LTCC MICROREACTORS APPLICATION IN A MICROFLUIDIC INTEGRATED SYSTEM FOR HYDROPHOBIC DRUG ENCAPSULATION IN POLYMERIC NANO/MICROPARTICLES

2015 ◽  
Vol 2015 (CICMT) ◽  
pp. 000263-000268
Author(s):  
L. K. Rincon Ardila ◽  
H. Cobas-Gomez ◽  
V.A. Feitosa ◽  
V.T. Kimura ◽  
O. Paiva ◽  
...  
Keyword(s):  
Particle Production ◽  
Pressure Sensors ◽  
Particle Morphology ◽  
Integrated System ◽  
Production Performance ◽  
Control Loops ◽  
Control Programs ◽  
Processing Control ◽  
Measure Particle Size ◽  
And Control

Nanotechnology develops methods and processes for Drug Delivery Systems (DDS) based on the fabrication of polymeric nano/microparticles with encapsulated drug that can be applied for maximize therapeutic activity and minimizes undesirable effects. However, these processes entail several conditions to operate efficiently. They present high sensibility to changes in temperature, flow rate, pressure, and chemical solution composition. An optimal configuration of these parameters is required to guarantee stable particle production. For these reasons, integration of technological devices like sensors, actuators, microfluidic devices and control systems is essential to increase particle production performance. The proposal of this work is to develop an integrated monitored and controlled system using LTCC (Low Temperature Co-Fired Ceramic) microreactors to generate polymeric nano/microparticles for encapsulation of hydrocortisone drug with PCL and Pluronic polymers. The microfluidic integrated system is developed through devices integration, system characterization and control loops configuration, using pressure sensors, syringe and microgear pumps, mixer and vortex LTCC microfluidic reactors, communication drivers, and data processing/control programs. Dynamic Light Scattering, Optical and Scanning Electron Microscopy were employed to measure particle size, polydispersity (PdI) distribution and particle morphology. Preliminary results showed nano/microparticles with encapsulated hydrocortisone drug having a mean diameter size of 528–816 nm and Polidispersity Index (PdI) < 0.5.

Concept and principles of building an integrated system of management of activities of regional gas supply system entities Kaliningrad region

2019 ◽  
pp. 64-72
Author(s):  
G.G. Arunyants
Keyword(s):  
Control System ◽  
Natural Gas ◽  
Supply System ◽  
Integrated System ◽  
Software Complex ◽  
Geographically Distributed ◽  
Basic Solutions ◽  
Kaliningrad Region ◽  
And Control ◽  
Gas Supply

The results of analysis of problems of regulation of gas supply complex of Kaliningrad region and main ways to increase its efficiency, as well as basic solutions for creation of a software complex Т-GAZ-2 automated calculation of natural gas tariffs for ACS of gas supply system subjects, geographically distributed and information connected to the regional automated information and control system (RAIS).

Using advanced control, post-denitrification and equalisation to improve the performance of a submerged filter

2000 ◽  
Vol 41 (4-5) ◽  
pp. 177-184 ◽  
Author(s):  
K.H. Sørensen ◽  
D. Thornberg ◽  
K.F. Janning
Keyword(s):  
Energy Consumption ◽  
Total N ◽  
Control Loops ◽  
Effluent Quality ◽  
Advanced Control ◽  
Before And After ◽  
And Control ◽  
Side Flow ◽  
Configuration Control ◽  
Control Post

In 1998, the capacity of the BIOSTYR® submerged biofilter at Nyborg WWTP was extended from 48,000 PE to 60,000 PE including advanced sensor based control, post-denitrification in BIOSTYR® and equalization of side flows. The existing configuration with 8 BIOSTYR® DN/N cells is based on pre-denitrification and an internal recirculation of 600–800%. The extended plant comprises 7 BIOSTYR® DN/N cells with 50–225% recirculation followed by 3 BIOSTYR DN cells for post-denitrification. The advanced control loops include blower control, control of the number of active cells (stand-by), automatic switch to high load configuration, control of the side flow equalization, control of the internal recirculation and control of the external carbon source dosing. In this paper, the achieved improvements are documented by comparing influent and effluent data, methanol and energy consumption from comparable periods before and after the extension. Although the nitrogen load to the plant was increased by 20% after the extension, the effluent quality has improved significantly with a reduction of Total-N from 7–8 mg/l to 3–4 mg/l. Simultaneously, the methanol consumption has been reduced by more than 50% per kg removed nitrogen. The energy consumption remained constant although the nitrogen load was increased by 20% and the inflow by 80%.

scholarly journals Gene processing control loops suggested by sequencing, splicing, and RNA folding

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Clark D Jeffries ◽  
Diana O Perkins ◽  
Xiaojun Guan
Keyword(s):  
Rna Folding ◽  
Control Loops ◽  
Processing Control

Historical perspective of cyathostomes: prevalence, treatment and control programs

1999 ◽  
Vol 85 (2-3) ◽  
pp. 97-112 ◽  
Author(s):  
E.T Lyons ◽  
S.C Tolliver ◽  
J.H Drudge
Keyword(s):  
Historical Perspective ◽  
Control Programs ◽  
And Control

Proportional Navigation and Model Predictive Control of an Unmanned Autonomous Vehicle for Obstacle Avoidance

2018 ◽  
Author(s):  
Ryan P. Shaw ◽  
David M. Bevly
Keyword(s):  
Obstacle Avoidance ◽  
Autonomous Vehicle ◽  
Integrated System ◽  
Reference Trajectory ◽  
Ground Vehicles ◽  
Proportional Navigation ◽  
Predictive Controller ◽  
Proportional Navigation Law ◽  
Vehicle Dynamic Model ◽  
And Control

This paper presents a new approach for the guidance and control of a UGV (Unmanned Ground Vehicle). An obstacle avoidance algorithm was developed using an integrated system involving proportional navigation (PN) and a nonlinear model predictive controller (NMPC). An obstacle avoidance variant of the classical proportional navigation law generates command lateral accelerations to avoid obstacles, while the NMPC is used to track the reference trajectory given by the PN. The NMPC utilizes a lateral vehicle dynamic model. Obstacle avoidance has become a popular area of research for both unmanned aerial vehicles and unmanned ground vehicles. In this application an obstacle avoidance algorithm can take over the control of a vehicle until the obstacle is no longer a threat. The performance of the obstacle avoidance algorithm is evaluated through simulation. Simulation results show a promising approach to conditionally implemented obstacle avoidance.

Design a PLC-Based Variable-Frequency Governing Pressure-Constant Water-Supply Control System

2014 ◽  
Vol 1044-1045 ◽  
pp. 755-758
Author(s):  
Xin Hui Yang
Keyword(s):  
Control System ◽  
Water Supply ◽  
Pressure Sensors ◽  
Variable Frequency ◽  
Pipe Network ◽  
Monitoring And Control ◽  
Control Software ◽  
Industrial Control ◽  
Time Basis ◽  
And Control

This paper provides a design for a PLC-based, variable-frequency governing, pressure-constant, automatic water-supply control system. This design is based on the current situations at the water supply plants found in small and medium cities in China. In this control system, the pressure signal across the pipe network is acquired by pressure sensors and then transmitted to PID modules in the PLC in order to control switching between pump motors. At the same time, the PLC is connected with a personal computer for industrial control purposes. On this computer, monitoring and control software has been installed in order to monitor and control the pressure-constant water-supply system on a real-time basis.

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