scholarly journals Co-expression of CD34 and h-caldesmon in a benign meningioma-like dermal neoplasm, a case report

2020 ◽  
Vol 12 (3) ◽  
Author(s):  
Haitham Kussaibi
Keyword(s):  
Case Report ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Benign Meningioma ◽  
Left Hand ◽  
Histopathological Evaluation ◽  
Vascular Component ◽  
A Minor ◽  
Dermal Lesion ◽  
Diffuse Positivity

Meningioma-like dermal tumor with diffuse coexpression of CD34 and hcaldesmon is rarely reported. Herein, we report a case of a 58-years-old woman who complained of a solitary dome-shaped papule on the left hand. An ellipse of skin measuring 1 x 0.5 x 0.5 cm was excised and sent for histopathological evaluation. Upon sectioning, the specimen showed a whitish firm dermal nodule measuring 3 mm in its greatest dimension. Microscopic examination revealed a well-circumscribed barely encapsulated dermal lesion showing compact round whorled sheets formed of round to ovoid uniform cells with abundant pink cytoplasm. Occasional intranuclear vacuoles were seen. A minor capillary-sized vascular component was seen in the background. Immunohistochemical (IHC) study revealed a diffuse positivity of tumor cells to CD34 and h-caldesmon along with faint reaction to Smooth Muscle Actin (SMA) and ER. However, Desmin, S100, HMB45, EMA, Pan Cytokeratin, and Chromogranin were all negative. Ki67 was very low (1%). The main differential diagnoses of the current lesion are meningioma and glomus family tumors. While the current lesion is morphologically reminiscent of cutaneous meningioma; neither the location nor the IHC stains support that diagnosis. The glomus family is highly suggestive. However, the location, the compact nature of the proliferation, and the positivity of CD34, all are unusual in such entities.

scholarly journals Case Report: A giant myopericytoma involving the occipital region of the scalp - a rare entity

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2905 ◽  
Author(s):  
Sunil Munakomi ◽  
Pramod Chaudhary
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Histological Examination ◽  
Rare Case ◽  
Smooth Muscle Actin ◽  
Positive Staining ◽  
Occipital Region ◽  
Rare Entity ◽  
Muscle Actin ◽  
Complete Excision

Herein we report a rare case of a giant myopericytoma presenting in a 16-year-old girl as a slowly progressive swelling involving the scalp in the occipital region. It was managed by complete excision. Histological examination of the lesion revealed  spindle-shaped cells forming characteristic rosettes around the blood vessels, and positive staining with smooth muscle actin.

Solitary Testicular Myofibroma: A Case Report and Review of the Literature

2005 ◽  
Vol 129 (10) ◽  
pp. 1322-1325
Author(s):  
Samson W. Fine ◽  
North J. Davis ◽  
Lawrence E. Lykins ◽  
Elizabeth Montgomery
Keyword(s):  
Case Report ◽  
Soft Tissues ◽  
Smooth Muscle Actin ◽  
Male Infant ◽  
Muscle Actin ◽  
Review Of The Literature ◽  
Infantile Myofibromatosis ◽  
Internal Organs ◽  
Mesenchymal Neoplasms ◽  
Spindle Cells

Abstract Myofibromas are benign mesenchymal neoplasms of myofibroblastic origin. Most present as solitary lesions at any age, but the presentation of multiple lesions in newborns and infants is known as infantile myofibromatosis. Multicentric lesions commonly involve soft tissues and bone and may involve internal organs, where they are associated with an unfavorable prognosis. Solitary lesions involving the viscera are rare. We report a case of a 3-month-old male infant with a left testicular mass detected during an evaluation for suspected torsion. The patient underwent orchiectomy, revealing a nodular mass with grossly evident foci of necrosis. Histologically, the lesion exhibited small fascicles of plump eosinophilic, smooth muscle actin–positive spindle cells, alternating with larger areas of primitive cells with vesicular nuclei and scant cytoplasm arranged around a hemangiopericytoma-like vasculature. To our knowledge, this is the first report of a myofibroma localized within the testis.

scholarly journals Temporal primary cutaneous carcinosarcoma in the ear: A case report

2021 ◽  
Vol 12 (2) ◽  
pp. 180-182
Author(s):  
Issam Msakni ◽  
Aya Khemir ◽  
Nada Mansouri
Keyword(s):  
Case Report ◽  
Smooth Muscle Actin ◽  
The Body ◽  
Muscle Actin ◽  
Epithelial Component ◽  
Spindle Cells ◽  
Stromal Component ◽  
Peripheral Palisading ◽  
Biphasic Tumor

Carcinosarcoma is a rare biphasic tumor made of two malignant components—the epithelial component and the stromal component—that can develop anywhere on the body, but mainly in sun-exposed areas. We report the case of a 78-year-old male who presented himself with a right temporal tumor in the ear 10 cm in diameter. A biopsy suggested a sarcoma. The patient underwent an extensive surgical resection of the temporal mass and the ipsilateral ear. A microscopic examination of the tumor revealed two intermixed malignant contingents. The epithelial component was made of atypical basaloid cells arranged in nests with peripheral palisading and expressing cytokeratin. The stromal component was made of atypical spindle cells expressing smooth muscle actin (SMA). A diagnosis of primary cutaneous carcinosarcoma with clear margins was reached. The patient is alive and without recurrence after twelve months of a follow-up period.

scholarly journals Anterior Mediastinal Leiomyosarcoma: A Case Report and Literature Review

2021 ◽  
pp. 101-106
Author(s):  
Akira Ishikawa ◽  
Kazuya Kuraoka ◽  
Junichi Zaitsu ◽  
Akihisa Saito ◽  
Atsushi Kamigaichi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Literature Review ◽  
Tumor Cells ◽  
Growth Pattern ◽  
Mediastinal Mass ◽  
Smooth Muscle Actin ◽  
Anterior Mediastinum ◽  
Anterior Mediastinal Mass ◽  
Muscle Actin

Primary mediastinal sarcomas are extremely rare. Additionally, mediastinal leiomyosarcomas account for approximately 9% of mediastinal sarcoma cases. Until date, only few cases of anterior mediastinal leiomyosarcomas have been reported. Herein, we report a case of an 85-year-old female with an anterior mediastinal mass of 15 mm. Histological examination revealed spindle tumor cells showing a fascicular growth pattern. Immunohistochemically, the tumor cells were focal positive for desmin, calponin, and α-smooth muscle actin. The pathological diagnosis was leiomyosarcoma. In conclusion, we encountered a case of a very rare leiomyosarcoma that occurred in the anterior mediastinum, and our report may contribute to the understanding of this disease.

scholarly journals Cutaneous leiomyosarcoma with osteoid metaplasia in a budgerigar (Melopsittacus undulatus): a case report

2016 ◽  
Vol 61 (No. 9) ◽  
pp. 533-537 ◽  
Author(s):  
N. Timurkaan ◽  
H. Eroksuz ◽  
A. Cevik ◽  
B. Karabulut
Keyword(s):  
Case Report ◽  
Immunohistochemical Staining ◽  
Staining Method ◽  
Smooth Muscle Actin ◽  
Tumour Cells ◽  
Tumour Mass ◽  
Right Wing ◽  
Muscle Actin ◽  
The Right ◽  
Nodular Appearance

Cutaneous leiomyosarcoma with osteoid metaplasia was diagnosed at the base of the right wing in a five-year-old female budgerigar. Grossly, the tumour mass was well circumscribed and solitary, and had a nodular appearance on section. On histological examination, the mass was composed of randomly arranged bundles of spindle-shaped cells that included mitotic, multi-nucleated and bizarre cells. In addition, within and between tumour areas, there were osteoid metaplasia foci. The bony trabeculae were usually localised in the areas around the haemorrhage, and exhibited focal mineralisation. Tumour cells were stained red using Masson’s trichrome staining method. In addition, tumour cells were intensively positive for smooth muscle actin and focally positive for desmin and vimentin, but were negative for CD68 and S100 by immunohistochemical staining. The tumour reported here was defined as a cutaneous leiomyosarcoma with osteoid metaplasia by histopathological and immunohistochemical findings. Our findings may indicate that osteoid metaplasia should be considered in leiomyosarcoma in budgerigars.

scholarly journals Cutaneous myofibroblastic fibrosarcoma in a margay (Leopardus wiedii): a case report

2020 ◽  
Vol 13 (3) ◽  
pp. 597-601
Author(s):  
Raúl Bermúdez-Salas ◽  
Natalia Campos ◽  
Daniel Barrantes ◽  
Randall Arguedas ◽  
Alejandro Alfaro-Alarcón
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Smooth Muscle Actin ◽  
Histopathological Analysis ◽  
Muscle Actin ◽  
First Report ◽  
Mesenchymal Neoplasm

A routine check-up was performed on a captive 14-year-old female margay (Leopardus wiedii), a cutaneous mass was detected on the ventral thorax. The mass was surgically removed and sent for histopathological analysis. Histologically, the mass was a poorly-demarcated, highly cellular, infiltrative and unencapsulated mesenchymal neoplasm. Immunohistochemical labeling for smooth muscle actin and vimentin were positive, while desmin and cytokeratin were negative which is consistent with a myofibroblastic fibrosarcoma. This type of tumor has been diagnosed in wild felines, however this seems to be the first report of its occurrence in this L. wiedii. Wildlife oncology studies should be performed to promote our understanding of cancer in a species.

scholarly journals Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): case report and review

2010 ◽  
Vol 54 (7) ◽  
pp. 657-662 ◽  
Author(s):  
Luiz Antônio Magnata Filho ◽  
Maria Alice Neves Bordallo ◽  
Cencita H. C. N. Pessoa ◽  
Rossana Corbo ◽  
Daniel Alves Bulzico ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Immunohistochemical Study ◽  
Smooth Muscle Actin ◽  
Malignant Neoplasm ◽  
Cell Component ◽  
Epithelial Tumor ◽  
Spindle Cell Component ◽  
Thyroid Mass ◽  
A Minor ◽  
Diffuse Positivity

Spindle epithelial tumor with thymus-like element (SETTLE) is a rare malignant neoplasm of the thyroid, occurring predominantly in children, adolescents, and young adults. SETTLE usually presents itself as a thyroid mass, without metastases at diagnosis. It is believed to derive from branchial pouch or thymic remnant tissue showing primitive thymic differentiation. This article reports the clinical, cytological, histological and immunohistochemical features of a SETTLE in a 3-year-old girl. Microscopic exam revealed a nodular, highly cellular neoplasm displayed in the classic biphasic pattern, with mixture of prominent spindle cell component and a minor glandular component lined by mucinous or respiratory-type epithelium. The immunohistochemical study showed strong and diffuse positivity for pan-CK, vimentin and smooth muscle actin. The present case is the first SETTLE case reported in Brazil. To date, the patient described remains without evidence of recurrence or metastasis 5 years after surgery.

MESENCHYMAL TUMOR LEIOMYOSARCOMA OF PROSTATE, A RARE CASE REPORT

2021 ◽  
pp. 21-22
Author(s):  
Ekta Rani ◽  
Sarita Nibhoria ◽  
Bikramjit Singh ◽  
Aradhana Singh Hada ◽  
Parminderjeet Singh Sandhu
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Tumor Cells ◽  
Poor Prognosis ◽  
Rare Case ◽  
Smooth Muscle Actin ◽  
Mesenchymal Tumor ◽  
Muscle Actin ◽  
Rare Case Report ◽  
Rare Malignancy

Primary prostate sarcoma is a rare malignancy of the prostate with poor prognosis. It accounts for <1% of the tumors of the prostate. Leiomyosarcoma is the most common sarcoma involving the prostate in adults affecting men between the ages of 40 and 78 years. Tumor cells commonly express vimentin, smooth muscle actin and desmin, and up to 25% express cytokeratins.

Renal Myopericytoma: Case Report and Review of Literature

2012 ◽  
Vol 136 (5) ◽  
pp. 563-566 ◽  
Author(s):  
Sadhna Dhingra ◽  
Alberto Ayala ◽  
Hong Chai ◽  
Vanessa Moreno ◽  
Bihong Zhao
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Renal Mass ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Review Of Literature ◽  
Computed Tomography Scan ◽  
Muscle Myosin ◽  
Cd34 Expression ◽  
Tomography Scan

Myopericytoma arising in the visceral organs is rare and only 1 case of renal myopericytoma has been reported in the literature to date. We report the second case of myopericytoma arising in the kidney in a 40-year-old Hispanic woman who presented with pain on the left side of the abdomen and frequent urination. Abdominal computed tomography scan showed an exophytic left-sided renal mass. Partial nephrectomy was performed. The patient remains free of disease at 24 months after diagnosis. Our case is histologically distinct from the previously described case as it lacks the “hemangiopericytic/glomangiopericytoma” pattern. The tumor in our case showed the characteristic pattern of myopericytoma and an additional glomus tumorlike pattern. The tumor cells showed diffuse reactivity for vimentin, smooth muscle actin, smooth muscle myosin heavy chain, and muscle-specific actin in both morphologic patterns and strong diffuse CD34 expression in glomus tumorlike focus. This case report adds to the morphologic heterogeneity of myopericytomas.

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