scholarly journals Principles and Process in the Development of the Mayo Clinic's Individual and Institutional Conflict of Interest Policy

2005 ◽  
Vol 80 (10) ◽  
pp. 1340-1346 ◽  
Author(s):  
Michael Camilleri ◽  
Gail L. Gamble ◽  
Stephen L. Kopecky ◽  
Michael B. Wood ◽  
Marianne L. Hockema
Keyword(s):  
Conflict Of Interest ◽  
Interest Policy ◽  
Institutional Conflict

scholarly journals Conflict of interest policy

Hepatology ◽  
2007 ◽  
Vol 47 (1) ◽  
pp. 1-1 ◽  
Author(s):  
Keith Lindor ◽  
Jorge Rakela ◽  
John Fung
Keyword(s):  
Conflict Of Interest ◽  
Interest Policy

Institutional conflict of interest: attempting to crack the deferiprone mystery

2020 ◽  
pp. medethics-2019-105498
Author(s):  
Arthur Schafer
Keyword(s):  
Conflict Of Interest ◽  
Ethical Issues ◽  
Mission Statement ◽  
Historical Context ◽  
First Line ◽  
Harm Minimisation ◽  
Safety And Efficacy ◽  
Explanatory Hypothesis ◽  
Large Numbers ◽  
Institutional Conflict

A recent study by Olivieri et al, published in PLOS ONE, reports that between 2009 and 2015 a third of patients with thalassaemia in Canada’s largest hospital were switched from first-line licensed drugs to regimens of deferiprone, an unlicensed drug of unproven safety and efficacy. Based on retrospective data from patient records, the PLOS Study reports that patients treated with deferiprone, either as monotherapy or in combination with first-line drugs, suffered serious (and often irreversible) adverse effects. The data reported by Olivieri et al give rise to a number of ethical issues. These ethical issues are identified, placed in historical context and analysed. For purposes of this analysis, reliance is placed on two core principles of research ethics, harm minimisation and informed consent, and also on the hospital’s mission statement. Then a mystery is explored: How and why did it happen that Toronto’s University Health Network treated large numbers of patients with an unlicensed drug over a period of many years? ‘Institutional conflict of interest’ is considered as a possible explanatory hypothesis.

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