and a thorough pretransplantation evaluation ensure improvement in the morbidity and mortality of ESRD patients. Basic knowledge of immune biology and an in-depth understanding of the different induction and maintenance therapies used post kidney transplantation are imperative for optimal patient management. In this review, we discuss the multidisciplinary process of pretransplantation evaluation of kidney transplant recipients. We also discuss state-of–the-art early management post kidney transplantation with the different immunosuppressive therapies currently available. This review contains 3 figures, 11 tables, and 106 references. Key words: crossmatch, donor-specific antibody, immunosuppression, human leukocyte antigen, immunosuppression, induction, maintenance, medical evaluation, transplantation

The role of single nucleotide polymorphisms of CYP3A and ABCB1 on tacrolimus predose concentration in kidney transplant recipients

2017 ◽  
Vol 88 (S1) ◽  
pp. 115-118 ◽  
Author(s):  
Gregor Mlinšek ◽  
Vita Dolžan ◽  
Katja Goričar ◽  
Jadranka Buturović-Ponikvar ◽  
Miha Arnol
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Kidney Transplant ◽  
Nucleotide Polymorphisms ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Single Nucleotide

scholarly journals The Risk of Stroke in Kidney Transplant Recipients with End-Stage Kidney Disease

2019 ◽  
Vol 16 (3) ◽  
pp. 326 ◽  
Author(s):  
Shih-Ting Huang ◽  
Tung-Min Yu ◽  
Ya-Wen Chuang ◽  
Mu-Chi Chung ◽  
Chen-Yu Wang ◽  
...  
Keyword(s):  
Kidney Disease ◽  
General Population ◽  
Kidney Transplant ◽  
Lower Risk ◽  
Cox Regression ◽  
Research Database ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Increased Risk ◽  
End Stage

Background: The incidence of stroke after kidney transplantation is poorly understood. Our study aimed to determine the incidence and predictors of stroke as well as mortality from stroke in kidney transplant recipients (KTRs). Methods: This retrospective cohort study used the National Health Insurance Research Database in Taiwan to study KTRs (N = 4635), patients with end-stage renal disease (ESRD; N = 69,297), and patients from the general population who were chronic kidney disease (CKD)-free and matched by comorbidities (N = 69,297) for the years 2000 through 2010. The risk of stroke was analyzed using univariate and multivariate Cox regression models and compared between study cohorts. Findings: Compared with the ESRD subgroup, KTRs had a significantly lower risk of overall stroke (adjusted hazard ratio (aHR) = 0.37, 95% confidence interval (CI) = 0.31–0.44), ischemic stroke (aHR = 0.45, 95% CI = 0.37–0.55), and hemorrhagic stroke (aHR = 0.20, 95% CI = 0.14–0.29). The risk patterns for each type of stroke in the KTR group were not significantly different than those of the CKD-free control subgroup. The predictors of stroke were age and diabetes in KTRs. All forms of stroke after transplantation independently predicted an increased risk of subsequent mortality, and the strongest risk was related to hemorrhagic events. Interpretation: KTRs had a lower risk of stroke than ESRD patients, but this risk was not significantly different from that of the CKD-free comorbidities-matched general population group. Although stroke was relatively uncommon among cardiovascular events, it predicted unfavorable outcome in KTRs.

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