scholarly journals O blood group as a risk factor for Helicobacter pylori IgG seropositivity among pregnant Sudanese women

2017 ◽  
Vol 7 (3) ◽  
Author(s):  
Gasim I. Gasim ◽  
Abdelmageed Elmugabil ◽  
Hamdan Z. Hamdan ◽  
Duria A. Rayis ◽  
Ishag Adam
Keyword(s):  
Helicobacter Pylori ◽  
Blood Group ◽  
Binary Logistic Regression ◽  
Maternity Hospital ◽  
Igg Antibody ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Significant Difference ◽  
Group A ◽  
H Pylori

The objective was to investigate the prevalence and the association between blood groups and <em>Helicobacter pylori</em> IgG seropositivity among pregnant Sudanese women. A cross-sectional survey was carried- out at Saad Abul Ela Maternity Hospital, Khartoum, Sudan during the period of July 2014 through December 2015. Questionnaires covering socio-demographic and obstetrics information were administered. Specific <em>H. pylori</em> IgG antibody was analysed using ELISA. One hundred eighty six pregnant women were enrolled. The mean (SD) of the age, parity was 28.3 (2.6) years and 2.6 (3.5), respectively. Of the 186 women, 42 (22.6%), 24 (12.9%), 11(5.9%) and 109 (58.6%) had blood group A, B, AB and O, respectively. <em>H. pylori</em> IgG seropositivity rate was 132/186 (71.0%). There was no significant difference in age and parity between women with <em>H. pylori</em> IgG seropositive and seronegative. Compared with the women with <em>H. pylori</em> IgG seronegative, significantly higher numbers of women with <em>H. pylori</em> IgG seropositive had O blood group, [84/132(63.6) <em>versus</em> 25/54(46.3), P&lt;0.001]. In binary logistic regression, women with O blood group (OR= 2.084, 95% CI=1.060 -4.097, P=0.033) were at a higher <em>H. pylori</em> IgG seropositivity. The current study showed that women with blood group O were at higher risk for <em>H. pylori</em> IgG seropositivity.

scholarly journals Helicobacter pylori infection according to ABO blood group among blood donors in Kosovo

2011 ◽  
Vol 1 (2) ◽  
pp. 83-89 ◽  
Author(s):  
Bukurije Zhubi ◽  
Zana Baruti-Gafurri ◽  
Ymer Mekaj ◽  
Mimoza Zhubi ◽  
Idriz Merovci ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Blood Group ◽  
Blood Donors ◽  
Mean Value ◽  
Blood Groups ◽  
Helicobacter Pylori Infection ◽  
Igg Antibody ◽  
Significant Difference ◽  
Rhesus Blood Group ◽  
H Pylori

Introduction: Numerous studies have reported a high prevalence of Helicobacter pylori infection among healthy and non-healthy persons in different places. The Aim of the study is to investigate the seroprevalence of H. pylori infection among Kosovo’s Blood donor associated with ABO/Rhesus blood group.Methods: 671 blood donors are tested for H. pylori antibodies and results are classifi ed by way of donation, age, gender, blood groups and education level. Serum antibodies are analyzed by Enzyme Linked Fluorescent Assay test for H. pylori IgG with Biomerieux HPY-VIDAS.Results: The frequency of IgG antibody for H. pylori among healthy blood donors is 56.9%, there is not found any difference between voluntary and non-voluntary blood donors (57.4% respectively 56.3%)(OR=1.05; 95% CI 0.76 to 1.43; p=0.8). H pylori IgG antibodies positive are detected in 57.0 % ( 126 of 221) of women, compared with 56.9 % ( 256 of 450) of men(OR=0.99; 95% CI 0.72 to 1.38; p=0.96). Serpositive donors are older than seronegative ones (31.9 years, respectively 29.5 years, p=0.02). Mean value of IgG antibody of H. pylori is 3.61 with no significant difference between males and females (3.72 respectively 3.44; p=0.2). The seroprevalence of H. pylori infection is similar among blood groups: O (57.4%), A (56.2%), B (59.6%), AB (51.4%), RhD positive (56.7%) and RhD negative (58.3%).Conclusions: The seropositivity of H. pylori is moderately higher in the non voluntary and familiar blood donors among the total Kosovo blood donors. There is not found a significant relationship between infection with H. pylori and ABO/Rhesus blood group among blood donors.

scholarly journals Seroprevalence of Helicobacter pylori in patients with colon adenomas in a brazilian university hospital

2009 ◽  
Vol 46 (2) ◽  
pp. 97-101 ◽  
Author(s):  
Abadia Gilda Buso ◽  
Haroldo Luis Oliva Gomes Rocha ◽  
Débora Miranda Diogo ◽  
Priscila Miranda Diogo ◽  
Augusto Diogo-Filho
Keyword(s):  
Helicobacter Pylori ◽  
Solid Phase ◽  
Positive Association ◽  
University Hospital ◽  
Igg Antibody ◽  
Chi Square ◽  
Colon Adenomas ◽  
Colonic Adenomas ◽  
Significant Difference ◽  
H Pylori

CONTEXT: The association between Helicobacter pylori infection and colon neoplasia has been the subject of recent investigations which have produced controversial results. OBJECTIVE: To evaluate the prevalence of H. pylori infection in patients with colonic adenomas and also in patients whose colonoscopy exams were normal. METHODS: After colonoscopy, the individuals were distributed into two groups: patients with colon adenomas (cases) and patients whose colons were normal (controls). The groups were similar regarding age and gender. The individuals of both groups were subjected to a dosage of IgG antibody against H. pylori. The dosage was applied according to the solid phase, chemiluminescent immunometric assay. The chi-square test was used to analyze the data. RESULTS: There were 30 men and 64 women in each group (94 cases and 94 controls). The mean age of the cases was 59.79 ± 12.25 years and that of the controls was 58.98 ± 11.55 years. The H. pylori serology was positive for 66 (70.21%) of the cases and for 51 (54.25%) of the controls. There was a significant difference (P = 0.024). The odds ratio was 1.98 (CI 95%, 0.82-3.15). The prevalence of H. pylori in cases and controls according to gender, histological type and location of the colon lesions showed a significant difference only among women (P = 0.03), among patients with tubular adenomas (P = 0.03), and in those with distal adenomas (P = 0.038). CONCLUSION: There is a positive association between H. pylori infection and colonic adenomas. This association is more evident in women, especially for tubular adenomas and distal colonic location.

scholarly journals Correlates of infection with Helicobacter pylori positive and negative cytotoxin-associated gene A phenotypes among Arab and Jewish residents of Jerusalem

2019 ◽  
Vol 147 ◽  
Author(s):  
K. Muhsen ◽  
R. Sinnereich ◽  
G. Beer-Davidson ◽  
H. Nassar ◽  
W. Abu Ahmed ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Former Soviet Union ◽  
Enzyme Linked Immunosorbent Assay ◽  
Igg Antibodies ◽  
Multinomial Regression ◽  
Igg Antibody ◽  
Sibship Size ◽  
Cross Sectional ◽  
Cytotoxin Associated Gene A ◽  
H Pylori

Abstract We examined the prevalence and correlates of Helicobacter pylori (H. pylori) infection according to cytotoxin-associated gene A (CagA) phenotype, a main virulence antigen, among the ethnically diverse population groups of Jerusalem. A cross-sectional study was undertaken in Arab (N = 959) and Jewish (N = 692) adults, randomly selected from Israel's national population registry in age-sex and population strata. Sera were tested for H. pylori immunoglobulin G (IgG) antibodies. Positive samples were tested for virulence IgG antibodies to recombinant CagA protein, by enzyme-linked immunosorbent assay. Multinomial regression models were fitted to examine associations of sociodemographic factors with H. pylori phenotypes. H. pylori IgG antibody sero-prevalence was 83.3% (95% confidence interval (CI) 80.0%–85.5%) and 61.4% (95% CI 57.7%–65.0%) among Arabs and Jews, respectively. Among H. pylori positives, the respective CagA IgG antibody sero-positivity was 42.3% (95% CI 38.9%–45.8%) and 32.5% (95% CI 28.2%–37.1%). Among Jews, being born in the Former Soviet Union, the Middle East and North Africa, vs. Israel and the Americas, was positively associated with CagA sero-positivity. In both populations, sibship size was positively associated with both CagA positive and negative phenotypes; and education was inversely associated. In conclusion, CagA positive and negative infection had similar correlates, suggesting shared sources of these two H. pylori phenotypes.

scholarly journals Association of Pre-hypertension with blood groups in young population.

2019 ◽  
Vol 26 (11) ◽  
pp. 1820-1824
Author(s):  
Benash Altaf ◽  
Shireen Jawed ◽  
Fakiha Behram ◽  
Zeeshan Ali Khan ◽  
Shakeela Naz
Keyword(s):  
Blood Group ◽  
Demographic Data ◽  
Cross Sectional Study ◽  
Blood Groups ◽  
P Value ◽  
Continuous Variables ◽  
Cross Sectional ◽  
Blood Group A ◽  
Significant Difference ◽  
Group A

Objectives: Pakistan has highest mortality rate due to hypertension and its complications. Hypertension is a squealed of Pre- hypertension which is believed to start at adolescent and continue to adulthood. Association of blood group with hypertension is evident but still hypothesized. This study aims to find the frequency of prehypertension and its association with blood group. Study Design: Cross sectional study. Setting:  Aziz Fatimah Medical and Dental College, Faisalabad. Period: 15 March’18 to 15 Sep’18. Material and Methods:  It was comprised of in comprised of 100 MBBS students. Demographic data including age, weight, height, waist and hip circumference, and BMI was determined. Blood group was determined with help of conventional slide method. Blood pressure was measured by auscultatory method. Data was analyzed by using SPSS 21. Continuous variables are given in mean and standard deviation. Categorical data was given in frequency and percentages. P value≤ 0.05 is taken as significant. Results: Out of 100 participants most common blood group was group ‘O’ (43%) followed by B (35 %) and AB (13%) and A (9%).36% of total population was pre-hypertensive and 64% were normotensive. Prehypertension is most commonly found in blood group ‘A’ (77%) followed by blood group ‘O’ (46.5%). Significant difference was found in means of SBP (p value= 0.001*) and DBP (p value= 0.000*) among the various blood groups. Conclusion: Most common blood group in studied population was ‘O’ although hypertension was most commonly observed in blood group A followed by ‘O’.

scholarly journals Relationship of Blood Group Determinants on Helicobacter pylori Lipopolysaccharide with Host Lewis Phenotype and Inflammatory Response

2000 ◽  
Vol 68 (2) ◽  
pp. 937-941 ◽  
Author(s):  
Michael A. Heneghan ◽  
Ciaran F. McCarthy ◽  
Anthony P. Moran
Keyword(s):  
Helicobacter Pylori ◽  
Inflammatory Response ◽  
Blood Group ◽  
Chronic Gastritis ◽  
Bacterial Colonization ◽  
Neutrophil Infiltration ◽  
Blood Group Antigens ◽  
Significant Difference ◽  
H Pylori ◽  
Relationship Of

ABSTRACT As Lewis a (Lea) and Lewis b (Leb) blood group antigens are isoforms of Lewis x (Lex) and Lewis y (Ley) and are expressed in the gastric mucosa, we evaluated whether the patterns of expression of Lex and Ley on Helicobacter pylorilipopolysaccharides reflected those of host expression of Lea and Leb. When 79 patients (secretors and nonsecretors) were examined for concordance between bacterial and host Le expression, no association was found (χ2 = 5.734, 3 df, P = 0.125), nor was there a significant difference between the amount of Lex or Ley expressed on isolates from ulcer and chronic gastritis patients (P > 0.05). Also, the effect of host and bacterial expression of Le antigens on bacterial colonization and the observed inflammatory response was assessed. In ulcer patients, Lex expression was significantly related to neutrophil infiltration (r s = 0.481,P = 0.024), whereas in chronic gastritis patients significant relationships were found between Lexexpression and H. pylori colonization density (r s = 0.296, P = 0.03), neutrophil infiltrate (r s = 0.409,P = 0.001), and lymphocyte infiltrate (r s = 0.389, P = 0.002). Furthermore, bacterial Ley expression was related to neutrophil (r s = 0.271, P= 0.033) and lymphocyte (r s = 0.277,P = 0.029) infiltrates. Thus, although no evidence of concordance was found between bacterial and host expression of Le determinants, these antigens may be crucial for bacterial colonization, and the ensuing inflammatory response appears, at least in part, to be influenced by Le antigens.

scholarly journals The Relationship Between Duration of Hemodialysis, Helicobacter pylori and CagA Seropositivity in Patients with Chronic Kidney Disease

2020 ◽  
Vol 25 (3) ◽  
pp. 383-390
Author(s):  
Oğuzhan Özcan ◽  
Hüseyin Erdal ◽  
Burçin Özer ◽  
Filiz Kaçmaz ◽  
Faruk Turgut
Keyword(s):  
Helicobacter Pylori ◽  
Short Term ◽  
Igg Antibody ◽  
Dialysis Treatment ◽  
Reactive Protein ◽  
Significant Difference ◽  
Automated Hematology Analyzer ◽  
H Pylori ◽  
The Relationship

Introduction: The aim of this study was to investigate the relationship between Helicobacter pylori occurrence and, Cytotoxinassociated gene A (CagA) seropositivity with hemodialysis (HD) duration, Serum C-reactive protein (CRP) and hemogram parameters in hemodialysis patients. Materials and Methods: This study included 165 prevalent HD patients. Blood samples were collected before dialysis treatment of the patients. The samples were then centrifuged at 1500 x g for 10 min. immediately after collection. The presence of serum IgG antibody for H. pylori was determined using commercial ELISA kits. Serum anti-CagA IgG antibody of H. pylori positive patients was determined by ELISA method using commercial ELISA kits. CRP levels were measured by nephelometric method, and hemogram parameters were analyzed using fully automated hematology analyzer. Results: We found that the CRP levels of the patients having H. pylori were significantly high. However, there was no significant difference between CRP levels of long-term hemodialysis (LTHD) and short -term hemodialysis (STHD) patients. The possibility of being seropositive of CagA for STHD patients having H. pylori was found to be 2.3 times higher than that of LTHD patients. In addition to that, the periodicity of gastrointestinal (GI) bleeding was significantly high in STHD patients. Conclusion: In conclusion, we found no relationship between dialysis duration and H. pylori prevalence. However, we observed significantly higher odds ratio for CagA seropositivity in patients receiving STHD. These findings suggest that longer dialysis treatment can cause improving effects on H. pylori virulence. Further studies are needed to verify these findings.

scholarly journals Helicobacter Pylori Infection in Iran: Demographic, Endoscopic and Pathological Factors

2021 ◽  
Author(s):  
Seyedeh Amineh Hojati ◽  
Sara Kokabpeyk ◽  
Salma Yaghoubi ◽  
Farahnaz Joukar ◽  
Mehrnaz Asgharnezhad ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Tap Water ◽  
Helicobacter Pylori Infection ◽  
Common Symptom ◽  
Significant Relation ◽  
Cross Sectional ◽  
Significant Difference ◽  
Pathologic Findings ◽  
H Pylori

Abstract Background: Helicobacter pylori infection is the most important risk factor for Gastritis and Peptic Ulcer. But other factors except H. pylori play roles in its pathogenesis. In current study we compare the clinical manifestation and endoscopic and histopathology findings in patients with and without H. pylori infection.Methods: In this cross-sectional study, 233 of patients with dyspepsia who referred for endoscopy were studied about presence of H. pylori infection. During endoscopy 5 biopsies were taken from each individual. The criteria for presence of H. pylori infection was the presence and recognition of bacteria in pathologic specimen which was done for all patient. These two groups of patient were compared with their demographic, background, endoscopic and pathologic findings. Results: From 233 cases, 154 (66.1%) cases were non-smoker, 201 (86.3%) cases were not alcohol user, 153 (65.7%) cases used tap water and the most common symptom was reported in 157 individual (67.4%) was epigastria pain. There was a significant relation between the number of family member, marital status and presence of H. pylori infection. Also there is a significant relation between endoscopic findings and pathologic findings in patients with H. pylori.Conclusions: the results of current studt demonstrated that H. pylori infection was not associated with sex, alcohol and NSAID drugs. According to the role of H. pylori in pathophysiology of peptic ulcer was clarified, also in this study there were a significant difference in endoscopic and pathological findings H. pylori.

scholarly journals Comparison of Clarithromycin-based Triple Therapy and Furazolidone-based Quadruple Therapy in Eradicating Helicobacter pylori Infection

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Alireza Bakhshipour ◽  
Narges Mohsenpour Mohammadi ◽  
Seyed Mahdi Hashemi ◽  
Mohammad Kazem Momeni
Keyword(s):  
Helicobacter Pylori ◽  
Cross Sectional Study ◽  
Helicobacter Pylori Infection ◽  
Cross Sectional ◽  
Female Ratio ◽  
First Choice ◽  
Group A ◽  
H Pylori ◽  
Triple Regimen ◽  
Group B

Background: Helicobacter pylori infection is the most common infection of human. This organism is responsible for the majority of peptic ulcer diseases, MALToma and gastric cancer, worldwide. Several regimen therapies against H. pylori had developed and are prescribed empirically, but therapies have rarely been optimized. Objectives: In this study, we compared two regimens that are widely used in Iran, triple regimen (clarithromycin, amoxicillin, and omeprazole) and furazolidone-based quadruple regimen (furazolidone, amoxicillin, bismuth, and omeprazole) in some dyspeptic patients. Methods: In this cross-sectional study, 373 consecutive dyspeptic patients that H. pylori infection was established, randomized into one of the following groups; 188 in group A (treated with clarithromycin 500 mg, amoxicillin 1,000 mg, and omeprazole 20 mg twice daily for 10 days) and 185 in group B (furazolidone 200 mg, amoxicillin 1000 mg, bismuth subcitrate 240 mg and omeprazole 20 mg twice daily for 14 days). One month after discontinuation of the treatment, H. pylori eradication was evaluated with UBT. Results: Mean age of the patients was 35.9 ± 12.3 years, and the male to female ratio was 1: 1.6. In the per-protocol analysis, the eradication rate of H. pylori was 63.7% in comparison to 93% in group A and B, respectively (P < 0.004). Conclusions: Our study showed furazolidone-based quadruple regimen is superior to the standard triple regimen; thus, it is recommended as the first choice.

scholarly journals Correlation between virulence markers of Helicobacter pylori in the oral cavity and gastric biopsies

2017 ◽  
Vol 54 (3) ◽  
pp. 217-221 ◽  
Author(s):  
Myriam Lucrecia MEDINA ◽  
Marcelo Gabriel MEDINA ◽  
Luis Antonio MERINO
Keyword(s):  
Helicobacter Pylori ◽  
Oral Cavity ◽  
Virulence Genes ◽  
Gastric Biopsy ◽  
Oral Diseases ◽  
Cross Sectional ◽  
Virulence Markers ◽  
Significant Difference ◽  
Gastric Biopsies ◽  
H Pylori

ABSTRACT BACKGROUND: The clinical outcome of Helicobacter pylori infection has been associated with virulence factors. The presence of these factors is useful as molecular markers in the identification of the high risk for developing severe gastric pathologies. OBJECTIVE: To correlate the presence of virulence markers cagA and bab2A of H. pylori in oral and gastric biopsy samples. METHODS: An observational, prospective, descriptive, and cross-sectional study was carried out between September 2011 and September 2012. Patients suffering dyspepsia with indication for upper gastrointestinal video endoscopy who attended the Gastroenterology Service of the Hospital Dr. Julio C. Perrando were included. Epidemiological investigation was completed. To detect the bacteria and their virulence genes, samples of saliva, dental plaque and gastric biopsy were taken and processed by PCR. RESULTS: Sixty-one patients were selected for this study (30 women and 31 men). H. pylori was detected in 31 gastric biopsies and 31 oral samples. Significant difference between oral and gastric samples was found in cagA genotype. Agreement between oral and gastric genotypes was found in 38.7% of samples from the same patient. CONCLUSION: This study is the first in provide information about the genotypes of the Argentinean Northeast H. pylori strains. Despite the high prevalence of H. pylori infection, the most of patients had less virulent genotypes in oral cavity and gastric tissue. The cagA / babA2 combination was not frequent in the samples studied. There was not a statistical correlation between the virulence genes and gastroduodenal or oral diseases. Although in some patients the same genotype was found both in oral and gastric samples, it cannot be ensure that they corresponding to the same strain because a DNA sequencing was not performed.

scholarly journals Helicobacter pylori-Specific Immune Responses of Children: Implications for Future Vaccination Strategy

2002 ◽  
Vol 9 (5) ◽  
pp. 1126-1128 ◽  
Author(s):  
Günter Bode ◽  
Isolde Piechotowski ◽  
Dietrich Rothenbacher ◽  
Hermann Brenner
Keyword(s):  
Helicobacter Pylori ◽  
Confidence Interval ◽  
Immune Responses ◽  
Western Blot ◽  
Vaccination Strategy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Igg Antibody ◽  
Significant Difference ◽  
Specific Igg ◽  
H Pylori

ABSTRACT We analyzed the specific anti-Helicobacter pylori immunoglobulin G (IgG) antibody profile for a sample of 824 asymptomatic schoolchildren in southern Germany (mean age, 10.7 ± 0.65 years) with an H. pylori-specific IgG enzyme-linked immunosorbent assay and Western blot analysis. The prevalence of infection was 19.8% (95% confidence interval, 17.1 to 22.7%). The immunoresponses were characterized predominantly by antibodies against low-molecular-mass antigens of 14 and 29 kDa, with a significant difference between children of German and Turkish nationalities (P = 0.0012 and P < 0.0001, respectively).

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