scholarly journals Colonisation of basal cell carcinoma and actinic keratosis by malignant melanoma in situ in a patient with xeroderma pigmentosum variant

2012 ◽  
Vol 2 (2) ◽  
pp. 47 ◽  
Author(s):  
Louise J. Smith ◽  
Ehab A. Husain
Keyword(s):  
Malignant Melanoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Actinic Keratosis ◽  
Xeroderma Pigmentosum ◽  
Clinical Impression ◽  
Anatomical Site ◽  
History Of

Although malignant melanoma (MM) and both basal cell carcinoma (BCC) and actinic keratosis (AK) are sun-induced lesions, the coexistence of these entities at the same anatomical site (collision tumour) is exceedingly rare. We report the case of a 54-year-old woman with a known history of xeroderma pigmentosum variant (XPV) who presented with 2 separate skin lesions over the middle and upper right forearm, respectively. The clinical impression was that of BCCs or squamous cell lesions. On histological examination, both specimens showed features of melanoma <em>in situ </em>(MIS). In the first lesion, MIS merged with and colonised a superficial and focally invasive BCC. In the second lesion, MIS merged with an AK. No separate invasive nests of malignant melanoma were seen in either specimen. The atypical melanocytes were highlighted by Melan-A and HMB-45 immunostaining, whereas the epithelial cells in both the BCC and AK stained with the pancytokeratin MNF-116. The patient had a previous history of multiple MMs and non-melanomatous skin cancers and finally developed widespread metastatic malignant melanoma, which proved fatal. The rare and interesting phenomenon of collision tumours may pose diagnostic difficulties. To our knowledge, this is the first reported simultaneous presentation of cytologically malignant collision tumours in a patient with XPV.

Collision tumor comprising malignant melanoma and basal cell carcinoma in a patient with xeroderma pigmentosum

Skin Cancer ◽  
2021 ◽  
Vol 36 (1) ◽  
pp. 16-20
Author(s):  
Hiroko SAWADA ◽  
Akifumi OHSITA ◽  
Satoshi KOMORI ◽  
Jun ASAI ◽  
Norito KATOH
Keyword(s):  
Malignant Melanoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Xeroderma Pigmentosum ◽  
Collision Tumor

scholarly journals What should a cosmetologist know about dermatological lesions on the face?

2018 ◽  
Vol 12 (3) ◽  
pp. 47-52
Author(s):  
Klaudia Rubas ◽  
Joanna Maj
Keyword(s):  
Squamous Cell Carcinoma ◽  
Malignant Melanoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Actinic Keratosis ◽  
Skin Lesions ◽  
The Face ◽  
Seborrheic Keratoses

In everyday practice, cosmetologists often observe abnormalities on the facial skin of his or her clients. Facial lesions have a diverse clinical picture, although most are benign. However, some lesions may be malignant and demand fast diagnosis and treatment. Among benign lesions are xanthomas, epidermal cysts, milia and seborrheic keratoses. Xanthomas are usually localized on the eyelids and often coexist with dyslipidemia. They appear clinically as yellowish papules that vary in size. Epidermal cysts are the most common type of skin cyst. They typically occur on the head and neck, and usually affect young adults in their 20s. Milia are common skin lesions that are typically numerous in presence and appear as small-sized sebaceous papules. Seborrheic keratoses are another important type of lesion that are localized on the face and may be disturbing for clients. These are benign tumors that usually appear in individuals over 50 years of age and have an incidence that rises with age. Typically, they are brown in color but they can also be other colors including black, yellow, grey or bluish. Other skin changes include basal cell carcinoma, actinic keratosis, squamous cell carcinoma and lentiginous malignant melanoma. Basal cell carcinoma is a slow-growing, locally malignant epithelial cancer of the skin. This cancer presents mainly in areas exposed to ultraviolet (UV) radiation. Actinic keratosis is a pre-cancerous lesion that is associated with UV radiation. It predisposes to squamous cell carcinoma and other skin cancers rarely. In contrast to basal cell carcinoma, squamous cell carcinoma may cause metastases with high mortality. Melanoma on the head and face usually takes the form of a lentiginous malignant melanoma. This manifests clinically as a brown spot that slowly grows centrifugally. Melanomas vary in size and color. Dermoscopy is an important tool that may help during diagnosis of facial lesions. Given the severe consequences of some skin lesions, it is very important for cosmetologists to have knowledge of the conditions described above. This is because he or she is often the first person who can persuade the client to undergo further diagnosis.

scholarly journals Basal cell carcinoma: an updated epidemiological and therapeutically profile of an urban population

2006 ◽  
Vol 21 (2) ◽  
pp. 66-73 ◽  
Author(s):  
Roberta Lopes Bariani ◽  
Fábio Xerfan Nahas ◽  
Marcus Vinícius Jardini Barbosa ◽  
Andréia Bufoni Farah ◽  
Lydia Masako Ferreira
Keyword(s):  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Actinic Keratosis ◽  
Cell Cancer ◽  
Fatal Outcome ◽  
Previous History ◽  
Basal Cell Cancer ◽  
History Of

PURPOSE: To describe the epidemiological profile of basal cell carcinoma patients at a private hospital in São Paulo and to evaluate the treatment adopted. METHODS: A prospective study of 202 patients, on which 253 lesions were diagnosed for histopathological exam as basal cell carcinoma within the period of January 2001 to September 2003, in the Plastic Surgery Residency Program at the Hospital Jaraguá. The susceptibility factor of the host, the environment variables, the characteristics of the lesions and the efficacy of the treatment were examined. The data were statistically evaluated. RESULTS: The incidence of basal cell carcinoma was 126 cases per 100,000 patients in a period of 32 months (36 cases per 100,000 patients/year). The patients were evenly distributed in terms of sex: 48% male and 52% female. The greater incidence was in patients between the ages of 60 and 80 years and the average was 64 years. The survey revealed susceptibility factors such as white race and phototypes I and II in 95.5% of the patients. Exposition to ultraviolet radiation was reported by 77% of the patients and the most frequent location of tumors was on the face (71.2% of the cases). Actinic keratosis and a history of skin cancer were reported in 43.6% and in 25% of the cases, respectively. The adopted treatment was surgery in 99.4% of the cases and only one patient was treated with radiotherapy. Twenty lesions (8%) had incomplete excision.The recurrence rate was 2% (5 cases). There were no cases with metastasis or fatal outcome. CONCLUSIONS: The factors related to the development of basal cell cancer which were significantly present in the population surveyed were: older age, white individuals, phototypes I and II, presence of actinic keratosis, previous history of non-melanoma skin cancer and exposure to ultra-violet rays both in recreational and in occupational form.The surgical treatment employed was effective with a rate of incomplete excision and recurrence similar to those found in the literature.

scholarly journals Collision Cutaneous Neoplasms Consisting of Melanoma and Basal Cell Carcinoma

2021 ◽  
pp. 2021037
Author(s):  
Maryam Aghighi ◽  
David Chercover ◽  
Maral Rahvar
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Clinical Impression ◽  
Anatomical Location ◽  
Melanoma In Situ ◽  
Collision Tumors ◽  
Lateral Canthus ◽  
Lentigo Maligna Melanoma

Collision tumors are defined as two histologically different tumor types that arise at the same anatomical location. According to the literature review performed, there are reports of 27 cases of collision tumors involving lentigo maligna melanoma (LMM) in-situ and basal cell carcinoma (BCC). In the absence of melanocytic extension beyond the lamina propria of the BCC compartment, mixed tumors are considered as melanoma in-situ colonizing the BCC, rather than invasive melanomas. We report an uncommon case of collision of BCC with LMM, two primary skin tumors that are seen in patients with significant sunlight exposure. In our case, the patient is a 91-year-old male presented with a translucent plaque with areas of brown pigmentation on his left lateral canthus. He had a history of multiple BCCs, squamous cell carcinomas and an invasive melanoma of right cheek. Given the clinical impression of BCC, the lesion was curetted. Histological examination demonstrated melanoma in-situ heavily infiltrating the dermal nodules of BCC. Deposits of melanin pigment were scattered throughout the tumor. The BCC contained about 50% atypical melanocytes. Further immunohistochemical evaluation with melanocytic and epithelial markers (melanin A, SOX-10, pan-cytokeratin and p63) confirmed the diagnosis. An unequivocal independent invasive melanoma component was not identified in this material. The collision of BCC and LMM is very rare.  However, given the sun-damaged changes promote both tumors, their development at the same site, although unexpected, can be explained. Since the prognosis of the two entities is independent, wider excision to exclude invasive malignant melanoma is indicated.

Basal Cell Carcinoma of Prostate With MSMB–NCOA4 Fusion and a Probable Basal Cell Carcinoma In Situ: Case Report

2021 ◽  
pp. 106689692110173
Author(s):  
Vilde Pedersen ◽  
Katrine S. Petersen ◽  
Klaus Brasso ◽  
Olga Østrup ◽  
Anand C. Loya
Keyword(s):  
Prostate Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Carcinoma In Situ ◽  
Pathological Examination ◽  
Molecular Characteristics ◽  
Histological Lesion ◽  
Basal Cell Carcinomas

Basal cell carcinomas of prostate (BCCP) are very rare. Most arise in the transition zone and thus are associated with lower urinary tract symptoms and rarely associated with elevated prostate-specific antigen (PSA). These features make diagnosis/early diagnosis difficult because of the routine protocols followed. Basal cell carcinomas have distinctive histopathological, immunohistochemical, and to some extent also different molecular characteristics. Basal cell carcinoma in situ (BCCIS) is a nonexistent histological lesion as per the current literature, but here is an attempt to describe it through this case. A 74-year-old man presented with hematuria and previous diagnosis of prostatic hyperplasia. Based on this history, he underwent a prostatectomy ad modum Freyer. Pathological examination surprisingly revealed a diffusely infiltrative tumor with nonacinar adenocarcinoma morphology and many glandular structures probably representing BCCIS. Tumor was diagnosed as BCCP. Patient presented with metastasis to the abdominal wall 8 months postprostatectomy. BCCP is an aggressive type of prostate cancer, which might be challenging to diagnose based on routine protocols. This results in delayed diagnosis and treatment and thus poor prognosis. Furthermore, patients with this subtype of prostate cancer need appropriately designed, and maybe a totally different follow-up regimen as PSA is of no use for BCCP patients. Finally, diagnosis of BCCIS, if agreed upon its existence needs to be studied in larger cohorts as a precursor lesion.

scholarly journals Basal cell carcinoma mistaken for actinic keratosis

2006 ◽  
Vol 89 (3) ◽  
pp. 171-175 ◽  
Author(s):  
Robert J Jacobs ◽  
Geraint Phillips
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Actinic Keratosis
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