scholarly journals Common anti-oxidant vitamin C as an anti-infective agent with remedial role on SARS-CoV-2 infection. An update

2021 ◽  
Author(s):  
Christos Michailides ◽  
Dimitrios Velissaris
Keyword(s):  
Vitamin C ◽  
Potential Role ◽  
Distress Syndrome ◽  
Antiviral Drug ◽  
Mechanisms Of Action ◽  
Treatment Agent ◽  
Anti Oxidant ◽  
High Doses ◽  
Infective Agent

Coronavirus disease -2019 (COVID-19) has led to a worldwide multifaceted crisis. The medical world agonizes to contend with the problem, but a string of tested medications has been proven unavailing. Vitamin C is well described as a salutary antioxidant and some trials conclude that it may be a potential antiviral drug. In high doses, Vitamin C can alternate crucial steps in the pathogenesis of sepsis and acute respiratory distress syndrome. This dynamic was the driving force behind trials around the world that tried immunonutrition as a weapon against clinical entities. We summarize the mechanisms of action of Vitamin C and its role against infections and the current literature referring to the potential role of Vitamin C in SARS-CoV-2 infection, also as a contingent treatment agent.

scholarly journals Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 615
Author(s):  
Martin Doseděl ◽  
Eduard Jirkovský ◽  
Kateřina Macáková ◽  
Lenka Krčmová ◽  
Lenka Javorská ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Iron Absorption ◽  
Plasma Concentrations ◽  
Physiological Role ◽  
Renal Stones ◽  
Anti Oxidant ◽  
High Doses ◽  
Epigenetic Processes

Vitamin C (L-ascorbic acid) has been known as an antioxidant for most people. However, its physiological role is much larger and encompasses very different processes ranging from facilitation of iron absorption through involvement in hormones and carnitine synthesis for important roles in epigenetic processes. Contrarily, high doses act as a pro-oxidant than an anti-oxidant. This may also be the reason why plasma levels are meticulously regulated on the level of absorption and excretion in the kidney. Interestingly, most cells contain vitamin C in millimolar concentrations, which is much higher than its plasma concentrations, and compared to other vitamins. The role of vitamin C is well demonstrated by miscellaneous symptoms of its absence—scurvy. The only clinically well-documented indication for vitamin C is scurvy. The effects of vitamin C administration on cancer, cardiovascular diseases, and infections are rather minor or even debatable in the general population. Vitamin C is relatively safe, but caution should be given to the administration of high doses, which can cause overt side effects in some susceptible patients (e.g., oxalate renal stones). Lastly, analytical methods for its determination with advantages and pitfalls are also discussed in this review.

scholarly journals COVID-19: Up to 82% critically ill patients had low Vitamin C values

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Teresa Maria Tomasa-Irriguible ◽  
Lara Bielsa-Berrocal
Keyword(s):  
Vitamin C ◽  
Critically Ill ◽  
Potential Role ◽  
Plasma Vitamin ◽  
Single Center ◽  
Berlin Definition ◽  
Single Center Study ◽  
Prevention And Treatment ◽  
Center Study

AbstractThere are limited proven therapeutic options for the prevention and treatment of COVID-19. We underwent an observational study with the aim of measure plasma vitamin C levels in a population of critically ill COVID-19 adult patients who met ARDS criteria according to the Berlin definition. This epidemiological study brings to light that up to 82% had low Vitamin C values. Notwithstanding the limitation that this is a single-center study, it nevertheless shows an important issue. Given the potential role of vitamin C in sepsis and ARDS, there is gathering interest of whether supplementation could be beneficial in COVID-19.

scholarly journals Potential Role of Vitamins and Zinc on Acute Respiratory Infections Including Covid-19

2021 ◽  
Vol 8 ◽  
pp. 2333794X2110217
Author(s):  
Indah K. Murni ◽  
Endy P. Prawirohartono ◽  
Rina Triasih
Keyword(s):  
Vitamin A ◽  
Vitamin C ◽  
Large Dose ◽  
Common Cold ◽  
Potential Role ◽  
Respiratory Infections ◽  
Acute Respiratory Infections ◽  
Under Five ◽  
Short Period

Background. Vitamin C, E, D, A, zinc are considered to be essential in preventing and treating of acute respiratory infections (ARI) including COVID-19. Methods. We reviewed published studies evaluating the potential roles of these vitamin and zinc for ARIs and COVID-19 using Medline database, medRxiv, and bibliographic references. Results. Vitamins C, D, and E did not reduce incidence of common cold in general, but vitamin C reduced by half in population with physical and environment stresses. Vitamins C and E shortened duration and reduced severity of common cold. A large-dose vitamin A had no effect on recovery from pneumonia. Zinc improved clinical deterioration and pneumonia duration in under five. The effect on preventing COVID-19 morbidity and related-death was lacking. Conclusions. Although the effects of vitamins and zinc on ARIs including COVID-19 were inconclusive, taking these for a short period during pandemic may be beneficial when there is risks of deficiency.

scholarly journals Intravenous Vitamin C Administered as Adjunctive Therapy for Recurrent Acute Respiratory Distress Syndrome

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Amit Bharara ◽  
Catherine Grossman ◽  
Daniel Grinnan ◽  
Aamer Syed ◽  
Bernard Fisher ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Vitamin C ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Venous Catheter ◽  
Young Female ◽  
Gastrointestinal Polyposis ◽  
High Doses ◽  
Intravenous Vitamin

This case report summarizes the first use of intravenous vitamin C employed as an adjunctive interventional agent in the therapy of recurrent acute respiratory distress syndrome (ARDS). The two episodes of ARDS occurred in a young female patient with Cronkhite-Canada syndrome, a rare, sporadically occurring, noninherited disorder that is characterized by extensive gastrointestinal polyposis and malabsorption. Prior to the episodes of sepsis, the patient was receiving nutrition via chronic hyperalimentation administered through a long-standing central venous catheter. The patient became recurrently septic with Gram positive cocci which led to two instances of ARDS. This report describes the broad-based general critical care of a septic patient with acute respiratory failure that includes fluid resuscitation, broad-spectrum antibiotics, and vasopressor support. Intravenous vitamin C infused at 50 mg per kilogram body weight every 6 hours for 96 hours was incorporated as an adjunctive agent in the care of this patient. Vitamin C when used as a parenteral agent in high doses acts “pleiotropically” to attenuate proinflammatory mediator expression, to improve alveolar fluid clearance, and to act as an antioxidant.

Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancy

2008 ◽  
Vol 232 (2) ◽  
pp. 327-336 ◽  
Author(s):  
Maria J. Perez ◽  
Beatriz Castaño ◽  
Silvia Jimenez ◽  
Maria A. Serrano ◽  
Jose M. Gonzalez-Buitrago ◽  
...  
Keyword(s):  
Vitamin C ◽  
Biliverdin Reductase ◽  
Anti Oxidant ◽  
Oxidant Effect

scholarly journals Introduction to DOK2 and its Potential Role in Cancer

2021 ◽  
pp. 671-685
Author(s):  
P SUN ◽  
R LI ◽  
Y MENG ◽  
S XI ◽  
Q WANG ◽  
...  
Keyword(s):  
Tyrosine Kinases ◽  
Potential Role ◽  
Suppressor Gene ◽  
Modern Medicine ◽  
Mechanisms Of Action ◽  
Multiple Tumor ◽  
Tyrosine Kinase 2 ◽  
Prevention And Treatment ◽  
Tumor Types

Cancer is a complex, multifactorial disease that modern medicine ultimately aims to overcome. Downstream of tyrosine kinase 2 (DOK2) is a well-known tumor suppressor gene, and a member of the downstream protein DOK family of tyrosine kinases. Through a search of original literature indexed in PubMed and other databases, the present review aims to extricate the mechanisms by which DOK2 acts on cancer, thereby identifying more reliable and effective therapeutic targets to promote enhanced methods of cancer prevention and treatment. The review focuses on the role of DOK2 in multiple tumor types in the lungs, intestines, liver, and breast. Additionally, we discuss the potential mechanisms of action of DOK2 and the downstream consequences via the Ras/MPAK/ERK or PI3K/AKT/mTOR signaling pathways.

scholarly journals Music For Youth During the Covid 19 Pandemic

2022 ◽  
Vol 4 (2) ◽  
pp. 874-878
Author(s):  
Nita Arisanti Yulanda ◽  
Suhendri Suhendri ◽  
Keti Andriani ◽  
Riszky Safitri
Keyword(s):  
Clinical Trials ◽  
Vitamin C ◽  
Community Service ◽  
Lower Respiratory Tract ◽  
Antiviral Effect ◽  
Extension Agent ◽  
Service Activity ◽  
Difficulty Breathing ◽  
High Doses

SARS-CoV-2 virus was found to be targeted cells may be located in the lower respiratory tract, COVID-19 infection can cause mild, moderate to severe symptoms. The main symptoms that appear are fever (> 38oC), cough and difficulty breathing. Vitamin C treatment has an antiviral effect. Clinical trials have shown that administering high doses of vitamin C has a beneficial effect against colds. As a nurse, one of the roles as an extension agent can be carried out in handling Covid-19 patients, namely providing communication, information, and education about health to the community. The role of nurses in providing education to the community is very necessary because it can make people who are given education understand the information conveyed. In this Community Service activity, the focus is on teenagers as one of the preventive efforts against the transmission of the Covid-19 virus through the provision of Health Education on the importance of consuming vitamin C according to the needs of the adolescent body.

ARDS in the setting of FOLFOX/cetuximab based chemoradiotherapy for locally advanced esophageal adenocarcinoma (E2205).

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 121-121
Author(s):  
Ramla NAMISANGO Kasozi ◽  
Anita Choudhary ◽  
Michael K. Gibson ◽  
Paul J. Catalano ◽  
Lawrence Kleinberg ◽  
...  
Keyword(s):  
Potential Role ◽  
Distress Syndrome ◽  
Locally Advanced ◽  
Growth Factor Receptor ◽  
Target Volume ◽  
Normal Lung ◽  
Radiation Technique ◽  
Epidermal Growth ◽  
Clinical Trial Information

121 Background: E2205 was a single-arm, phase II trial that added an epidermal growth factor receptor (EGF-R) inhibitor, cetuximab (C), to CRT. The trial was closed early due to pulmonary toxicity. We investigated the potential role of cetuximab and type of radiation (IMRT vs conventional). Methods: Patients were treated with CRT: Oxaliplatin (OX) 85mg/m2 days 1,15,29; infusional 5-fluorouracil (5-FU) 180mg/m2/24hours x 35 days; C 400mg/m2 day 1 then 250mg/m2days 8,15,22,29 and radiation (IMRT allowed) 180cGy/day x 25 fractions (Monday-Friday), followed by esophagectomy. Results: Of 21 eligible patients enrolled, 17 had surgery (died pulmonary embolism 4 days after CRT, died G3 diarrhea/PD during CRT, died sepsis/hypoxia during CRT). pCR = 7/17. Four post-op deaths from acute respiratory distress syndrome (ARDS) resulted in 7 total study-related deaths. None of the patients who received IMRT died (0/3). 1/6 had ARDS if more than 4 fields with conventional or 3D planning was used. 3 of 15 treated with RT that met the criteria of E1201 guidelines (no more than 3-4 RT fields, normal lung more than 2 cm outside the target volume < 40 Gy, no IMRT). Overall, there was no demonstrable association of ARDS to radiation technique: 4/22 overall, 0/3 if IMRT was used. Conclusions: This regimen is not recommended. There is no clear association between use of IMRT and ARDS. The cause of ARDS remains undetermined. Cetuximab may have played a role. Clinical trial information: NCT00551759.

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