scholarly journals From autoimmune hepatitis to Q fever

2015 ◽  
Vol 10 (1) ◽  
pp. 58
Author(s):  
Davide Tizzani ◽  
Silvia Totaro ◽  
Valentina Laura Crudo ◽  
Andrea Viola ◽  
Vittorio Gallo ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Liver Biopsy ◽  
Autoimmune Hepatitis ◽  
Medical History ◽  
Coxiella Burnetii ◽  
Fever Of Unknown Origin ◽  
Clinical Presentation ◽  
Q Fever ◽  
Unknown Origin ◽  
Granulomatous Hepatitis

Q fever is an infectious disease caused by <em>Coxiella burnetii.</em> Its clinical presentation is often nonspecific and the serological diagnosis difficult to make, especially in the absence of specific and suspected medical history. This article presents a case of fever of unknown origin (FUO), interpreted as an autoimmune hepatitis, later proven by the liver biopsy to be a granulomatous hepatitis caused by <em>C. burnetii</em>. The approach to FUO, the features of granulomatous hepatitis and Q fever are presented and discussed.

scholarly journals Granulomatous hepatitis caused by Q fever: a differential diagnosis of fever of unknown origin

2013 ◽  
Vol 12 (1) ◽  
pp. 138-141 ◽  
Author(s):  
Nancy Aguilar-Olivos ◽  
María del Carmen Manzano-Robleda ◽  
Ylse Gutiérrez-Grobe ◽  
Fredy Chablé-Montero ◽  
Jorge Albores-Saavedra ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Fever Of Unknown Origin ◽  
Q Fever ◽  
Unknown Origin ◽  
Granulomatous Hepatitis

Q Fever as a Cause of Fever of Unknown Origin and Thrombocytosis: First Molecular Evidence of Coxiella burnetii in Brazil

2011 ◽  
Vol 11 (1) ◽  
pp. 85-87 ◽  
Author(s):  
Elba R.S. Lemos ◽  
Tatiana Rozental ◽  
Maria Angélica M. Mares-Guia ◽  
Daniele N.P. Almeida ◽  
Namir Moreira ◽  
...  
Keyword(s):  
Coxiella Burnetii ◽  
Fever Of Unknown Origin ◽  
Q Fever ◽  
Unknown Origin ◽  
Molecular Evidence

scholarly journals Role of Coxiella burnetii in the development of fever of unknown origin: А mini review

2019 ◽  
Vol 22 (3) ◽  
pp. 251-265
Author(s):  
P. Genova-Kalou ◽  
S. Ivanova ◽  
A. Pavlova ◽  
K. Simeonov ◽  
D. Pencheva ◽  
...  
Keyword(s):  
Fever Of Unknown Origin ◽  
Clinical Presentation ◽  
Q Fever ◽  
Unknown Origin ◽  
Accurate Diagnosis ◽  
Diagnostic Methods ◽  
Molecular Diagnostic ◽  
Agricultural Systems ◽  
The World

Q fever is a widespread zoonosis throughout the world in the form of numerous natural and agricul-tural outbreaks. C. burnetii infects various hosts, including humans, ruminants and pets and in rare cases, reptiles, birds, and ticks. This bacterium is excreted in urine, milk, faeces, and birth products. In humans Q fever occurs as acute or chronic disease with diverse clinical presentation, as isolated cases and epidemics. It affects various organs and systems, and in pregnant women can cause miscar-riage or premature birth. Untreated Q fever can become chronic with adverse effects on patients. Diversity in the clinical picture in the absence of specific pathological syndrome often hinders accurate diagnosis and proper etiological significance. Therefore, improvement of diagnostic methods and in particular the development and introduction of new molecular diagnostic methods is the basis of effective therapeutic and prophylactic approach. Тhe purpose of the review is to renew the interest to Q fever – on one hand, because of its serious impact on human health and agricultural systems, and on the other, the ability for development and introduction of new molecular diagnostic methods.

scholarly journals HMGB1, anti-HMGB1 antibodies, and ratio of HMGB1/anti-HMGB1 antibodies as diagnosis indicator in fever of unknown origin

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mingkun Chen ◽  
Li Zhu ◽  
Miao Xue ◽  
Rongrong Zhu ◽  
Liling Jing ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Autoimmune Disease ◽  
Serum Concentration ◽  
Malignant Tumor ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Healthy Control Group ◽  
Control Group ◽  
Elisa Kit ◽  
Healthy Control

AbstractTo evaluate the feasibility of serum HMGB1, anti-HMGB1 antibodies, and HMGB1/anti-HMGB1 ratio as a diagnosis indicator of initial clinical classification in patients with fever of unknown origin (FUO). Ninety-four patients with classical FUO and ninety healthy controls were enrolled in this study. The subjects’ clinical data and serum were collected. The serum concentration of HMGB1 was detected by a commercial HMGB1 ELISA kit, while the serum concentration of anti-HMGB1 antibodies were detected by an in-house built anti-HMGB1 antibodies ELISA kit and further confirmed by immunoblotting. According to the hospital diagnosis on discharge, ninety-four FUO patients were divided into four groups, Infectious disease subgroup, autoimmune disease subgroup, malignant tumor subgroup, and undetermined subgroup. The concentrations of HMGB1 in the infectious disease subgroup and autoimmune disease subgroup were higher than those in the malignant tumor subgroup, undetermined subgroup, and healthy control group. The concentration of anti-HMGB1 antibodies in autoimmune disease subtype group was higher than those in other subgroups as well as healthy control group. According to the distribution of HMGB1 and anti-HMGB1 in scatter plots of the patients with FUO, we found that the ratio of serum HMGB1/anti-HMGB1 is an ideal clinical indicator for differential diagnosis of different subtypes of FUO. The best cut-off was 0.75, and the sensitivity, specificity, and AUC were 66.67%, 87.32%, and 0.8, respectively. Correlation analysis showed that serum concentration of HMGB1 was moderately correlated with CRP in infectious diseases subgroup, and the serum concentration of anti-HMGB1 antibodies was strongly correlated with erythrocyte sedimentation rate in autoimmune disease subgroup. Our study had showed that serum HMGB1/anti-HMGB1 antibodies ratio can help clinicians identify FUO subtypes, thereby avoiding many unnecessary examinations and tests, and improving the effectiveness of clinical diagnosis and treatment of FUO.

scholarly journals Questing one Brazilian query: reporting 16 cases of Q fever from Minas Gerais, Brazil

2006 ◽  
Vol 48 (1) ◽  
pp. 5-9 ◽  
Author(s):  
Paulo Sérgio Gonçalves da Costa ◽  
Marco Emilio Brigatte ◽  
Dirceu Bartolomeu Greco
Keyword(s):  
Phase I ◽  
Phase Ii ◽  
Fever Of Unknown Origin ◽  
Q Fever ◽  
Acute Infection ◽  
Case Series ◽  
Febrile Illness ◽  
Unknown Origin ◽  
Clinical Form ◽  
Chronic Q Fever

Q fever has been considered non-existing in Brazil where reports of clinical cases still cannot be found. This case-series of 16 patients is a result of a systematic search for such illness by means of clinical and serologic criteria. Serologic testing was performed by the indirect microimmunofluorescence technique using phase I/II C. burnetii antigens. Influenza-like syndrome was the most frequent clinical form (eight cases - 50%), followed by pneumonia, FUO (fever of unknown origin), mono-like syndrome (two cases - 12.5% each), lymphadenitis (one case - 6.3%) and spondylodiscitis associated with osteomyelitis (one case - 6.3%). The ages varied from four to 67 years old with a median of 43.5. All but one patient had positive serologic tests for phase II IgG whether or not associated with IgM positivity compatible with acute infection. One patient had both phase I and phase II IgG antibodies compatible with chronic Q fever. Seroconvertion was detected in 10 patients. Despite the known limitations of serologic diagnosis, the cases here reported should encourage Brazilian doctors to include Q fever as an indigenous cause of febrile illness.

THE ROLE OF LIVER BIOPSY IN ESTABLISHING DIAGNOSIS IN A PATIENT WITH FEVER OF UNKNOWN ORIGIN: REPORT OF A CASE

2011 ◽  
Vol 22 ◽  
pp. S52
Author(s):  
Fani Kyriakou ◽  
Nikolaos Nikolaou ◽  
Makrina Koutsouraki ◽  
Georgios Erotokritou ◽  
Ekaterini Parassi ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Fever Of Unknown Origin ◽  
Unknown Origin

scholarly journals Unusual presentation of paediatric anaplastic large cell lymphoma

1970 ◽  
Vol 8 (4) ◽  
pp. 135-138
Author(s):  
M Irfan ◽  
MM Yusri ◽  
ABM Farveen
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Fever Of Unknown Origin ◽  
Clinical Presentation ◽  
Cell Lymphoma ◽  
Unknown Origin ◽  
Large Cell ◽  
Medical Sciences ◽  
Non Hodgkin Lymphoma ◽  
Large Cell Lymphoma ◽  
Alk Positive

Anaplastic large cell lymphoma (ALCL) is a rare disease. Among childhood non-Hodgkin lymphoma, it constitutes less than 20% of the incidence of all cases. The clinical presentation though is known to be much diversified, most of the patients will present with an enlarged palpable cervical lymphadenopaty. Other reported features include fever of unknown origin, nonspecific pain, cough, shortness of breath, fatigue and malaise. We report a case of ALK-positive ALCL in a patient who presented with submandibular abscess. After defaulted treatment, the mass became fungating externally with everted edge that mimic squamous cell carcinoma. Keywords: ALCL; pediatric; clinical presentation DOI: 10.3329/bjms.v8i4.4711 Bangladesh Journal of Medical Sciences Vol.8(4); October 2009 pp135-138

A One Health Perspective on Q Fever

2019 ◽  
pp. 174-194
Author(s):  
Rita Cruz ◽  
Carmen Vasconcelos-Nobrega ◽  
Fernando Esteves ◽  
Catarina Coelho ◽  
Ana Sofia Ferreira ◽  
...  
Keyword(s):  
Public Health ◽  
Infectious Disease ◽  
Coxiella Burnetii ◽  
One Health ◽  
Q Fever ◽  
Human Infection ◽  
Sheep And Goats ◽  
Veterinary Public Health ◽  
Human Infections

Q fever is a worldwide zoonotic infectious disease caused by Coxiella burnetii and ruminants, namely, cattle, sheep, and goats, are known to be the main reservoir for human infection. C. burnetii infection in animals can result in epizootic abortions which are often associated with vast bacteria shedding in birth fluids and placentas. Human infections mainly occur in persons handling infected animals and their products. Here the authors describe the history, bacteriology, biosafety, and epidemiology of Q fever, now known to be a serious threat to veterinary public health.

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