Increased Left Atrial Volume Index: Potent Biomarker for First-Ever Ischemic Stroke

2008 ◽  
Vol 83 (10) ◽  
pp. 1107-1114 ◽  
Author(s):  
Kaniz Fatema ◽  
Kent R. Bailey ◽  
George W. Petty ◽  
Irene Meissner ◽  
Martin Osranek ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Left Atrial ◽  
Left Atrial Volume ◽  
Volume Index ◽  
Atrial Volume ◽  
Left Atrial Volume Index

Left Atrial Volume Index Predicts New-Onset Atrial Fibrillation and Stroke Recurrence in Patients with Embolic Stroke of Undetermined Source

2020 ◽  
Vol 49 (3) ◽  
pp. 285-291
Author(s):  
Benjamin Y.Q. Tan ◽  
Jamie Sin Ying Ho ◽  
Ching-Hui Sia ◽  
Yushan Boi ◽  
Anthia S.M. Foo ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Left Atrial ◽  
Left Atrial Volume ◽  
Volume Index ◽  
Stroke Recurrence ◽  
Atrial Volume ◽  
Left Atrial Volume Index ◽  
Onset Atrial Fibrillation ◽  
New Onset

Introduction: It is unclear which surrogate of atrial cardiopathy best predicts the risk of developing a recurrent ischemic stroke in embolic stroke of undetermined source (ESUS). Left atrial diameter (LAD) and LAD index (LADi) are often used as markers of left atrial enlargement in current ESUS research, but left atrial volume index (LAVi) has been found to be a better predictor of cardiovascular outcomes in other patient populations. Objective: We aim to compare the performance of LAVi, LAD, and LADi in predicting the development of new-onset atrial fibrillation (AF) and stroke recurrence in ESUS. Methods: Between October 2014 and October 2017, consecutive patients diagnosed with ESUS were followed for new-onset AF, ischemic stroke recurrence, and a composite outcome of occult AF and stroke recurrence. LAVi and LADi were measured by transthoracic echocardiogram; “high” LAVi was defined as ≥35 mL/m2 in accordance with American Society of Echocardiography guidelines. Results: 185 ischemic stroke patients with ESUS were recruited and followed for a median duration of 2.1 years. Increased LAVi was associated with new-onset AF detection (aOR 1.08; 95% CI 1.03–1.14; p = 0.003) and stroke recurrence (aOR 1.05; 95% CI 1.01–1.10; p = 0.026). Patients with “high” LAVi had a higher likelihood of developing a composite of AF detection and stroke recurrence (HR 3.45; 95% CI 1.55–7.67; p = 0.002). No significant association was observed between LADi and either occult AF or stroke recurrence. Conclusions: LAVi is associated with new-onset AF and stroke recurrence in ESUS patients and may be a better surrogate of atrial cardiopathy.

The Role of Left Atrial Volume Index in Patients with a First-ever Acute Ischemic Stroke

2017 ◽  
Vol 26 (2) ◽  
pp. 321-326 ◽  
Author(s):  
Murat Biteker ◽  
Kadir Kayataş ◽  
Özcan Başaran ◽  
Volkan Dogan ◽  
Eda Özlek ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Left Atrial ◽  
Left Atrial Volume ◽  
Volume Index ◽  
Atrial Volume ◽  
Left Atrial Volume Index

Abstract 25: Left Atrial Volume Index is Associated With Atrial Fibrillation and Recurrent Stroke in Embolic Stroke of Undetermined Source (ESUS)

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Jamie S Ho ◽  
Ching-Hui Sia ◽  
Yushan Boi ◽  
Anthia S Foo ◽  
Mayank Dalakoti ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Left Atrial ◽  
Recurrent Stroke ◽  
Left Atrial Volume ◽  
Embolic Stroke ◽  
Volume Index ◽  
Stroke Recurrence ◽  
Atrial Volume ◽  
Left Atrial Volume Index ◽  
Kaplan Meier

In ESUS, the relationship between atrial cardiopathy, occult AF and embolic stroke risk remains unclear. Studies suggest that left atrial volume index (LAVi) may be a better estimate of atrial cardiopathy than LA diameter. We explored LAVi as a marker of occult AF detection and ischemic stroke recurrence. Methods: From 2015-2017, consecutive ESUS patients diagnosed based on consensus criteria were studied. LAVi was measured using the Biplane Area-Length Method on TTE by trained cardiologists. Clinical outcomes measured were occult AF detection and ischemic stroke recurrence in a time-to-event analysis. Kaplan-Meier curves were constructed to compare outcomes in those with high versus low LAVi at optimized cut-off values. Results: 199 consecutive ESUS patients were followed up for 2.2±1.0 years. 9 patients were excluded due to technically inadequate views. Increased LAVi was associated with AF detection (36.63mL/m 2 ± 12.2 vs 26.93mL/m 2 ± 9.6) and stroke recurrence (32.13mL/m 2 ± 9.3 vs 27.23mL/m 2 ± 10.1). On multivariate regression adjusting for age, sex, hypertension and diabetes mellitus, LAVI was independently associated with AF detection (OR 1.08, CI 95% 1.03-1.14; p=0.003) and stroke recurrence (OR 1.05, CI 95% 1.01-1.10; p=0.026). Kaplan-Meier curves showed significant differences in occult AF (log-rank 8.67, p=0.003) and stroke recurrence (log-rank 5.31, p=0.021) between high (>27.7ml/m 2 ) and low LAVi (≤27.7ml/m 2 ) groups. Conclusion: Increased LAVi in ESUS patients was associated with AF detection and stroke recurrence, suggesting that this may be a useful echocardiographic marker to identify high-risk patients who may potentially benefit from anticoagulation.

scholarly journals Right atrial to left atrial volume index ratio is associated with increased mortality in patients with pulmonary hypertension

2018 ◽  
Vol 35 (11) ◽  
pp. 1729-1735 ◽  
Author(s):  
Manu M. Mysore ◽  
Kenneth C. Bilchick ◽  
Priscilla Ababio ◽  
Benjamin K. Ruth ◽  
William C. Harding ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Left Atrial ◽  
Left Atrial Volume ◽  
Right Atrial ◽  
Volume Index ◽  
Atrial Volume ◽  
Left Atrial Volume Index ◽  
Index Ratio
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