scholarly journals Correlation of Pulse Wave Velocity with Left Ventricular Mass in Patients with Hypertension Once Blood Pressure has been Normalized

2012 ◽  
Vol 7 (1) ◽  
pp. hi.2012.e5 ◽  
Author(s):  
Simon W. Rabkin ◽  
Siu H. Chan
Keyword(s):  
Blood Pressure ◽  
Pulse Wave Velocity ◽  
Left Ventricular Mass ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Left Ventricular ◽  
Ventricular Mass

A new technique for study of impact of arterial elasticity on left ventricular mass in rats

1996 ◽  
Vol 270 (3) ◽  
pp. H981-H987
Author(s):  
F. Amin ◽  
N. Niederhoffer ◽  
R. Tatchum-Talom ◽  
T. Makki ◽  
J. Guillou ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Elastic Modulus ◽  
Pulse Wave Velocity ◽  
Left Ventricular Mass ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Left Ventricular ◽  
New Technique ◽  
Arterial Elasticity ◽  
Ventricular Mass

We investigated possible links between left ventricular mass and central arterial elasticity in the adult spontaneously hypertensive rat (SHR) and in a subgroup of SHR in which blood pressure was normalized by chronic antihypertensive drug treatment; results were compared with those of age-matched normotensive Wistar-Kyoto rats. Two indexes of arterial elasticity, based on the measurement of aortic pressure pulse wave velocity, were used. First, the slope relating carotidofemoral pulse wave velocity to blood pressure in the phenylephrine-infused pithed preparation was used as a pressure-independent index of wall elasticity. Second, to account for hypertension- and treatment-induced aortic remodeling, elastic modulus was determined from the pulse wave velocity recorded when blood pressure reached that measured in awake animals before anesthesia and pithing, together with values for wall thickness and lumen diameter evaluated by histomorphometric analysis after in situ fixation at the same pressure. In control SHR, regression analysis of variance revealed significant correlations between left ventricular mass and both wave velocity/pressure slope and elastic modulus. Chronic antihypertensive treatment normalized all three parameters. In conclusion, this new technique provides experimental evidence of a link between left ventricular mass and central arterial elasticity.

scholarly journals Cardiovascular Organ Damage and Blood Pressure Levels Predict Adverse Events in Multiple Myeloma Patients Undergoing Carfilzomib Therapy

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 622 ◽  
Author(s):  
Giulia Bruno ◽  
Sara Bringhen ◽  
Ilaria Maffei ◽  
Andrea Iannaccone ◽  
Teresa Crea ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Multiple Myeloma ◽  
Adverse Events ◽  
Pulse Wave Velocity ◽  
Left Ventricular Mass ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Organ Damage ◽  
Left Ventricular ◽  
Ventricular Mass

Carfilzomib is a second-generation proteasome inhibitor approved for the treatment of multiple myeloma (MM). It seems to determine cardiovascular toxicity, primarily arterial hypertension. No predictive factors for cardiovascular adverse events (CVAEs) are known in patients affected by multiple myeloma treated with carfilzomib. We evaluated the role of cardiovascular organ damage parameters to predict CVAEs in MM patients taking carfilzomib. Seventy patients affected by MM were prospectively enrolled. A comprehensive cardiovascular evaluation was performed before carfilzomib therapy; they underwent a transthoracic echocardiogram and the assessment of carotid-femoral pulse wave velocity. All the patients were followed up (FU) to determine the incidence of CVAEs. The mean age was 60.3 ± 8.2, and 51% were male. The median FU was 9.3 (4.3; 20.4) months. A proportion of 33% experienced CVAEs, 91% of them had uncontrolled hypertension, 4.5% acute coronary syndrome, and 4.5% cardiac arrhythmias. Subjects with CVAEs after carfilzomib treatment had significantly higher blood pressure values, left ventricular mass (98 ± 23 vs. 85 ± 17 g/m2, p = 0.01), and pulse wave velocity (8.5 ± 1.7 vs. 7.5 ± 1.6 m/s, p = 0.02) at baseline evaluation compared to the others. Furthermore, baseline uncontrolled blood pressure, left ventricular hypertrophy, and pulse wave velocity ≥ 9 m/s were able to identify patients at higher risk of developing CVAEs during FU. These preliminary findings indicate that blood pressure control, left ventricular mass, and pulse wave velocity may predict CVAEs in MM patients treated with carfilzomib.

scholarly journals Association of Aortic Arch Pulse Wave Velocity with Left Ventricular Mass and Lacunar Brain Infarcts in Hypertensive Patients: Assessment with MR Imaging

Radiology ◽  
2009 ◽  
Vol 253 (3) ◽  
pp. 681-688 ◽  
Author(s):  
Anne Brandts ◽  
Saskia G. C. van Elderen ◽  
Jos J. M. Westenberg ◽  
Jeroen van der Grond ◽  
Mark A. van Buchem ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Pulse Wave Velocity ◽  
Aortic Arch ◽  
Left Ventricular Mass ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Left Ventricular ◽  
Hypertensive Patients ◽  
Brain Infarcts ◽  
Ventricular Mass

scholarly journals Blood Pressure and Body Weight Have Different Effects on Pulse Wave Velocity and Cardiac Mass in Children

2020 ◽  
Vol 9 (9) ◽  
pp. 2954
Author(s):  
Simonetta Genovesi ◽  
Paolo Salvi ◽  
Elisa Nava ◽  
Elena Tassistro ◽  
Marco Giussani ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Left Ventricular ◽  
Cardiac Mass ◽  
Excess Weight ◽  
Gold Standard Method ◽  
Z Scores ◽  
The Impact

Background: High blood pressure (BP) and excess weight can lead to early cardiovascular organ damage already in children. Carotid-femoral pulse wave velocity (cf-PWV) is the non-invasive gold standard method for assessing aortic stiffness, while carotid-radial PWV (cr-PWV) provides information on the distensibility of the upper limb arteries. The aim of this study was to evaluate the relationship of BP and BMI z-scores with arterial stiffness and left ventricular mass index (LVMI) in a pediatric population. Methods: In 343 children (57.7% males; age ± SD 11.7 ± 2.9 years), systolic (SBP) and diastolic (DBP) BP, BMI, cf-PWV, cr-PWV and LVMI were measured. A multiple linear regression model was used to assess the impact of BMI and SBP (or DBP) z-scores on cf-PWV, cr-PWV and LVMI. Results: About 21% of children were normal weight, 34% were overweight and 45% obese. Adjusted for possible confounders, SBP and DBP z-scores were significantly associated with cf-PWV (p < 0.001), while only DBP z-scores were related to cr-PWV (p < 0.01). BMI was neither associated with cf-PWV nor with cr-PWV values but was a strong predictor of LVMI (<0.001), whereas cardiac mass and BP z-scores were not related. Conclusions: Our study suggests that, in children, elevated BP values and excess weight may have different effects on the heart and the vessels in causing early cardiovascular alterations.

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