scholarly journals Association of Interatrial Septal Abnormalities with Cardiac Impulse Conduction Disorders in Adult Patients: Experience from a Tertiary Center in Kosovo

2011 ◽  
Vol 6 (1) ◽  
pp. hi.2011.e4 ◽  
Author(s):  
Aurora Bakalli ◽  
Ejup Pllana ◽  
Dardan Koçinaj ◽  
Tefik Bekteshi ◽  
Gani Dragusha ◽  
...  
Keyword(s):  
Adult Patients ◽  
Impulse Conduction ◽  
Conduction Disorders ◽  
Cardiac Impulse ◽  
Tertiary Center ◽  
Patients Experience

scholarly journals Cardiac macrophages prevent sudden death during heart stress

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Junichi Sugita ◽  
Katsuhito Fujiu ◽  
Yukiteru Nakayama ◽  
Takumi Matsubara ◽  
Jun Matsuda ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Sudden Death ◽  
Gap Junctions ◽  
Adrenergic Receptor ◽  
Cardiac Death ◽  
Connexin 43 ◽  
Pressure Overload ◽  
Impulse Conduction ◽  
Cardiac Impulse ◽  
Medical Need

AbstractCardiac arrhythmias are a primary contributor to sudden cardiac death, a major unmet medical need. Because right ventricular (RV) dysfunction increases the risk for sudden cardiac death, we examined responses to RV stress in mice. Among immune cells accumulated in the RV after pressure overload-induced by pulmonary artery banding, interfering with macrophages caused sudden death from severe arrhythmias. We show that cardiac macrophages crucially maintain cardiac impulse conduction by facilitating myocardial intercellular communication through gap junctions. Amphiregulin (AREG) produced by cardiac macrophages is a key mediator that controls connexin 43 phosphorylation and translocation in cardiomyocytes. Deletion of Areg from macrophages led to disorganization of gap junctions and, in turn, lethal arrhythmias during acute stresses, including RV pressure overload and β-adrenergic receptor stimulation. These results suggest that AREG from cardiac resident macrophages is a critical regulator of cardiac impulse conduction and may be a useful therapeutic target for the prevention of sudden death.

scholarly journals Depressive symptoms in patients with epilepsy and clinically associated features in a single tertiary center

2021 ◽  
Author(s):  
Mariacarolina Vacca ◽  
Mariana Fernandes ◽  
Matteo Spanetta ◽  
Fabio Placidi ◽  
Francesca Izzi ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Clinical Features ◽  
Item Analysis ◽  
Well Being ◽  
Adult Patients ◽  
Self Report ◽  
Depression Severity ◽  
Cross Sectional ◽  
Tertiary Center ◽  
Patients With Epilepsy

AbstractAlthough depressive symptoms are the most common psychiatric comorbidity in epilepsy, they remain underestimated and untreated in a large proportion of patients. The purpose of this study was to evaluate depression severity and related clinical features in people with epilepsy using a well-reliable self-report index of mood, the Beck Depression Inventory-II (BDI-II). One-hundred seventeen adult patients with epilepsy were recruited from a tertiary epilepsy center and completed the BDI-II. A single-item analysis of the 21 questions of the BDI-II was computed and differences between women and men in each depressive symptom were evaluated. Correlation and regression analyses were used to identify clinical features associated with the severity of depression. Results showed gender differences in some items, with women reporting overall higher depression severity than men. The most common symptoms regarded domains of sleeping patterns, tiredness, and loss of energy. Regression evidence suggested that being female, having an epilepsy duration < 10 years, as well as being treated with psychotropic drugs and reporting generalized seizure, were associated with higher depression severity. Despite its cross-sectional nature, this study reinforces the importance of investigating and possibly treating depressive symptoms in adult patients with epilepsy, since they negatively impact well-being, daytime activities, and sleep. Further studies identifying pharmacological and non-pharmacological treatments for depression in epilepsy need to be planned.

scholarly journals P620 The particularities of adult patients with ulcerative colitis in a tertiary center in North-East of Romania

2013 ◽  
Vol 7 ◽  
pp. S260
Author(s):  
M. Dranga ◽  
C. Mihai ◽  
E. Toader ◽  
G. Dumitrescu ◽  
I. Pintilie ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Adult Patients ◽  
North East ◽  
Tertiary Center

scholarly journals Acute Myocardial Infarction in Young Adults: Prevalence, Clinical Background and In-Hospital Outcomes with Particular Reference to Socio-Economic Influences a Middle Eastern Tertiary Center Experience

2020 ◽  
pp. 1-8
Author(s):  
Ghada Shalaby ◽  
◽  
Sheeren Khaled ◽  
Najeeb Jaha ◽  
◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Older Adults ◽  
Acute Myocardial Infarction ◽  
Young Adults ◽  
Young Adult ◽  
Left Ventricular ◽  
Adult Patients ◽  
Left Ventricular Ejection ◽  
Tertiary Center ◽  
Clinical Background

Background: Acute myocardial infarction in young individuals can cause death and disability in early life and has serious consequences for the patients, their family causing an increased economic burden on health system. Identifying the risk factors for acute myocardial infarction in this group of people is necessary for risk factor modification and developing cost-effective secondary prevention strategies as young. The aim of this study was to determine the prevalence, clinical background and in-hospital outcome of AMI among young (age ≤45 years) adults and its socioeconomic burden. Results: All Acute myocardial infarction patients during the period from 2016-2019 were divided into two groups: young adults (age≤45) and older adults (age>45). Age data were available for 3081 patients admitted with acute myocardial infarction. Out of these 593 (19%) patients were young adults with mean age of 39±6.2 whilst 2488 (80.7%) were older adults with mean age of 60±9. Young adult Patients were more of male gender (92% vs 82%, p<0.001) more smoker (47% vs 30 %, p<0.001) and had more prevalence of obesity (BMI ≥30 34% vs 27%, p<0.001) but were less diabetics (43% vs 57%, p<0.001) and less hypertensive (35% vs 58 %, p<0.001).Young adult patients had higher level of LDL (120±47 vs. 112.9±41.6, P=0.02), total cholesterol (189.2±54.4 vs. 173.9±47.7, P<0.001) and triglycerides (157.7±104.4 vs. 126.6±91, P<0.001).Young adult patients had more extensive thrombus and frequently required thrombus aspiration (16 % vs. 11%, p=0.003) but less common left main disease (0.9% vs 4%, p<0.001) and 3 vessels disease (8% vs 18%, p<0.001). Young adult patients had less deterioration of left ventricular function (EF 42.4±10.4 vs. 41.1±10.6, P=0.04). There was highly significant negative correlation between left ventricular ejection fraction (LVEF) and age (P<0.001) but positive correlation between age and length of in hospital stay (p=0.02).In-hospital complications including pulmonary edema, cardiogenic shock, cardiac arrest and mortality were similar in the two groups. Age, female gender and diabetes were found to be the independent predictors for in-hospital mortality among our patients (P=0.003, 0.05 and 0.05 respectively) Conclusion: Young adult patients presented with acute myocardial infarction are more frequently smokers, obese and dyslipidaemic. These patients also have more thrombus burden. These results underscores the importance of smoking cessation, weight reduction programs and Health education for public especially of this age. Age still showed high risk prediction for lower LVEF and prolonged in-hospital length of stay in AMI patients with more burden on the health care system although the great improvement in management of AMI patients which lead to decrease in hospital complications.

scholarly journals P1583Cardiac macrophage contributes to cardiac impulse conduction

2017 ◽  
Vol 38 (suppl_1) ◽  
Author(s):  
J. Sugita ◽  
K. Fujiu ◽  
Y. Nakayama ◽  
T. Matsubara ◽  
J. Matsuda ◽  
...  
Keyword(s):  
Impulse Conduction ◽  
Cardiac Impulse

Pharmacoresistant Cav2·3 (E-type/R-type) voltage-gated calcium channels influence heart rate dynamics and may contribute to cardiac impulse conduction

2012 ◽  
Vol 31 (5) ◽  
pp. 434-449 ◽  
Author(s):  
Thomas Galetin ◽  
Etienne E. Tevoufouet ◽  
Jakob Sandmeyer ◽  
Jan Matthes ◽  
Filomain Nguemo ◽  
...  
Keyword(s):  
Heart Rate ◽  
Calcium Channels ◽  
Voltage Gated ◽  
Impulse Conduction ◽  
Voltage Gated Calcium Channels ◽  
Cardiac Impulse ◽  
Heart Rate Dynamics

scholarly journals Clinical Trials Perception in Rheumatology Patients: Experience from a Single Rheumatology Tertiary Center

2015 ◽  
Vol 42 (6) ◽  
pp. 988-993 ◽  
Author(s):  
Coziana Ciurtin ◽  
Maria Leandro ◽  
Halina Fitz-Clarence ◽  
Hanh Nguyen ◽  
Stephen B. Walsh ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Response Rate ◽  
Willingness To Participate ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Tertiary Center ◽  
The Mean ◽  
Open Question ◽  
Patients Experience ◽  
Correct Response Rate

Objective.To investigate the perception and willingness of rheumatology patients to participate in clinical trials. No previous similar studies are available.Methods.We conducted a cross-sectional survey of rheumatology patients using a questionnaire, which comprised 2 demographic questions, two 5-point Likert opinion questions, 19 true/false/unsure knowledge questions, and 1 open question addressing what would help the participant to gain a better understanding about clinical trials.Results.Eighty-five patients returned the questionnaires (response rate 84.1%). The mean number of correct answers to the 19 knowledge questions was 10.5 ± 2.87. Patients with higher versus lower levels of education had significantly higher knowledge scores (mean correct answers 59.4 ± 13.1 vs 39.8 ± 20.4, p = 0.013). They also expressed greater willingness to take part in research (87.5% vs 48.2%, p < 0.001). The patients who agreed to participate in research provided significantly more correct answers (59.4 ± 15.3% vs 47.7 ± 27.2%, p = 0.032). Poor disease control as the main reason to join a clinical trial correlated well with patients’ previous participation in research (r = 0.71; p < 0.05) and the lack of understanding of research principles (defined as less than 50% correct answers to the knowledge questions) correlated with the lack of willingness to participate in clinical trials (r = 0.72; p < 0.05).Conclusion.The results of our study revealed that patients lack information about clinical trials (the correct response rate was only slightly above 50%), and that they had a moderate willingness to take part in clinical trials. The need for educational programs about clinical research was highlighted by the participants to the survey.

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