scholarly journals Reticulocytes in untreated Obstructive Sleep Apnoea

2016 ◽  
Vol 70 (3) ◽  
Author(s):  
O. Marrone ◽  
A. Salvaggio ◽  
M. Gioia ◽  
A. Bonanno ◽  
M. Profita ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Blood Cells ◽  
Univariate Analysis ◽  
Transferrin Saturation ◽  
Sleep Time ◽  
Sleep Apnoea ◽  
Male Adult ◽  
Obstructive Sleep ◽  
Wide Range ◽  
Nocturnal Polysomnography

Background and Aim. The short, repetitive hypoxaemic episodes observed in obstructive sleep apnoea (OSA) may determine small augmentations in mature red blood cells. It is unknown whether they affect reticulocyte release. This study explored whether the number and degree of maturation of circulating reticulocytes may be altered in OSA, possibly through the effect of erythropoietin. Methods. Fifty male adult patients with suspected OSA, normoxic during wakefulness, were studied. After nocturnal polysomnography, a blood sample was withdrawn for blood cells count, erythropoietin, iron and transferrin determination. Reticulocyte concentration and degree of immaturity [high (H), medium (M), or low (L)] were also determined. Immature reticulocyte fraction (IRF) was calculated as (M+H) percentage of reticulocytes. Results. A wide range of OSA severity was found [apnoea/ hypopnoea index (AHI): 44.3±30.4, range 0.3-105; sleep time spent at oxyhaemoglobin saturation 2% had higher EPO levels (p<0.05), but not worse nocturnal desaturations, than those with values <2%. By contrast, subjects with IRF <15% showed worse desaturations (p<0.05), but similar EPO concentrations, when compared to subjects whose IRF was <10%. At univariate analysis, reticulocyte count correlated to erythropoietin, while IRF to transferrin saturation, BMI and OSA severity. At multiple regression, only lowest nocturnal oxygen saturation remained a significant contributor to IRF (r2 0.223, p<0.05). Conclusions. This data suggests that hypoxaemia due to OSA could influence the release of immature reticulocytes, but this effect is not mediated by erythropoietin.

scholarly journals The association between beta-blocker therapy and daytime sleepiness in obstructive sleep apnoea

2021 ◽  
Author(s):  
Martina Meszaros ◽  
Alexander G. Mathioudakis ◽  
Maria Xanthoudaki ◽  
Victoria Sircu ◽  
Evangelia Nena ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Beta Blocker ◽  
Daytime Sleepiness ◽  
Beta Blockers ◽  
Multivariate Logistic Regression Analysis ◽  
Sleep Time ◽  
Sleep Apnoea ◽  
Sensitivity Analyses ◽  
Obstructive Sleep ◽  
Cardinal Symptom

AbstractDaytime sleepiness is a cardinal symptom of obstructive sleep apnoea (OSA) and a well-recognised side effect of beta-blockers, therefore patients with OSA under this treatment may have worse sleepiness. However, the interaction between daytime sleepiness and beta-blockers use has not been thoroughly investigated in patients with OSA before. We analysed the data of 2183 individuals (1852 patients with OSA and 331 snorer controls) from 3 countries (Greece, Hungary and Moldova). Medical history, including medication usage and the Epworth Sleepiness Scale (ESS) were recorded. Patients and controls were divided into somnolent (ESS ≥ 11) and non-somnolent (ESS < 11) groups, and the association between-blocker use with the somnolent group was investigated with multivariate logistic regression analysis adjusted for confounders. Sensitivity analyses were performed in each cohort, in the severity subgroups, in patients who did not take statins and in those who had polysomnography as a diagnostic test. There was no relationship between beta-blocker usage and the somnolent OSA (p = 0.24) or control (p = 0.64) groups. These results were similar in sensitivity analyses (all p > 0.05). ESS was related to BMI (ρ = 0.25), total sleep time (ρ = 0.07), AHI (ρ = 0.32), oxygen desaturation index (ρ = 0.33) and minimum oxygen saturation (ρ =  – 0.32, all p < 0.05) in OSA, and was higher in patients with hypertension, diabetes and cerebro/cardiovascular disease and those who took statins (all p < 0.05). In general, beta-blockers are not associated with increased daytime sleepiness in OSA. Thus, the diagnosis of OSA should not discourage initiation of beta-blocker treatment, if it is clinically indicated.

scholarly journals Triglyceride-Glucose Index in Non-Diabetic, Non-Obese Patients with Obstructive Sleep Apnoea

2021 ◽  
Vol 10 (9) ◽  
pp. 1932
Author(s):  
Andras Bikov ◽  
Stefan M. Frent ◽  
Martina Meszaros ◽  
Laszlo Kunos ◽  
Alexander G. Mathioudakis ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Oxygen Saturation ◽  
Obstructive Sleep Apnoea ◽  
Sleep Time ◽  
Sleep Apnoea ◽  
Obese Patients ◽  
Triglyceride Glucose Index ◽  
Cigarette Pack ◽  
Obstructive Sleep ◽  
And Control

Obstructive sleep apnoea (OSA) is associated with increased insulin resistance. Triglyceride-glucose index (TyG) is a simple marker of insulin resistance; however, it has been investigated only by two studies in OSA. The aim of this study was to evaluate TyG in non-diabetic, non-obese patients with OSA. A total of 132 patients with OSA and 49 non-OSA control subjects were included. Following a diagnostic sleep test, fasting blood was taken for the analysis of the lipid profile and glucose concentrations. TyG was calculated as ln(triglyceride [mg/dL] × glucose [mg/dL]/2). Comparison analyses between OSA and control groups were adjusted for age, gender, body mass index (BMI) and smoking. TyG was higher in men (p < 0.01) and in ever-smokers (p = 0.02) and it was related to BMI (ρ = 0.33), cigarette pack-years (ρ = 0.17), apnoea–hypopnoea index (ρ = 0.38), oxygen desaturation index (ρ = 0.40), percentage of total sleep time spent with oxygen saturation below 90% (ρ = 0.34), and minimal oxygen saturation (ρ = −0.29; all p < 0.05). TyG values were significantly higher in OSA (p = 0.02) following adjustment for covariates. OSA is independently associated with higher TyG values which are related to disease severity in non-obese, non-diabetic subjects. However, the value of TyG in clinical practice should be evaluated in follow-up studies in patients with OSA.

New forehead device in positional obstructive sleep apnoea: a randomised clinical trial

Thorax ◽  
2021 ◽  
pp. thoraxjnl-2020-216167
Author(s):  
Laura Hidalgo Armas ◽  
Sandra Ingles ◽  
Rafaela Vaca ◽  
Jose Cordero-Guevara ◽  
Joaquin Duran Carro ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Supine Position ◽  
Total Sleep Time ◽  
Controlled Trial ◽  
Randomised Clinical Trial ◽  
Sleep Time ◽  
Sleep Apnoea ◽  
Active Device ◽  
Link Type ◽  
Obstructive Sleep

RationaleApproximately 60% of the patients with obstructive sleep apnoea suffer from a positional effect, and approximately 25% of these patients present events only in the supine position.ObjectiveTo validate a new positional vibrating device and evaluate its efficacy in reducing the Apnoea–Hypopnoea Index and the total sleep time in the supine position without disturbing sleep.MethodsA total of 128 patients were recruited for this multicentre, prospective, parallel, randomised controlled trial and were distributed in three arms (general recommendations, inactive and active device). Full overnight polysomnography was performed at baseline and at 12 weeks. Anthropometric variables and sleep and quality of life questionnaires were collected at 4, 8 and 12 weeks.ResultsThe Apnoea-Hypopnoea Index decreased from 30.6 per hour to 20.4 per hour (p<0.001) in the active device (AD) group. In this group the reduction was 2.3-fold and 3.3-fold than the ones in the general recommendations (GR) and inactive device (ID) groups, respectively (p=0.014). Sleep time in supine position decreased 17.7%±26.3% in GR group (p<0.001), 13.0%±22.4% with ID group (p<0.001) and 21.0%±25.6% in the AD group (p<0.001). Furthermore, total sleep time increased significantly only in the AD group (22.1±57.5 min, p=0.016), with an increased percentage of time in the N3 (deep sleep) and N3+REM (rapid eye movement) stages, without sleep fragmentation.ConclusionThe device was effective in reducing the Apnoea–Hypopnoea Index and time spent in the supine position also in improving sleep architecture. Therefore, the device could be a good option for the management of patients with positional obstructive sleep apnoea.Trial registration detailsThe trial was registered at www.clinicaltrials.gov (NCT03336515).

scholarly journals Comparison of Hospital-Based and Home-Based Obstructive Sleep Apnoea Severity Measurements with a Single-Lead Electrocardiogram Patch

Sensors ◽  
2021 ◽  
Vol 21 (23) ◽  
pp. 8097
Author(s):  
Wen-Te Liu ◽  
Shang-Yang Lin ◽  
Cheng-Yu Tsai ◽  
Yi-Shin Liu ◽  
Wen-Hua Hsu ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Sleep Time ◽  
Sleep Apnoea ◽  
Health Concern ◽  
Lower Percentage ◽  
Short Sleep Duration ◽  
Patch Type ◽  
Home Based ◽  
Obstructive Sleep ◽  
Supine Sleep

Obstructive sleep apnoea (OSA) is a global health concern, and polysomnography (PSG) is the gold standard for assessing OSA severity. However, the sleep parameters of home-based and in-laboratory PSG vary because of environmental factors, and the magnitude of these discrepancies remains unclear. We enrolled 125 Taiwanese patients who underwent PSG while wearing a single-lead electrocardiogram patch (RootiRx). After the PSG, all participants were instructed to continue wearing the RootiRx over three subsequent nights. Scores on OSA indices—namely, the apnoea–hypopnea index, chest effort index (CEI), cyclic variation of heart rate index (CVHRI), and combined CVHRI and CEI (Rx index), were determined. The patients were divided into three groups based on PSG-determined OSA severity. The variables (various severity groups and environmental measurements) were subjected to mean comparisons, and their correlations were examined by Pearson’s correlation coefficient. The hospital-based CVHRI, CEI, and Rx index differed significantly among the severity groups. All three groups exhibited a significantly lower percentage of supine sleep time in the home-based assessment, compared with the hospital-based assessment. The percentage of supine sleep time (∆Supine%) exhibited a significant but weak to moderate positive correlation with each of the OSA indices. A significant but weak-to-moderate correlation between the ∆Supine% and ∆Rx index was still observed among the patients with high sleep efficiency (≥80%), who could reduce the effect of short sleep duration, leading to underestimation of the patients’ OSA severity. The high supine percentage of sleep may cause OSA indices’ overestimation in the hospital-based examination. Sleep recording at home with patch-type wearable devices may aid in accurate OSA diagnosis.

scholarly journals Apnoea–Hypopnoea Index during Rapid Eye Movement and Non-Rapid Eye Movement Sleep in Obstructive Sleep Apnoea

2008 ◽  
Vol 36 (5) ◽  
pp. 906-913 ◽  
Author(s):  
M Muraki ◽  
S Kitaguchi ◽  
H Ichihashi ◽  
R Haraguchi ◽  
T Iwanaga ◽  
...  
Keyword(s):  
Eye Movement ◽  
Obstructive Sleep Apnoea ◽  
Rem Sleep ◽  
Nrem Sleep ◽  
Sleep Apnoea ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep ◽  
Multivariate Logistic Regression ◽  
Obstructive Sleep ◽  
Nocturnal Polysomnography

This study investigated the differences in apnoea-hypopnoea index (AHI) during rapid eye movement (REM) sleep (AHI-REM) and AHI during non-REM (NREM) sleep (AHI-NREM) in patients with obstructive sleep apnoea (OSA). Nocturnal polysomnography was performed in 102 Japanese OSA patients and their AHI along with a variety of other factors were retrospectively evaluated. Regardless of the severity of AHI, mean apnoea duration was longer and patients' lowest recorded oxygen saturation measured by pulse oximetry was lower during REM sleep than during NREM sleep. Approximately half of the patients ( n = 50) had a higher AHI-NREM than AHI-REM. In subjects with AHI ≤ 60 events/h, AHI-NREM was significantly higher than AHI-REM. On multivariate logistic regression, severe AHI ≤ 30 events/h was the only predictor of a higher AHI-NREM than AHI-REM. This may indicate that important, but unknown, factors related to the mechanism responsible for the severity of OSA are operative during NREM sleep.

scholarly journals Postprandial glucose and HbA1c are associated with severity of obstructive sleep apnoea in non-diabetic obese subjects

2021 ◽  
Author(s):  
A. Cignarelli ◽  
A. Ciavarella ◽  
M. Barbaro ◽  
S. Kounaki ◽  
A. Di Trani ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Sleep Time ◽  
Postprandial Glucose ◽  
Tolerance Test ◽  
Sleep Apnoea ◽  
Oral Glucose ◽  
Reactive Protein ◽  
Obstructive Sleep ◽  
Obese Subjects ◽  
Main Determinants

Abstract Introduction Obstructive sleep apnoea (OSA) is an underdiagnosed condition frequently associated with glycaemic control impairment in patients with type 2 diabetes. Aim To assess the relationship between glycometabolic parameters and OSA in obese non-diabetic subjects. Methods Ninety consecutive subjects (mean age 44.9 ± 12 years, mean BMI 42.1 ± 9 kg/m2) underwent polysomnography and a 2-h oral glucose tolerance test (OGTT). Results OSA was identified in 75% of subjects, with a higher prevalence of males compared to the group of subjects without OSA (62% vs 32%, p = 0.02). Patients with OSA had comparable BMI (42.8 kg/m2 vs 39.4 kg/m2), a higher average HbA1c (5.8% vs 5.4%, p < 0.001), plasma glucose at 120 min during OGTT (2 h-PG; 123 mg/dl vs 97 mg/dl, p = 0.009) and diastolic blood pressure (81.1 mmHg vs 76.2 mmHg, p = 0.046) than obese subjects without OSA. HbA1c and 2 h-PG were found to be correlated with the apnoea-hypopnoea index (AHI; r = 0.35 and r = 0.42, respectively) and with percent of sleep time with oxyhaemoglobin saturation < 90% (ST90; r = 0.44 and r = 0.39, respectively). Further, in a linear regression model, ST90 and AHI were found to be the main determinants of 2 h-PG (β = 0.81, p < 0.01 and β = 0.75, p = 0.02, respectively) after controlling for age, sex, waist circumference, physical activity, and C-reactive protein. Similarly, ST90 and AHI persisted as independent determinants of HbA1c (β = 0.01, p = 0.01 and β = 0.01, p = 0.01, respectively). Conclusion Beyond the traditional clinical parameters, the presence of a normal-high value of 2 h-PG and HbA1c should raise suspicion of the presence of OSA in obese subjects.

scholarly journals Hospital-Based Polysomnography May Overestimate Obstructive Sleep Apnoea Severity: Comparison of Hospital-Based and Home-Based Measurements with a Single-Lead Electrocardiogram Patch

2021 ◽  
Author(s):  
Wen-Te Liu ◽  
Shang-Yang Lin ◽  
Cheng-Yu Tsai ◽  
Yi-Shin Liu ◽  
Chia-Mo Lin ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Sleep Time ◽  
Sleep Apnoea ◽  
Health Concern ◽  
Lower Percentage ◽  
Patch Type ◽  
Home Based ◽  
Obstructive Sleep ◽  
Supine Sleep ◽  
Sleep Recording

Abstract Purpose: Obstructive sleep apnoea (OSA) is a global health concern, and polysomnography (PSG) is the gold standard for assessing OSA severity. However, the sleep parameters of home-based and in-laboratory PSG vary because of environmental factors, and the magnitude of these discrepancies remains unclear.Methods: We enrolled 125 Taiwanese patients who underwent PSG while wearing a single-lead electrocardiogram patch (RootiRx). After the PSG, all participants were instructed to continue wearing the RootiRx over the 3 subsequent nights. Scores on OSA indexes, namely the apnoea–hypopnea index, chest effort index (CEI), cyclic variation of heart rate index (CVHRI), and combined CVHRI and CEI (Rx index), were determined. The patients were divided into 3 groups based on PSG-determined OSA severity. The variables (various severity groups and environmental measurements) were subjected to mean comparisons and their correlations were examined by Pearson’s correlation coefficient. Results: The hospital-based CVHRI, CEI, and Rx index differed significantly among the severity groups. All 3 groups exhibited a significantly lower percentage of supine sleep time in the home-based assessment relative to in the hospital-based assessment. Significant positive correlations were noted between the variations in the supine percentage (∆Supine%) and the OSA indexes. For the patients with high sleep efficiency (≥ 80%), significant correlations were observed between the ∆Supine% and ∆Rx index.Conclusion: The high supine percentage of sleep may cause OSA indexes’ overestimation in hospital-based PSG. Sleep recording at home with patch-type wearable devices may aid accurate OSA diagnosis.

Clinical predictors of working memory performance in obstructive sleep apnoea patients before and during extended wakefulness

SLEEP ◽  
2021 ◽  
Author(s):  
David Stevens ◽  
Angela D'Rozario ◽  
Hannah Openshaw ◽  
Delwyn Bartlett ◽  
Caroline D Rae ◽  
...  
Keyword(s):  
Working Memory ◽  
Obstructive Sleep Apnoea ◽  
Memory Performance ◽  
High Sensitivity ◽  
Hierarchical Cluster ◽  
Sleep Time ◽  
Sleep Apnoea ◽  
Clinical Predictors ◽  
Obstructive Sleep ◽  
The Impact

Abstract Study Objectives Extended wakefulness (EW) and obstructive sleep apnoea (OSA) impair working memory (WM), but their combined effects are unclear. This study examined the impact of EW on WM function in OSA patients and identified clinical predictors of WM impairment. Methods Following polysomnography (PSG), 56 OSA patients (Mean ± SD, age 49.5 ± 8.9, AHI 38.1 ± 25.0) completed WM 2-back performance tasks 10 times over 24 hours of wakefulness to assess average accuracy and completion times measured after 6-12 hours awake (baseline) compared to 18-24 hours awake (EW). Hierarchical cluster analysis classified participants with poorer versus better WM performance at baseline and during EW. Clinical predictors of performance were examined via regression and receiver operator characteristic (ROC) analyses. Results WM performance decreased following EW and showed consistent correlations with age, ESS, total sleep time and hypoxemia (O2 nadir and mean O2 desaturation) at baseline and with EW (all p&lt;0.01). O2 nadir and age were significant independent predictors of performance at baseline (adjusted R 2=0.30, p&lt;0.01), while O2 nadir and ESS were predictors of WM following EW (adjusted R 2=0.38, p&lt;0.001). ROC analysis demonstrated high sensitivity and specificity of models to predict poorer vs better performing participants at baseline (83% and 69%) and during EW (84% and 74%). Conclusions O2 nadir, age and sleepiness show prognostic value for predicting WM impairment in both rested and sleep deprived OSA patients and may guide clinicians in identifying patients most at risk of impaired WM under both rested and heightened sleep pressure conditions.

scholarly journals Analysis of red blood cells in children diagnosed with obstructive sleep apnoea syndrome

2020 ◽  
Vol 92 (4) ◽  
pp. 234-236
Author(s):  
Jesús Rodríguez-Catalán ◽  
Juan López Carnero ◽  
Gloria Pérez Tejerizo ◽  
Paula Rodríguez Rodríguez ◽  
Genoveva del-Río Camacho
Keyword(s):  
Red Blood Cells ◽  
Obstructive Sleep Apnoea ◽  
Blood Cells ◽  
Sleep Apnoea ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Sleep Apnoea Syndrome ◽  
Obstructive Sleep
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