scholarly journals Take a second look: it's Kikuchi’s disease! A case report and review of literature

2018 ◽  
Vol 8 (4) ◽  
Author(s):  
Oana Joean ◽  
Thea Thiele ◽  
Mieke Raap ◽  
Reinhold E. Schmidt ◽  
Matthias Stoll
Keyword(s):  
Differential Diagnosis ◽  
Lymph Node Biopsy ◽  
Review Of Literature ◽  
Common Cause ◽  
Systemic Involvement ◽  
Kikuchi’S Disease ◽  
Node Biopsy ◽  
Necrotizing Lymphadenitis ◽  
Generalized Lymphadenopathy ◽  
Kikuchi's Disease

Generalized lymphadenopathy is a common cause of concern for both patients and clinicians. Possible etiologies include infections, malignancies and autoimmune diseases. Kikuchi Fujimoto disease (KFD) is a hyperergic condition that presents with fever, lymphadenopathy and can include systemic involvement, thus being easily mistaken for the above-mentioned entities. We report the case of a previously healthy 18-year-old male who presented with a selflimiting generalized lymphadenopathy, high fevers, skin vasculitis and polyserositis. The lymph-node biopsy revealed a histiocytotic necrotizing lymphadenitis, suggestive of Kikuchi’s disease. This case emphasizes the importance of KFD in the differential diagnosis of lymphadenopathy, especially in young adults.

scholarly journals Kikuchi-Fujimoto Disease: A Report of 3 Cases

2007 ◽  
Vol 86 (7) ◽  
pp. 412-413 ◽  
Author(s):  
Eimear Phelan ◽  
Emer Lang ◽  
Peter Gormley ◽  
John Lang
Keyword(s):  
Weight Loss ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Accurate Diagnosis ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Kikuchi’S Disease ◽  
Node Biopsy ◽  
Night Sweats ◽  
Necrotizing Lymphadenitis ◽  
Kikuchi's Disease

Cervical lymphadenopathy has many underlying etiologies. One of its rare causes is Kikuchi-Fujimoto disease (Kikuchi's disease, histiocytic necrotizing lymphadenitis). We discovered such a cause in a 37-year-old woman who had presented with malaise, night sweats, and weight loss in addition to cervical lymphadenopathy. We based our diagnosis on excisional lymph node biopsy. We also review 2 other cases of Kikuchi's disease that were diagnosed by others at our institution. Clinically and histologically, Kikuchi's disease is very similar to lymphoma, and distinguishing the two is difficult. However, despite the fact that Kikuchi's disease is benign, an accurate diagnosis is important because misdiagnosis might lead to unnecessary surgery and/or chemotherapy.

scholarly journals Kikuchi's Disease: A Rare Cause of Fever and Lymphadenopathy

2012 ◽  
Vol 5 ◽  
pp. CPath.S8685 ◽  
Author(s):  
A Vivekanandarajah ◽  
B Krishnarasa ◽  
M Hurford ◽  
S Gupta
Keyword(s):  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Imaging Studies ◽  
Benign Condition ◽  
Kikuchi’S Disease ◽  
Node Biopsy ◽  
Cervical Lymph Node Biopsy ◽  
Necrotizing Lymphadenitis ◽  
Work Up ◽  
Kikuchi's Disease

Kikuchi's disease is a benign condition that occurs in women. A young woman presented to the hospital with fevers and cervical lymphadenopathy. Infectious work-up was negative except for streptococcus pharyngitis. Imaging studies revealed the presence of diffuse cervical and axillary lymphadenopathy. The fevers persisted and she underwent excisional cervical lymph node biopsy that revealed histiocytic necrotizing lymphadenitis corresponding to a benign diagnosis of Kikuchi's disease. Three months later, the patient was afebrile and there was complete resolution of the cervical lymphadenopathy.

scholarly journals Kikuchi-Fujimoto disease with multiple extra-nodal features - A clinical mimic

Reumatismo ◽  
2019 ◽  
Vol 71 (2) ◽  
pp. 105-107
Author(s):  
C.A. Mansoor ◽  
Z. Shemin
Keyword(s):  
Lymph Node ◽  
Lupus Erythematosus ◽  
Maculopapular Rash ◽  
Lymph Node Biopsy ◽  
High Grade Fever ◽  
Extranodal Involvement ◽  
Kikuchi’S Disease ◽  
Node Biopsy ◽  
Extranodal Manifestations ◽  
Kikuchi's Disease

Extranodal involvement in Kikuchi’s disease is uncommon. A 31-year-old previously healthy Indian woman was admitted with high grade fever, multiple joint pain and skin rash for 3 weeks. She had negative anti-nuclear antibodies and had features of Kikuchi’s disease on lymph node biopsy. She also had multiple extranodal manifestations including erythematous maculopapular rash, symmetric polyarthritis and hepatosplenomegaly. Kikuchi’s disease with extranodal involvement can clinically mimic diseases like hematological malignancies, connective tissue disorders and certain infections. A lymph node biopsy plays a crucial role in making an accurate diagnosis by excluding other diseases. A discussion on the importance of differentiating Kikuchi’s disease from systemic lupus erythematosus is included.

scholarly journals Kikuchi's Disease: A Case Report

2014 ◽  
Vol 8 (2) ◽  
pp. 96-98
Author(s):  
Md Shafiq-Ur Rahman ◽  
Golam Muktadir ◽  
SK Abdul Momen Ahmed
Keyword(s):  
Early Recognition ◽  
Cervical Lymphadenopathy ◽  
Needle Aspiration ◽  
Lymph Node Biopsy ◽  
Unknown Etiology ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Cervical Lymphadenitis ◽  
Kikuchi’S Disease ◽  
Necrotizing Lymphadenitis ◽  
Kikuchi's Disease

Kikuchi's disease is also known as histiocytic necrotizing lymphadenitis. Kikuchi-Fujimoto disease (KFD) or histiocytic necrotizing lymphadenitis, is a rare benign, self-limiting cervical lymphadenitis of unknown etiology. It predominantly affects young women and can closely mimic infective and immunological disorders. Recognition of this condition is crucial, specially because it can easily be mistaken for tuberculosis, lymphoma, or even adenocarcinoma. We report an 18 years old girl who presented with fever and cervical lymphadenopathy. She had multiple enlarged cervical lymphadenopathy. Examination of other systems was normal. Laboratory investigations were also normal. Fine needle aspiration cytology of the cervical node was not done. The patient took a course of oral antibiotics. Since the patient did not respond, lymph node biopsy was done and the histological features suggested the diagnosis of Kikuchi's disease. The Patient was treated symptomatically and complete remission occurred in few weeks. Although the incidence of Kikuchi-Fujimoto disease is rare, clinicians should be aware of this condition as early recognition of the disease will minimize potentially harmful and unnecessary evaluations and treatments. DOI: http://dx.doi.org/10.3329/fmcj.v8i2.20395 Faridpur Med. Coll. J. 2013;8(2): 96-98

Histiocytic necrotizing lymphadenitis (Kikuchi's disease)

Head & Neck ◽  
1989 ◽  
Vol 11 (4) ◽  
pp. 349-352 ◽  
Author(s):  
Bruce M. Sterman ◽  
Michael S. Benninger ◽  
Isaac Eliachar
Keyword(s):  
Histiocytic Necrotizing Lymphadenitis ◽  
Kikuchi’S Disease ◽  
Necrotizing Lymphadenitis ◽  
Kikuchi's Disease

scholarly journals Kikuchi necrotizing lymphadenopathy: a tip of the iceberg disease?

2021 ◽  
Vol 8 (9) ◽  
pp. 1602
Author(s):  
Sushil Singla ◽  
Mohitesh Kumar ◽  
Vinod Kumar Jat ◽  
Deepika Parwan
Keyword(s):  
Lymph Node ◽  
Laboratory Test ◽  
Young Patient ◽  
Healthy Individual ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Benign Condition ◽  
Node Biopsy ◽  
Necrotizing Lymphadenitis

Kikuchi-Fujimoto disease (KFD) is a rare benign condition also called histiocytic necrotizing lymphadenitis, which typically presented as fever with cervical lymphadenopathy in previously healthy individual. We presented a case of 11 year old boy with fever and cervical lymphadenopathy since 2 months. Lymph node biopsy was performed which suggested of KFD and was treated symptomatically. KFD incidence is rare but clinicians should be alert if young patient comes with fever and cervical lymphadenopathy to lower the chance of unwanted laboratory test and harmful treatment. 

GENERALIZED LYMPHADENOPATHY AND HEPATOSPLENOMEGALY INDUCED BY DIPHENYLHYDANTOIN

PEDIATRICS ◽  
1961 ◽  
Vol 28 (6) ◽  
pp. 943-945
Author(s):  
Mehdi Bajoghli
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Drug Therapy ◽  
Biopsy Specimen ◽  
Lymphoid Hyperplasia ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Generalized Lymphadenopathy

A 6-year-old child developed generalized lymphadenopathy and hepatosplenomegaly 2 weeks after diphenylhydantoin therapy was begun. The patient recovered 4 weeks after discontinuance of the drug therapy. There was eosinophilia in blood and in bone marrow, and a lymph node biopsy specimen showed reticulum and lymphoid hyperplasia.

Results of initial lymph node biopsy in homosexual men with generalized lymphadenopathy.

1986 ◽  
Vol 4 (2) ◽  
pp. 165-169 ◽  
Author(s):  
A M Levine ◽  
P R Meyer ◽  
P S Gill ◽  
R L Burkes ◽  
M Krailo ◽  
...  
Keyword(s):  
Lymph Node ◽  
Laboratory Data ◽  
Clinical Parameter ◽  
Lymph Node Biopsy ◽  
Homosexual Men ◽  
Laboratory Findings ◽  
Node Biopsy ◽  
Significant Difference ◽  
Generalized Lymphadenopathy ◽  
Persistent Generalized Lymphadenopathy

Persistent, generalized lymphadenopathy (PGL) is considered part of the acquired immunodeficiency syndrome (AIDS)-related complex. The clinical course is usually benign, although some patients may evolve to AIDS. Characteristic features on lymph node biopsy have been described. Recently, large series of PGL have been reported in which many study patients have not undergone initial diagnostic biopsy. The value of such biopsy has been questioned. We report the clinical, pathologic, and laboratory findings in six homosexual men initially considered as potential candidates for study of the natural history of PGL. They were excluded by initial lymph node biopsy, which revealed small-cleaved lymphoma in two, focal Kaposi's sarcoma in two, disseminated mycobacterium tuberculosis in one, and histoplasma encapsulatum in one. The clinical and laboratory data from these six patients were compared with those from 34 patients with biopsy-proven PGL; no statistically significant difference in any prebiopsy clinical parameter was found. We conclude that initial lymph node biopsy may reveal changes other than reactive hyperplasia in homosexual men with generalized lymphadenopathy.

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