scholarly journals The Mississippi Decision Exchanging Parole for Kidney Donation: Is This the Beginning of Change for Altruistic-Based Human Organ Donation Policy in the United States?

2011 ◽  
Vol 86 (5) ◽  
pp. 414-418 ◽  
Author(s):  
Christopher M. Burkle
Keyword(s):  
United States ◽  
Organ Donation ◽  
The United States ◽  
Kidney Donation ◽  
Human Organ

scholarly journals A Standardized Approach to Orthotopic (Life-Supporting) Porcine Cardiac Xenotransplantation in a Non-Human Primate Model

2021 ◽  
Author(s):  
Corbin E. Goerlich ◽  
Bartley P. Griffith ◽  
John A. Treffalls ◽  
Tianshu Zhang ◽  
Avneesh K. Singh ◽  
...  
Keyword(s):  
United States ◽  
Heart Failure ◽  
Genetically Modified ◽  
Human Study ◽  
The United States ◽  
Large Animal ◽  
Term Survival ◽  
Human Organ ◽  
Large Animal Models

Abstract There are 5.7 million people in the United States with heart failure, which is life-limiting in 20% of patients.1 While data is most robust in the United States for this cohort, it is known to be a global problem with over 23 million people carrying the diagnosis.1 For end-stage heart failure, many require a heart transplantation, however, there is a shortage in the supply of organ donors. Cardiac xenotransplantation has been proposed to “bridge the gap” in supply for these patients requiring transplantation. Recent pre-clinical success using genetically modified pig donors in baboon recipients has demonstrated survival greater than 6 months.2–5 First-in-human transplantation of a genetically modified pig kidney demonstrated 54 hour rejection-free function when perfused by a deceased human recipient, demonstrating the feasibility of cross-species transplantation and invigorating enthusiasm further to utilize this new organ source for a population that would otherwise die waiting for a human organ.6 While this human study demonstrated proof-of-principle of overcoming hyperacute rejection, further regulatory oversight by Food and Drug Administration (FDA) may be required with pre-clinical trials in large animal models of xenotransplantation with long-term survival. These studies not only require a multi-disciplinary team and expertise in orthotopic transplantation (cardiac surgery, anesthesia and cardiopulmonary bypass), immunology and genetic engineering; but also, specifically handling large animal recipients that cannot communicate their symptoms. Here we detail our approach to pig-to-primate large animal model of orthotopic cardiac xenotransplantation perioperatively and in the months thereafter in long-term surviving animals. We also detail xenograft surveillance methods and common issues that arise in the postoperative period specific to this model and ways to overcome them.

scholarly journals The first increase in live kidney donation in the United States in 15 years

2020 ◽  
Vol 20 (12) ◽  
pp. 3590-3598 ◽  
Author(s):  
Fawaz Al Ammary ◽  
Yifan Yu ◽  
Alexander Ferzola ◽  
Jennifer D. Motter ◽  
Allan B. Massie ◽  
...  
Keyword(s):  
United States ◽  
The United States ◽  
Kidney Donation ◽  
Live Kidney Donation

Trauma Patients’ Attitudes toward Organ Donation at an Urban Level I Trauma Center

2018 ◽  
Vol 84 (9) ◽  
pp. 1493-1497
Author(s):  
John D. Cull ◽  
Katarina Ivkovic ◽  
Benjamin Manning ◽  
Edie Y. Chan
Keyword(s):  
United States ◽  
Organ Donation ◽  
Trauma Center ◽  
Family Members ◽  
Organ Donor ◽  
The United States ◽  
Trauma Patients ◽  
Willingness To Donate ◽  
Patient Responses ◽  
Level I

Many health-care workers (HCWs) surveyed at a trauma center believed their patients distrusted the organ allocation system. This study compares urban trauma patients’ (TPs) attitudes toward organ donation with attitudes from the 2012 National Survey of Organ Donation Attitudes (NSODA). TPs presenting to the trauma clinic between September 2014 and August 2015 were surveyed. Patient responses were compared with the 2012 NSODA. One hundred and thirty-three TPs (95.0%) responded to the survey. Compared with the 2012 NSODA, groups were similar with regard to a patient's desire for OD after death (Trauma: 62.4% [Confidence interval [CI]: 53.6–70.7] vs NSODA: 59.3% [CI: 56.6–61.8]) and the belief that doctors are less likely to save their life if they are an organ donor (24.8% [CI: 17.7–33.0] vs 19.6% [CI: 18.3–21.0]). Approximately, 30 per cent of patients believed discrimination prevented minority patients from receiving transplants (27.1 [CI: 19.7–35.5] vs 30.3 [CI: 28.8–31.9]). TPs were less likely than the NSODA group to donate a family members’ organs, if they did not know the family members’ wishes (56.4% [CI: 47.5–65.0] vs 75.6% [CI: 68.7–71.8]); TPs were less likely to believe the United States transplant system uses a fair approach to distribute organs (47.4% [38.7–56.2] vs 64.6% [CI: 63.0–66.2]). Adjusting for race, both groups were similar in their willingness to donate a family members’ organs; black TPs were less likely to believe the United States transplant system, which follows a fair approach in distributing organs (43.0% [CI: 32.4–54.2] vs 63.7% [59.7–67.6]). Despite HCWs perceptions, TPs had a positive view of OD. Educating HCWs on patient attitudes toward OD may decrease institutional barriers to OD.

Beliefs and Brain Death

2017 ◽  
Author(s):  
Eelco F.M. Wijdicks
Keyword(s):  
United States ◽  
Native American ◽  
Brain Death ◽  
Cultural Diversity ◽  
Organ Donation ◽  
The United States ◽  
Neurological Injury ◽  
Brain Death Determination ◽  
Death Determination

Globalization has increased cultural diversity in many communities. This has immediate implications for care of patients with catastrophic neurological injury and later discussions of brain death and organ donation. While the major religions in the United States—Christianity, Islam, and Judaism—have taken a tolerant position in these matters, some denominations within them are vigorously opposed to it. This chapter presents a range of cultural and religious views of brain death determination and organ donation. In addition to the three major religions, Buddhist and native American views regarding brain death determination as well as organ donation are discussed. Conflict resolution over organ donation is discussed along with the role of clergy in mediating such conflicts between families and medical staff.

scholarly journals The landscape of international living kidney donation in the United States

2019 ◽  
Vol 19 (7) ◽  
pp. 2009-2019 ◽  
Author(s):  
Fawaz Al Ammary ◽  
Alvin G. Thomas ◽  
Allan B. Massie ◽  
Abimereki D. Muzaale ◽  
Ashton A. Shaffer ◽  
...  
Keyword(s):  
United States ◽  
The United States ◽  
Kidney Donation ◽  
Living Kidney Donation

scholarly journals Organ Donation and Utilization in the United States, 1997–2006

2008 ◽  
Vol 8 (4p2) ◽  
pp. 922-934 ◽  
Author(s):  
R. S. Sung ◽  
J. Galloway ◽  
J. E. Tuttle-Newhall ◽  
T. Mone ◽  
R. Laeng ◽  
...  
Keyword(s):  
United States ◽  
Organ Donation ◽  
The United States

scholarly journals Trends in Organ Donation and Transplantation in the United States, 1996?2005

2007 ◽  
Vol 7 (s1) ◽  
pp. 1319-1326 ◽  
Author(s):  
F. K. Port ◽  
R. M. Merion ◽  
M. P. Finley ◽  
N. P. Goodrich ◽  
R. A. Wolfe
Keyword(s):  
United States ◽  
Organ Donation ◽  
The United States
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