scholarly journals Relations between cognitive status and medication adherence in patients treated for memory disorders

2012 ◽  
Vol 3 (1) ◽  
pp. 2 ◽  
Author(s):  
Raymond L. Ownby ◽  
Christopher Hertzog ◽  
Sara J. Czaja

Medication adherence has been increasingly recognized as an important factor in elderly persons’ health. Various studies have shown that medication non-adherence is associated with poor health status in this population. As part of a study of the effects of two interventions to promote medication adherence in patients treated for memory problems, information on medication adherence and cognitive status was collected at 3-month intervals. Twenty-seven participants (16 men, 11 women, age 71-92 years) were assigned to control or treatment conditions and adherence was evaluated with an electronic monitoring device. Cognitive status was evaluated at 3- month intervals beginning in April of 2003 and continuing through September of 2006. We have previously reported on the effectiveness of these interventions to promote adherence. In this paper, we examine the relations of cognitive status and adherence over time using a partial least squares path model in order to evaluate the extent to which adherence to cholinesterase medications was related to cognitive status. Adherence predicted cognitive status at later time points while cognition did not, in general, predict adherence. Results thus suggest that interventions to ensure high levels of medication adherence may be important for maintaining cognitive function in affected elderly people.

Sensors ◽  
2010 ◽  
Vol 10 (3) ◽  
pp. 1535-1552 ◽  
Author(s):  
Leentje De Bleser ◽  
Birgit Vincke ◽  
Fabienne Dobbels ◽  
Mary Beth Happ ◽  
Bart Maes ◽  
...  

2010 ◽  
Vol 23 (2) ◽  
pp. 149-154 ◽  
Author(s):  
H. A. W. van Onzenoort ◽  
W. J. Verberk ◽  
A. G. H. Kessels ◽  
A. A. Kroon ◽  
C. Neef ◽  
...  

2017 ◽  
Vol 20 (6) ◽  
pp. 856-868 ◽  
Author(s):  
Maria Cecília Azevedo de Aguiar ◽  
Natália Cristina Garcia Pinheiro ◽  
Karolina Pires Marcelino ◽  
Kenio Costa de Lima

Abstract Objective: to evaluate the prevalence of halitosis and associated factors in institutionalized elderly persons. Methods: a sectional study was performed with 268 elderly persons from 11 long-term care institutions in Natal in the northeast of Brazil. Data collection included an oral epidemiologic examination and questions about self-perception of oral health, as well as a consultation of medical records and the application of a questionnaire to the directors of the institutions. Halitosis was measured using the organoleptic test. The independent variables were oral, sociodemographic, institutional, general health and functional conditions. Bivariate analysis was performed using the Pearson chi-square test and Fisher's exact test, and the magnitude of effect was verified by the prevalence ratio for the independent variables in relation to the outcome, with a 95% confidence level. Results: the prevalence of halitosis was 26.1%, which was exhaled by the mouth in 98.57% of cases and by the nose in 10% of cases. Prevalence was 43% higher among non-white individuals (p=0.006); 65% higher among those living in non-profit institutions (p=0.039); 52% higher in elderly persons with oriented cognitive status (p=0.047); 41% higher in elderly persons with root caries (p=0.029); 62% higher in those who did not use dentures (p=0.046); 57% lower in edentulous persons (p<0.001); and 73% higher in elderly individuals with tongue biofilm (p=0.001). Conclusion: The occurrence of halitosis in institutionalized elderly persons was similar to other studies, but there was an expressive number of extrabuccal cases and an association with oral health problems, as well as sociodemographic, institutional and functional factors.


Author(s):  
Caitlin J. Cain ◽  
Andrea R. Meisman ◽  
Kirstin Drucker ◽  
Evrosina I. Isaac ◽  
Tanvi Verma ◽  
...  

Previous research suggests that children and adolescents with acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) often have difficulty adhering to complex treatment regimens during the maintenance phase of therapy. Measurement of treatment adherence can be done via objective (e.g., electronic monitoring (EM), pharmacological assays) or subjective methods (patient, parent, or physician reports). This paper provides an illustration of recommended strategies for comparing discrepancies between two objective measures of medication adherence (e.g., behavioral adherence using electronic monitoring versus pharmacological adherence using 6-mercaptopurine (6MP) metabolite data) within a relatively large cohort of pediatric patients with ALL or LBL (N = 139) who had longitudinal data for both measures of medication adherence over a 15-month period. Additionally, individual- and family-level factors such as gender, socioeconomic status, household environment, and dose intensity will be examined to identify possible sources of discrepancies between adherence measures. This information will provide practical advice for physicians, healthcare providers, and psychologists in identifying nonadherence and the caveats therein so patients achieve the best possible health outcomes.


2019 ◽  
Vol 33 (5) ◽  
pp. 250-255 ◽  
Author(s):  
Stephen Smilowitz ◽  
Awais Aftab ◽  
Michelle Aebi ◽  
Jennifer Levin ◽  
Curtis Tatsuoka ◽  
...  

Objective: We present a secondary analysis of data reporting differences in medication adherence, psychiatric symptom severity, and internalized stigma levels in older (age ≥ 55 years) versus younger (age < 55 years) adults with bipolar disorder (BD) and poor medication adherence. Methods: Data used for this analysis came from 184 participants in a National Institute of Mental Health–funded randomized controlled trial, comparing a customized adherence enhancement (CAE) intervention intended to promote BD medication adherence with a BD-specific educational program (EDU). At screen, study participants were ≥20% nonadherent with BD medications as measured by the Tablets Routine Questionnaire (TRQ). Psychiatric symptoms, functional status, and internalized stigma were measured using validated scales. Results: Older adults had significantly lower anxiety disorder comorbidity ( P < .01 for 1 or more anxiety disorders), depressive symptom severity scores ( P = .011), and self-stigma scores ( P = .001) compared to their younger counterparts. In the analyses evaluating change over time in TRQ between older and younger participants by treatment arm (ie, CAE and EDU), there was a significant finding of interaction between time, age-group, and treatment arm ( P = .007). Conclusions: Older adults may be less anxious and depressed, with less self-stigma, compared to younger people with BD and poor adherence. With respect to medication adherence, older individuals in EDU appear to do less well than younger individuals over time.


2019 ◽  
Vol 45 (Supplement_2) ◽  
pp. S245-S245
Author(s):  
Seung Hyun Kim ◽  
Jungseo Lee ◽  
Jung Jin Kim ◽  
Yujin Lee

2016 ◽  
Vol 3 (1) ◽  
pp. e000128 ◽  
Author(s):  
Janine Pilcher ◽  
Mark Holliday ◽  
Stefan Ebmeier ◽  
Steve McKinstry ◽  
Fatiha Messaoudi ◽  
...  

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