scholarly journals Osteosarcoma of talus with heterotopic ossifications and lung metastases

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jieun Jeong ◽  
Young Jin Jeong ◽  
Do-Young Kang ◽  
Kook Cho
Keyword(s):  
Male Patient ◽  
Bone Tumor ◽  
Older Patients ◽  
Lung Metastases ◽  
Imaging Modalities ◽  
Long Bones ◽  
Malignant Bone Tumor ◽  
Heterotopic Ossifications ◽  
Disease Patterns

Osteosarcoma is the most common malignant bone tumor and is known to occur mainly in the metaphyses of long bones. However, a few cases of osteosarcoma in talus have been reported in older patients. We experienced an osteosarcoma of an 80-year-old male patient with a talus which is rarely reported and evaluated disease patterns with four different imaging modalities.

scholarly journals Osteoblastoma of the Os Capitatum

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Çağrı Kaptan ◽  
Halil Atmaca
Keyword(s):  
Male Patient ◽  
Bone Tumor ◽  
Case Reports ◽  
Diagnosis And Treatment ◽  
Long Bones ◽  
Benign Bone Tumor ◽  
Hand Bones ◽  
Female Case ◽  
Capitate Bone

An osteoblastoma is a primary benign bone tumor, which is rarely seen in hand bones. Osteoblastoma is generally seen in spine, pelvis, and long bones. However, there are a few case reports of osteoblastoma in wrist and hand bones. To our knowledge, up to now, only one male patient with osteoblastoma in capitate bone was reported. We report the first female case of osteoblastoma of capitate bone and discuss diagnosis and treatment.

Delayed Initiation of Treatment Is Associated With Metastasis of Malignant Bone Tumor

2021 ◽  
Vol 41 (6) ◽  
pp. 2993-2999
Author(s):  
YOSHIHIRO ARAKI ◽  
NORIO YAMAMOTO ◽  
KATSUHIRO HAYASHI ◽  
AKIHIKO TAKEUCHI ◽  
SHINJI MIWA ◽  
...  
Keyword(s):  
Bone Tumor ◽  
Malignant Bone Tumor ◽  
Delayed Initiation

Mechanical Failure of Unsupported Huckstep Intramedullary Nail in Malignant Bone Tumor Reconstruction

2001 ◽  
Vol 393 ◽  
pp. 272-278 ◽  
Author(s):  
Satoshi Abe ◽  
Akio Tateishi ◽  
Toru Tokizaki ◽  
Shinsei Takeyama ◽  
Hirotaka Nakano ◽  
...  
Keyword(s):  
Bone Tumor ◽  
Intramedullary Nail ◽  
Mechanical Failure ◽  
Malignant Bone Tumor

scholarly journals KPNA2 expression is a potential marker for differential diagnosis between osteosarcomas and other malignant bone tumor mimickers

2020 ◽  
Author(s):  
Lucen Jiang ◽  
Jianghuan Liu ◽  
Qingzhu Wei ◽  
Yiyang Wang
Keyword(s):  
Bone Tumor ◽  
Bone Tumors ◽  
Diagnostic Value ◽  
Benign Tumors ◽  
Malignant Bone Tumor ◽  
Malignant Bone Tumors ◽  
Potential Marker ◽  
Tumors Of Bone ◽  
Bone Sarcomas ◽  
Malignant And Benign Tumors

Abstract Background Karyopherin α 2 (KPNA2), a member of the Karyopherin α family, has been observed in several cancers but lack substantial investigation in malignant bone tumors. The purpose of the current study was to evaluate KPNA2 expression level and its utility as a novel diagnostic biomarker in osteosarcomas and their malignant bone tumor mimickers, such as chondrosarcomas and Ewing sarcomas.Method We investigated the expression of KPNA2 protein by immunohistochemistry on paraffin embedded surgical specimens from 217 patients with malignant and benign tumors of bone, including 81 osteosarcomas, 42 chondrosarcomas, 9 Ewing sarcomas, 28 osteoid osteoma, 20 osteochondroma and 37 Chondroblastoma. Immunoreactivity was scored semi quantitatively based on stain extent and intensity.Results Seventy one of 81 (87.7%) osteosarcomas, zero of 42 (0%) chondrosarcomas and one of 9 (11.1%) Ewing sarcomas showed immunoreactivity for KPNA2. Negative KPNA2 expression was observed in all of benign bone tumors. Much more positive expression of KPNA2 was found in osteosarcomas as compared with chondrosarcomas and Ewing sarcomas. The sensitivity and specificity of KPNA2 immuno-expression for osteosarcoma was 87.7% and 100%, respectively. In several subtypes of osteosarcomas, immunohistochemical expression of KNA2 was more frequent in osteoblastic (94.5%), with 39 (70.9%) showing strong-intensity staining. KPNA2 positivity was observed in eleven of 13 (84.6%) chondroblastic, three of 6 (50%) fibroblastic, three of 4 (75%) telangiectatic and two of 3 (66.7%) giant cell-rich osteosarcoma. Stronger-intensity staining was observed in osteoblastic osteosarcoma.Conclusion KPNA2 is most frequently expressed in osteosarcomas, particularly in osteoblastic and chondroblastic tumors, but is rarely positive in chondrosarcomas and Ewing sarcomas. This feature may have diagnostic value since it is very useful for distinguishing between osteosarcomas and other bone sarcomas mimickers. This report supports KPNA2 as a novel marker for the diagnosis of osteosarcoma.

Sensitive Osteosarcoma Diagnosis Through Five-Base Telomerase Product-Triggered CRISPR-Cas12a Enhanced Rolling Circle Amplification

2021 ◽  
Author(s):  
Xing Zhou ◽  
Jun-Liang Zhang ◽  
Meng-Han Chang ◽  
Gentao Fan ◽  
Xiao-Zhou Liu ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Bone Tumor ◽  
Rolling Circle Amplification ◽  
Mesenchymal Cells ◽  
Pivotal Role ◽  
Sensitive Detection ◽  
Malignant Bone Tumor ◽  
Rolling Circle ◽  
Primary Malignant Bone Tumor

Osteosarcoma is the most frequent primary malignant bone tumor composed of mesenchymal cells producing osteoid and immature bone. Sensitive detection of telomerase plays a pivotal role for the early diagnosis...

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