scholarly journals Dynamics of inflammatory factors expression in ischemic brain tissue injury

2019 ◽  
Vol 11 (4) ◽  
Author(s):  
Tonko Marinović ◽  
Silvio Bašić ◽  
Dominik Romić ◽  
Branimir Nevajda ◽  
Lovorka Đerek ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Tissue Injury ◽  
Interleukin 10 ◽  
Inflammatory Factors ◽  
Modern World ◽  
C Reactive Protein ◽  
High Association ◽  
Reactive Protein ◽  
Initial Onset

Ischemic stroke is one of the most common cause of mortality and disability in the modern world. Still, therapeutic options remains modest. Aim of the study was to present dynamics of inflammatory factors expression (C reactive protein, procalcitonin, interleukin 10) in patients after ischemic stroke. Our study included 101 patients divided in thrombolised and non-thrombolised groups. Inflammatory factors concentration in serum was determinate at admission, 24, 48 hours and seven days after the initial onset, while neurological assessment was measured at the admission, 24 hours, seven days and three months after the initial onset using National Institute of Health Stroke Scale and Rankin Scale. Certain pattern was observed in dynamics of inflammatory factors: intensive increase in first and second day after the stroke, followed by decrease till day seven in both groups. Additionally, thrombolised group showed significant neurological improvement. Although well investigated, the role of inflammatory factors in the ischemic stroke still stays controversial. High association of C reactive protein and interleukin 10 values suggest potential prognostic role in patients follow-up, while the role of procalcitonin values still remains unclear.

scholarly journals The Association of Plasma Fractalkine and Inflammation After Ischemic Stroke

2016 ◽  
Vol 8 (2) ◽  
pp. 109
Author(s):  
Lucia Herminawati ◽  
Andi Wijaya ◽  
Mansyur Arief ◽  
Suryani As'ad
Keyword(s):  
Ischemic Stroke ◽  
Tissue Injury ◽  
Cross Sectional Study ◽  
Stroke Onset ◽  
C Reactive Protein ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Reactive Protein ◽  
The Brain ◽  
Sensitive Marker

BACKGROUND: Inflammation affects the brain after stroke with main functions to rapidly eliminate the source of the disturbance, remove damaged tissue and then restore tissue homeostasis. High sensitive C-reactive protein (hsCRP) is a sensitive marker of inflammation and tissue injury in the arterial wall, while fractalkine is a distinct chemokine that promotes inflammatory signaling after neuronal death on ischemic stroke. We aim to investigate the association of fractalkine with hsCRP as a marker of inflammation in ischemic stroke patients.METHODS: This study was designed as a cross-sectional study. Soon after patients with ischemic stroke admitted to hospital, plasma fractalkine and hsCRP concentrations were assesed. Subjects had to be at least 30 years old and maximum 30 days of stroke onset. High inflammation was defined as hsCRP value >3 mg/L.RESULTS: High fractalkine levels were found on 24 ischemic stroke patients (49%) and mean of fractalkine 0.719 ng/mL on patients with stroke onset <7 days was higher than patients with stroke onset 7-30 days. Low fractalkine levels (<0.527 ng/mL) were found on ischemic stroke patients with onset 7-30 days accompanied by high inflammation (hsCRP >3 mg/L), but no significant correlation between fractalkine and hsCRP (p=0.613).CONCLUSION: High inflammation and low plasma fractalkine profile was found after 7 days of onset in ischemic stroke patients. No significant correlation between fractalkine and hsCRP in ischemic stroke patients.KEYWORDS: CRP, fractalkine, inflammation, ischemic stroke

scholarly journals The Role of D-Dimer, Fibrinogen and C-Reactive Protein as Plasma Biomarkers in Acute Ischemic Stroke

2015 ◽  
Vol 5 (6) ◽  
pp. 277-282 ◽  
Author(s):  
Mostafa Saleh Melake ◽  
Rasha Ali El-Kabany ◽  
Aktham Ismail Al-Emam ◽  
Ahmed Mohamed El-Shereef ◽  
Mohamed Okda
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
C Reactive Protein ◽  
Plasma Biomarkers ◽  
Reactive Protein ◽  
D Dimer

scholarly journals Assessing the level of infectious and inflammatory factors in acute ischemic stroke in diabetic and non-diabetic patients

2021 ◽  
Vol 16 (3) ◽  
pp. 370-379
Author(s):  
Nicolae Ovidiu POP ◽  
◽  
Petru Aurel BABEȘ ◽  
Larisa Bianca HOLHOȘ ◽  
Eugenia GAVRILUȚ ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Plasma Level ◽  
Mean Value ◽  
Arithmetic Mean ◽  
Inflammatory Factors ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Significant Difference ◽  
Igg Level

Introduction. Stroke is one of the principal leading causes of death globally. In 2005, stroke cause approximate 5.7 million death, 87% of deaths was in low and middle-income countries. Recently period, collecting evidence indicated that inflammation and atherosclerosis play important roles in stroke evolution. Material and method. In this prospective longitudinal observational study including 340 patients with acute ischemic stroke with / without diabetes mellitus we analyzed as main criteria infectious factors, inflammatory factors and biochemical factors. The patients were divided into 2 groups: 101 diabetic patients (study group) and 239 non-diabetic patients (control group), were we analyzed as main criteria infectious factors (cytomegalovirus IgG plasma level, cytomegalovirus IgM plasma level, Helicobacter pylori IgG plasma level), inflammatory factors (leucocyte, C-reactive protein) and biochemical (plasma level of fibrinogen). Results. Cytomegalovirus-IgG levels are lower in diabetic versus non-diabetic patients with an arithmetic mean of 1170 AU/ml (95% CI 862.4169 to 1477.8326) versus 1398 AU/ml (95% CI 1169.6839 to 1627,2042) but this difference, although it exists, is not statistically significant p = 0.123. The cytomegalovirus-IgM level is lower in diabetic versus non-diabetic patients a statistically significant difference, p 0.001. The Helicobacter IgG level is lower in diabetic patients with a mean value of 1.0763 U/ml with a 95% CI from 0.8141 to 1.3386 versus non-diabetics with an average of 1.3943 U/ml with a CI of 95% from 1.1963 to 1.5923, but this difference, although there, is not statistically significant, p = 0.07.The number of leukocytes diagnosed in diabetic patients is lower than that of people without diabetes (p = 0.0001). The level of C-reactive protein at diagnosis of diabetic patients is lower (an average value of 3.0207mg/dl with a 95% CI of 0.9726 to 5.0688) than in people who do not suffer from diabetes (arithmetic mean of 5.8218 mg/dl with a 95% CI of 0.5894 to 11.0542), but this difference is not statistically significant. The serum level of fibrinogen at the diagnosis of diabetic patients is lower, with a mean value of 399.4 mg/dl with a 95% CI of 327.7993 to 471.0749, than that of people without diabetes, with an arithmetic mean of 653.8 mg/dl, with a 95% CI of 497.8700 to 809.8647, the difference being statistically significant, p = 0.041. Conclusions. Inflammatory markers such as leukocyte levels at intake, C-reactive protein (CRP), and fibrinogen levels showed lower levels at admission in diabetic patients versus non-diabetic patients. There is no statistically significant difference between diabetic vs. non-diabetic patients regarding cytomegalovirus IgG levels, referring to cytomegalovirus IgM level is lower in diabetic versus non-diabetic patients with significant statistically difference. The Helicobacter IgG level is lower in diabetic patients versus non-diabetics patients.

Role of high sensitivity C - Reactive protein and some of heavy metals in patients with rheumatoid arthritis

2020 ◽  
Vol 23 (16) ◽  
Author(s):  
Nashwan S. Albabawaty ◽  
Ali Y. Majid ◽  
Mohammed H. Alosami ◽  
Halla G. Mahmood
Keyword(s):  
Rheumatoid Arthritis ◽  
Heavy Metals ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein
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