scholarly journals Report on Abstracts of the 15th Meeting of IIM, the Interuniversity Institute of Myology - Assisi (Italy), October 11-14, 2018

2018 ◽  
Vol 28 (4) ◽  
Author(s):  
Davide Gabellini ◽  
Antonio Musarò
Keyword(s):  
Scientific Session ◽  
Muscle Physiology ◽  
Therapeutic Approaches ◽  
Muscle Stem Cells ◽  
Muscle Diseases ◽  
Muscle Research ◽  
Muscle Formation ◽  
Oral Communications ◽  
Organismal Development ◽  
The City

On October 11-14, 2018, the 15th Meeting of the Interuniversity Institute of Myology (IIM) took place in the city Assisi, Italy. Muscle researchers from Italy, and various European and North-American countries gathered to discuss recent results on the physiology and diseases of skeletal muscle. The program showcased keynote lectures from world-renowned international speakers presenting advances in muscle stem cells, circadian rhythm, organismal development and growth, muscle physiology, and bioengineering. Novel, unpublished results from young trainees were presented as oral communications or posters, based on selection from submitted abstracts. Young trainees where directly involved in several aspects of the meeting by being responsible of organizing a scientific session, arranging three round tables tailored to the interests of their peers and chairing all scientific sessions. The meeting offered a unique opportunity for young researchers to present their work, have feedback from more experienced colleagues and establish collaborations to further understanding of muscular diseases and develop therapeutic strategies. The open, informal and friendly atmosphere of the meeting stimulated lively discussions, instrumental to highlight key areas of muscle research and foster scientific cross-fertilization and new collaborations. The meeting was very successful. A sign that the IIM community will continue to deliver important contributions to the training of young students and fellows, promoting our understanding of muscle formation and activity, the mechanism of muscle diseases and the progress toward therapeutic approaches. The Myology field is strong and articulated in basic, translational and early clinical research, moving toward the development of treatments for several muscle diseases as documented by the abstracts of the IIM meeting.

scholarly journals Report and Abstracts of the 14th Meeting of IIM, the Interuniversity Institute of Myology, - Assisi (Italy), October 12-15, 2017

2017 ◽  
Vol 27 (4) ◽  
Author(s):  
Diego Gabellini ◽  
Antonio Musaro
Keyword(s):  
Muscle Development ◽  
Scientific Session ◽  
Oral Communication ◽  
Muscle Physiology ◽  
Therapeutic Approaches ◽  
Muscle Diseases ◽  
Poster Sessions ◽  
Muscle Research ◽  
Muscle Biology ◽  
And Function

The 14th Meeting of the Interuniversity Institute of Myology (IIM), October 12-15, 2017 - Assisi, Italy gathered together researchers from Italy, European and North-American countries to discuss recent results on muscle research. The program showcased keynote lectures from world-renowned international speakers presenting advances in muscle physiology, bioengineering, metabolism and therapeutics. Based on selection from submitted abstracts, participants presented their novel, unpublished results in seven oral communication and two poster sessions. Particular emphasis was devoted to young trainees. For example, trainees where directly involved in organizing a scientific session and three round tables tailored to the interests of their peers. The meeting attracted a broad audience from Italy, various European countries and from North America. It offered a unique opportunity to all researchers involved in the field of muscle biology to exchange ideas and foster scientific collaborations to better understand the causative mechanisms of muscular diseases and to improve the design of more efficient therapeutic strategies. The friendly and inclusive atmosphere promoted the active participation of junior scientists to exciting discussions, which allowed to identify emerging areas of myology research and encouraged scientific cross-fertilization to facilitate exchanges between different laboratories in different countries. The meeting was a success and this community will continue to deliver major contributions to our understanding of muscle development and function, the pathogenesis of muscle diseases and the development of novel therapeutic approaches. Here, we report abstracts of the meeting discussing recent results of basic, translational and early clinical studies confirming that the field of Myology is strong and articulated, maturing toward clinical development for the treatment of muscle diseases.

The Sliding Filament Theory Since Andrew Huxley: Multiscale and Multidisciplinary Muscle Research

2021 ◽  
Vol 50 (1) ◽  
Author(s):  
Joseph D. Powers ◽  
Sage A. Malingen ◽  
Michael Regnier ◽  
Thomas L. Daniel
Keyword(s):  
Muscle Contraction ◽  
Muscle Function ◽  
Historical Research ◽  
Annual Review ◽  
Muscle Physiology ◽  
Publication Date ◽  
Multiscale Dynamics ◽  
Structural And Functional Properties ◽  
Muscle Research ◽  
Sliding Filament Theory

Two groundbreaking papers published in 1954 laid out the theory of the mechanism of muscle contraction based on force-generating interactions between myofilaments in the sarcomere that cause filaments to slide past one another during muscle contraction. The succeeding decades of research in muscle physiology have revealed a unifying interest: to understand the multiscale processes—from atom to organ—that govern muscle function. Such an understanding would have profound consequences for a vast array of applications, from developing new biomimetic technologies to treating heart disease. However, connecting structural and functional properties that are relevant at one spatiotemporal scale to those that are relevant at other scales remains a great challenge. Through a lens of multiscale dynamics, we review in this article current and historical research in muscle physiology sparked by the sliding filament theory. Expected final online publication date for the Annual Review of Biophysics, Volume 50 is May 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals 16th Meeting of the Interuniversity Institute of Myology (IIM) - Assisi (Italy), October 17-20, 2019: Foreword, Program and Abstracts

2020 ◽  
Author(s):  
Davide Gabellini ◽  
Antonio Musarò
Keyword(s):  
Muscle Development ◽  
Therapeutic Approaches ◽  
Poster Sessions ◽  
Muscle Research ◽  
Muscle Biology ◽  
October 17 ◽  
And Function ◽  
Cross Fertilization ◽  
Selection Of ◽  
Scientific Collaborations

The 16th Meeting of the Interuniversity Institute of Myology (IIM), October 17-20, 2019, Assisi, Italy brought together scientists, pharma and patient organization representatives discussing new results on muscle research. Internationally renowned Keynote speakers presented advances on muscle development, homeostasis, metabolism, and disease. Speakers selected among submitted abstracts presented their new, unpublished data in seven scientific sessions. The remaining abstracts were showcased in two poster sessions. Young trainees where directly involved in the selection of keynote speakers, the organizing scientific sessions and roundtables discussions tailored to the interests of their peers. A broad Italian, European and North-American audience participated to the different initiatives. The meeting allowed muscle biology researchers to discuss ideas and scientific collaborations aimed at better understanding the mechanisms underlaying muscle diseases in order to develop better therapeutic strategies. The active participation of young trainees was facilitated by the friendly and inclusive atmosphere, which fostered lively discussions identifying emerging areas of myology research and stimulated scientific cross-fertilization. The meeting was a success and the IIM community will continue to bring forward significant contributions to the understanding of muscle development and function, the pathogenesis of muscular diseases and the development of novel therapeutic approaches. Here, we report abstracts of the meeting illustrating novel results of basic, translational, and clinical research, which confirms that the Myology field is strong and healthy.

scholarly journals CORP: Using transgenic mice to study skeletal muscle physiology

2020 ◽  
Vol 128 (5) ◽  
pp. 1227-1239
Author(s):  
C. Brooks Mobley ◽  
Ivan J. Vechetti ◽  
Taylor R. Valentino ◽  
John J. McCarthy
Keyword(s):  
Skeletal Muscle ◽  
Transgenic Mice ◽  
Research Program ◽  
Gene Function ◽  
Cell Biology ◽  
Muscle Physiology ◽  
Basic Information ◽  
Adult Skeletal Muscle ◽  
Tissue Specific ◽  
Muscle Research

The development of tissue-specific inducible transgenic mice has provided a powerful tool to study gene function and cell biology in almost any tissue of interest at any given time within the animal’s life. The purpose of this review is to describe how to use two different inducible transgenic systems, the Cre-loxP system and the Tet-ON/OFF system, that can be used to study skeletal muscle physiology. Myofiber- and satellite cell-specific Cre-loxP transgenic mice are described as is how these mice can be used to knockout a gene of interest or to deplete satellite cells in adult skeletal muscle, respectively. A myofiber-specific Tet-ON system is described as is how such mice can be used to overexpress a gene of interest or to label myonuclei. How to effectively breed and genotype the transgenic mice are also described in detail. The hope is this review will provide the basic information necessary to facilitate the incorporation of tissue-specific inducible transgenic mice into a skeletal muscle research program.

scholarly journals Miraculous fish therapy for leprosy (‘elephant disease’) and other skin diseases in Byzantium

2016 ◽  
Vol 40 (1) ◽  
pp. 170-175
Author(s):  
Petros Bouras-Vallianatos
Keyword(s):  
Skin Diseases ◽  
Fifth Century ◽  
Spa Therapy ◽  
Therapeutic Approaches ◽  
Unique Case ◽  
The City

This article discusses a unique case of a miraculous fish therapy used for a variety of skin diseases, which seems to have been practised in the mid-fifth century at the shrine of St. Michael in the city of Germia (mod. Gümüşkonak). It aims to enhance our knowledge of Byzantine therapeutic approaches to ‘elephant disease’ and contribute to debates on modern fish spa therapy.

Therapeutic Approaches for Dominant Muscle Diseases: Highlight on Myotonic Dystrophy

2015 ◽  
Vol 15 (4) ◽  
pp. 329-337 ◽  
Author(s):  
A. Klein ◽  
S. Dastidar ◽  
D. Furling ◽  
M. Chuah
Keyword(s):  
Myotonic Dystrophy ◽  
Therapeutic Approaches ◽  
Muscle Diseases

scholarly journals A human in vitro model of Duchenne muscular dystrophy muscle formation and contractility

2016 ◽  
Vol 215 (1) ◽  
pp. 47-56 ◽  
Author(s):  
Alexander P. Nesmith ◽  
Matthew A. Wagner ◽  
Francesco S. Pasqualini ◽  
Blakely B. O’Connor ◽  
Mark J. Pincus ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Dystrophic Muscle ◽  
Muscle Stem Cells ◽  
Functional Behavior ◽  
Muscle Tissues ◽  
Muscle Formation ◽  
Structural Aberrations ◽  
Vitro Model

Tongue weakness, like all weakness in Duchenne muscular dystrophy (DMD), occurs as a result of contraction-induced muscle damage and deficient muscular repair. Although membrane fragility is known to potentiate injury in DMD, whether muscle stem cells are implicated in deficient muscular repair remains unclear. We hypothesized that DMD myoblasts are less sensitive to cues in the extracellular matrix designed to potentiate structure–function relationships of healthy muscle. To test this hypothesis, we drew inspiration from the tongue and engineered contractile human muscle tissues on thin films. On this platform, DMD myoblasts formed fewer and smaller myotubes and exhibited impaired polarization of the cell nucleus and contractile cytoskeleton when compared with healthy cells. These structural aberrations were reflected in their functional behavior, as engineered tongues from DMD myoblasts failed to achieve the same contractile strength as healthy tongue structures. These data suggest that dystrophic muscle may fail to organize with respect to extracellular cues necessary to potentiate adaptive growth and remodeling.

scholarly journals 16th Meeting of the Interuniversity Institute of Myology (IIM) - Assisi (Italy), October 17-20, 2019: Foreword, Program and Abstracts

2020 ◽  
Vol 30 (3) ◽  
Author(s):  
Davide Gabellini ◽  
Antonio Musarò
Keyword(s):  
Muscle Development ◽  
Therapeutic Approaches ◽  
Poster Sessions ◽  
Muscle Research ◽  
Muscle Biology ◽  
October 17 ◽  
And Function ◽  
Cross Fertilization ◽  
Selection Of ◽  
Scientific Collaborations

The 16th Meeting of the Interuniversity Institute of Myology (IIM), October 17-20, 2019, Assisi, Italy brought together scientists, pharma and patient organization representatives discussing new results on muscle research. Internationally renowned Keynote speakers presented advances on muscle development, homeostasis, metabolism, and disease. Speakers selected among submitted abstracts presented their new, unpublished data in seven scientific sessions. The remaining abstracts were showcased in two poster sessions. Young trainees where directly involved in the selection of keynote speakers, the organizing scientific sessions and roundtables discussions tailored to the interests of their peers. A broad Italian, European and North-American audience participated to the different initiatives. The meeting allowed muscle biology researchers to discuss ideas and scientific collaborations aimed at better understanding the mechanisms underlaying muscle diseases in order to develop better therapeutic strategies. The active participation of young trainees was facilitated by the friendly and inclusive atmosphere, which fostered lively discussions identifying emerging areas of myology research and stimulated scientific cross-fertilization. The meeting was a success and the IIM community will continue to bring forward significant contributions to the understanding of muscle development and function, the pathogenesis of muscular diseases and the development of novel therapeutic approaches. Here, we report abstracts of the meeting illustrating novel results of basic, translational, and clinical research, which confirms that the Myology field is strong and healthy.

scholarly journals In July 2019 the Portuguese Society of Myology was officially born: the first message from the founders

2019 ◽  
Vol 29 (4) ◽  
Author(s):  
Paula Tavares ◽  
Carlos Fontes Ribeiro
Keyword(s):  
Skeletal Muscle ◽  
International Collaboration ◽  
Muscle Physiology ◽  
System Call ◽  
Muscle System ◽  
Adaptation Capacity ◽  
Public Events ◽  
Portuguese Society ◽  
Scientific Meetings ◽  
The City

The amazing behaviour and adaptation capacity of the skeletal muscle system call the attention of several scientists, including us. Thus, we have the pleasure to announce that it was born in the city of Coimbra, Portugal, the Portuguese Society of Myology (SPMyo), a society which the main aim is to spread skeletal muscle knowledge in the areas of muscle physiology, physiopathology and pharmacology in a multidisciplinary organization that reflects the different areas of the skeletal muscle study. The commitment of SPMyo is the progress of skeletal muscle awareness as well as its investigation, encouraging interdisciplinary, national and international collaboration. These goals will be achieved by organization of scientific meetings, formation courses, publications of books and other scientific and didactic materials. It is also a goal of the SPMyo to organize public events allowing general public to understand skeletal muscle system.

scholarly journals Working around the clock: circadian rhythms and skeletal muscle

2009 ◽  
Vol 107 (5) ◽  
pp. 1647-1654 ◽  
Author(s):  
Xiping Zhang ◽  
Thomas J. Dube ◽  
Karyn A. Esser
Keyword(s):  
Skeletal Muscle ◽  
Molecular Clock ◽  
Time Of Day ◽  
Muscle Disease ◽  
Muscle Physiology ◽  
Skeletal Muscle Function ◽  
Temporal Specificity ◽  
Muscle Research ◽  
Normal Expression ◽  
Normal Metabolism

The study of the circadian molecular clock in skeletal muscle is in the very early stages. Initial research has demonstrated the presence of the molecular clock in skeletal muscle and that skeletal muscle of a clock-compromised mouse, Clock mutant, exhibits significant disruption in normal expression of many genes required for adult muscle structure and metabolism. In light of the growing association between the molecular clock, metabolism, and metabolic disease, it will also be important to understand the contribution of circadian factors to normal metabolism, metabolic responses to muscle training, and contribution of the molecular clock in muscle-to-muscle disease (e.g., insulin resistance). Consistent with the potential for the skeletal muscle molecular clock modulating skeletal muscle physiology, there are findings in the literature that there is significant time-of-day effects for strength and metabolism. Additionally, there is some recent evidence that temporal specificity is important for optimizing training for muscular performance. While these studies do not prove that the molecular clock in skeletal muscle is important, they are suggestive of a circadian contribution to skeletal muscle function. The application of well-established models of skeletal muscle research in function and metabolism with available genetic models of molecular clock disruption will allow for more mechanistic understanding of potential relationships.

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