Cutis marmorata as a manifestation of decompression illness

Antonio Villa; Mara Fiocchi

doi:10.4081/ecj.2020.8950

Cutis marmorata as a manifestation of decompression illness

Emergency Care Journal ◽

10.4081/ecj.2020.8950 ◽

2020 ◽

Vol 16 (3) ◽

Author(s):

Antonio Villa ◽

Mara Fiocchi

Keyword(s):

Skin Lesions ◽

Warning Sign ◽

Decompression Illness ◽

Severe Manifestation

We present imagines of skin lesions due to a decompression illness (known as cutis marmorata). These alterations are usually transient, but they could be a warning sign of a more severe manifestation of decompression illness.

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Toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosus

Rheumatology Science and Practice ◽

10.14412/1995-4484-2018-785-790 ◽

2019 ◽

Vol 56 (6) ◽

pp. 785-790

Author(s):

L. D. Vorobyeva ◽

E. A. Aseeva ◽

S. K. Solovyev ◽

T. A. Belousova ◽

N. E. Lopatina ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Toxic Epidermal Necrolysis ◽

Lupus Erythematosus ◽

Drug Allergy ◽

English Language ◽

Skin Lesions ◽

Systemic Lupus ◽

Good Therapeutic Effect ◽

Severe Manifestation ◽

Language Literature

Toxic epidermal necrolysis (TEN) has been long believed to be the most severe manifestation of drug allergy. However, cutaneous changes as TEN in systemic lupus erythematosus (SLE) were first described in the late 1970s. As of now, the English-language literature published reports of 30 cases of such lesions in SLE. This paper describes a clinical case of TEN as a direct manifestation of SLE; the positive experience has been first depicted in using not only intravenous immunoglobulin, but also rituximab with a good therapeutic effect in Russian clinical practice.

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Eruptive xanthomas: a warning sign of future hyperlipidemia complications

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20202672 ◽

2020 ◽

Vol 6 (4) ◽

pp. 579

Author(s):

Trevor A. Nessel ◽

Connor C. Kerndt ◽

John A. Bills ◽

Lynn Sikorski

Keyword(s):

Primary Care ◽

Emergency Department ◽

Laboratory Tests ◽

Lifestyle Modification ◽

Subcutaneous Tissue ◽

Skin Lesions ◽

Warning Sign ◽

Histological Findings ◽

Laboratory Findings ◽

Eruptive Xanthomas

<p>Eruptive xanthomas are localized lipid deposits in the skin or subcutaneous tissue that are associated with both primary and secondary hyperlipidemia. Typical presentation manifests as small yellow papules on the buttocks or extensor surfaces. Xanthomas can be diagnosed clinically with an extensive history and physical examination, however, can be confirmed via biopsy and histological findings. It is essential to identify the underlying cause of the skin lesions and take appropriate measures to prevent future hyperlipidemia-induced consequences. Here we report a 42-year-old female with eruptive xanthomas on her trunk and extremities. Previous visits to the primary care provider and emergency department resulted in diagnoses of viral exanthems. The consulted dermatologist ordered laboratory tests remarkable for extreme hypertriglyceridemia, hypercholesterolemia, and hyperglycemia. Lifestyle modification in conjunction with cholesterol and triglyceride lowering medications led to the resolution of abnormal laboratory findings and remission of eruptive xanthoma lesions.</p>

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Interruption of Sneddon-Wilkinson Subcorneal Pustulation with Infliximab

Case Reports in Dermatology ◽

10.1159/000468917 ◽

2017 ◽

Vol 9 (1) ◽

pp. 140-144 ◽

Cited By ~ 6

Author(s):

Lorenz Kretschmer ◽

Julia-Tatjana Maul ◽

Thomas Hofer ◽

Alexander A. Navarini

Keyword(s):

Maintenance Therapy ◽

Skin Lesions ◽

First Line ◽

First Line Therapy ◽

Tnf Α ◽

Subcorneal Pustular Dermatosis ◽

Severe Manifestation ◽

Chemotactic Factors ◽

Systemic Symptoms

Subcorneal pustular dermatosis (SCPD, Sneddon-Wilkinson disease) is a rare chronic-relapsing skin disorder that typically manifests as flaccid sterile pustules without systemic symptoms. Although the accumulation of neutrophils is acknowledged to be a hallmark of SCPD, its exact pathomechanism is still not known. Several chemotactic factors have been implicated in neutrophil recruitment and invasion, including the proinflammatory cytokine TNF-α. These findings correspond well with clinical reports of successful off-label use of TNF blocking agents in cases that were refractory to first-line therapy, mostly with dapsone. We report the case of a 29-year-old male with atypical and severe manifestation of SCPD that resolved after a single dose of infliximab. Consolidation was observed 1 day after treatment and regression of skin lesions occurred after a few days. Residual scarring and postlesional hyperpigmentation was seen at a 2-month follow-up appointment. The patient was initiated on a daily maintenance therapy with dapsone, which led to a drop in hemoglobin and had to be stopped. Upon development of small, scaly lesions, a maintenance therapy with infliximab was started and the patient has had no recurrence to date. Anti-TNF agents present a promising option for patients affected by severe SCPD. We review the reports of similar cases in the literature to date.

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Fine Structural Alterations in Thyroid Follicular Cells (FC) and Changes in Serum Thyroxine Produced by Feeding Polychlorinated Biphenyl (PCB) to Rats

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100079929 ◽

1977 ◽

Vol 35 ◽

pp. 498-499

Author(s):

W.T. Collins ◽

Charles C. Capen ◽

Louis Kasza

Keyword(s):

Feed Efficiency ◽

Polychlorinated Biphenyl ◽

Serum Proteins ◽

Skin Lesions ◽

Hepatic Necrosis ◽

Ultrastructural Changes ◽

Lymphoid Tissues ◽

Heat Transfer Fluids ◽

Thyroid Follicular Cells ◽

Peripheral Metabolism

The widespread contamination of the environment with PCB, a compound used extensively by industry in hydraulic and heat transfer fluids as well as plasticizers and solvents in adhesives and sealants, has resulted in detectable tissue levels in a large portion of the human population, domestic animals, and wildlife. Intoxication with PCB produces severe hepatic necrosis, degeneration of lymphoid tissues and kidney, skin lesions, decreased reproductive performance, reduced feed efficiency, and decreased weight gain. PCB also has been reported to reduce the binding of thyroid hormone to serum proteins and enhance the peripheral metabolism of thyroxine with increased excretion of thyroxine-glucuronide in the bile (Bastomsky, Endocrinology 95: 1150-1155, 1974).The objectives of this investigation were (1) to investigate the histopathologic, histochemical, and ultrastructural changes in thyroid FC produced by the acute (4 week) and chronic (12 week) administration of low (50 ppm) and high (500 ppm) doses of PCB to rats, (2) to correlate these alterations to changes in serum immunoreactive thyroxine concentration, and (3) to investigate the persistence of the effects of PCB on the thyroid gland.

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