scholarly journals Evaluation of central nervous system depressant activity of Cleome rutidosperma

2012 ◽  
Vol 2 (1) ◽  
pp. 8
Author(s):  
Anindya Bose ◽  
Anuradha Khuntia ◽  
Jayanta Kumar Gupta ◽  
Sudam Si
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ethanol Extract ◽  
Traditional Use ◽  
Cns Depressant ◽  
Aerial Parts ◽  
Central Nervous System Depressant ◽  
The Central Nervous System ◽  
Cns Depressant Activity ◽  
Cleome Rutidosperma

The central nervous system (CNS) depressant activity of the ethanol extract (200 and 400 mg/kg) and its fractions (200 mg/kg each) of the aerial parts of Cleome rutidosperma was investigated in various models. The tested extract and its fractions showed significant (P<0.01) anxiolytic, anticonvulsant activity (in treating petit mal epilepsy) without any unwanted sedation effect. These findings justify the traditional use of this plant in CNS disorders.

PENENTUAN NILAI PARAMETER LIPOFILITAS SENYAWA 4-KLOROBENZOILTIOUREA DAN UJI POTENSIASI TERHADAP TIOPENTAL PADA MENCIT PUTIH (Mus musculus)

2019 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Dini Kesuma
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Electronic Properties ◽  
Mus Musculus ◽  
Log P ◽  
P Value ◽  
Lead Compounds ◽  
Significant Difference ◽  
Central Nervous System Depressant ◽  
The Central Nervous System

Synthesis of the 4-chlorobenzoylthiourea compound was carried out by acylating thiourea with 4-chlorobenzoyl chloride. The 4-chlorobenzoylthiourea compound  will increase the lipophilic and the electronic properties other than the lead compounds of benzoylthiourea in order to, by expectation, raise the central nervous system depressant as well. The lipophilic would affect the ability of the compounds in penetrating biological membranes, which is highly dependent on the solubility of the drug within lipid/water. Log P is the most common method used in determining the parameter value. This experiment was to mix two dissolvents (octanol and water) which are immissible. The both levels of the compounds were carefully observed by a spectrophotometer UV-Vis. From the test, the result of log P value of the 4-chlorobenzoylthiourea compound was 2.32, while the theoretical log P value of the compounds, by using the π Hansch-Fujita method is 1.62 and the f Rekker-Mannhold method is 2.225. Consequently, the result of the test shows that there is a significant difference between the progress experiment and both theoretical log P methods. Moreover, in the test of the central nervous system depressant through the potentiation test to thiopental using mice indicates that the 4-chlorobenzoylthiourea compound have potentiation effects to thiopental compared to the lead compounds of benzoylthiourea.

scholarly journals Central nervous system depressant activity of fractions of Globimetula braunii Engl. (Loranthaceae) growing on Terminalia catappa L. (Combretaceae) and isolation of lupeol

2021 ◽  
Vol 18 (3) ◽  
pp. 196-206
Author(s):  
Suleiman Danladi ◽  
Mohammed Ibrahim Sule ◽  
Musa Aliyu Muhammad ◽  
Abdullahi Hamza Yaro
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Normal Saline ◽  
Treated Group ◽  
Hexane Fraction ◽  
Dependent Manner ◽  
Active Fraction ◽  
Terminalia Catappa ◽  
Cns Depressant ◽  
Cns Depressant Activity

Globimetula braunii is a parasitic plant belonging to the family Loranthaceae. Traditionally, the plant has been reported to be used in the treatment of insomnia. The study was carried out to investigate the central nervous system (CNS) depressant activity of the fractions of Globimetula braunii growing on Terminalia catappa and to isolate the phytochemical compound(s) present in the most active fraction. The CNS depressant activity of all the fractions was investigated using diazepam induced sleep. The most active fraction was further subjected to the hole board test and beam walk assay. The chromatographic technique was used for the isolation of phytochemical compound. Hexane fraction significantly (p<0.05) reduced latency to sleep and prolonged the sleeping time. Both chloroform and ethylacetate fractions at highest and median doses showed significant increase in the duration of sleep compared to normal saline. The n-butanol fraction at all doses tested do not have any effect on time of onset and duration of sleep when compared with normal saline treated group. Hexane fraction significantly (p<0.05) decreased the number of head dip in a dose dependent manner and delayed the time to reach the goal box compared to normal saline treated group. Lupeol was isolated from n-hexane fraction.

scholarly journals Importance of Herba Passiflorae in Medicinal Applications: Review on Experimental and Clinical Pharmacology

2021 ◽  
Vol 11 (5) ◽  
pp. 12886-12900
Keyword(s):  
Central Nervous System ◽  
Clinical Pharmacology ◽  
Nervous System ◽  
Water Extract ◽  
Passion Fruit ◽  
Aerial Parts ◽  
Experimental Pharmacology ◽  
Sedative Effects ◽  
Central Nervous System Depressant ◽  
Anti Inflammatory

The dried aerial parts of Passiflora incarnate L. plant are called Herba Passiflorae. This plant belongs to the Passifloraceae family. This review aims to focus on the importance of Herba Passiflorae in medicinal applications with special reference to its experimental and clinical pharmacology. Herba Passiflorae possesses flavonoids and alkaloids ingredients. The major constituents of Herba Passiflorae are flavonoids such as vicenin-2, orientin, isoorientin, vitexin, and isovitexin. Herba Passiflorae is applied for the cure of dysmenorrhoea, neuralgia, and nervous tachycardia. It is a slight sedative for nervous restlessness, insomnia, and anxiety. The fruit of Herba Passiflorae is used for jams, jellies, and desserts. The juice is a favorite flavoring in drinks. The pharmacology effect of Herba Passiflorae includes experimental and clinical pharmacology. Experimental pharmacology includes analgesic, antipyretic, anti-inflammatory, antimicrobial, cardiovascular, central nervous system depressant, and uterine stimulant effects. Clinical pharmacology includes anxiolytic, analgesic, and sedative effects, as well as its effect on nausea, menopause, dysmenorrhea, and diabetes. Herba Passiflorae stimulates uterine contractions, so it is used during pregnancy. The water extract of Herba Passiflorae is not genotoxic. The passion fruit is more appropriate for children's use due to the incorporation of Lactobacillus casei in passion fruit. The daily oral intake of passion fruit at public doses is non-toxic and safe. The daily dose in adults as a sedative is 0.5-2 g of aerial parts 3-4 times. In conclusion, Herba Passiflorae has analgesic, antipyretic, anti-inflammatory, antimicrobial, cardiovascular, central nervous system depressant, uterine stimulant, anxiolytic, analgesic, and sedative effects, as well as, its effect on nausea, menopause, dysmenorrhea, and diabetes.

scholarly journals Evaluation of central nervous system depressant activity of methanolic and petroleum ether extract of Manilkara zapota leaves (in vivo)

2016 ◽  
Vol 8 (3) ◽  
pp. 308
Author(s):  
Manirujjaman ◽  
Trudi Collet
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Locomotor Activity ◽  
Petroleum Ether ◽  
Open Field ◽  
Dependent Manner ◽  
Manilkara Zapota ◽  
Cns Depressant ◽  
Cns Depressant Activity

<p>The purpose of this study was to examine the central nervous system (CNS) -depressant activity of methanolic and petroleum ether extracts of leaves obtained from <em>Manilkara zapota </em>(Sapotaceae) <em>in vivo</em>. CNS-depressant action was evaluated by observing the effects of plant extracts on both exploratory and spontaneous locomotor activity in mice using open field and hole cross tests respectively. The extracts were found to exhibit CNS-depressant activity in a dose-dependent manner. In the open field test, both the methanolic and petroleum ether extracts reduced the exploratory behavior of mice significantly (p&lt;0.05). Although the extracts reduced locomotor activity in the hole cross test, the results were found to be insignificant. Overall, these findings indicate that both types of extracts derived from <em>M. zapota</em> leaves possess CNS-depressant activity.</p>

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