scholarly journals Chronic rhinosinusitis with nasal polyposis: the role of personalized and integrated medicine

2021 ◽  
Author(s):  
Giorgio Ciprandi ◽  
Matteo Gelardi
Keyword(s):  
Personalized Medicine ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyposis ◽  
Biological Agents ◽  
Point Of View ◽  
Integrated Medicine ◽  
Intranasal Corticosteroids ◽  
Ideal Candidate ◽  
The Ideal

Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a common disorder. From a clinical and immunopathological point of view, different phenotypes and endotypes have been identified. As asthma is frequent comorbidity, biological agents for treating CRSwNP associated with asthma may be an attractive strategy. Biological agents have several mechanisms, such as antagonizing IgE, interleukin (IL) 4, IL-5, and IL-13. However, a workup is mandatory, mainly concerning pheno-endotyping. In this regard, clinical cytological grading (CCG) has been proposed as a useful tool to manage patients with CRSwNP as it allows us to define clinical and immunopathological phenotypes able to identify the ideal candidate for biologics. In particular, the mixed cellular pattern, such as eosinophils and mast cells, could be sensitive to anti-IL-4 agents. There is still a need for well-established indications, criteria of responsiveness, duration, and safety. Moreover, personalized medicine could be opportunely integrated and/or alternated with intranasal corticosteroids to prevent relevant adverse events.

scholarly journals Toward a Better Understanding of Metal Nanoparticles, a Novel Strategy from Eucalyptus Plants

Plants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 929
Author(s):  
Hanadi Sawalha ◽  
Rambod Abiri ◽  
Ruzana Sanusi ◽  
Noor Azmi Shaharuddin ◽  
Aida Atiqah Mohd Noor ◽  
...  
Keyword(s):  
Metal Nanoparticles ◽  
Woody Plants ◽  
Woody Species ◽  
Forest Products ◽  
Ideal Candidate ◽  
Promising Tool ◽  
Novel Strategy ◽  
The Ideal

Nanotechnology is a promising tool that has opened the doors of improvement to the quality of human’s lives through its potential in numerous technological aspects. Green chemistry of nanoscale materials (1–100 nm) is as an effective and sustainable strategy to manufacture homogeneous nanoparticles (NPs) with unique properties, thus making the synthesis of green NPs, especially metal nanoparticles (MNPs), the scientist’s core theme. Researchers have tested different organisms to manufacture MNPs and the results of experiments confirmed that plants tend to be the ideal candidate amongst all entities and are suitable to synthesize a wide variety of MNPs. Natural and cultivated Eucalyptus forests are among woody plants used for landscape beautification and as forest products. The present review has been written to reflect the efficacious role of Eucalyptus in the synthesis of MNPs. To better understand this, the route of extracting MNPs from plants, in general, and Eucalyptus, in particular, are discussed. Furthermore, the crucial factors influencing the process of MNP synthesis from Eucalyptus as well as their characterization and recent applications are highlighted. Information gathered in this review is useful to build a basis for new prospective research ideas on how to exploit this woody species in the production of MNPs. Nevertheless, there is a necessity to feed the scientific field with further investigations on wider applications of Eucalyptus-derived MNPs.

Biologic Agents for the Treatment of Chronic Rhinosinusitis With Nasal Polyps

2018 ◽  
Vol 33 (2) ◽  
pp. 203-211 ◽  
Author(s):  
Alison G. Kartush ◽  
Jane K. Schumacher ◽  
Rachna Shah ◽  
Monica O. Patadia
Keyword(s):  
Clinical Trials ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyposis ◽  
Biologic Therapy ◽  
Biologic Agents ◽  
Inflammatory Disorder ◽  
Review Of Literature ◽  
Sinus Disease ◽  
Adjunct Treatment

Background Chronic rhinosinusitis with nasal polyposis is a complex inflammatory disorder, which is often recalcitrant to medical and surgical management. Recently, biologic agents have been studied as an adjunct treatment for this patient population. Objective The purpose of this study is to examine the role of biologic agents for chronic rhinosinusitis patients by reviewing literature and clinical trials. Methods A comprehensive review of literature and clinical trials—both recently completed and ongoing—was undertaken to examine up-to-date evidence of current biologic therapy and its role in chronic rhinosinusitis patients—including anti-IgE, anti-IL-4, anti-IL-5, anti-IL-13, and GATA-3 DNAzyme. Results Specific biologic agents discussed include omalizumab, reslizumab, mepolizumab, benralizumab, dupilumab, and Hgd40/SB010. Risks, side effects, and administration information are also reviewed. An algorithm for the use of biologics in patients with chronic rhinosinusitis with nasal polyposis is proposed. Conclusion These treatments have promising results and may prove to be an important adjunct for patients with recalcitrant sinus disease.

Perception of Role of the President: A Nine-Year Follow up

1974 ◽  
Vol 38 (3_suppl) ◽  
pp. 1259-1262 ◽  
Author(s):  
Gary R. Morrow ◽  
Peter F. Merenda ◽  
Walter V. Clarke
Keyword(s):  
United States ◽  
The United States ◽  
Point Of View ◽  
Vector Analysis ◽  
Age And Sex ◽  
The Ideal ◽  
Activity Vector

The Activity Vector Analysis was administered to 31 Ss matched for age and sex to a prior sample under the instructions to select those words which they felt described the kind of person the President of the United States should be. Comparing the significant resulting cluster with one discovered 9 yr. previously showed that there has been slight change in the stereotyped perception of the Ideal President in that the new ideal is generally less opinionated and decisive as well as more receptive and appreciative of another person's point of view than was previously found.

scholarly journals Motive of Hope in Works by Mykola Bazhan

2019 ◽  
pp. 26-32
Author(s):  
Roman Tkachenko
Keyword(s):  
Social Problems ◽  
Social Role ◽  
Class Struggle ◽  
Point Of View ◽  
Human Being ◽  
The Social ◽  
The Future ◽  
The Ideal

The paper off ers an attempt to read the works of M. Bazhan focusing on the evolving motive of hope. It is stated that this motive has its cultural and historical scope and practical content. Presently the experience of hope becomes energy of progress and cultural creation. Hope is energized by active work and nourishes work, art, science, creativity. The methods of overcoming despair in Bazhan’s poetry have been updated over the course of decades in connection with the changes in perception of the social role of poetry. Although initially the comprehension of integrity was seen in the stream of the class struggle, later the poet preferred healing the soul with art. The philosophy of the author of the “Hoff man’s Night” was not contemplative; it was focused on existential and social problems and directed by humanistic values. It is no coincidence that the poet chose the least irrational of the three main Christian virtues, the most earthly and human one – the hope. Instead, most poets at all times cultivated predominantly faith and love. This fact might explain why Bazhan’s poetry never gained vast popularity but constantly attracted attention of critics and scholars. The author’s path from despair and fear to hope is the path from the local, psychological, individual to the universal, social, and philosophical. The continual motive of hope gives some unexpected coloring to a seemingly trivial Enlightenment-like picture of the future. The concepts of progress are being filled with drama and dynamics. Existential problems proved to be much more important than the ideal future projects. The sources and plan of the progress are contained not in the objective laws of the history, but exclusively in a human being, permanently fighting in the darkness and chaos. From this point of view, Bazhan is not a representative of the Soviet-style Marxism. In fact, his worldview is rather in tune with E. Bloch’s neo-Marxism or J.-P. Sartre’s existentialism.

scholarly journals PROBLEMY Z OBSADZENIEM NUNCJATURY W POLSCE (XI 1935 – V 1937)

2016 ◽  
Vol 13 (1) ◽  
pp. 125
Author(s):  
Karol Łopatecki
Keyword(s):  
Final Outcome ◽  
Holy See ◽  
Political Situation ◽  
Ideal Candidate ◽  
Secretary Of State ◽  
Number Of Factors ◽  
The Republic ◽  
Polish Government ◽  
The Ideal

PROBLEMS WITH THE APPOINTMENT OF THE PAPAL NUNCIO TO POLAND, NOVEMBER 1935 – APRIL 1937SummaryThe article describes the appointment of Filippo Cortesi to the office of papal nuncio to the Republic of Poland, and reviews the role of the Polish diplomats accredited to the Holy See in this process. The appointment of a nuncio following the departure of Francesco Marmaggi was extremely complicated. The list of candidates was the resultant of a number of factors. The individuals whose names were on it had used influence with the pope, the Vatican’s secretary of state, or former nuncios to Warsaw. Both the Polish government and the bishops of Poland had a say in the final outcome. In addition there was also the volatile political situation in Europe at the time, especially in Spain and Yugoslavia, which exerted an effect on the process. In June 1936 Carlo Chiarlo received the nomination for the office. However, the unanimously negative position of the Conference of the Bishops of Poland, especially Cardinals Kakowski and Hlond, stopped the appointment at the last moment. The Polish Government did not want Ermenegildo Pellegrinetti to be appointed and tried to prevent it, considering Angelo Giuseppe Roncalli the ideal candidate. Eventually Pius XI appointed Filippo Cortesi, formerly nuncio to Argentina.

scholarly journals EL PAPEL DEL ALUMNADO EN EL TRABAJO DE FIN DE GRADO: UNA VISIÓN DESDE LA PERSPECTIVA DE SOLUCIÓN DE PROBLEMAS

2016 ◽  
Vol 4 (1) ◽  
pp. 265
Author(s):  
María A. Inmaculada Calleja González
Keyword(s):  
Self Regulation ◽  
Point Of View ◽  
Problem Definition ◽  
Problem Representation ◽  
Metacognitive Skills ◽  
Personal Approach ◽  
The Impact ◽  
Ideal Method ◽  
The Ideal

Abstract.This paper presents a personal approach on how the supervision of a Degree Disseration could be carried out, focusing on the problem from the point of view of the student. The execution of the Degree Dissertation is a personal challenge that can be considered as a problem to be solved by the student and it can offer different solutions. The role of the professor of university as tutor, following the phases of the IDEAL method of Bransford and Barry Stein (1984): Identification of the problem, Definition and problem representation, Exploration of the different and possible strategies, Intervention based on a strategy, Achievements and assessment of the impact, can help students to develop metacognitive skills (thinking and personal motivations skills), strengthening planning, self-regulation, autonomy and self-efficiency in performing the Degree Dissertation.Key Words: Degree Dissertation, professor of university as tutor, student, problems solution, skills development.Resumen.Este trabajo presenta un planteamiento personal de cómo podría llevarse a cabo la tutela de un Trabajo de Fin de Grado (TFG) enfocando el problema desde el punto de vista del alumno. La realización del TFG es un reto personal que se puede plantear como un problema a resolver por el estudiante pudiendo derivar en soluciones diversas. El papel del tutor, siguiendo las fases del método IDEAL de Bransford y Barry Stein (1984): Identificación del problema, Definición y representación del problema, Exploración de diferentes y posibles estrategias, Actuación fundada en una estrategia, Logros y evaluación de efectos, puede ayudar al alumnado en el desarrollo de competencias metacognitivas, de pensamiento y de motivación, potenciando la planificación, la autorregulación, la autonomía y la autoeficacia en la realización del Trabajo Fin de Grado.Palabras Clave: TFG, tutor, alumno, solución de problemas, desarrollo de competencias.

scholarly journals A Scholarly Review of the Safety and Efficacy of Intranasal Corticosteroids Preparations in the Treatment of Chronic Rhinosinusitis

2020 ◽  
pp. 014556132096772
Author(s):  
Luis Macias-Valle ◽  
Alkis J. Psaltis
Keyword(s):  
Chronic Rhinosinusitis ◽  
Search Strategy ◽  
Intranasal Corticosteroids ◽  
Quality Of Life Measures ◽  
General Quality ◽  
Comprehensive Search ◽  
High Level ◽  
Comprehensive Search Strategy

Objective: The purpose of this scholarly review is to present an update of the efficacy, safety, and distribution of intranasal corticosteroids (INCS) in the context of treatment for chronic rhinosinusitis (CRS). Materials and Methods: A literature review from 1999 to 2020 of MEDLINE, PubMed, and EMBASE databases was performed, using a comprehensive search strategy. Studies reporting on efficacy, safety, and distribution of all INCS formulations, both Food and Drug Administration (FDA) and non-FDA approved, were reviewed. Results and Conclusions: High-level evidence publications and position papers support the role of INCS in medical treatment for CRS. Significant improvement in disease-specific and general quality of life measures is observed with all formulations of INCS. Overall, the use of both FDA and published non-FDA INCS appears to be safe. Several novel distribution devices might improve penetration to specific areas within the sinuses.

Role of Biologics in Chronic Rhinosinusitis With Nasal Polyposis: State of the Art Review

2020 ◽  
pp. 019459982093996 ◽  
Author(s):  
Christine Kim ◽  
Joseph Han ◽  
Tara Wu ◽  
Claus Bachert ◽  
Wytske Fokkens ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Large Scale ◽  
Nasal Polyposis ◽  
Therapeutic Option ◽  
Cochrane Review ◽  
Clinical Problem ◽  
Randomized Controlled ◽  
Systemic Treatments

Objective To review the current literature regarding the role of biologics in the treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP). Data Sources PubMed/MEDLINE, EMBASE, Cochrane Review, ClinicalTrials.gov Review Methods We conducted a comprehensive review of the literature on clinical studies investigating the efficacy of emerging biologics in CRSwNP, with a focus on randomized controlled trials. Conclusions There appears to be promising evidence to support the safety and efficacy of biologics in CRSwNP with and without asthma for select patients. However, additional large-scale randomized studies with longer follow-up are necessary to determine which patients would benefit the most from these novel systemic treatments. Implications for Practice Chronic rhinosinusitis with nasal polyposis refractory to medical and surgical therapy remains a challenging clinical problem for otolaryngologists. However, emerging biologic therapies may offer a new therapeutic option for such patients with recalcitrant disease.

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