Treatment of anthracycline extravasation from centrally inserted venous catheters

Seppo W. Langer

doi:10.4081/117

Other uses of dexrazoxane: savene, the first proven antidote against anthracycline extravasation injuries

Cardiovascular Toxicology ◽

10.1007/s12012-007-0021-5 ◽

2007 ◽

Vol 7 (2) ◽

pp. 151-153 ◽

Cited By ~ 7

Author(s):

Seppo W. Langer ◽

Peter Buhl Jensen ◽

Maxwell Sehested

Keyword(s):

Anthracycline Extravasation

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A murine experimental anthracycline extravasation model: Pathology and study of the involvement of topoisomerase II alpha and iron in the mechanism of tissue damage

Toxicology ◽

10.1016/j.tox.2010.01.007 ◽

2010 ◽

Vol 269 (1) ◽

pp. 67-72 ◽

Cited By ~ 8

Author(s):

Annemette V. Thougaard ◽

Seppo W. Langer ◽

Bo Hainau ◽

Morten Grauslund ◽

Birgitte Ravn Juhl ◽

...

Keyword(s):

Tissue Damage ◽

Topoisomerase Ii ◽

Topoisomerase Ii Alpha ◽

Anthracycline Extravasation

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Delayed presentation of doxorubicin extravasation into pleural space: Case report and review of literature

Journal of Oncology Pharmacy Practice ◽

10.1177/1078155220975848 ◽

2020 ◽

pp. 107815522097584 ◽

Cited By ~ 1

Author(s):

Vera Kazakova ◽

Yenny A Moreno Vanegas ◽

Tyion A Torres ◽

Olga Kozyreva

Keyword(s):

Case Report ◽

Chest Pain ◽

Soft Tissues ◽

Rare Complication ◽

Delayed Presentation ◽

Review Of Literature ◽

Chemotherapy Administration ◽

Chemotherapy Infusion ◽

Space Case ◽

Anthracycline Extravasation

Introduction Intrathoracic extravasation of anthracyclines is a dangerous and very rare complication of chemotherapy administration. While management of extravasation into soft tissues has been established, the data on treatment of mediastinal and intrapleural anthracycline extravasation is limited. Case Report We present a case of a 52-year-old woman with intrapleural doxorubicin extravasation who presented to the hospital 24-hrs after chemotherapy infusion with chest pain and shortness of breath. Management & Outcome The patient underwent urgent surgical intervention and received IV dexrazoxane 36-hrs after the event. Her pain improved, but she continued to have chest soreness and pleural effusion at the site of extravasation even 3 months later. Discussion We conducted review of literature using Medline/PubMed and Google Scholar databases and identified 7 cases of intrapleural and mediastinal anthracycline extravasation. No data is currently available regarding the outcome of delayed management of intrapleural anthracycline extravasation with dexrazoxane. Prevention and confirmation of adequate port catheter placement is the most important step to avoid such cases. Catheter misplacement should be suspected in any patient presenting with post procedural chest pain and should trigger a thorough evaluation prior to any chemotherapy administration.

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