scholarly journals Role of interferon-gamma release assays (IGRAs) for the screening of latent tuberculosis infection in patients candidates for TNF-α antagonist

2010 ◽  
Vol 25 (2) ◽  
Author(s):  
Ilaria Sauzullo ◽  
Fabio Mengoni ◽  
Rossana Scrivo ◽  
Guido Valesini ◽  
Concetta Potenza ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Tnf Α ◽  
Interferon Gamma Release Assays

scholarly journals Elevated Rates of Indeterminate Results on QuantiFERON®-TB Gold Plus in COVID-19 Patients

2021 ◽  
Author(s):  
Kileen L. Shier
Keyword(s):  
Critically Ill ◽  
Interferon Gamma ◽  
Clinical Microbiology ◽  
Latent Tuberculosis Infection ◽  
Immunosuppressive Agents ◽  
Latent Tuberculosis ◽  
Interferon Γ ◽  
Cytokine Expression ◽  
Tuberculosis Infection ◽  
Interferon Gamma Release Assays

Interferon-gamma release assays are used to screen various patient populations for latent tuberculosis infection. In this issue of the Journal of Clinical Microbiology, Ward et al. (J Clin Microbiol 59:e00811-21, 2021, https://doi.org/10.1128/JCM.00811-21 ) investigated an increased indeterminate rate in the QuantiFERON-TB Gold Plus assay among COVID-19 patients that was independent of immunosuppressive agents and lymphopenia. In their study, COVID-19 patients with indeterminate QuantiFERON-TB Gold Plus results trended toward decreased survival as well as increased serum IL-6 and IL-10 levels, though the differences were not statistically significant. They suggest that this pattern of cytokine expression supports an impairment of Th1, and specifically interferon-γ production, in critically ill COVID-19 patients, as indicated by indeterminate QuantiFERON-TB Gold Plus results. Clinicians should be aware of the increased rate of indeterminate QuantiFERON-TB Gold Plus results in critically ill COVID-19 patients.

PLACE OF IGRA TESTS (TESTS FOR INTERFERON-GAMMA DETERMINATION) IN TUBERCULOSIS INFECTION DIAGNOSIS

2020 ◽  
Vol 99 (6) ◽  
pp. 231-235
Author(s):  
O.E. Russkikh ◽  
◽  
D.A. Kudlay ◽  
◽  
Keyword(s):  
Interferon Gamma ◽  
Significant Role ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Scientific Data ◽  
Tuberculosis Infection ◽  
Population Groups ◽  
Infection Diagnosis ◽  
Immunological Tests

The review presents scientific data available to date on the concept of the emergence and spread of latent tuberculosis infection (TI) in the current tuberculosis epidemic situation in society. Information on modern immunological tests for TI diagnosis is presented and the significant role of IGRA tests in the diagnostic tactics of detecting latent TI in various population groups is determined.

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