Effect of Intermittent Administration of hPTH(1-34) on Cortical Bone Geometry in Rats Treated with High-Dose Glucocorticoids

2014 ◽  
Vol 57 (5) ◽  
pp. 231-237 ◽  
Author(s):  
Jun Iwamoto
Keyword(s):  
Cortical Bone ◽  
Bone Geometry ◽  
High Dose ◽  
Intermittent Administration ◽  
Cortical Bone Geometry

Lifetime loading enhances cortical bone geometry and bone mass distribution in older men

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S99-S100
Author(s):  
C.A. Bailey ◽  
S. Kukuljan ◽  
R.M. Daly
Keyword(s):  
Bone Mass ◽  
Cortical Bone ◽  
Mass Distribution ◽  
Bone Geometry ◽  
Older Men ◽  
Cortical Bone Geometry

scholarly journals Pentosidine Is Associated With Cortical Bone Geometry and Insulin Resistance in Otherwise Healthy Children

2019 ◽  
Vol 34 (8) ◽  
pp. 1446-1450
Author(s):  
Joseph M Kindler ◽  
Emma M Laing ◽  
Weixi Liu ◽  
Joel A Dain ◽  
Richard D Lewis
Keyword(s):  
Insulin Resistance ◽  
Cortical Bone ◽  
Bone Geometry ◽  
Healthy Children ◽  
Cortical Bone Geometry

Computed tomographic measurement of cortical bone geometry

1989 ◽  
Vol 22 (6-7) ◽  
pp. 649-653 ◽  
Author(s):  
D.R. Sumner ◽  
C.L. Olson ◽  
P.M. Freeman ◽  
J.J. Lobick ◽  
T.P. Andriacchi
Keyword(s):  
Cortical Bone ◽  
Bone Geometry ◽  
Computed Tomographic ◽  
Cortical Bone Geometry ◽  
Tomographic Measurement

scholarly journals Development of Cortical Bone Geometry in the Human Femoral and Tibial Diaphysis

2013 ◽  
Vol 296 (5) ◽  
pp. 774-787 ◽  
Author(s):  
James H. Gosman ◽  
Zachariah R. Hubbell ◽  
Colin N. Shaw ◽  
Timothy M. Ryan
Keyword(s):  
Cortical Bone ◽  
Bone Geometry ◽  
Tibial Diaphysis ◽  
Cortical Bone Geometry

scholarly journals Glucocorticoid Excess Affects Cortical Bone Geometry in Premenopausal, but not Postmenopausal, Women

2008 ◽  
Vol 82 (3) ◽  
pp. 182-190 ◽  
Author(s):  
Hiroshi Kaji ◽  
Mika Yamauchi ◽  
Kazuo Chihara ◽  
Toshitsugu Sugimoto
Keyword(s):  
Cortical Bone ◽  
Postmenopausal Women ◽  
Bone Geometry ◽  
Cortical Bone Geometry

scholarly journals Connexin43 and Runx2 Interact to Affect Cortical Bone Geometry, Skeletal Development, and Osteoblast and Osteoclast Function

2017 ◽  
Vol 32 (8) ◽  
pp. 1727-1738 ◽  
Author(s):  
Atum M Buo ◽  
Ryan E Tomlinson ◽  
Eric R Eidelman ◽  
Max Chason ◽  
Joseph P Stains
Keyword(s):  
Cortical Bone ◽  
Skeletal Development ◽  
Bone Geometry ◽  
Cortical Bone Geometry ◽  
Osteoclast Function

scholarly journals Technetium-99 Conjugated with Methylene Diphosphonate Ameliorates Glucocorticoid Induced Osteoporosis by Inhibiting Osteoclastogenesis

2018 ◽  
Vol 2018 ◽  
pp. 1-9
Author(s):  
Lianjie Shi ◽  
Ying Ning ◽  
Liling Xu ◽  
Jianhong Li ◽  
Xuewu Zhang
Keyword(s):  
Cortical Bone ◽  
Bone Microarchitecture ◽  
Osteoclast Differentiation ◽  
Bone Geometry ◽  
Negative Control ◽  
High Dose ◽  
Micro Ct ◽  
Sprague Dawley ◽  
Blank Group ◽  
Methylene Diphosphonate

Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) is an effective anti-inflammatory drug in treating rheumatoid arthritis (RA) for over 15 years in China. However, as a special form of bisphosphonate, the antiosteoporotic effect of99Tc-MDP is unclear. We systematically investigated the effects of99Tc-MDP on cancellous and cortical bone, respectively, in glucocorticoid induced osteoporosis (GIO) animal models. Forty-eight Sprague-Dawley rats were randomly divided into six groups: blank, negative control, high dose, medium dose, low dose, and positive control groups. After dexamethasone was given to all groups except the blank group to induce osteoporosis, the rats in different groups were treated with saline, MDP, or different doses of99Tc-MDP. After treatment, all rats were sacrificed, and their tibiae and femora were analyzed with microcomputed tomography (micro-CT), histology and biomechanics. Micro-CT analyses showed that (1)99Tc-MDP reversed glucocorticoid induced bone microarchitecture destruction by increasing BV/TV, Tb.Th, and Tb.N and decreasing BS/BV, Tb.Sp, and TBPf; (2) effect of99Tc-MDP increased as its dosage increased; and (3)99Tc-MDP could improve cortical bone thickness while MDP failed to do so. Micro-CT spatial structure analysis and histology also yielded consistent results, indicating that99Tc-MDP increased trabecular number and connectivity morphologically. Secondly, biomechanics revealed that99Tc-MDP can enhance the extrinsic stiffness of bone by changing bone geometry. Finally,99Tc-MDP could inhibit osteoclastogenesis in PBMCs in human. In conclusion,99Tc-MDP exerted antiosteoporotic effect by improving both cancellous and cortical bone, as well as increasing extrinsic bone stiffness which might be attributed to the its inhibition of osteoclast differentiation. The antiosteoporotic effect of99Tc-MDP may suggest a potential clinical application for patients with GIO.

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