scholarly journals The Golgi apparatus is a primary site of intracellular damage after photosensitization with Rose Bengal acetate

10.4081/919 ◽  
2009 ◽  
Vol 48 (4) ◽  
pp. 443 ◽  
Author(s):  
C Soldani ◽  
MG Bottone ◽  
AC Croce ◽  
A Fraschini ◽  
G Bottiroli ◽  
...  
Keyword(s):  
Golgi Apparatus ◽  
Rose Bengal ◽  
Primary Site ◽  
Rose Bengal Acetate

Enzyme-assisted photosensitization activates different apoptotic pathways in Rose Bengal acetate treated HeLa cells

2008 ◽  
Vol 131 (3) ◽  
pp. 391-399 ◽  
Author(s):  
Maria Grazia Bottone ◽  
Cristiana Soldani ◽  
Annunzia Fraschini ◽  
Anna Cleta Croce ◽  
Giovanni Bottiroli ◽  
...  
Keyword(s):  
Rose Bengal ◽  
Hela Cells ◽  
Rose Bengal Acetate ◽  
Apoptotic Pathways

In vitro and in vivo clearance of Rose Bengal Acetate-PhotoDynamic Therapy-induced autophagic and apoptotic cells

2013 ◽  
Vol 238 (7) ◽  
pp. 765-778 ◽  
Author(s):  
Elisa Panzarini ◽  
Valentina Inguscio ◽  
Bernardetta Anna Tenuzzo ◽  
Luciana Dini
Keyword(s):  
Photodynamic Therapy ◽  
Rose Bengal ◽  
Apoptotic Cells ◽  
Rose Bengal Acetate

Apoptosis in tumour cells photosensitized with Rose Bengal acetate is induced by multiple organelle photodamage

2007 ◽  
Vol 128 (5) ◽  
pp. 485-495 ◽  
Author(s):  
C. Soldani ◽  
A. C. Croce ◽  
M. G. Bottone ◽  
A. Fraschini ◽  
M. Biggiogera ◽  
...  
Keyword(s):  
Rose Bengal ◽  
Tumour Cells ◽  
Rose Bengal Acetate

Apoptosis induction and mitochondria alteration in human HeLa tumour cells by photoproducts of Rose Bengal acetate

2006 ◽  
Vol 83 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Elisa Panzarini ◽  
Bernadette Tenuzzo ◽  
Fabio Palazzo ◽  
Alfonsina Chionna ◽  
Luciana Dini
Keyword(s):  
Rose Bengal ◽  
Tumour Cells ◽  
Apoptosis Induction ◽  
Rose Bengal Acetate

scholarly journals Overview of Cell Death Mechanisms Induced by Rose Bengal Acetate-Photodynamic Therapy

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Elisa Panzarini ◽  
Valentina Inguscio ◽  
Luciana Dini
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Rose Bengal ◽  
Intracellular Localization ◽  
Photochemical Reactions ◽  
Ros Generation ◽  
Invasive Treatment ◽  
Rose Bengal Acetate ◽  
Efficient Induction ◽  
Apoptotic Pathways

Photodynamic Therapy (PDT) is a non-invasive treatment for different pathologies, cancer included, using three key components: non-toxic light-activated drug (Photosensitizer, PS), visible light, and oxygen. Their interaction triggers photochemical reactions leading to Reactive Oxygen Species (ROS) generation, that mediate cytotoxicity and cell death. In the present paper, the most important findings about the synthetic dye Rose Bengal Acetate (RBAc), an emerging photosensitizer for its efficient induction of cell death, will be reported with the aim to integrate RBAc phototoxicity to novel therapeutic PDT strategies against tumour cells. After its perinuclear intracellular localization, RBAc causes multiple subcellular organelles damage, that is, mitochondria, Endoplasmic Reticulum (ER), lysosomes, and Golgi complex. Indeed, RBAc exerts long-term phototoxicity through activation of both caspase-independent and- dependent apoptotic pathways and autophagic cell death. In particular, this latter cell death type may promote cell demise when apoptotic machinery is defective. The deep knowledge of RBAc photocytotoxicity will allow to better understand its potential photomedicine application in cancer.

scholarly journals Rose Bengal Acetate photodynamic therapy-induced autophagy

2010 ◽  
Vol 10 (10) ◽  
pp. 1048-1055 ◽  
Author(s):  
Luciana Dini ◽  
Valentina Inguscio ◽  
Bernardetta Tenuzzo ◽  
Elisa Panzarini
Keyword(s):  
Photodynamic Therapy ◽  
Rose Bengal ◽  
Rose Bengal Acetate
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