scholarly journals Non oncologic elevated levels of chromogranin A in a symptomatic patient without a carcinoid tumor

2013 ◽  
Vol 3 (2) ◽  
pp. 7
Author(s):  
Juan Camilo Duque ◽  
Luis Fernando Pineda ◽  
Tatiana Lopez
Keyword(s):  
Carcinoid Tumor ◽  
Chromogranin A ◽  
Symptomatic Patient

scholarly journals Library of Sequence-specific Radioimmunoassays for Human Chromogranin A

1999 ◽  
Vol 45 (4) ◽  
pp. 549-560 ◽  
Author(s):  
Tine Børglum Jensen ◽  
Linda Hilsted ◽  
Jens F Rehfeld
Keyword(s):  
Carcinoid Tumor ◽  
Neuroendocrine Tumors ◽  
Chromogranin A ◽  
Acidic Protein ◽  
Binding Affinities ◽  
Cleavage Sites ◽  
Tumor Patients ◽  
High Binding ◽  
Low Concentrations ◽  
Different Tissues

Abstract Background: Human chromogranin A (CgA) is an acidic protein widely expressed in neuroendocrine tissue and tumors. The extensive tissue- and tumor-specific cleavages of CgA at basic cleavage sites produce multiple peptides. Methods: We have developed a library of RIAs specific for different epitopes, including the NH2 and COOH termini and three sequences adjacent to dibasic sites in the remaining part of CgA. Results: The antisera raised against CgA(210–222) and CgA(340–348) required a free NH2 terminus for binding. All antisera displayed high titers, high indexes of heterogeneity (∼1.0), and high binding affinities (Keff0 ∼ 0.1 × 1012 to 1.0 × 1012 L/mol), implying that the RIAs were monospecific and sensitive. The concentration of CgA in different tissues varied with the assay used. Hence, in a carcinoid tumor the concentration varied from 0.5 to 34.0 nmol/g tissue depending on the specificity of the CgA assay. The lowest concentration in all tumors was measured with the assay specific for the NH2 terminus of CgA. This is consistent with the relatively low concentrations measured in plasma from carcinoid tumor patients by the N-terminal assay, whereas the assays using antisera raised against CgA(210–222) and CgA(340–348) measured increased concentrations. Conclusion: Only some CgA assays appear useful for diagnosis of neuroendocrine tumors, but the entire library is valuable for studies of the expression and processing of human CgA.

Bronchial Carcinoid Tumor With Crystalloid Cytoplasmic Inclusions

2002 ◽  
Vol 126 (1) ◽  
pp. 93-96
Author(s):  
Karen L. Grogg ◽  
Chandrashekar Padmalatha ◽  
Kevin O. Leslie
Keyword(s):  
Light Microscopy ◽  
Carcinoid Tumor ◽  
Chromogranin A ◽  
Bronchial Carcinoid ◽  
Cytoplasmic Inclusions ◽  
Ultrastructural Studies ◽  
Crystalloid Inclusions ◽  
Cytoplasmic Structures

Abstract We report a bronchial carcinoid tumor with distinctive, cytoplasmic, rod-shaped crystalloid inclusions that were visible by light microscopy. These cytoplasmic structures were immunoreactive with antibodies against chromogranin A and synaptophysin in paraffin-embedded tissue. Ultrastructural studies showed them to be paracrystalline in nature and located within lysosomes. This case highlights an interesting, and potentially confusing, histologic manifestation in an otherwise typical bronchial carcinoid tumor.

A Carcinoid Tumor in the Gallbladder of a Dog

2002 ◽  
Vol 39 (6) ◽  
pp. 756-758 ◽  
Author(s):  
C. N. Morrell ◽  
M. V. Volk ◽  
J. L. Mankowski
Keyword(s):  
Weight Loss ◽  
Liver Enzyme ◽  
Carcinoid Tumor ◽  
Enzyme Activities ◽  
Chromogranin A ◽  
Secretory Granules ◽  
Domestic Animals ◽  
Mixed Breed ◽  
Histologic Pattern ◽  
Ultrastructural Finding

A cholecystectomy was performed on a 10-year-old spayed female mixed-breed dog with chronic weight loss, persistently increased liver enzyme activities, and cholecystomegaly identified by ultrasonographic examination. A subsequent diagnosis of a biliary carcinoid was made based on a neuroendocrine-type histologic pattern, cytoplasmic argyrophilia by Grimelius staining, immunopositivity for chromogranin A, and the ultrastructural finding of cytoplasmic secretory granules in neoplastic cells. Extrahepatic biliary carcinoid tumors are rare tumors of humans and have not been documented in domestic animals.

scholarly journals Three Cases of Carcinoid in the Equine Nasal Cavity and Maxillary Sinuses: Histologic and Immunohistochemical Features

1996 ◽  
Vol 33 (1) ◽  
pp. 92-95 ◽  
Author(s):  
C. van Maanen ◽  
W. R. Klein ◽  
K. J. Dik ◽  
T. S. G. A. M. van den Ingh
Keyword(s):  
Nasal Cavity ◽  
Carcinoid Tumor ◽  
Nasal Mucosa ◽  
Chromogranin A ◽  
Neuron Specific Enolase ◽  
Carcinoid Tumors ◽  
Neuroendocrine Cells ◽  
Maxillary Sinuses

Three cases of carcinoid tumor in horses are described. The tumors originated from the maxillary sinuses and the retrobulbar region and caused exophthalmos. Histologically, they had a characteristic endocrine pattern and were argyrophilic with the Grimelius stain. All tumors contained reactivity for neuron-specific enolase and synaptophysin. Two of three tumors were reactive for both bovine and porcine chromogranin A. These immunohistochemical results confirm the neuroendocrine nature of these tumors. Neuroendocrine cells could not be detected in the nasal mucosa and maxillary sinuses of a normal horse; therefore, the origin of these carcinoid tumors remains obscure.

Clear Cell Carcinoid Tumor of the Gallbladder

2003 ◽  
Vol 127 (6) ◽  
pp. 745-747 ◽  
Author(s):  
Eiichi Konishi ◽  
Yasuaki Nakashima ◽  
Thomas C. Smyrk ◽  
Seiji Masuda
Keyword(s):  
Carcinoid Tumor ◽  
Chromogranin A ◽  
Clear Cell ◽  
Epigastric Pain ◽  
S100 Protein ◽  
Endocrine Tumors ◽  
Current Case ◽  
Von Hippel Lindau ◽  
Golden Yellow ◽  
Von Hippel Lindau Disease

Abstract A golden yellow polyp was detected in the gallbladder of a 64-year-old man who presented with epigastric pain. The lesion was composed of clear polygonal cells arranged in a trabecular and glandular pattern. The tumor invaded through the wall into the perimuscular subserosal layer. Immunohistochemical stains showed that neoplastic cells were positive for chromogranin A, synaptophysin, somatostatin, gastrin, and pancreatic polypeptide and negative for glucagon, serotonin, insulin, S100 protein, and inhibin. This tumor resembles the recently described clear cell endocrine tumors of the gallbladder and pancreas that are associated with von Hippel-Lindau disease. Our patient, however, had neither personal nor family history indicative of von Hippel-Lindau disease. Furthermore, published accounts of clear cell endocrine tumors in von Hippel-Lindau disease describe immunoreactivity for inhibin; the current case was negative for the disease. There may be a subtype of clear cell carcinoid tumor not associated with von Hippel-Lindau disease, which is characterized by its lack of immunoreactivity against inhibin.

Gastrointestinal Bleeding Associated with Carcinoid Tumor of the Duodenum

1964 ◽  
Vol 47 (4) ◽  
pp. 421-423 ◽  
Author(s):  
Arthur S. Loebel ◽  
Roger Jerez ◽  
Leonard S. Danzig
Keyword(s):  
Gastrointestinal Bleeding ◽  
Carcinoid Tumor

Carcinoid Tumor (Argentaffinoma) of the Stomach

1949 ◽  
Vol 12 (4) ◽  
pp. 682-689 ◽  
Author(s):  
C. Wilmer Wirts ◽  
Robert L. Breckenridge
Keyword(s):  
Carcinoid Tumor
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