scholarly journals Hyaluronic acid levels are increased in complicated parapneumonic pleural effusions

2015 ◽  
Vol 75 (3) ◽  
Author(s):  
T. Zaga ◽  
D. Makris ◽  
I. Tsilioni ◽  
T. Kiropoulos ◽  
S. Oikonomidi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Extracellular Matrix ◽  
Congestive Heart Failure ◽  
Hyaluronic Acid ◽  
Pleural Fluid ◽  
Inflammatory Process ◽  
Serum Levels ◽  
Pleural Effusions ◽  
Tnf Α ◽  
Malignant Effusions

Background and Aim. Hyaluronic acid (HA) is a component of extracellular matrix and may play a role in the pleural inflammation which is implicated in parapneumonic effusions.The aim of the current study was to investigate HA levels in serum and pleura in patients with parapneumonic effusions. Methods. We prospectively studied pleural and serum levels of HA in 58 patients with pleural effusions due to infection (complicated and uncomplicated parapneumonic effusions), malignant effusions and transudative effusions due to congestive heart failure. In addition to HA, TNF-α and IL-1β levels were determined in pleural fluid and serum by ELISA. Results. The median±SD HA levels (pg/ml) in pleural fluid of patients with complicated effusions (39.058±11.208) were significantly increased (p<0.005), compared to those with uncomplicated parapneumonic effusions (11.230±1.969), malignant effusions (10.837±4.803) or congestive heart failure (5.392±3.133). There was no correlation between pleural fluid and serum HA values. Pleural fluid TNF-α levels (146±127 pg/mL) and IL-1β levels (133.4±156 pg/mL) were significantly higher in patients with complicated parapneumonic effusions compared to patients with other types of effusion (p<0.05). No significant association between HA and TNF-α or IL-1β was found. Conclusions. HA may play a significant role in the inflammatory process which characterises exudative infectious pleuritis. Further investigation might reveal whether HA is a useful marker in the management of parapneumonic effusions.

Fibronectin is unsuitable as a tumor marker in pleural effusions.

1989 ◽  
Vol 35 (1) ◽  
pp. 166-168 ◽  
Author(s):  
P Delpuech ◽  
G Desch ◽  
F Fructus
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Pulmonary Tuberculosis ◽  
Diagnostic Accuracy ◽  
Tumor Marker ◽  
Pleural Fluid ◽  
Pleural Effusions ◽  
Malignant Pleural Effusions ◽  
High Concentrations

Abstract We studied 75 patients with nonmalignant pleural effusions (50 with pneumopathy, 16 with pulmonary tuberculosis, and nine with congestive heart failure) and 33 patients with malignant pleural effusions. We selected 105 mg/L as the most suitable cutoff concentration of fibronectin for distinguishing between the two groups. We found high concentrations of fibronectin in 21 of the 33 patients with malignant pleural fluid but also in 37 of the 75 patients with nonmalignant pleural fluid. Evidently, measuring fibronectin in pleural fluid will not help in differentiating nonmalignant from malignant pleural fluids (diagnostic accuracy: 55%).

l-Carnitine: a potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in heart failure

2002 ◽  
Vol 283 (3) ◽  
pp. C802-C810 ◽  
Author(s):  
Giorgio Vescovo ◽  
Barbara Ravara ◽  
Valerio Gobbo ◽  
Marco Sandri ◽  
Annalisa Angelini ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Congestive Heart Failure ◽  
Muscle Metabolism ◽  
Muscle Cells ◽  
Serum Levels ◽  
Skeletal Muscle Cells ◽  
Tnf Α ◽  
Factor Α

Skeletal muscle in congestive heart failure is responsible for increased fatigability and decreased exercise capacity. A specific myopathy with increased expression of fast-type myosins, myocyte atrophy, secondary to myocyte apoptosis triggered by high levels of circulating tumor necrosis factor-α (TNF-α) has been described. In an animal model of heart failure, the monocrotaline-treated rat, we have observed an increase of apoptotic skeletal muscle nuclei. Proapoptotic agents, caspase-3 and -9, were increased, as well as serum levels of TNF-α and its second messenger sphingosine. Treatment of rats withl-carnitine, known for its protective effect on muscle metabolism injuries, was found to inhibit caspases and to decrease the levels of TNF-α and sphingosine, as well as the number of apoptotic myonuclei. Staurosporine was used in in vitro experiments to induce apoptosis in skeletal muscle cells in culture. Whenl-carnitine was applied to skeletal muscle cells, before staurosporine treatment, we observed a reduction in apoptosis. These findings show that l-carnitine can prevent apoptosis of skeletal muscles cells and has a role in the treatment of congestive heart failure-associated myopathy.

Serum Levels of Soluble Form of Fas Molecule in Patients with Congestive Heart Failure

1997 ◽  
Vol 79 (12) ◽  
pp. 1698-1701 ◽  
Author(s):  
Masaki Okuyama ◽  
Seiji Yamaguchi ◽  
Naoki Nozaki ◽  
Minako Yamaoka ◽  
Masanori Shirakabe ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Serum Levels ◽  
Soluble Form

scholarly journals Assessment of Serum Levels of MicroRNAs in Patients with Congestive Heart Failure

2013 ◽  
Vol 62 (18) ◽  
pp. C105
Author(s):  
Huseyin Altug Cakmak ◽  
Hasan Ali Barman ◽  
Ender Coskunpinar ◽  
Yasemin Musteri Oltulu ◽  
Baris Ikitimur ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Serum Levels

Serum Levels of Tenascin-C Variants in Congestive Heart Failure Patients: Comparative Analysis of Ischemic, Dilated, and Hypertensive Cardiomyopathy

2014 ◽  
Vol 60 (06/2014) ◽  
Author(s):  
Marcus Franz ◽  
Alexander Berndt ◽  
Friedhelm Kuethe ◽  
Michael Fritzenwanger ◽  
Hans-Reiner Figulla ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Comparative Analysis ◽  
Serum Levels ◽  
Heart Failure Patients ◽  
Tenascin C

Lactate dehydrogenase, creatine kinase, and their isoenzymes in pleural effusions

1991 ◽  
Vol 37 (11) ◽  
pp. 1909-1912 ◽  
Author(s):  
T Paavonen ◽  
K Liippo ◽  
H Aronen ◽  
U Kiistala
Keyword(s):  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Protein Content ◽  
Pleural Fluid ◽  
Clinical Diagnosis ◽  
Body Fluids ◽  
Pleural Effusions ◽  
Inflammatory Lesions ◽  
Malignant Effusions ◽  
The Mean

Abstract Lactate dehydrogenase (LD; EC 1.1.1.27) and creatine kinase (CK; EC 2.7.3.2) are widely distributed cytoplasmic enzymes. LD has five and CK has three isoenzymes distributed in different proportions in various tissues. The amounts of LD and CK and the distribution of isoenzymes in different body fluids are not thoroughly characterized. We have measured the total LD and CK concentrations and their isoenzyme distribution in pleural aspirates and in serum from 22 patients with benign conditions and from 14 patients with malignant effusions. In malignant pleural fluid, the mean total LD was 662 U/L; in benign conditions, it was nearly 5840 U/L with large variations (91-43 400 U/L) according to clinical diagnosis, the highest values being reached in inflammatory lesions. The mean total CK concentration in pleural fluid was close to the serum value in both groups of patients, as was the pleural CK isoenzyme distribution. The LD isoenzyme distribution in pleural effusions differed from that in serum in both groups, with LD-4 and -5 being the main isoenzymes in their pleural fluid specimens (greater than 42% of total LD). The total LD concentration correlated somewhat (r = 0.57) with the total pleural protein content. In conclusion, the pleural LD isoenzyme distribution, both in benign and malignant conditions, differs from that in serum, having shifted towards more anaerobic and embryonic isoenzymes (LD-4 and -5). Moreover, the greater the concentration of pleural total LD, the greater the proportion of LD-4 and -5. These data suggest that visceral or parietal pleural cells are rich in LD isoenzymes 4 and 5.

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