scholarly journals Disease Associations With Monoclonal Gammopathy of Undetermined Significance: A Population-Based Study of 17,398 Patients

2009 ◽  
Vol 84 (8) ◽  
pp. 685-693 ◽  
Author(s):  
John P. Bida ◽  
Robert A. Kyle ◽  
Terry M. Therneau ◽  
L. Joseph Melton ◽  
Matthew F. Plevak ◽  
...  
Keyword(s):  
Monoclonal Gammopathy ◽  
Population Based ◽  
Population Based Study ◽  
Disease Associations ◽  
Undetermined Significance

scholarly journals Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: a population-based study

2017 ◽  
Vol 1 (24) ◽  
pp. 2186-2192 ◽  
Author(s):  
Marianna Thordardottir ◽  
Ebba K. Lindqvist ◽  
Sigrun H. Lund ◽  
Rene Costello ◽  
Debra Burton ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Multiple Myeloma ◽  
Body Mass ◽  
Monoclonal Gammopathy ◽  
High Body Mass Index ◽  
Population Based ◽  
Population Based Study ◽  
Increased Risk ◽  
Key Points ◽  
Undetermined Significance

Key PointsObesity is not associated with MGUS or LC-MGUS. High body mass index during midlife is associated with increased risk of progressing from MGUS and LC-MGUS to MM and other LP diseases.

Peripheral neuropathy and monoclonal gammopathy of undetermined significance: A population-based study including 15,351 cases and 58,619 matched controls

2019 ◽  
Vol 19 (10) ◽  
pp. e329
Author(s):  
Sæmundur Rögnvaldsson ◽  
Vilhjálmur Steingrímsson ◽  
Ingemar Turesson ◽  
Magnus Björkholm ◽  
C. Ola Landgren ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Monoclonal Gammopathy ◽  
Population Based ◽  
Population Based Study ◽  
Undetermined Significance

scholarly journals Parental longevity and survival among patients with multiple myeloma and monoclonal gammopathy of undetermined significance: a population‐based study

2019 ◽  
Vol 186 (1) ◽  
pp. 37-44
Author(s):  
Ingigerður S. Sverrisdóttir ◽  
Sigrún H. Lund ◽  
Ingemar Turesson ◽  
Magnus Björkholm ◽  
Lynn R. Goldin ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Monoclonal Gammopathy ◽  
Population Based ◽  
Population Based Study ◽  
Parental Longevity ◽  
Undetermined Significance

scholarly journals Peripheral neuropathy and monoclonal gammopathy of undetermined significance: a population-based study including 15,351 cases and 58,619 matched controls

Haematologica ◽  
2020 ◽  
Vol 105 (11) ◽  
pp. 2679-2681 ◽  
Author(s):  
Sæmundur Rögnvaldsson ◽  
Vilhjálmur Steingrímsson ◽  
Ingemar Turesson ◽  
Magnus Björkholm ◽  
Ola Landgren ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Monoclonal Gammopathy ◽  
Population Based ◽  
Population Based Study ◽  
Undetermined Significance

Familial Aggregation of Multiple Myeloma and Its Precursor Monoclonal Gammopathy of Undetermined Significance (MGUS): A Population-Based Study in Sweden.

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 1678-1678
Author(s):  
Sigurdur Y Kristinsson ◽  
Magnus Bjorkholm ◽  
Lynn R. Goldin ◽  
Cecilie Blimark ◽  
Ulf-Henrik Mellqvist ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Hodgkin Lymphoma ◽  
Monoclonal Gammopathy ◽  
Familial Aggregation ◽  
Large Population ◽  
Population Based ◽  
Case Control ◽  
Population Based Study ◽  
First Degree Relatives ◽  
Undetermined Significance

Abstract Background: Evidence from multiply affected families, case-control and population-based registry studies implicate a role for genetic factors in multiple myeloma (MM). The aim of this large population-based familial case-control study was to quantify risks of MM, monoclonal gammopathy of undetermined significance (MGUS), and other lymphoproliferative disorders among first-degree relatives of MM patients. Methods: We identified 13,963 MM patients diagnosed in Swedish hospitals 1958–2005, with linkable relatives. Using the population-based central Population- and Multigenerational registries, we obtained 54,610 matched controls and first-degree relatives of MM patients (n=37,838) and controls (n=151,068). Relatives of MM patients and controls were linked with hospital-based outpatient registries and the central Swedish Cancer Registry to define occurrence of MGUS and lymphoproliferative malignancies. Measures of familial aggregation were calculated by a marginal survival model using relatives as the cohort. Results: First-degree relatives of MM patients had a significantly increased risk of developing MM [relative risk (RR)=2.1; (95% confidence interval (CI), 1.6–2.9)] and MGUS [2.1 (1.5–3.1)]. The risk estimates were very similar when we conducted analyses by gender of proband, by type of first-degree relative (parent, sibling, offspring), and by age at MM diagnosis (below/above 65 yrs) for probands. Among relatives of MM patients, we found no excess risk of chronic lymphocytic leukemia, non-Hodgkin lymphoma, Hodgkin lymphoma, or lymphoplasmacytic lymphoma/Waldenström’s macroglobulinemia. Conclusions: In this large population-based study, we found relatives of MM patients to have a 2-fold excess risk of developing MM and MGUS compared with relatives of controls. Our findings support the theory that there are common, shared susceptibility genes that predispose to MM and MGUS. Better characterization of early genetic lesions mediating monoclonal plasma-cell proliferation, survival, and migration in the bone marrow microenvironment will potentially provide clues to pathogenesis and allow identification of novel molecular targets.

scholarly journals Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study

Haematologica ◽  
2011 ◽  
Vol 97 (6) ◽  
pp. 854-858 ◽  
Author(s):  
S. Y. Kristinsson ◽  
M. Tang ◽  
R. M. Pfeiffer ◽  
M. Bjorkholm ◽  
L. R. Goldin ◽  
...  
Keyword(s):  
Monoclonal Gammopathy ◽  
Population Based ◽  
Population Based Study ◽  
Undetermined Significance

scholarly journals Bone disease in monoclonal gammopathy of undetermined significance: results from a screened population-based study

2017 ◽  
Vol 1 (27) ◽  
pp. 2790-2798 ◽  
Author(s):  
Sigrun Thorsteinsdottir ◽  
Sigrun H. Lund ◽  
Ebba K. Lindqvist ◽  
Marianna Thordardottir ◽  
Gunnar Sigurdsson ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Bone Disease ◽  
Monoclonal Gammopathy ◽  
Population Based ◽  
Bone Volume ◽  
Population Based Study ◽  
Key Points ◽  
Undetermined Significance

Key PointsIndividuals with MGUS did not have a decreased BMD compared with others in a screened population. Individuals with MGUS had an increased bone volume at the hip and lumbar spine compared with others.

scholarly journals Patterns of survival and causes of death following a diagnosis of monoclonal gammopathy of undetermined significance: a population-based study

Haematologica ◽  
2009 ◽  
Vol 94 (12) ◽  
pp. 1714-1720 ◽  
Author(s):  
S. Y. Kristinsson ◽  
M. Bjorkholm ◽  
T. M-L Andersson ◽  
S. Eloranta ◽  
P. W. Dickman ◽  
...  
Keyword(s):  
Monoclonal Gammopathy ◽  
Causes Of Death ◽  
Population Based ◽  
Population Based Study ◽  
Undetermined Significance
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