scholarly journals Giant condyloma acuminate due human papilloma virus type 16 in an infant successfully treated with topical imiquimod therapy

2015 ◽  
Vol 7 (3) ◽  
Author(s):  
Meltem Dinleyici ◽  
Nurhan Saracoglu ◽  
Makbule Eren ◽  
Ömer Kiliç ◽  
Evrim Ciftci ◽  
...  
Keyword(s):  
Personal Hygiene ◽  
Human Papilloma Virus Type ◽  
Hpv 16 ◽  
Women's Shelter ◽  
Giant Condyloma ◽  
Topical Imiquimod ◽  
Condyloma Acuminate ◽  
Malignant Lesions ◽  
Definition Of ◽  
Giant Condyloma Acuminata

Anogenital warts related to human papillomavirus (HPV) have been observed in children. Definition of the transmission mode, therapy, and follow-up for long term potential complications is important. A 27-month old girl was admitted with multiple pedunculated red-purple colored cauliflower-like lesions of 1.5 years duration. Clinical/histopathological and microbiological diagnosis was condyloma acuminate due to HPV type 16. After 12 weeks of imiquimod 5% cream application (pea-sized) overnight three times per week, the perianal warts had completely disappeared. The mode of transmission of HPV 16 in our case was probably horizontal, related to the sharing of common personal hygiene items in the women’s shelter. We report herein the case of an infant living in a women’s shelter with giant condyloma acuminata due to HPV 16, which was successfully treated with topical imiquimod therapy. This patient should be followed up for recurrence and potential malignant lesions related to HPV type 16.

scholarly journals Identification of Two Cross-Neutralizing Linear Epitopes within the L1 Major Capsid Protein of Human Papillomaviruses

2002 ◽  
Vol 76 (13) ◽  
pp. 6480-6486 ◽  
Author(s):  
Alba-Lucia Combita ◽  
Antoine Touzé ◽  
Latifa Bousarghin ◽  
Neil D. Christensen ◽  
Pierre Coursaget
Keyword(s):  
Neutralizing Antibodies ◽  
Polyclonal Antibodies ◽  
Human Papillomaviruses ◽  
Hpv 16 ◽  
Human Papillomavirus Type 16 ◽  
Linear Epitopes ◽  
Cross Neutralization ◽  
Definition Of ◽  
L1 Protein

ABSTRACT The neutralizing activities of polyclonal antibodies and monoclonal antibodies (MAbs) obtained by immunization of mice with L1 virus-like particles (VLPs) were investigated by using pseudovirion infectivity assays for human papillomavirus type 16 (HPV-16), HPV-31, HPV-33, HPV-45, HPV-58, and HPV-59 to obtain a better definition of cross-neutralization between high-risk HPVs. In this study, we confirmed and extended previous studies indicating that most genital HPV genotypes represent separate serotypes, and the results suggest that the classification of serotypes is similar to that of genotypes. In addition, three cross-neutralizing MAbs were identified (HPV-16.J4, HPV-16.I23, and HPV-33.E12). MAb HPV-16.J4 recognized a conserved linear epitope located within the FG loop of the L1 protein, and HPV-16.I23 recognized another located within the DE loop. The results suggested that reactivity of MAb HPV-16.I23 to L1 protein is lost when leucine 152 of the HPV-16 L1 protein is replaced by phenylalanine. This confirmed the existence of linear epitopes within the L1 protein that induce neutralizing antibodies, and this is the first evidence that such linear epitopes induce cross-neutralization. However, the cross-neutralization induced by L1 VLPs represents less than 1% of the neutralizing activity induced by the dominant conformational epitopes, and it is questionable whether this is sufficient to offer cross-protection in vivo.

scholarly journals Successful ablation of giant condyloma acuminata in an adolescent

2021 ◽  
Vol 12 (4) ◽  
pp. 430-432
Author(s):  
Shikhar Ganjoo ◽  
Pratiksha Mishra ◽  
Mohinder Pal Singh Sawhney
Keyword(s):  
General Anesthesia ◽  
Surgical Intervention ◽  
Condyloma Acuminata ◽  
Recurrent Infections ◽  
Single Session ◽  
Giant Condyloma ◽  
Giant Condyloma Acuminata ◽  
Slow Growing ◽  
Early Surgical Intervention

Condyloma acuminata are usually associated with persistent and recurrent infections and early surgical intervention is often required to prevent recurrences. The Buschke–Löwenstein tumor, a locally invasive, slow-growing, cauliflower-like growth, is an example of a giant condyloma acuminatum. Herein, we report a case of sexually-acquired perianal giant condyloma acuminata in a fourteen-year-old male successfully treated by electrofulguration with radiofrequency cautery under general anesthesia in a single session with no evidence of recurrence over a follow-up period of six months.

scholarly journals Löwenstein-buschke: clinicopathologic analysis of 78 cases of large and giant condyloma acuminata of the anus

2020 ◽  
Author(s):  
Orhun Cig Taskin ◽  
Burcin Pehlivanoglu ◽  
Michelle D. Reid ◽  
Theodore Friedman ◽  
Michael Lee ◽  
...  
Keyword(s):  
Condyloma Acuminata ◽  
Giant Condyloma ◽  
Giant Condyloma Acuminata

Invasive squamous cell carcinoma originating from a giant penile condyloma

2016 ◽  
Vol 28 (6) ◽  
pp. 619-622 ◽  
Author(s):  
Emin Sir ◽  
Melike Gungor ◽  
Oktay Ucer ◽  
Tulu Kebat
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Condyloma Acuminata ◽  
Split Thickness Skin Graft ◽  
Histopathological Analysis ◽  
Invasive Squamous Cell Carcinoma ◽  
Giant Condyloma ◽  
First Case ◽  
Giant Condyloma Acuminata

In this case study, we present an unusual case with squamous cell carcinoma originating from a giant condyloma acuminata completely surrounding the penis. A 57-year-old circumcised heterosexual male patient presented with a penile lesion existing for 20 years. Incisional biopsy revealed acanthosis of the squamous epithelium. The patient was operated on under spinal anaesthesia. The lesion was resected circumferentially with macroscopic clearance, resulting in complete degloving of the penile shaft. Neurovascular bundles were preserved. The penile skin was constructed with a split thickness skin graft. Histopathological analysis of the lesion revealed an invasive and well-differentiated squamous cell carcinoma arising on a condyloma, and the surgical margins were free from tumour. The patient was staged as G2 T1 N0 M0 and was followed for one year. He did not have any erectile dysfunction and could engage in intercourse. Pelvic tomographic and physical examination findings did not reveal any episode of recurrence or metastasis. When encountering patients with giant condyloma acuminata, it should not be forgotten that it may be accompanied by squamous cell carcinoma. In addition, tissue excision should be as extensive as possible while keeping in mind the importance of the function. This is the first case of a penile-degloving surgery for giant penile condyloma, supporting conservative and preserving penile surgery for such tumours.

scholarly journals Perianal giant condyloma acuminata [buschke lowenstein tumour] — first case report from the Kashmir valley

2007 ◽  
Vol 69 (5) ◽  
pp. 203-205
Author(s):  
Nisar A. Chowdri ◽  
Mushtaq A. Gagloo ◽  
Fazal Q. Parray ◽  
Zahoor A. Sheikh ◽  
A. Rouf ◽  
...  
Keyword(s):  
Case Report ◽  
Condyloma Acuminata ◽  
Kashmir Valley ◽  
Giant Condyloma ◽  
First Case ◽  
Giant Condyloma Acuminata
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