scholarly journals Neisseria gonorrhoeae resistance test against cefixime in gonorrhea patients in Surabaya

2019 ◽  
Author(s):  
Amalia Rositawati ◽  
S. Sawitri ◽  
Afif Nurul Hidayati

Gonorrhea remains as one of the most common sexually transmitted diseases in developing countries. The third generation cephalosporin such as cefixime is now one of the first-line therapies in many regions. Over the last decade, strains of Neisseria gonorrhoeae have been reported to develop high levels of resistance against several antimicrobial agent cefixime. The purpose of this study is to evaluate the susceptibility of cefixime to Neisseria gonorrhoeae. Methods: The study design was descriptive laboratory observational cross sectional from June 2017 to September 2017. Twenty isolates Neisserria gonorrhoeae taken from outpatients with positive complaints of purulent secretions, who visited 7 Community Health Centre in Surabaya and met the inclusion criterias, were tested with cefixime diffusion susceptibility test. Results: 7 of 20 isolates (35%) were resistant to cefixime and 13 of 20 isolates (65%) sensitive to cefixime. Conclusions: Neisseria gonorhoeae strain was proven to be resistant to cefixime by performing diffusion test.

2020 ◽  
Vol 32 (2) ◽  
pp. 103
Author(s):  
Lita Setyowatie ◽  
Tantari SHW ◽  
Inneke Yulian

Background: Gonorrhea remains the second most common sexually transmitted infection (STI) in the world with an increasing number of cases. Oral cefixime and IM ceftriaxone are still the mainstay therapy for gonorrhea in Indonesia. However, previous studies suggested possible resistance to ceftriaxone and cefixime, which are the first-line treatment of gonorrhea. To date, there are no data available regarding the susceptibility of these antibiotics for the treatment of gonorrhea in Dr. Saiful Anwar General Hospital (RSSA) Malang. Purpose: Determine susceptibility pattern of Neisseria gonorrhoeaetowards cefixime and ceftriaxone in RSSA Malang. Methods: The samples were patients of the Outpatient Clinic of Dermatology and Venereology Department with a symptom of discharge which contained Gram-negative diplococcus after Gram staining and had a positive culture of Neisseria gonorrhoeae. Susceptibility testing for cefixime and ceftriaxone antibiotics were performed using the Kirby-Bauer method. The data are presented in percentages. Result: Antibiotic susceptibility test results showed that 80.77% of Neisseria gonorrhoeaeisolates were still susceptible to cefixime, and 80.77% of isolates were still susceptible to ceftriaxone. Conclusion: Cefixime and ceftriaxone are still effective as gonorrhea therapy in RSSA Malang. 


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
A. Calas ◽  
N. Zemali ◽  
G. Camuset ◽  
J. Jaubert ◽  
R. Manaquin ◽  
...  

Abstract Background Recommendations for sexually transmitted infection (STI) screening vary significantly across countries. This study evaluated the prevalence of urogenital and extragenital infections with Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Mycoplasma genitalium (MG) in patients visiting a French STI clinic in the Indian Ocean region to determine whether current STI screening practices should be updated. Methods This cross-sectional study examined all patients who visited the STI clinic between 2014 and 2015. Triplex polymerase chain reaction screening for CT, NG, and MG was performed on urine, vaginal, pharyngeal, and anal specimens (FTD Urethritis Basic Kit, Fast Track Diagnostics, Luxembourg). Results Of the 851 patients enrolled in the study, 367 were women (367/851, 43.2%) and 484 were men (484/851, 56.0%). Overall, 826 urogenital specimens (826/851, 97.1%), 606 pharyngeal specimens (606/851, 71.2%), and 127 anal specimens (127/851, 14.9%) were taken from enrolled patients. The prevalence of urogenital CT and MG was high in women ≤25 years (19/186, 10.21%; 5/186, 2.69%) and in men who have sex with women ≤30 years (16/212, 7.54%; 5/212, 2.36%). Among patients with urogenital CT infection, 13.7% (7/51) had urethritis. All patients with urogenital MG infection were asymptomatic. Men who have sex with men had a high prevalence of pharyngeal CT (2/45, 4.44%) and NG (3/44, 6.81%) and a high prevalence of anal CT (2/27, 7.41%), NG (2/27, 7.40%), and MG (1/27, 3.70%). After excluding patients with concomitant urogenital infection, extragenital infections with at least 1 of the 3 pathogens were found in 20 swabs (20/91, 21.9%) taken from 16 patients (16/81, 19.7%), all of them asymptomatic. Conclusions Routine multisite screening for CT, NG, and MG should be performed to mitigate the transmission of STIs in high-risk sexually active populations.


BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e037608
Author(s):  
Mario Martín-Sánchez ◽  
Richard Case ◽  
Christopher Fairley ◽  
Jane S Hocking ◽  
Catriona Bradshaw ◽  
...  

ObjectivesIn the 2010s, there has been an increase in sexually transmitted infections (STI) in men who have sex with men (MSM) in Australia, and since 2015 also in urban heterosexuals. Men who have sex with both men and women (MSMW) have characteristics that may differ from both men who have sex with men only (MSMO) and heterosexual men. We aimed to compare the sexual practices and the trends in HIV/STI positivity between MSMO and MSMW.DesignRepeated cross-sectional study.SettingA sexual health centre in Melbourne, Australia.ParticipantsMSM aged 18 years and above who attended the Melbourne Sexual Health Centre for the first time between 2011 and 2018. This includes 12 795 MSMO and 1979 MSMW.Primary outcome measuresDemographic characterics, sexual practices and HIV/STI positivity.ResultsCompared with MSMW, MSMO were more likely to practice anal sex and to have condomless receptive anal sex with casual male partners, and less likely to have a current regular relationship. Over the 8-year period, there was an increase in condomless receptive anal sex with casual male partners for both groups (MSMO: from 46.2% to 63.3%, ptrend <0.001; MSMW: from 41.3% to 57.9%, ptrend=0.011). Syphilis positivity increased in MSMO (from 5.5% to 7.9%, ptrend=0.012) and MSMW (from 0.9% to 6.4%, ptrend=0.004) and HIV remained stable. Gonorrhoea increased among MSMO from 2011 to 2014 (from 6.7% to 9.6%, ptrend=0.002), and remained stable from 2015 to 2018. MSMO had higher odds of testing positive for gonorrhoea (adjusted OR (aOR) 1.36, 95% CI 1.13 to 1.64), chlamydia (aOR 1.39, 95% CI 1.16 to 1.67), syphilis (aOR 1.74, 95% CI 1.37 to 2.22) and HIV (aOR 4.60, 95% CI 2.43 to 8.70) than MSMW.ConclusionsMSMW have overall lower condomless sex and lower HIV/STI positivity. In the last years, changes in sexual practices in MSM have affected both MSMW and MSMO leading to an increased STI risk.


2018 ◽  
Vol 35 (4) ◽  
pp. 311-319
Author(s):  
Milan Bjekić ◽  
Sandra Šipetić-Grujičić ◽  
Hristina Vlajinac ◽  
Ivana Dunić

Abstract Penis size is a major body image concern for the majority of men in western nations, while in gay culture the penis has become a body part linked to sexual attractiveness and viability. The aim of this study was to reveal influence of the perceived penis size on sexual behaviour, condom use, sexually transmitted infections and men’s sexual positioning among men who have sex with men. In this cross-sectional study, the data were collected from consecutive men who have sex with men who attended Counselling for Sexually Transmitted Diseases at the City Institute for Skin and Venereal Diseases in Belgrade, Serbia. Out of 319 participants, 6.6% perceived their penis as "below average", 71.5% as "average", and 21.9% as "above average". In comparison with men with an average penis, men with below average penis were more frequently unsatisfied with their penis size (p < 0.05), more frequently lied to others about their penis size (p < 0.001) and took more frequently the passive sexual role (p < 0.05). Men with above average penis were more frequently satisfied with their penis size (p < 0.001), took more frequently the active sexual role (p < 0.01), they had more sexual partners (p < 0.05), more problems with a tight condom (p < 0.001) and more gonorrhoea/Chlamydia infections (p < 0.001) than men with an average penis. Perception of one’s penis size was associated with some aspects of sexual behaviour and the frequency of sexually transmitted diseases.


Author(s):  
Deepak Anand ◽  
Khurshid Parveen ◽  
Gyan Prakash

Background: Providing information about changes during adolescence and sexually transmitted diseases is an important means of promoting healthy development and reducing negative outcomes of social behaviors in adolescents. For this purpose we must know their level of knowledge. So this study was designed to assess the knowledge of male students of class VIth to IXth about issues related to adolescence, their attitude for sexuality related problem and their source of information.Methods: It is a cross-sectional study, sample size was 400. Data was collected between August 2017 and December 2017 by using structured questionnaire.Results: Regarding physical changes 4.5% students have no knowledge, 58.75% have some knowledge and 36.75% have satisfactory knowledge. Whereas 9.75% have no knowledge, 80.75% have some knowledge and 9.50% have satisfactory knowledge regarding sexually transmitted diseases. Only 24.75% students knew legal age for marriage.Conclusions: It was found in study that majority of students do not have satisfactory knowledge and there is a need for targeted education for providing proper knowledge.


Author(s):  
Judith Owokuhaisa ◽  
Joel Bazira

Background: Gonococcus is one of the most common sexually transmitted diseases in developing countries and it has become a global health burden, hence a need for effective treatment. However, there is growing trend of antimicrobial resistant strains, in many parts of the world, to the previously effective antimicrobials thus creating serious health concerns. Setting: Mbarara Regional Referral Hospital -South-Western Uganda. Objectives: 1) To determine the prevalence of gonococcus among out patients presenting with urethral and vaginal discharges at MRRH. 2) To determine the level of antimicrobial resistance of gonococcus based on phenotypic methods at MRRH. Design: The study was cross sectional and enrolled 189 participants presenting with urethral and vaginal discharges. The urethral and endo cervical swab samples collected were cultured on Chocolate media supplemented with 5%-10% carbondioxide in candle jar (inoculated plates were placed in a jar and a burning candle placed in the same jar, then closed, by the time the candle went off, that 5%-10% carbondioxide atmosphere would have been created). Isolates obtained were identified according to the laboratory standard operating procedures. Drug Sensitivity Test (DST) on confirmed Neisseria gonorrheae isolates was performed using the Kirby Bauer technique. The colonies of the test organism were emulsified in peptone water and then inoculated on prepared sterile chocolate agar and the following discs were applied to it (Ceftriaxone discs (30µg), Erythromycin (15ug), Ciprofloxacin (10ug) and Penicillin (10IU). The plates were incubated at 37°C for 24- 48 hours under 5% carbon dioxide atmospheres. The Zone of inhibition was seen around an antibiotic disc to which the organism was sensitive. Results: Out of the 189 participants whose urethral swabs and Endo cervical swabs were cultured, 89 were positive cultures (47%), out of which 25 (28%) were found to have gonococcal infection, 64 (72%) patients had other micro-organisms. The prevalence of Neisseria Gonorrhoeae was 13%. In total, 4% of the isolates were resistant to Ceftriaxone, 28% to Ciprofloxacin, 68% to Erythromycin and 80% to Penicillin. A high percentage of resistance was observed against Penicillin (80%) and Erythromycin (68%). Conclusion: Adults aged 18 years and above who present at Mbarara Regional Referral Hospital with urethral or vaginal discharges are more likely to have a Neisseria gonorrhoeae which is resistant to Penicillin and Erythromycin.


2018 ◽  
Vol 29 (2) ◽  
pp. 47-56
Author(s):  
MR Haque ◽  
K Ghosh ◽  
H Sultana ◽  
E Saha ◽  
A Kafi ◽  
...  

Objective: The main objective of the study was to assess the level of awareness on prevention and control of sexually transmitted diseases among 120 sex workers.Material and Methods: The cross-sectional study was conducted for one year. Data were collected through face to face interview using Bengali questionnaire. Data analysis was done using SPSS 17.0 software.Place and Period of Study: The study was conducted from January 1st to December 31st of 2014 among 120 sex workersliving in brothel of Daulodia,Rajbariin Bangladesh.Results: More than half (58.7%) of the respondents had children in the brothels. All the respondents (100%) heard about the sexually transmitted diseases. Majority (86.7%) of the respondents had knowledge on AIDS. Only a few (4.2%) respondents had knowledge on AIDS and Gonorrhea. Majority (91.7 %) of the respondents had knowledge on STD transmission from pregnant women. Almost all (97.5%, 98.3%)) of the respondents had the knowledge about STD transmissionnot from toilet or shaking hands respectively.Almost all of the (95.8%, 94.2%, 94.2%, 85.8% )respondents had the knowledge on STD transmission through sexual intercourse,injection,through mosquito,sharing same razor respectively. Most of them (81.7%) had good level of knowledge on STD transmission. Only above one tenth (11.7%) had moderate and poor level of knowledge.Almost all of them (96.7%, 95.9%, 95.9%) were found touse condom, agreed to keep one partner at a time,to reduce the number of sex partner respectively.Most of them (89.3%)did not knowthe HIV status of partner before sex,almost all (97.5%, 94.2% and 97.5%) agreed to avoid risky sex,to screen blood during transfusion, to avoid sharing needles & blade respectively. All (100%)of the respondents agreed for need of sexuality education for preventing STD.Almost all (98.30%)of the respondents had good awareness on Prevention and Control of Sexually Transmitted Diseases. There was no association between level of education and level of awareness (P> 0.005), between age and level of awareness (P> 0.005) and between duration of work and level of awareness (P> 0.005).Conclusion: Education is the most consistent and important determinant for prevention of STDs among all classes of people.TAJ 2016; 29(2): 47-56


2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
L Kundisova ◽  
N Nante ◽  
C Lorenzini ◽  
V Valeri ◽  
G Messina ◽  
...  

Abstract Background In the majority of European countries, sex education is mandatory, but Italy is still an exception. Despite sexually transmitted diseases (STD) are believed to be less common today, long-time “forgotten” disease, as syphilis, are returning. The aims of study are i) to examine the knowledge and perceptions of adolescents regarding sex education and STD and ii) to compare our results with Italian national survey. Methods This descriptive cross-sectional study was conducted in 6 middle schools in Siena (Italy) during May-June 2018. Data were anonymous collected using a validate questionnaire previously adopted by the Italian National Institute of Health (NIH). The results were compared with the national survey realized in 1998 by NIH. The analysis was performed using Stata 12. Results From 691 questionnaires, 540 returned fulfilled (78% response rate). The majority (95%) of respondents considered sex education “important” and thought it should be guaranteed by the school; 48% described information received so far as “sufficient”, 40% as “adequate”. “School” was indicated as the principal source of information (44%), instead of “friends” which resulted in 1998. The respondents were asked to choose from the list the STDs they knew: 96% indicated “AIDS”, 62% “syphilis”, 38% “HBV” and 36% “gonorrhoea”. In comparison to 1998, knowledge of syphilis has decresed (2018:17% vs. 1998:62%) and HBV (2018:38% vs. 1998:58%). Regarding STD, the “mass media” were cited as the principal source of information (56%), followed by “school” (41%) and “General Practitioner” (20%). Conclusions In comparison to 1998 sex education in Italian schools improved, but the knowledge of adolescents regarding the STD worsened. This result can be attributed to the fact that the survey of 1998 was realized during the years when the AIDS awareness was higher. It is necessary to further improve the sex education in Italy in order to prevent STDs. Key messages The “forgotten” sexually transmitted diseases are becoming common again, the adequate sex education in schools is necessary to prevent them. In confrontation to 1998, the sex education in Italian schools improved, but the knowledge of adolescents regarding the STD worsened.


2015 ◽  
Vol 23 (4) ◽  
pp. 628-634 ◽  
Author(s):  
Rafael Alves Guimarães ◽  
Leandro Nascimento da Silva ◽  
Divânia Dias da Silva França ◽  
Nativa Helena Alves Del-Rios ◽  
Megmar Aparecida dos Santos Carneiro ◽  
...  

AbstractObjectives: to investigate the prevalence and risk behaviors by means of reporting of sexually transmitted diseases among crack users.Method: cross-sectional study carried out with 588 crack users in a referral care unit for the treatment of chemical dependency. Data were collected by means of face-to-face interview and analyzed using Stata statistical software, version 8.0.Results: of the total participants, 154 (26.2%; 95% CI: 22.8-29.9) reported antecedents of sexually transmitted diseases. Ages between 25 and 30 years (RP: 2.1; 95% CI: 1.0-4.0) and over 30 years (RP: 3.8; 95% CI: 2.1-6.8), alcohol consumption (RP: 1.9; 95% CI: 1.1-3.3), antecedents of prostitution (RP: 1.9; 95% CI: 1.3-2.9) and sexual intercourse with person living with human immunodeficiency virus/AIDS (RP: 2.7; 95% CI: 1.8-4.2) were independently associated with reporting of sexually transmitted diseases.Conclusion: the results of this study suggest high risk and vulnerability of crack users for sexually transmitted diseases.


Sign in / Sign up

Export Citation Format

Share Document